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Cited by 526Folate and B Vitamins ResearchPorphyrin Metabolism and DisordersNutrition and Health Studies

The DOI matches its Crossref record; 97 of the 100 references it cites were found in a registry or an index.

Vitamin B12 in Health and Disease

Open access
O’Leary, Fiona, Samman, Samir·2010·Nutrients
DOI 10.3390/nu2030299PMC PMC3257642
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Abstract

Vitamin B(12) is essential for DNA synthesis and for cellular energy production.This review aims to outline the metabolism of vitamin B(12), and to evaluate the causes and consequences of sub-clinical vitamin B(12) deficiency. Vitamin B(12) deficiency is common, mainly due to limited dietary intake of animal foods or malabsorption of the vitamin. Vegetarians are at risk of vitamin B(12) deficiency as are other groups with low intakes of animal foods or those with restrictive dietary patterns. Malabsorption of vitamin B(12) is most commonly seen in the elderly, secondary to gastric achlorhydria. The symptoms of sub-clinical deficiency are subtle and often not recognized. The long-term consequences of sub-clinical deficiency are not fully known but may include adverse effects on pregnancy outcomes, vascular, cognitive, bone and eye health.

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  1. (1998). Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline, National Academy Press.
  2. Carmel, 2006, Diagnosis and management of clinical and subclinical cobalamin deficiency: advances and controversies, Curr. Hematol. Rep., 5, 23
  3. Wai, 2007, No effect of Proton Pump Inhibitor (PPI) medications on vitamin B12 status in elderly rehabilitation patients. Is there a dietary component?, Asia Pac. J. Clin. Nutr., 31, S96
  4. Flood, 2009, Nutritional status, micronutrient levels and length of stay in an elderly rehabilitation unit, Asia Pac. J. Clin. Nutr., 33, 106
  5. Wai, 2009, Vitamin B status and length of stay in elderly rehabilitation patients, Nutr. Diet., 66, A43

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Metadata

Authors
O’Leary, F., & Samman, S.
Affiliations
The University of Sydney (AU)
Corresponding author
Samman, Samir
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2010-03-05
Volume
2
Issue
3
Pages
299-316
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu2030299
PMC
PMC3257642
OpenAlex
W2165998744
Cited by
524
References
100
Citations by year
2026: 91 · 2025: 71 · 2024: 56 · 2023: 61 · 2022: 45 · 2021: 42 · 2020: 26 · 2019: 33 · 2018: 20 · 2017: 16 · 2016: 16 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 6
FWCI
0.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords
vitamin B12, vitamin B12 metabolism, dietary intake, malabsorption, achlorhydria, vegetarians, restrictive diets, pregnancy outcomes, cognitive health, bone health, eye health, vascular health
MeSH terms
Absorption, Cardiovascular Diseases, Cognition Disorders, Female, Food, Humans, Male, Neural Tube Defects, Nutritional Requirements, Osteoporosis, Pregnancy, Pregnancy Complications, Vitamin B 12, Vitamin B 12 Deficiency, Biomarkers

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