Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects

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Equol: History, Chemistry, and Formation

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Method of Defining Equol-Producer Status and Its Frequency among Vegetarians

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Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women

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Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella

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Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin

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An insight into the health benefits of fermented soy products

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Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women

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Equol Is a Novel Anti-Androgen that Inhibits Prostate Growth and Hormone Feedback1

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Comparisons of Percent Equol Producers between Prostate Cancer Patients and Controls: Case-controlled Studies of Isoflavones in Japanese, Korean and American Residents

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A Meta-Analysis of the Effect of Soy Protein Supplementation on Serum Lipids

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Isolation and characterisation of an equol-producing mixed microbial culture from a human faecal sample and its activity under gastrointestinal conditions

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Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones

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Enantioselective Synthesis of S-Equol from Dihydrodaidzein by a Newly Isolated Anaerobic Human Intestinal Bacterium

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Emerging evidence of the health benefits of S-equol, an estrogen receptor β agonist

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The Role of Colonic Bacteria in the Metabolism of the Natural Isoflavone Daidzin to Equol

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Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review

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Plasma phytoestrogens and subsequent breast cancer risk

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Systematic review of soy isoflavone supplements on osteoporosis in women

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Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects.

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Systematic review, meta-analysis and regression of randomised controlled trials reporting an association between an intake of circa 25g soya protein per day and blood cholesterol

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Isoflavones and Functional Foods Alter the Dominant Intestinal Microbiota in Postmenopausal Women

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Microbial and Dietary Factors Are Associated with the Equol Producer Phenotype in Healthy Postmenopausal Women , ,3

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The Isoflavone Equol Mediates Rapid Vascular Relaxation

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Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine

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New equol supplement for relieving menopausal symptoms

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Phytoestrogens and cognitive function: a review

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In Vitro Incubation of Human Feces with Daidzein and Antibiotics Suggests Interindividual Differences in the Bacteria Responsible for Equol Production

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Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks

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Daidzein and Genistein Are Converted to Equol and 5-Hydroxy-Equol by Human Intestinal Slackia isoflavoniconvertens in Gnotobiotic Rats3

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Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women

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Fecal Bacterial Community Changes Associated with Isoflavone Metabolites in Postmenopausal Women after Soy Bar Consumption

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Equol, a new inactive phenol isolated from the ketohydroxyoestrin fraction of mares' urine

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Soy and soy isoflavones in prostate cancer: a systematic review and meta‐analysis of randomized controlled trials

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Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial

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Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women

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Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones

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The Family Coriobacteriaceae

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Isolation and Characterization of a Novel Equol-Producing Bacterium from Human Feces

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Identification and Expression of Genes Involved in the Conversion of Daidzein and Genistein by the Equol-Forming Bacterium Slackia isoflavoniconvertens

Schröder, C., Matthies, A., Engst, W., Blaut, M., & Braune, A. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03693-12 · Cited by 124

A Natural S -Equol Supplement Alleviates Hot Flushes and Other Menopausal Symptoms in Equol Nonproducing Postmenopausal Japanese Women

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Soy isoflavones’ osteoprotective role in postmenopausal women: mechanism of action

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Oxidative metabolism and genotoxic potential of major isoflavone phytoestrogens

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Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine

Minamida, K., Tanaka, M., Abe, A., Sone, T., Tomita, F., Hara, H., & Asano, K. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.102.247 · Cited by 114

Disposition of soy isoflavones in normal human breast tissue

Bolca, S., Urpí-Sardà, M., Blondeel, P. N., Roche, N. A., Vanhaecke, L., Possemiers, S., Al‐Maharik, N., Botting, N. P., Keukeleire, D. D., Bracke, M., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28854 · Cited by 113

Absorption, distribution, metabolism, and excretion of isoflavonoids after soy intake

Franke, A. A., Lai, J. F., & Halm, B. M. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.06.007 · Cited by 112

Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms

Bolaños, R., Castillo, A. D., & Romero, J. F. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181cb4fb5 · Cited by 104

Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol

Jin, J., Kitahara, M., Sakamoto, M., Hattori, M., & Benno, Y. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.016774-0 · Cited by 104

Phytoestrogens and prevention of breast cancer: The contentious debate

Bilal, I. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i4.705 · Cited by 102

Effect of S-equol and Soy Isoflavones on Heart and Brain

Sekikawa, A. M., Ihara, M., López, O. L., Kakuta, C., Lopresti, B. J., Higashiyama, A., Aizenstein, H. J., Chang, Y., Mathis, C. A., Miyamoto, Y., et al. (2018) · Current Cardiology Reviews · doi:10.2174/1573403x15666181205104717 · Cited by 102

The antioxidant activity of daidzein metabolites, O-desmethylangolensin and equol, in HepG2 cells

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The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study

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Variations in Plasma Phytoestrogen Concentrations in European Adults

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Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation

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Effect of soy nuts and equol status on blood pressure, lipids and inflammation in postmenopausal women stratified by metabolic syndrome status

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O-Desmethylangolensin: The Importance of Equol's Lesser Known Cousin to Human Health

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Effects of soy isoflavone supplements on bone turnover markers in menopausal women: Systematic review and meta-analysis of randomized controlled trials

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Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal women

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Phase II metabolism of the soy isoflavones genistein and daidzein in humans, rats and mice: a cross-species and sex comparison

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Cloning and Expression of a Novel NADP(H)-Dependent Daidzein Reductase, an Enzyme Involved in the Metabolism of Daidzein, from Equol-Producing Lactococcus Strain 20-92

Shimada, Y., Yasuda, S., Takahashi, M., Hayashi, T., Miyazawa, N., Sato, I., Abiru, Y., Uchiyama, S., & Hishigaki, H. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01101-10 · Cited by 91

Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a randomized crossover trial

Pawlowski, J. W., Martin, B. R., McCabe, G. P., McCabe, L. D., Jackson, G. S., Peacock, M., Barnes, S., & Weaver, C. M. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.093906 · Cited by 91

Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones

Jou, H., Wu, S., Chang, F.-W., Ling, P., Chu, K. S., & Wu, W.-H. (2008) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2008.01.028 · Cited by 90

Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation

Mizushina, Y., Shiomi, K., Kuriyama, I., Takahashi, Y., & Yoshida, H. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2032 · Cited by 89

Production of phytoestrogen S-equol from daidzein in mixed culture of two anaerobic bacteria

Wang, X., Kim, H.-J., Kang, S.-I., Kim, S., & Hur, H. (2006) · Archives of Microbiology · doi:10.1007/s00203-006-0183-8 · Cited by 82

Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells

Rowlands, D. J., Chapple, S. J., Siow, R. C. M., & Mann, G. E. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.162198 · Cited by 82

The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women.

Fournier, L. R., Ryan-Borchers, T., Robison, L. M., Wiediger, M. D., Park, J. S., Chew, B. P., McGuire, S., Sclar, D. A., Skaer, T. L., & Beerman, K. A. (2007) · PubMed · Cited by 81

Familial Correlations, Segregation Analysis, and Nongenetic Correlates of Soy Isoflavone–Metabolizing Phenotypes

Frankenfeld, C. L., Atkinson, C., Thomas, W. K., Goode, E., Gonzalez, A. J., Jokela, T., Wähälä, K., Schwartz, S. M., Li, S. S., & Lampe, J. W. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900906 · Cited by 81

Identification of a Novel Dihydrodaidzein Racemase Essential for Biosynthesis of Equol from Daidzein in Lactococcus sp. Strain 20-92

Shimada, Y., Takahashi, M., Miyazawa, N., Abiru, Y., Uchiyama, S., & Hishigaki, H. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.00410-12 · Cited by 79

Isolation and characterization of the equol-producing bacterium Slackia sp. strain NATTS

Tsuji, H., Moriyama, K., Nomoto, K., Miyanaga, N., & Akaza, H. (2010) · Archives of Microbiology · doi:10.1007/s00203-010-0546-z · Cited by 78

Isolation of an isoflavone-metabolizing, Clostridium-like bacterium, strain TM-40, from human faeces

Tamura, M., Tsushida, T., & Shinohara, K. (2006) · Anaerobe · doi:10.1016/j.anaerobe.2006.10.001 · Cited by 77

Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Daily, J. W., Ko, B., Ryuk, J., Liu, M., Zhang, W., & Park, S. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2018.4265 · Cited by 76

Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study

Ward, H. A., Chapelais, G., Kuhnle, G. G., Luben, R., Khaw, K., & Bingham, S. A. (2008) · Breast Cancer Research · doi:10.1186/bcr1995 · Cited by 75

Effects of soy protein containing isoflavones in patients with chronic kidney disease: A systematic review and meta-analysis

Zhou, J., & Wei‐jie, Y. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.03.012 · Cited by 73

Stereospecific Biotransformation of Dihydrodaidzein into (3 S )-Equol by the Human Intestinal Bacterium Eggerthella Strain Julong 732

Kim, M., Kim, S., Han, J., Wang, X., Song, D., & Kim, S.-U. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02058-08 · Cited by 73

Health impact of childhood and adolescent soy consumption

Messina, M. J., Rogero, M. M., Fisberg, M., & Waitzberg, D. L. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux016 · Cited by 73

Effect of Soy and Soy Isoflavones on Obesity-Related Anthropometric Measures: A Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials

Akhlaghi, M., Zare, M., & Nouripour, F. (2017) · Advances in Nutrition · doi:10.3945/an.117.015370 · Cited by 73

Biochemical investigation and gene analysis of equol: A plant and soy‐derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications

Gopaul, R., Knaggs, H. E., & Lephart, E. D. (2012) · BioFactors · doi:10.1002/biof.191 · Cited by 72

Do soy isoflavones improve cognitive function in postmenopausal women? A meta-analysis

Cheng, P.-F., Chen, J., Zhou, X., Ren, Y., Huang, W. C., Zhou, J.-J., & Xie, P. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000290 · Cited by 71

Equol status and changes in fecal microbiota in menopausal women receiving long-term treatment for menopause symptoms with a soy-isoflavone concentrate

Guadamuro, L., Delgado, S., Redruello, B., Flórez, A. B., Suárez, A., Martínez‐Camblor, P., & Mayo, B. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00777 · Cited by 68

A Pilot Study on the Effects of S -Equol Compared to Soy Isoflavones on Menopausal Hot Flash Frequency

Jenks, B. H., Iwashita, S., Nakagawa, Y., Ragland, K., Lee, J., Carson, W. H., Ueno, T., & Uchiyama, S. (2012) · Journal of Women s Health · doi:10.1089/jwh.2011.3153 · Cited by 67

Isolation and identification of equol-producing bacterial strains from cultures of pig faeces

Yu, Z., Yao, W., & Zhu, W. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2008.01108.x · Cited by 66

Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells

Lehmann, L., Esch, H. L., Wagner, J., Rohnstock, L., & Metzler, M. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.02.011 · Cited by 64

Identification of an Enzyme System for Daidzein-to-Equol Conversion in Slackia sp. Strain NATTS

Tsuji, H., Moriyama, K., Nomoto, K., & Akaza, H. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06779-11 · Cited by 64

Dietary Phytoestrogen Intake and Cognitive Function in Older Women

Kreijkamp‐Kaspers, S., Kok, L., Grobbee, D. E., de Haan, E. H. F., Aleman, A., & van der Schouw, Y. T. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.5.556 · Cited by 64

Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells

Pugazhendhi, D., Watson, K. A., Mills, S. E. E., Botting, N. P., Pope, G. S., & Darbre, P. D. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0384 · Cited by 63

The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption

Nettleton, J. A., Greany, K. A., Thomas, W., Wangen, K. E., Adlercreutz, H., & Kurzer, M. S. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.603 · Cited by 62

Equol production changes over time in postmenopausal women

Franke, A. A., Lai, J. F., Halm, B. M., Pagano, I., Kono, N., Mack, W. J., & Hodis, H. N. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.03.002 · Cited by 62

Administration of Equol-Producing Bacteria Alters the Equol Production Status in the Simulator of the Gastrointestinal Microbial Ecosystem (SHIME)

Decroos, K., Eeckhaut, E., Possemiers, S., & Verstraete, W. (2006) · Journal of Nutrition · doi:10.1093/jn/136.4.946 · Cited by 61

Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian-American women in Los Angeles County

Wu, A. H. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg189 · Cited by 60

Equol Inhibits LPS-Induced Oxidative Stress and Enhances the Immune Response in Chicken HD11 Macrophages

Gou, Z., Jiang, S., Zheng, C., Tian, Z., & Lin, X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430124 · Cited by 59

S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway

Lu, Z., Zhou, R., Kong, Y., Wang, J., Xia, W., Guo, J., Liu, J., Sun, H., Liu, K., Yang, J., et al. (2016) · Current Cancer Drug Targets · doi:10.2174/1568009616666151207105720 · Cited by 59

Lactobacillus intestinalis efficiently produces equol from daidzein and chungkookjang, short-term fermented soybeans

Heng, Y., Kim, M. J., Yang, H. J., Kang, S., & Park, S. (2019) · Archives of Microbiology · doi:10.1007/s00203-019-01665-5 · Cited by 58

The effects of natural S-equol supplementation on skin aging in postmenopausal women

Oyama, A., Ueno, T., Uchiyama, S., Aihara, T., Miyake, A., Kondo, S., & Matsunaga, K. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318227427b · Cited by 57

Effects of Phytoestrogens Genistein and Daidzein on Prostacyclin Production by Human Endothelial Cells

Hermenegildo, C., Oviedo, P. J., García‐Pérez, M. Á., Tarín, J. J., & Cano, A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.090456 · Cited by 57

The production of S-equol from daidzein is associated with a cluster of three genes in Eggerthella sp. YY7918

Kawada, Y., Yokoyama, S., Yanase, E., Niwa, T., & Suzuki, T. (2016) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2015-023 · Cited by 55

Food factors for atherosclerosis prevention: Asian perspective derived from analyses of worldwide dietary biomarkers.

Yamori, Y. (2006) · PubMed · Cited by 54

Resistant starch promotes equol production and inhibits tibial bone loss in ovariectomized mice treated with daidzein

Tousen, Y., Abe, F., Ishida, T., Uehara, M., & Ishimi, Y. (2011) · Metabolism · doi:10.1016/j.metabol.2011.02.009 · Cited by 52

Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice

Gonzalez-Granillo, M. A., Steffensen, K. R., Granados, O., Torres, N., Korach-André, M., Ortíz-Ortega, V. M., Aguilar-Salinas, C., Jakobsson, T., Díaz‐Villaseñor, A., Loza‐Valdes, A., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2599-9 · Cited by 51

Dairy consumption is a significant correlate of urinary equol concentration in a representative sample of US adults

Frankenfeld, C. L. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.011825 · Cited by 51

Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers

Thorp, A. A., Howe, P. R. C., Mori, T. A., Coates, A. M., Buckley, J. D., Hodgson, J. M., Mansour, J., & Meyer, B. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.298 · Cited by 51

Soy isoflavones and glucose metabolism in menopausal women: A systematic review and meta‐analysis of randomized controlled trials

Fang, K., Dong, H., Wang, D., Gong, J., Huang, W., & Lu, F. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501024 · Cited by 51

Quantification of Slackia and Eggerthella spp. in Human Feces and Adhesion of Representatives Strains to Caco-2 Cells

Cho, G., Ritzmann, F., Eckstein, M., Huch, M., Briviba, K., Behsnilian, D., Neve, H., & Franz, C. M. A. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00658 · Cited by 51

Effects of Equol Supplement on Bone and Cardiovascular Parameters in Middle-Aged Japanese Women: A Prospective Observational Study

Yoshikata, R., Myint, K. Z. Y., & Ohta, H. (2018) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2018.0050 · Cited by 51

Inter-relationship between diet, lifestyle habits, gut microflora, and the equol-producer phenotype: baseline findings from a placebo-controlled intervention trial

Yoshikata, R., Myint, K. Z. Y., Ohta, H., & Ishigaki, Y. (2018) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001202 · Cited by 51

Soy intake and blood cholesterol concentrations: a cross-sectional study of 1033 pre- and postmenopausal women in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition

Rosell, M., Appleby, P. N., Spencer, E. A., & Key, T. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1391 · Cited by 50

Identification of Two Novel Reductases Involved in Equol Biosynthesis in Lactococcus Strain 20–92

Shimada, Y., Takahashi, M., Miyazawa, N., Ohtani, T., Abiru, Y., Uchiyama, S., & Hishigaki, H. (2011) · Microbial Physiology · doi:10.1159/000335049 · Cited by 49

Equol status and blood lipid profile in hyperlipidemia after consumption of diets containing soy foods

Wong, J. M., Kendall, C. W., Marchie, A., Liu, Z., Vidgen, E., Holmes, C., Jackson, C.-J., Josse, R. G., Pencharz, P. B., Rao, A. V., et al. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.017418 · Cited by 47

Equol inhibits prostate cancer growth through degradation of androgen receptor by S‐phase kinase‐associated protein 2

Itsumi, M., Shiota, M., Takeuchi, A., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Kajioka, S., Uchiumi, T., Naito, S., Eto, M., et al. (2016) · Cancer Science · doi:10.1111/cas.12948 · Cited by 47

Complete Genomic Sequence of the Equol-Producing Bacterium Eggerthella sp. Strain YY7918, Isolated from Adult Human Intestine

Yokoyama, S., Oshima, K., Nomura, I., Hattori, M., & Suzuki, T. (2011) · Journal of Bacteriology · doi:10.1128/jb.05626-11 · Cited by 46

Isoflavone supplement composition and equol producer status affect gene expression in adipose tissue: a double-blind, randomized, placebo-controlled crossover trial in postmenopausal women

van der Velpen, V., Geelen, A., Hollman, P. C. H., Schouten, E. G., Veer, P. V. ’., & Afman, L. A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088484 · Cited by 46

Development and Use of a Real-Time Quantitative PCR Method for Detecting and Quantifying Equol-Producing Bacteria in Human Faecal Samples and Slurry Cultures

Vázquez, L., Guadamuro, L., Giganto, F., Mayo, B., & Flórez, A. B. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01155 · Cited by 46

Randomized controlled trial of whole soy and isoflavone daidzein on menopausal symptoms in equol-producing Chinese postmenopausal women

Liu, Z., Ho, S. C., Woo, J., Chen, Y., & Wong, C. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000102 · Cited by 45

Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells

Zhang, T., Hu, Q., Shi, L., Li, Q., Zhang, Q., & Mi, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167020 · Cited by 44

Biosynthesis of (−)-5-Hydroxy-equol and 5-Hydroxy-dehydroequol from Soy Isoflavone, Genistein Using Microbial Whole Cell Bioconversion

Lee, P., Kim, J., Kim, E., Lee, S.-H., Choi, K.-Y., Kazlauskas, R. J., & Kim, B. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00624 · Cited by 44

Bioconversion of daidzein to equol by Bifidobacterium breve 15700 and Bifidobacterium longum BB536

Elghali, S., Mustafa, S., Amid, M., Manap, M. Y. A., Ismail, A., & Abas, F. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.04.013 · Cited by 42

Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice

Lin, I.-C., Yamashita, S., Murata, M., Kumazoe, M., & Tachibana, H. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.02.012 · Cited by 41

A cross-sectional study of equol producer status and self-reported vasomotor symptoms

Newton, K. M., Reed, S. D., Uchiyama, S., Qu, C., Ueno, T., Iwashita, S., Gunderson, G., Fuller, S., & Lampe, J. W. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000363 · Cited by 41

Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men

Ahuja, V., Miura, K., Vishnu, A., Fujiyoshi, A., Evans, R., Zaid, M., Miyagawa, N., Hisamatsu, T., Kadota, A., Okamura, T., et al. (2017) · British Journal Of Nutrition · doi:10.1017/s000711451600458x · Cited by 41

Elucidation of the metabolic pathway of S-equol in rat, monkey and man

Schwen, R. J., Nguyen, L., & Jackson, R. L. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.03.048 · Cited by 40

Prevalence of Dementia in China

Liu, L., Guo, X.-E., Zhou, Y.-Q., & Xia, J. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000068784 · Cited by 40

Pre-Treatment Effect of Different Doses of Soy Isoflavones on Spatial Learning and Memory in an Ovariectomized Animal Model of Alzheimer`s Disease

Sarkaki, A., Amani, R., Badavi, M., Moghadd, A. Z., Aligholi, H., Safahani, M., & Haghigh, M. H. (2008) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2008.1114.1119 · Cited by 40

Over 3 decades of research on dietary flavonoid antioxidants and cancer prevention: What have we achieved?

Alfa, H. H., & Arroo, R. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09632-0 · Cited by 40

Impact of dose, frequency of administration, and equol production on efficacy of isoflavones for menopausal hot flashes

Crawford, S. L., Jackson, E. A., Churchill, L., Lampe, J. W., Leung, K., & Ockene, J. K. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182829413 · Cited by 39

S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice

Horiuchi, H., Usami, A., Shirai, R., Harada, N., Ikushiro, S., Sakaki, T., Nakano, Y., Inui, H., & Yamaji, R. (2017) · Journal of Nutrition · doi:10.3945/jn.117.250860 · Cited by 38

P212A Mutant of Dihydrodaidzein Reductase Enhances ( S )-Equol Production and Enantioselectivity in a Recombinant Escherichia coli Whole-Cell Reaction System

Lee, P., Kim, J., Kim, E.-J., Jung, E., Pandey, B. P., & Kim, B. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.03584-15 · Cited by 36

Isolation and identification of new bacterial stains producing equol from Pueraria lobata extract fermentation

Kwon, J. E., Lim, J., Kim, I., Kim, D., & Kang, S. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192490 · Cited by 36

Transcriptional Regulation of the Equol Biosynthesis Gene Cluster in Adlercreutzia equolifaciens DSM19450T

Flórez, A. B., Vázquez, L., Rodríguez, J., Redruello, B., & Mayo, B. (2019) · Nutrients · doi:10.3390/nu11050993 · Cited by 36

Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens

Hertrampf, T., Schmidt, S., Laudenbach-Leschowsky, U., Seibel, J., & Diel, P. R. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.08.007 · Cited by 35

Equol Status Modifies the Association of Soy Intake and Mammographic Density in a Sample of Postmenopausal Women

Fuhrman, B. J., Teter, B. E., Barba, M., Byrne, C., Cavalleri, A., Grant, B. J. B., Horvath, P. J., Morelli, D., Venturelli, E., & Muti, P. C. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0193 · Cited by 35

S-(−)equol production is developmentally regulated and related to early diet composition

Brown, N. M., Galandi, S. L., Summer, S. S., Zhao, X., Heubi, J. E., King, E. C., & Setchell, K. D. R. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.03.005 · Cited by 34

Implications of Gene-Environment Interaction in Studies of Gene Variants in Breast Cancer: An Example of Dietary Isoflavones and the D356N Polymorphism in the Sex Hormone-Binding Globulin Gene

Low, Y.-L., Dunning, A. M., Dowsett, M., Luben, R., Khaw, K., Wareham, N. J., & Bingham, S. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2432 · Cited by 33

Distribution of Soy-Derived Phytoestrogens in Human Breast Tissue and Biological Fluids

Maubach, J., Depypere, H. T., Goeman, J., der Eycken, J. V., Heyerick, A., Bracke, M. E., Blondeel, P., & Keukeleire, D. D. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000124983.66521.6a · Cited by 33

Equol Enhances Apoptosis-inducing Activity of Genistein by Increasing Bax/Bcl-xL Expression Ratio in MCF-7 Human Breast Cancer Cells

Ono, M., Ejima, K., Higuchi, T., Takeshima, M., Wakimoto, R., & Nakano, S. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1367945 · Cited by 32

Intakes and sources of isoflavones, lignans, enterolignans, coumestrol and soya-containing foods in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk), from 7 d food diaries, using a newly updated database

Mulligan, A. A., Kuhnle, G., Lentjes, M. A. H., van Scheltinga, V., Powell, N., McTaggart, A., Bhaniani, A., & Khaw, K. (2012) · Public Health Nutrition · doi:10.1017/s1368980012003904 · Cited by 31

The presence of monoiodinated derivates of daidzein and genistein in human urine and its effect on thyroid gland function

Kolátorová, L., Cihlářová, P., Bičı́ková, M., Kaňová, N., & Lapčı́k, O. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.05.037 · Cited by 31

Antioxidant effect of a phytoestrogen equol on cultured muscle cells of embryonic broilers

Wei, X., Wu, J., Ni, Y., Lu, L., & Zhao, R. (2011) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-011-9464-x · Cited by 31

Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men

Shinkaruk, S., Durand, M., Lamothe, V., Carpaye, A., Martinet, A., Chantre, P., Vergne, S., Noguès, X., Moore, N. D., & Bennetau‐Pelissero, C. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.03.135 · Cited by 30

Scientific Opinion on the substantiation of health claims related to soy isoflavones and maintenance of bone mineral density (ID 1655) and reduction of vasomotor symptoms associated with menopause (ID 1654, 1704, 2140, 3093, 3154, 3590) (further assessmen

EFSA Panel on Dietetic Products, N. A. A. (. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2847 · Cited by 30

Equol Induces Mitochondria-Dependent Apoptosis in Human Gastric Cancer Cells via the Sustained Activation of ERK1/2 Pathway

Yang, Z., Zhao, Y., Yao, Y., Li, J., Wang, W., & Wu, X. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.0162 · Cited by 30

Effects of Equol on Oxidized Low-Density Lipoprotein-Induced Apoptosis in Endothelial Cells

Kamiyama, M., Kishimoto, Y., Tani, M., Utsunomiya, K., & Kondo, K. N. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.1057 · Cited by 29

Complete Genome Sequence of the Equol-Producing Bacterium Adlercreutzia equolifaciens DSM 19450 T

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