Cited by 220Gut microbiota and healthCeliac Disease Research and ManagementProbiotics and Fermented Foods

Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease

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Collado, Maria Carmen, Donat, Ester, Ribes-Koninckx, Carmen, Calabuig, Miguel, Sanz, Yolanda·2008·BMC Microbiology

Abstract

Background: Gut bifidobacteria are believed to influence immune-related diseases. The objective of this study was to assess the possible relationships between the gut bifidobacteria composition and coeliac disease (CD) in children. A total of 48 faecal samples (30 and 18 samples from active and no active CD patients, respectively) and 33 duodenal biopsy specimens of CD patients (25 and 8 samples from active and non-active CD patients, respectively) were analysed. Samples (30 faecal samples and 8 biopsies) from a control age-matched group of children were also included for comparative purposes. Gut Bifidobacterium genus and species were analyzed by real-time PCR. Results: Active and non-active CD patients showed lower numbers of total Bifidobacterium and B. longum species in faeces and duodenal biopsies than controls, and these differences were particularly remarkable between active CD patients and controls. B. catenulatum prevalence was higher in biopsies of controls than in those of active and non-active CD patients, whereas B. dentium prevalence was higher in faeces of non-active CD patients than in controls. Correlations between levels of Bifidobacterium and B. longum species in faecal and biopsy samples were detected in both CD patients and controls. Conclusion: Reductions in total Bifidobacterium and B. longum populations were associated with both active and non-active CD when compared to controls. These bacterial groups could constitute novel targets for adjuvant dietary therapies although the confirmation of this hypothesis would require further investigations.

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  • Reduced levels of Bifidobacterium species in celiac disease do not become normal with a gluten-free diet.

    “but reduced levels of Bifidobacterium species, a replicable finding, do not become normal with a gluten-free diet.52,53”

    From The Gut Microbiome and the Brain (2014) · cites this paper as [53]

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Authors
Collado, M. C., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y.
Affiliations
  • Hospital Universitari i Politècnic La Fe (ES)
  • Hospital General Universitario De Valencia (ES)
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
Sanz, Yolanda
Venue
BMC Microbiology
Published
2008-12
Volume
8
Issue
1
Pages
232-232
ISSN
1471-2180 (ISSN-L)
OpenAlex
W2104944380
Cited by
220
References
28
Citations by year
2026: 3 · 2025: 10 · 2024: 15 · 2023: 8 · 2022: 16 · 2021: 17 · 2020: 16 · 2019: 15 · 2018: 13 · 2017: 12 · 2016: 17 · 2015: 17 · 2014: 13 · 2013: 18 · 2012: 11
FWCI
2.60
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Ministerio de Ciencia e Innovación (CSD2007-00063)
  • European Social Fund
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
celiac disease, Bifidobacterium, Bifidobacterium longum, Bifidobacterium catenulatum, Bifidobacterium dentium, gut microbiota, fecal microbiota, duodenal biopsy, children, dietary therapy
MeSH terms
Bifidobacterium, Celiac Disease, Child, Child, Preschool, Duodenum, Feces, Female, Humans, Infant, Male, Chi-Square Distribution, Case-Control Studies, Polymerase Chain Reaction, Statistics, Nonparametric, Diet, Gluten-Free

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