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Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity
Open accessAbstract
Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly regulated by a complex interaction between genetics and excess energy intake. However, the genetic regulation of adipose tissue expansion is yet to be fully understood. Obesity can be divided into common multifactorial/polygenic obesity and monogenic obesity, non-syndromic and syndromic. Several genes related to obesity were found through studies of monogenic non-syndromic obesity models. However, syndromic obesity, characterized by additional features other than obesity, suggesting a more global role of the mutant genes related to the syndrome and, thus, an additional peripheral influence on the development of obesity, were hardly studied to date in this regard. This review summarizes present knowledge regarding the hyperplasia and hypertrophy of adipocytes in common obesity. Additionally, we highlight the scarce research on syndromic obesity as a model for studying adipocyte hyperplasia and hypertrophy, focusing on Bardet–Biedl syndrome (BBS). BBS obesity involves central and peripheral mechanisms, with molecular and mechanistic alternation in adipocyte hyperplasia and hypertrophy. Thus, we argue that using syndromic obesity models, such as BBS, can further advance our knowledge regarding peripheral adipocyte regulation in obesity.
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“Hyperplasia and hypertrophy can occur in a depot-specific manner, as intra-abdominal fat depots primarily expand through hypertrophy, while subcutaneous WAT has been seen to expand through both methods (54).”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [54]
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Metadata
- Authors
- Horwitz, A., & Birk, R.
- Affiliations
- Ariel University (IL)
- Corresponding author
- Birk, Ruth
- ORCID
- Birk, Ruth
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2023-08-04
- Volume
- 15
- Issue
- 15
- Pages
- 3445
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC10421039
- OpenAlex
- W4385577907
- Cited by
- 143
- References
- 264
- Citations by year
- 2026: 50 · 2025: 52 · 2024: 37 · 2023: 4
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- adipose tissue hyperplasia, adipocyte hypertrophy, syndromic obesity, Bardet-Biedl syndrome, monogenic obesity, polygenic obesity
- MeSH terms
- Adipose Tissue, Animals, Humans, Hyperplasia, Hypertrophy, Obesity, Syndrome, Adipocytes, Bardet-Biedl Syndrome
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