Effect of Personalized Nutrition on Dietary, Physical Activity, and Health Outcomes: A Systematic Review of Randomized Trials
Open accessAbstract
Personalized nutrition is an approach that tailors nutrition advice to individuals based on an individual’s genetic information. Despite interest among scholars, the impact of this approach on lifestyle habits and health has not been adequately explored. Hence, a systematic review of randomized trials reporting on the effects of personalized nutrition on dietary, physical activity, and health outcomes was conducted. A systematic search of seven electronic databases and a manual search resulted in identifying nine relevant trials. Cochrane’s Risk of Bias was used to determine the trials’ methodological quality. Although the trials were of moderate to high quality, the findings did not show consistent benefits of personalized nutrition in improving dietary, behavioral, or health outcomes. There was also a lack of evidence from regions other than North America and Europe or among individuals with diseases, affecting the generalizability of the results. Furthermore, the complex relationship between genes, interventions, and outcomes may also have contributed to the scarcity of positive findings. We have suggested several areas for improvement for future trials regarding personalized nutrition.
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Despite the good methodological quality of the trials, consistent benefits of personalized nutrition were scarce.
“Despite the good methodological quality of the trials, consistent benefits were scarce.”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [142]
The trials of personalized nutrition were mainly conducted in North American and European populations, which limits their global applicability.
“In addition, the trials were mainly conducted in North American and European populations, which limits their global applicability.”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [142]
Positive effects of personalized nutrition were observed in reducing salt intake and, in some cases, improvements in fat consumption patterns.
“Positive effects were observed in reducing salt intake and, in some cases, improvements in fat consumption patterns.”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [142]
Changes in weight, lipid markers, or quality of life from personalized nutrition were generally inconsistent or not significant.
“However, changes in parameters such as weight, lipid markers, or quality of life were generally inconsistent or not significant.”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [142]
A recent systematic review of randomized controlled trials evaluated the impact of personalized nutrition (including genetic information) on diet, physical activity, and health outcomes.
“A recent systematic review of randomized controlled trials evaluated the impact of personalized nutrition (including genetic information) on diet, physical activity, and health outcomes [142].”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [142]
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ІНДИВІДУАЛЬНІ ОСОБЛИВОСТІ ЗАСВОЄННЯ ХАРЧОВИХ ПРОДУКТІВ: РОЛЬ ГЕНЕТИЧНИХ ФАКТОРІВ
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- Authors
- Shyam, S., Lee, K. X., Tan, A. S. W., Khoo, T. A., Harikrishnan, S., Lalani, S. A., & Ramadas, A.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Monash University Malaysia (MY)
- University of Warwick (GB)
- Dalhousie University (CA)
- Corresponding author
- Ramadas, Amutha
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-10-02
- Volume
- 14
- Issue
- 19
- Pages
- 4104
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9570623
- OpenAlex
- W4303961880
- Cited by
- 76
- References
- 44
- Citations by year
- 2026: 21 · 2025: 32 · 2024: 19 · 2023: 4
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- Rovira & Virgili repository (submittedVersion, cc-by)
- Monash University Research Portal (Monash University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- personalized nutrition, dietary behavior, physical activity, health outcomes, gene-diet interaction, lifestyle intervention
- MeSH terms
- Diet, Humans, Life Style, Nutritional Status, Exercise, Randomized Controlled Trials as Topic
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