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Cited by 162Magnesium in Health and DiseaseMagnesium Alloys: Properties and ApplicationsMaternal Mental Health During Pregnancy and Postpartum

The DOI matches its Crossref record; 90 of the 94 references it cites were found in a registry or an index.

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

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Boyle, Neil, Lawton, Clare, Dye, Louise·2017·Nutrients
DOI 10.3390/nu9050429PMC PMC5452159
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Abstract

Background: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress. Methods: A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016. Ovid Medline, PsychInfo, Embase, CINAHL and Cochrane databases were searched using equivalent search terms. A grey literature review of relevant sources was also undertaken. Results: 18 studies were included in the review. All reviewed studies recruited samples based upon an existing vulnerability to anxiety: mildly anxious, premenstrual syndrome (PMS), postpartum status, and hypertension. Four/eight studies in anxious samples, four/seven studies in PMS samples, and one/two studies in hypertensive samples reported positive effects of Mg on subjective anxiety outcomes. Mg had no effect on postpartum anxiety. No study administered a validated measure of subjective stress as an outcome. Conclusions: Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples. However, the quality of the existing evidence is poor. Well-designed randomised controlled trials are required to further confirm the efficacy of Mg supplementation.

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  1. Rouillon, F., Lejoyeux, M., and Martineau, C. (October, January 30). A Double-blind Controlled Study of PCR 7060 vs. Buspirone in the Treatment of Generalised Anxiety Disorder Conference Abstract. Proceedings of the 8th European College of Neuropsychopharmacology Congress, Venice, Italy.
  2. Spielberger, C.D. (1989). State-Trait Anxiety Inventory, Bibliography Consulting Psychologists Press. [2nd ed.].
  3. Bourgeois, 1987, Rôle du Magne-B6 dans les Manifestations Anxueuses en Pratique Medicale Courante Psychiatr, Pract. Med., 39, 18
  4. Scharbach, 1988, Anxiété et Magné B6, La Vie Médicale, 17, 867
  5. Gendle, 2015, Oral Magnesium Supplementation and Test Anxiety in University Undergraduates, J. Artic. Support Null Hypothesis, 11, 21
  6. Campbell, D.T., and Kenny, D.A. (1999). Primer on Regression Artifacts, Guildford Press.

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Metadata

Authors
Boyle, N., Lawton, C., & Dye, L.
Affiliations
University of Leeds (GB)
Corresponding author
Boyle, Neil
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2017-04-26
Volume
9
Issue
5
Pages
429
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu9050429
PMC
PMC5452159
OpenAlex
W2610150444
Cited by
162
References
94
Citations by year
2026: 20 · 2025: 21 · 2024: 29 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 15 · 2019: 11 · 2018: 12 · 2017: 2
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Sanofi
  • European Food Safety Authority
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
  • Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
magnesium supplementation, subjective anxiety, stress, premenstrual syndrome, postpartum anxiety, hypertension, anxiety vulnerability, dietary supplements
MeSH terms
Anxiety, Humans, Magnesium, Stress, Physiological, Dietary Supplements

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