The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants
Open accessAbstract
Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.
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Cites
Improvement of enzyme activity, stability and selectivity via immobilization techniques
Mateo, C., Palomo, J. M., Fernandez-Lorente, G., Guisan, J. M., & Fernandez-Lafuente, R. (2007) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2007.01.018 · Cited by 3,375
Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
Cushman, D. W., & Cheung, H. S. (1971) · Biochemical Pharmacology · doi:10.1016/0006-2952(71)90292-9 · Cited by 2,625
Ondetti, M. A., Rubin, B., & Cushman, D. W. (1977) · Science · doi:10.1126/science.191908 · Cited by 1,856
Evolutionary families of peptidases
Rawlings, N. D., & Barrett, A. J. (1993) · Biochemical Journal · doi:10.1042/bj2900205 · Cited by 923
Crystal structure of the human angiotensin-converting enzyme–lisinopril complex
Natesh, R., Schwager, S. L. U., Sturrock, E. D., & Acharya, K. R. (2003) · Nature · doi:10.1038/nature01370 · Cited by 888
Bioavailability of bioactive food compounds: a challenging journey to bioefficacy
Rein, M. J., Renouf, M., Cruz‐Hernandez, C., Actis‐Goretta, L., Thakkar, S. K., & da Silva Pinto, M. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04425.x · Cited by 861
Proteins from land plants – Potential resources for human nutrition and food security
Day, L. (2013) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2013.05.005 · Cited by 854
Immobilised enzymes: science or art?
Cao, L. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.02.014 · Cited by 634
Bioactive peptides from marine processing waste and shellfish: A review
Harnedy, P. A., & FitzGerald, R. J. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2011.09.001 · Cited by 606
Wu, J., Aluko, R. E., & Nakai, S. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051263l · Cited by 561
Cited by
Sharifi-Rad, J., Rodrigues, C. F., Sharopov, F., Docea, A. O., Can Karaca, A., Sharifi-Rad, M., Kahveci Karıncaoglu, D., Gülseren, G., Şenol, E., Demircan, E., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072326 · Cited by 285
Karabulut, G., Purkiewicz, A., & Goksen, G. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13372 · Cited by 85
O’Connor, J., Garcia-Vaquero, M., Meaney, S., & Tiwari, B. K. (2022) · Marine Drugs · doi:10.3390/md20050317 · Cited by 81
Barkia, I., Al‐Haj, L., Abdul Hamid, A., Zakaria, M., Saari, N., & Zadjali, F. (2019) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14006 · Cited by 76
Screening of Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from Caulerpa lentillifera
Joel, C. H., Sutopo, C. C. Y., Prajitno, A., Su, J.-H., & Hsu, J.-L. (2018) · Molecules · doi:10.3390/molecules23113005 · Cited by 48
Metadata
- Authors
- Daskaya-Dikmen, C., Yucetepe, A., Karbancioglu-Guler, F., Daskaya, H., & Ozcelik, B.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-03-23
- Volume
- 9
- Issue
- 4
- Pages
- 316
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2601789818
- Cited by
- 353
- References
- 105
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- gold
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- Daskaya-Dikmen, C., Yucetepe, A., Karbancioglu-Guler, F., Daskaya, H., & Ozcelik, B. (2017). Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants. Nutrients. https://doi.org/10.3390/nu9040316
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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