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Exercise: A Possibly Effective Way to Improve Vitamin D Nutritional Status
Abstract
Vitamin D deficiency has become a widespread public health problem owing to its potential adverse health effects. Generally, the nutritional status of vitamin D depends on sunlight exposure and dietary or supplementary intake. However, recent studies have found that exercise can influence circulating 25(OH)D levels; although, the results have been inconclusive. In this review, we focused on the effect of exercise on circulating vitamin D metabolites and their possible mechanisms. We found that endurance exercise can significantly increase serum 25(OH)D levels in vitamin D-deficient people but has no significant effect on vitamin D-sufficient people. This benefit has not been observed with resistance training. Only chronic endurance exercise training can significantly increase serum 1,25(OH)2D, and the effect may be sex-dependent. Exercise may influence 25(OH)D levels in the circulation by regulating either the vitamin D metabolites stored in tissues or the utilization by target tissues. The effects of exercise on 25(OH)D levels in the circulation may be dependent on many factors, such as the vitamin D nutritional status, exercise type and intensity, and sex. Therefore, further research on the effects and mechanisms of exercise on vitamin D metabolites is required.
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“In our study, the observed significant reduction of 27% in vitamin D levels among adolescent athletes after one year is concerning, as it contradicts previous studies that reported that regular exercise increases vitamin D levels (20–22).”
From The decline of vitamin D in adolescent athletes: insights from a one-year follow-up and its association with electrocardiographic changes (2025) · cites this paper as [21]
In the citing paper
“Exercise affects vitamin D levels, as physical activity stimulates fat metabolism and releases vitamin D stored in adipose tissue (21, 22).”
From The decline of vitamin D in adolescent athletes: insights from a one-year follow-up and its association with electrocardiographic changes (2025) · cites this paper as [21]
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“Zhang et al. (21) conducted a comprehensive cross-sectional analysis utilising data from both the NHANES-III and the Atherosclerosis Risk in Communities (ARIC) cohorts, comprising 7,312 participants, and identified no association between serum 25-hydroxyvitamin D levels and QT interval duration, which is in contrast to our findings.”
From The decline of vitamin D in adolescent athletes: insights from a one-year follow-up and its association with electrocardiographic changes (2025) · cites this paper as [21]
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Decreased bioavailability of vitamin D in obesity
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Cited by
Ramadan, M. M., Jaber, A. A., Aladwani, A. J., Alayyaf, A. E., Sayed-Noor, A. S., Ghanem, H. B., El-Sherbiny, M., Ebrahim, H. A., Ahmed, M. M., & Elsherbini, D. M. A. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1731919 · Cited by 1
Metadata
- Authors
- Zhang, J., & Cao, Z.-B.
- Affiliations
- Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-06-27
- Volume
- 14
- Issue
- 13
- Pages
- 2652
- ISSN
- 2072-6643
- Cited by
- 43
- References
- 5
- Language
- en
- Funders
- National Natural Science Foundation of Shanghai (20ZR1454400)
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