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Influence of Ultra-Processed Foods Consumption on Redox Status and Inflammatory Signaling in Young Celiac Patients

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Nestares, Teresa, Martín-Masot, Rafael, Flor-Alemany, Marta, Bonavita, Antonela, Maldonado, José, Aparicio, Virginia A.·2021·Nutrients
DOI 10.3390/nu13010156PMC PMC7825019
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Abstract

The current study was designed to assess the influence of consumption of ultra-processed (UPF) on oxidative/antioxidant balance and evoked inflammatory signaling in young patients with celiac disease (CD). The study included 85 children. The celiac group (n = 53) included children with CD with a long (>18 months, n = 17) or recent (<18 months, n = 36) adherence to a gluten-free diet (GFD). The control group (n = 32) included healthy children with a significantly lower consumption of UPF compared to the CD group, both expressed as kcal/day (p = 0.043) and as percentage of daily energy intake (p = 0.023). Among children with CD, the group with the lowest consumption of UPF (below the 50% of daily energy intake) had a greater Mediterranean diet (MD) adherence and higher moderate physical activity levels. In addition, CD children with the lowest consumption of UPF had healthier redox (lower soluble superoxide dismutase-1 and 15-F2t-isoprostanes) and inflammatory profiles (lower macrophage inflammatory protein-1α) compared to the group with the highest consumption of UPF (all, p < 0.05) regardless of the time on a GFD. These findings highlight the importance of a correct monitoring of the GFD. An unbalanced GFD with high consumption of UPF and an unhealthy pattern with less physical activity and worse adherence to MD results in a worse inflammatory profile, which could act as a parallel pathway that could have important consequences on the pathophysiology of the disease.

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Authors
Nestares, T., Martín-Masot, R., Flor-Alemany, M., Bonavita, A., Maldonado, J., & Aparicio, V. A.
Affiliations
  • Universidad de Granada (ES)
  • Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 19010 Málaga, Spain
  • Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
Corresponding author
Aparicio, Virginia A.
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2021-01-06
Volume
13
Issue
1
Pages
156
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu13010156
PMC
PMC7825019
OpenAlex
W3118767138
Cited by
24
References
6
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 5
FWCI
4.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Repository of the University of Granada (University of Granada) (publishedVersion, cc-by)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Regional Government of Andalusia. Excellence Research Project (P12-AGR-2581)
  • University of Granada (PP2017-PIP14)
  • Spanish Ministry of Education, Culture and Sports (FPU17/03715)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Consumer Attitudes and Food Labeling
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
ultra-processed foods, celiac disease, children, gluten-free diet, oxidative stress, antioxidant status, inflammation, Mediterranean diet adherence, physical activity, 8-isoprostane, macrophage inflammatory protein-1alpha, dietary adherence
MeSH terms
Superoxide Dismutase-1, Adolescent, Antibodies, Antioxidants, Energy Intake, Celiac Disease, Child, Female, Food, Humans, Male, Spain, Signal Transduction, Biomarkers, Oxidative Stress, Diet, Mediterranean, Diet, Gluten-Free

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