Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial
Open accessAbstract
Background: Optimal nutritional choices are linked with better health, but many current interventions to improve diet have limited effect. We tested the hypothesis that providing personalized nutrition (PN) advice based on information on individual diet and lifestyle, phenotype and/or genotype would promote larger, more appropriate, and sustained changes in dietary behaviour. Methods: : Adults from seven European countries were recruited to an internet-delivered intervention (Food4Me) and randomized to: (i) conventional dietary advice (control) or to PN advice based on: (ii) individual baseline diet; (iii) individual baseline diet plus phenotype (anthropometry and blood biomarkers); or (iv) individual baseline diet plus phenotype plus genotype (five diet-responsive genetic variants). Outcomes were dietary intake, anthropometry and blood biomarkers measured at baseline and after 3 and 6 months' intervention. Results: At baseline, mean age of participants was 39.8 years (range 18-79), 59% of participants were female and mean body mass index (BMI) was 25.5 kg/m 2 . From the enrolled participants, 1269 completed the study. Following a 6-month intervention, participants randomized to PN consumed less red meat [-5.48 g, (95% confidence interval:-10.8,-0.09), P = 0.046], salt [-0.65 g, (-1.1,-0.25), P = 0.002] and saturated fat [-1.14 % of energy, (-1.6,-0.67), P < 0.0001], increased folate [29.6 µg, (0.21,59.0), P = 0.048] intake and had higher Healthy Eating Index scores [1.27, (0.30, 2.25), P = 0.010) than those randomized to the control arm. There was no evidence that including phenotypic and phenotypic plus genotypic information enhanced the effectiveness of the PN advice. Conclusions: Among European adults, PN advice via internet-delivered intervention produced larger and more appropriate changes in dietary behaviour than a conventional approach.
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Among European adults, internet-delivered personalized nutrition advice led to more significant and appropriate dietary changes than conventional methods.
“Among European adults, internet-delivered personalized nutrition advice led to more significant and appropriate dietary changes than conventional methods.”
From Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control (2024) · cites this paper as [14]
Data were self-reported or collected remotely, introducing potential measurement errors.
“Data were self-reported or collected remotely, introducing potential measurement errors (14).”
From Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control (2024) · cites this paper as [14]
The online nature of this study limited the range of measures, with some key health biomarkers not recorded.
“However, the online nature of this study limited the range of measures, with some key health biomarkers, like blood pressure, not recorded.”
From Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control (2024) · cites this paper as [14]
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- Authors
- Celis-Morales, C., Livingstone, K. M., Marsaux, C. F. M., Macready, A. L., Fallaize, R., O’Donovan, C. B., Woolhead, C., Forster, H., Walsh, M. C., Navas-Carretero, S., San-Cristobal, R., Tsirigoti, L., Lambrinou, C. P., Mavrogianni, C., Moschonis, G., Kolossa, S., Hallmann, J., Godlewska, M., Surwiłło, A., Traczyk, I., Drevon, C. A., Bouwman, J., van Ommen, B., Grimaldi, K., Parnell, L. D., Matthews, J. N. S., Manios, Y., Daniel, H., Martinez, J. A., Lovegrove, J. A., Gibney, E. R., Brennan, L., Saris, W. H. M., Gibney, M., & Mathers;, J. C.
- Affiliations
- Newcastle University (GB)
- Maastricht University Medical Centre (NL)
- University of Reading (GB)
- University College Dublin (IE)
- Harokopio University of Athens (GR)
- Technical University of Munich (DE)
- Instytut Zywnosci Zywienia (PL)
- University of Oslo (NO)
- Netherlands Organisation for Applied Scientific Research (NL)
- Corresponding author
- Celis-Morales, Carlos
- Livingstone, Katherine M.
- ORCID
- Celis-Morales, Carlos
- Livingstone, Katherine M.
- Marsaux, Cyril F. M.
- Macready, Anna L.
- Fallaize, Rosalind
- O’Donovan, Clare B.
- Woolhead, Clara
- Forster, Hannah
- Walsh, Marianne C.
- Lambrinou, Christina P.
- Mavrogianni, Christina
- Moschonis, George
- Kolossa, Silvia
- Hallmann, Jacqueline
- Godlewska, Magdalena
- Surwiłło, Agnieszka
- Traczyk, Iwona
- Drevon, Christian A.
- Bouwman, Jildau
- Grimaldi, Keith
- Parnell, Laurence D.
- Matthews, John N.S.
- Daniel, Hannelore
- Lovegrove, Julie A.
- Gibney, Eileen R.
- Brennan, Lorraine
- Saris, Wim H. M.
- Gibney, Mike
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-08-14
- Volume
- 46
- Issue
- 2
- Pages
- dyw186
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2516593410
- Cited by
- 399
- References
- 27
- Citations by year
- 2026: 26 · 2025: 45 · 2024: 45 · 2023: 42 · 2022: 53 · 2021: 41 · 2020: 42 · 2019: 47 · 2018: 28 · 2017: 23 · 2016: 5 · 2012: 1
- FWCI
- 27.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- University of Hertfordshire Research Archive (University of Hertfordshire) (acceptedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- European Commission (265494)
- Rijksuniversiteit Groningen
- Medical Research Council (MR/K006312/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- personalized nutrition, dietary behavior change, online intervention, phenotyping, anthropometry, blood biomarkers, red meat consumption, salt intake, saturated fat intake, folate intake, Healthy Eating Index, dietary recommendations
- MeSH terms
- Adolescent, Adult, Aged, Diet, Europe, Female, Genotype, Health Education, Humans, Life Style, Male, Middle Aged, Nutritional Requirements, Phenotype, Genetic Variation, Health Behavior, Exercise, Body Mass Index, Internet, Young Adult, Precision Medicine
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