Cited by 162Magnesium in Health and DiseaseMagnesium Alloys: Properties and ApplicationsMaternal Mental Health During Pregnancy and Postpartum

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The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

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Boyle, Neil, Lawton, Clare, Dye, Louise·2017·Nutrients

DOI 10.3390/nu9050429PMC PMC5452159

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Abstract

Background: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress. Methods: A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016. Ovid Medline, PsychInfo, Embase, CINAHL and Cochrane databases were searched using equivalent search terms. A grey literature review of relevant sources was also undertaken. Results: 18 studies were included in the review. All reviewed studies recruited samples based upon an existing vulnerability to anxiety: mildly anxious, premenstrual syndrome (PMS), postpartum status, and hypertension. Four/eight studies in anxious samples, four/seven studies in PMS samples, and one/two studies in hypertensive samples reported positive effects of Mg on subjective anxiety outcomes. Mg had no effect on postpartum anxiety. No study administered a validated measure of subjective stress as an outcome. Conclusions: Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples. However, the quality of the existing evidence is poor. Well-designed randomised controlled trials are required to further confirm the efficacy of Mg supplementation.

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See all 162

Authors: Boyle, N., Lawton, C., & Dye, L.
Affiliations: University of Leeds (GB)
Corresponding author: Boyle, Neil
ORCID: Boyle, Neil
Lawton, Clare
Dye, Louise
Venue: Nutrients
Publisher: MDPI AG
Published: 2017-04-26
Volume: 9
Issue: 5
Pages: 429
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu9050429
PMC: PMC5452159
OpenAlex: W2610150444
Cited by: 162
References: 94
Citations by year: 2026: 20 · 2025: 21 · 2024: 29 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 15 · 2019: 11 · 2018: 12 · 2017: 2
FWCI: 1.13
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Sanofi
European Food Safety Authority
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: magnesium supplementation, subjective anxiety, stress, premenstrual syndrome, postpartum anxiety, hypertension, anxiety vulnerability, dietary supplements
MeSH terms: Anxiety, Humans, Magnesium, Stress, Physiological, Dietary Supplements

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The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

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