CoChat
Sign Up
Cited by 531Nutrition and Health in AgingClinical Nutrition and GastroenterologyBody Composition Measurement Techniques

Evaluation of blood biomarkers associated with risk of malnutrition in older adults: a systematic review and meta-analysis

Open access
Zhang, Zhiying, Pereira, Suzette, Luo, Menghua, Matheson, Eric·2017·Nutrients
DOI 10.3390/nu9080829PMC PMC5579622
Open this paper in CoChat — free accountOpen PDF

Abstract

Malnutrition is a common yet under-recognized problem in hospitalized patients. The aim of this paper was to systematically review and evaluate malnutrition biomarkers among order adults. Eligible studies were identified through Cochrane, PubMed and the ProQuest Dialog. A meta-regression was performed on concentrations of biomarkers according to malnutrition risks classified by validated nutrition assessment tools. A total of 111 studies were included, representing 52,911 participants (55% female, 72 ± 17 years old) from various clinical settings (hospital, community, care homes). The estimated BMI (p < 0.001) and concentrations of albumin (p < 0.001), hemoglobin (p < 0.001), total cholesterol (p < 0.001), prealbumin (p < 0.001) and total protein (p < 0.05) among subjects at high malnutrition risk by MNA were significantly lower than those without a risk. Similar results were observed for malnutrition identified by SGA and NRS-2002. A sensitivity analysis by including patients with acute illness showed that albumin and prealbumin concentrations were dramatically reduced, indicating that they must be carefully interpreted in acute care settings. This review showed that BMI, hemoglobin, and total cholesterol are useful biomarkers of malnutrition in older adults. The reference ranges and cut-offs may need to be updated to avoid underdiagnosis of malnutrition.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/nu9080829

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Interpreting nutrition-related biomarkers in a context-specific manner is more important for individuals with conditions that can compromise nutrition-sensitive systems, such as compromised immune systems or disease-related inflammation and the acute phase response.

    “Clearly, the nuances of interpreting nutrition-related biomarkers in a context-specific manner assumes greater importance for individuals with conditions that can potentially compromise nutrition-sensitive systems, e.g. those with compromised immune systems or disease-related inflammation and the concomitant acute phase response [[13], [14], [15], [16], [17]].”

    From The Value of Integrating the Nutritional Ecology into the Nutrition Care Continuum—A Conceptual and Systems Approach (2025) · cites this paper as [16]

    The Discussion (page not available) says that acute inflammation and infection can alter albumin and prealbumin, so these nutrition-related biomarkers must be interpreted with caution in affected patients. The paper does not specifically address people with compromised immune systems, and its caution concerns particular biomarkers rather than nutrition-related biomarkers generally. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • In catabolic states due to trauma, infection, or burns, serum albumin concentration decreases rapidly even when nutritional status may be preserved.

    “However, if an individual enters a state of catabolism because of trauma, infection, or burns, the serum albumin concentration decreases rapidly, even when their nutritional status may be preserved.”

    From The Value of Integrating the Nutritional Ecology into the Nutrition Care Continuum—A Conceptual and Systems Approach (2025) · cites this paper as [16]

    The Discussion (page unavailable) says serum albumin falls markedly with acute inflammatory stress, cautions against interpreting it in patients with infection or recent trauma, and notes that low albumin need not distinguish patients at risk of malnutrition. It does not specifically address burns, establish that the decrease is rapid, or attribute it to catabolism. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • In a nutrient-deficient state such as starvation, serum albumin decreases only slightly as the body compensates to maintain visceral protein status.

    “Serum albumin has a 3-wk half-life, and in a nutrient-deficient state such as starvation the serum albumin will decrease only slightly as the body compensates to maintain visceral protein status.”

    From The Value of Integrating the Nutritional Ecology into the Nutrition Care Continuum—A Conceptual and Systems Approach (2025) · cites this paper as [16]

    The Discussion reports that an albumin cutoff of 3.5 g/dL can miss older adults at risk of malnutrition, which lends limited support to the idea that albumin may not fall markedly with nutritional risk. It does not examine starvation or say that the body compensates to maintain visceral protein status. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Serum albumin has a 3-week half-life.

    “Serum albumin has a 3-wk half-life, and in a nutrient-deficient state such as starvation the serum albumin will decrease only slightly as the body compensates to maintain visceral protein status.”

    From The Value of Integrating the Nutritional Ecology into the Nutrition Care Continuum—A Conceptual and Systems Approach (2025) · cites this paper as [16]

    The Discussion addresses serum albumin as a malnutrition marker but does not state its half-life. Searches for a three-week or 21-day half-life found no passage in our copy that establishes the claimed duration. (LLM, conf=0.74)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 105

  1. [1]Corkins M.R. Guenter P. DiMaria-Ghalili R.A. Jensen G.L. Malone A. Miller S. Patel V. Plogsted S. Resnick H.E. American Society for Parenteral and Enteral Nutrition Malnutrition diagnoses in hospitalized patients: United States, 2010 J. Parenter. Enter. Nutr. 2014 38 186 195 10.1177/0148607113512154 24247093 · DOI
  2. [2]Agarwal E. Miller M. Yaxley A. Isenring E. Malnutrition in the elderly: A narrative review Maturitas 2013 76 296 302 10.1016/j.maturitas.2013.07.013 23958435 · DOI · Paper page
  3. [3]Barker L.A. Gout B.S. Crowe T.C. Hospital malnutrition: Prevalence, identification and impact on patients and the healthcare system Int. J. Environ. Res. Public Health 2011 8 514 527 10.3390/ijerph8020514 21556200 PMC3084475 · DOI · Paper page
  4. [4]White J. Guenter P. Jensen G. Consensus statement: Academy of nutrition and dietetics and American society for parenteral and enteral nutrition: Characteristics recommended for the identification and documentation of adult malnutrition (undernutrition) J. Parenter. Enter. Nutr. 2012 36 275 10.1177/0148607112440285 22535923 · DOI · Paper page
  5. [5]Goates S. Du K. Braunschweig C.A. Arensberg M.B. Economic burden of disease-associated malnutrition at the state level PLoS ONE 2016 11 e0161833 10.1371/journal.pone.0161833 27655372 PMC5031313 · DOI
  6. [6]Kondrup J.E.S.P.E.N. Allison S.P. Elia M. Vellas B. ESPEN guidelines for nutrition screening 2002 Clin. Nutr. 2003 22 415 421 10.1016/S0261-5614(03)00098-0 12880610 · DOI · Paper page
  7. [7]Skipper A. Ferguson M. Thompson K. Castellanos V.H. Porcari J. Nutrition screening tools: An analysis of the evidence J. Parenter. Enter. Nutr. 2012 36 292 298 10.1177/0148607111414023 22045723 · DOI
  8. [8]August D. Teitelbaum D. Albina J. Bothe A. Guenter P. Heitkemper M. Ireton-Jones C. Mirtallo J.M. Seidner D. Winkler M. Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients J. Parenter. Enter. Nutr. 2002 26 1SA 138SA 11841046
  9. [9]Bharadwaj S. Ginoya S. Tandon P. Gohel T.D. Guirguis J. Vallabh H. Jevenn A. Hanouneh I. Malnutrition: Laboratory markers vs. nutritional assessment Gastroenterol. Rep. 2016 4 272 280 10.1093/gastro/gow013 27174435 PMC5193064 · DOI
  10. [10]Beck F.K. Rosenthal T.C. Prealbumin: A marker for nutritional evaluation Am. Fam. Physician 2002 65 1575 1578 11989633
  11. [11]Omran M.L. Morley J.E. Assessment of protein energy malnutrition in older persons, Part II: Laboratory evaluation Nutrition 2000 16 131 140 10.1016/S0899-9007(99)00251-8 10696638 · DOI
  12. [12]Blanck H.M. Bowman B.A. Cooper G.R. Myers G.L. Miller D.T. Laboratory issues: Use of nutritional biomarkers J. Nutr. 2003 133 888S 894S 12612175
  13. [13]Kubota K. Kadomura T. Ohta K. Koyama K. Okuda H. Kobayashi M. Ishii C. Fujiwara Y. Nishiora T. Ohmae Y. Analyses of laboratory data and establishment of reference values and intervals for healthy elderly people J. Nutr. Health Aging 2012 16 412 416 10.1007/s12603-011-0355-3 22499467 · DOI
  14. [17]Baron M. Hudson M. Steele R. Is serum albumin a marker of malnutrition in chronic disease? The scleroderma paradigm J. Am. Coll. Nutr. 2010 29 144 151 10.1080/07315724.2010.10719828 20679150 · DOI
  15. [18]Rasheed S. Woods R.T. An investigation into the association between nutritional status and quality of life in older people admitted to hospital J. Hum. Nutr. Diet. 2014 27 142 151 10.1111/jhn.12072 23627733 · DOI
  16. [19]Holst M. Yifter-Lindgren E. Surowiak M. Nielsen K. Mowe M. Carlsson M. Jacobsen B. Cederholm T. Fenger-Groen M. Rasmussen H. Nutritional screening and risk factors in elderly hospitalized patients: Association to clinical outcome? Scand. J. Caring Sci. 2013 27 953 961 10.1111/scs.12010 23181396 · DOI
  17. [20]Kruizenga H.M. de Jonge P. Seidell J.C. Neelemaat F. van Bodegraven A.A. Wierdsma N.J. van Bokhorst-de van der Schueren M.A. Are malnourished patients complex patients? Health status and care complexity of malnourished patients detected by the short nutritional assessment questionnaire (SNAQ) Eur. J. Intern. Med. 2006 17 189 194 10.1016/j.ejim.2005.11.019 16618452 · DOI
  18. [21]Schnelldorfer T. Adams D.B. The effect of malnutrition on morbidity after surgery for chronic pancreatitis Am. Surg. 2005 71 466 473 16044924
  19. [22]De Groot L.C. Beck A.M. Schroll M. van Staveren W.A. Evaluating the determine your nutritional health checklist and the mini nutritional assessment as tools to identify nutritional problems in elderly Europeans Eur. J. Clin. Nutr. 1998 52 877 883 10.1038/sj.ejcn.1600658 9881882 · DOI
  20. [23]Vellas B. Guigoz Y. Baumgartner M. Garry P.J. Lauque S. Albarede J.L. Relationships between nutritional markers and the mini-nutritional assessment in 155 older persons J. Am. Geriatr. Soc. 2000 48 1300 1309 10.1111/j.1532-5415.2000.tb02605.x 11037019 · DOI
  21. [24]Soini H. Routasalo P. Lagstrom H. Nutritional status in cognitively intact older people receiving home care services—A pilot study J. Nutr. Healt Aging 2005 9 249 253 15980925
  22. [25]Neumann S.A. Miller M.D. Daniels L.A. Ahern M. Crotty M. Mini nutritional assessment in geriatric rehabilitation: Inter-rater reliability and relationship to body composition and nutritional biochemistry Nutr. Diet. 2007 64 179 185 10.1111/j.1747-0080.2007.00146.x · DOI
  23. [26]Demir M.V. Tamer A. Cinemre H. Uslan I. Yaylaci S. Erkorkmaz U. Nutritional status and laboratory parameters among internal medicine inpatients Niger. J. Clin. Pract. 2015 18 757 761 10.4103/1119-3077.158145 26289513 · DOI
  24. [27]Alves de Rezende C.H. Marquez Cunha T. Alvarenga Junior V. Penha-Silva N. Dependence of mini-nutritional assessment scores with age and some hematological variables in elderly institutionalized patients Gerontology 2005 51 316 321 10.1159/000086368 16110233 · DOI
  25. [28]De Luis D.A. Lopez Mongil R. Gonzalez Sagrado M. Lopez Trigo J.A. Mora P.F. Castrodeza Sanz J. Nutritional status in a multicenter study among institutionalized patients in spain Eur. Rev. Med. Pharmacol. Sci. 2011 15 259 265 21528771
  26. [29]Ulger Z. Halil M. Kalan I. Yavuz B.B. Cankurtaran M. Gungor E. Ariogul S. Comprehensive assessment of malnutrition risk and related factors in a large group of community-dwelling older adults Clin. Nutr. 2010 29 507 511 10.1016/j.clnu.2010.01.006 20117863 · DOI
  27. [30]Bonilla-Palomas J.L. Gamez-Lopez A.L. Anguita-Sanchez M.P. Castillo-Dominguez J.C. Garcia-Fuertes D. Crespin-Crespin M. Lopez-Granados A. Suarez de Lezo J. Impact of malnutrition on long-term mortality in hospitalized patients with heart failure Rev. Esp. Cardiol. 2011 64 752 758 10.1016/j.recesp.2011.03.009 21652135 · DOI
  28. [31]Jeejeebhoy K.N. Keller H. Gramlich L. Allard J.P. Laporte M. Duerksen D.R. Payette H. Bernier P. Vesnaver E. Davidson B. Nutritional assessment: Comparison of clinical assessment and objective variables for the prediction of length of hospital stay and readmission Am. J. Clin. Nutr. 2015 101 956 965 10.3945/ajcn.114.098665 25739926 · DOI
  29. [32]Kuyumcu M.E. Yeşil Y. Oztürk Z.A. Halil M. Ulger Z. Yavuz B.B. Cankurtaran M. Güngör E. Erdoğan G. Besler T. Challenges in nutritional evaluation of hospitalized elderly; always with mini-nutritional assessment? Eur. Geriatr. Med. 2013 4 231 236 10.1016/j.eurger.2013.01.010 · DOI
  30. [33]Delacorte R.R. Moriguti J.C. Matos F.D. Pfrimer K. Marchinil J.S. Ferriolli E. Mini-nutritional assessment score and the risk for undernutrition in free-living older persons J. Nutr. Health Aging 2004 8 531 534 15543428
  31. [34]Akin S. Tufan F. Bulut L. Genc S. Bahat G. Saka B. Erten N. Karan M.A. Limited utility of adipokine levels in the diagnosis of malnutrition in the elderly Aging Clin. Exp. Res. 2014 26 229 234 10.1007/s40520-013-0158-y 24146362 · DOI
  32. [35]Inoue K. Kato M. Usefulness of the mini-nutritional assessment (MNA) to evaluate the nutritional status of japanese frail elderly under home care Geriatr. Gerontol. Intern. 2007 7 238 244 10.1111/j.1447-0594.2007.00411.x · DOI
  33. [36]Cereda E. Pusani C. Limonta D. Vanotti A. The association of geriatric nutritional risk index and total lymphocyte count with short-term nutrition-related complications in institutionalised elderly J. Am. Coll. Nutr. 2008 27 406 413 10.1080/07315724.2008.10719718 18838529 · DOI
  34. [37]Kuzuya M. Izawa S. Enoki H. Okada K. Iguchi A. Is serum albumin a good marker for malnutrition in the physically impaired elderly? Clin. Nutr. 2007 26 84 90 10.1016/j.clnu.2006.07.009 16996659 · DOI
  35. [38]Kuzuya M. Kanda S. Koike T. Suzuki Y. Satake S. Iguchi A. Evaluation of mini-nutritional assessment for Japanese frail elderly Nutrition 2005 21 498 503 10.1016/j.nut.2004.08.023 15811771 · DOI
  36. [39]Lei Z. Qingyi D. Feng G. Chen W. Hock R.S. Changli W. Clinical study of mini-nutritional assessment for older Chinese inpatients J. Nutr. Health Aging 2009 13 871 875 10.1007/s12603-009-0244-1 19924346 · DOI
  37. [40]Rohrig G. Becker I. Polidori M.C. Schulz R.J. Noreik M. Association of anemia and hypoalbuminemia in german geriatric inpatients: Relationship to nutritional status and comprehensive geriatric assessment Z. Gerontol. Geriatr. 2015 48 619 624 10.1007/s00391-015-0872-5 25877770 · DOI
  38. [41]Donini L.M. Neri B. De Chiara S. Poggiogalle E. Muscaritoli M. Nutritional care in a nursing home in italy PLoS ONE 2013 8 e55804 10.1371/journal.pone.0055804 23405217 PMC3565979 · DOI
  39. [42]Sargento L. Satendra M. Almeida I. Sousa C. Gomes S. Salazar F. Lousada N. Palma Dos Reis R. Nutritional status of geriatric outpatients with systolic heart failure and its prognostic value regarding death or hospitalization, biomarkers and quality of life J. Nutr. Health Aging 2013 17 300 304 10.1007/s12603-013-0030-y 23538649 · DOI
  40. [43]Vischer U.M. Frangos E. Graf C. Gold G. Weiss L. Herrmann F.R. Zekry D. The prognostic significance of malnutrition as assessed by the mini nutritional assessment (MNA) in older hospitalized patients with a heavy disease burden Clin. Nutr. 2012 31 113 117 10.1016/j.clnu.2011.09.010 21996512 · DOI
  41. [44]Leandro-Merhi V.A. De Aquino J.L. Anthropometric parameters of nutritional assessment as predictive factors of the mini nutritional assessment (MNA) of hospitalized elderly patients J. Nutr. Health Aging 2011 15 181 186 10.1007/s12603-010-0116-8 21369664 · DOI
  42. [45]Alhamdan A.A. Alsaif A.A. The nutritional, glutathione and oxidant status of elderly subjects admitted to a university hospital Saud. J. Gastroenterol. 2011 17 58 63 10.4103/1319-3767.74474 21196655 PMC3099083 · DOI
  43. [46]Cereda E. Pedrolli C. Zagami A. Vanotti A. Piffer S. Opizzi A. Rondanelli M. Caccialanza R. Nutritional screening and mortality in newly institutionalised elderly: A comparison between the geriatric nutritional risk index and the mini nutritional assessment Clin. Nutr. 2011 30 793 798 10.1016/j.clnu.2011.04.006 21723010 · DOI
  44. [47]Amirkalali B. Sharifi F. Fakhrzadeh H. Mirarefein M. Ghaderpanahi M. Badamchizadeh Z. Larijani B. Low serum leptin serves as a biomarker of malnutrition in elderly patients Nutr. Res. 2010 30 314 319 10.1016/j.nutres.2010.05.002 20579523 · DOI
  45. [48]Venzin R.M. Kamber N. Keller W.C. Suter P.M. Reinhart W.H. How important is malnutrition? A prospective study in internal medicine Eur. J. Clin. Nutr. 2009 63 430 436 10.1038/sj.ejcn.1602948 17987052 · DOI
  46. [49]Reyes J.G. Zuniga A.S. Cruz M.G. Prevalence of hyponutrition in the elderly at admission to the hospital Nutr. Hosp. 2007 22 702 709 18051996
  47. [50]Peña E. Solano L. Valoración antropométrica y bioquímica de ancianos venezolanos institucionalizados Rev. Esp. Geriatr. Gerontol. 2004 39 360 366 10.1016/S0211-139X(04)74988-4 · DOI
  48. [51]Gerber V. Krieg M.A. Cornuz J. Guigoz Y. Burckhardt P. Nutritional status using the mini nutritional assessment questionnaire and its relationship with bone quality in a population of institutionalized elderly women J. Nutr Health Aging 2003 7 140 145 12766790
  49. [52]Magri F. Borza A. del Vecchio S. Chytiris S. Cuzzoni G. Busconi L. Rebesco A. Ferrari E. Nutritional assessment of demented patients: A descriptive study Aging Clin. Exp. Res. 2003 15 148 153 10.1007/BF03324493 12889847 · DOI
  50. [53]Ruiz-Lopez M.D. Artacho R. Oliva P. Moreno-Torres R. Bolanos J. de Teresa C. Lopez M.C. Nutritional risk in institutionalized older women determined by the mini nutritional assessment test: What are the main factors? Nutrition 2003 19 767 771 10.1016/S0899-9007(03)00125-4 12921887 · DOI
  51. [54]Hosseini S. Keshavarz S.A. Amin A. Bakshandeh H. Maleki M. Shahinfard A. Hosseini S. Heidarali M. Nutritional status assessment of the elderly patients with congestive heart failure by mini nutritional assessment test Res. Cardiovasc. Med. 2017 6 e31898 10.5812/cardiovascmed.31898 · DOI
  52. [55]De Luis D. Guzman A.L. Nutritional status of adult patients admitted to internal medicine departments in public hospitals in castilla y leon, Spain—A multi-center study Eur. J. Intern. Med. 2006 17 556 560 10.1016/j.ejim.2006.02.030 17142174 · DOI
  53. [56]Rambouskova J. Slavikova M. Krskova A. Prochazka B. Andel M. Dlouhy P. Nutritional status assessment of institutionalized elderly in prague, czech republic Ann. Nutr. Metab. 2013 62 201 206 10.1159/000346038 23485785 · DOI
  54. [57]Calderon Reyes M.E. Ibarra Ramirez F. Garcia J. Gomez Alonso C. Rodriguez-Orozco A.R. Compared nutritional assessment for older adults at family medicine settings Nutr. Hosp. 2010 25 669 675 20694306
  55. [58]Kagansky N. Berner Y. Koren-Morag N. Perelman L. Knobler H. Levy S. Poor nutritional habits are predictors of poor outcome in very old hospitalized patients Am. J. Clin. Nutr. 2005 82 784 791 16210707
  56. [59]Christensson L. Unosson M. Ek A.C. Evaluation of nutritional assessment techniques in elderly people newly admitted to municipal care Eur. J. Clin. Nutr. 2002 56 810 818 10.1038/sj.ejcn.1601394 12209369 · DOI
  57. [61]Abd-El-Gawad W.M. Abou-Hashem R.M. El Maraghy M.O. Amin G.E. The validity of geriatric nutrition risk index: Simple tool for prediction of nutritional-related complication of hospitalized elderly patients. Comparison with mini nutritional assessment Clin. Nutr. 2014 33 1108 1116 10.1016/j.clnu.2013.12.005 24418116 · DOI
  58. [62]Duran Alert P. Mila Villarroel R. Formiga F. Virgili Casas N. Vilarasau Farre C. Assessing risk screening methods of malnutrition in geriatric patients: Mini nutritional assessment (MNA) versus geriatric nutritional risk index (GNRI) Nutr. Hosp. 2012 27 590 598 22732988
  59. [63]Persson M.D. Brismar K.E. Katzarski K.S. Nordenstrom J. Cederholm T.E. Nutritional status using mini nutritional assessment and subjective global assessment predict mortality in geriatric patients J. Am. Geriatr. Soc. 2002 50 1996 2002 10.1046/j.1532-5415.2002.50611.x 12473011 · DOI
  60. [64]Murphy M.C. Brooks C.N. New S.A. Lumbers M.L. The use of the mini-nutritional assessment (MNA) tool in elderly orthopaedic patients Eur. J. Clin. Nutr. 2000 54 555 562 10.1038/sj.ejcn.1601055 10918465 · DOI
  61. [65]Drescher T. Singler K. Ulrich A. Koller M. Keller U. Christ-Crain M. Kressig R.W. Comparison of two malnutrition risk screening methods (MNA and NRS 2002) and their association with markers of protein malnutrition in geriatric hospitalized patients Eur. J. Clin. Nutr. 2010 64 887 893 10.1038/ejcn.2010.64 20485308 · DOI
  62. [66]Olveira G. Tapia M.J. Ocón J. Cabrejas-Gómez C. Ballesteros-Pomar M.D. Vidal-Casariego A. Arraiza-Irigoyen C. Olivares J. Conde-García M.C. García-Manzanares Á. The subjective global assessment predicts in-hospital mortality better than other nutrition-related risk indexes in noncritically ill inpatients who receive total parenteral nutrition in Spain (prospective multicenter study) J. Acad. Nutr. Diet. 2013 113 1209 1218 10.1016/j.jand.2013.05.027 23972272 · DOI
  63. [67]Filipovic B. Kovcevic N. Randjelovic T. Kostic S. Filipovic B. Nutritional status in hospitalized patients in the department of gastroenterohepatology Hepato-gastroenterology 2011 58 1229 1234 10.5754/hge09354 21937384 · DOI
  64. [68]Gupta B. Kant S. Mishra R. Subjective global assessment of nutritional status of chronic obstructive pulmonary disease patients on admission Intern. J. Tuberc. Lung Dis. 2010 14 500 505 20202310
  65. [69]Pham N.V. Cox-Reijven P.L. Wodzig W.K. Greve J.W. Soeters P.B. SGA and measures for muscle mass and strength in surgical vietnamese patients Nutrition 2007 23 283 291 10.1016/j.nut.2006.12.012 17350806 · DOI
  66. [70]Sacks G.S. Dearman K. Replogle W.H. Cora V.L. Meeks M. Canada T. Use of subjective global assessment to identify nutrition-associated complications and death in geriatric long-term care facility residents J. Am. Coll. Nutr. 2000 19 570 577 10.1080/07315724.2000.10718954 11022870 · DOI
  67. [71]Niyongabo T. Melchior J.C. Henzel D. Bouchaud O. Larouze B. Comparison of methods for assessing nutritional status in hiv-infected adults Nutrition 1999 15 740 743 10.1016/S0899-9007(99)00146-X 10501285 · DOI
  68. [72]Gloria L. Cravo M. Camilo M.E. Resende M. Cardoso J.N. Oliveira A.G. Leitao C.N. Mira F.C. Nutritional deficiencies in chronic alcoholics: Relation to dietary intake and alcohol consumption Am. J. Gastroenterol. 1997 92 485 489 9068475
  69. [73]Sungurtekin H. Sungurtekin U. Balci C. Zencir M. Erdem E. The influence of nutritional status on complications after major intraabdominal surgery J. Am. Coll. Nutr. 2004 23 227 232 10.1080/07315724.2004.10719365 15190047 · DOI
  70. [75]Duerksen D.R. Yeo T.A. Siemens J.L. O’Connor M.P. The validity and reproducibility of clinical assessment of nutritional status in the elderly Nutrition 2000 16 740 744 10.1016/S0899-9007(00)00398-1 10978854 · DOI
  71. [76]Coppini L.Z. Waitzberg D.L. Ferrini M.T. da Silva M.L. Gama-Rodrigues J. Ciosak S.L. Comparison of the subjective global nutrition assessment x objective nutrition evaluation Rev. Assoc. Med. Bras. 1995 41 6 10 7550417
  72. [78]Kim H. Choi-Kwon S. Changes in nutritional status in ICU patients receiving enteral tube feeding: A prospective descriptive study Inten. Crit. Care Nurs. 2011 27 194 201 10.1016/j.iccn.2011.05.002 21680184 · DOI
  73. [79]Sungurtekin H. Sungurtekin U. Oner O. Okke D. Nutrition assessment in critically ill patients Nutr. Clin. Pract. 2008 23 635 641 10.1177/0884533608326137 19033223 · DOI
  74. [80]Bector S. Vagianos K. Suh M. Duerksen D.R. Does the subjective global assessment predict outcome in critically ill medical patients? J. Inten. Care Med. 2016 31 485 489 10.1177/0885066615596325 26188013 · DOI
  75. [81]Atalay B.G. Yagmur C. Nursal T.Z. Atalay H. Noyan T. Use of subjective global assessment and clinical outcomes in critically ill geriatric patients receiving nutrition support J. Parenter. Enter Nutr. 2008 32 454 459 10.1177/0148607108314369 18596319 · DOI
  76. [83]Zhou J. Wang M. Wang H. Chi Q. Comparison of two nutrition assessment tools in surgical elderly inpatients in northern china Nutr. J. 2015 14 68 10.1186/s12937-015-0054-8 26170020 PMC4499876 · DOI
  77. [84]Guo H.M. Zhou L. Ma W.C. Zhu Y.T. Wang Y. Wang J. Sun X.L. Zhang C.Q. Duan Z.P. Prevalence of nutritional risk among in-patients with liver diseases Beijing, China Chin. J. Hepatol. 2013 21 734 738 24331629
  78. [85]Lee H.K. Choi H.S. Son E.J. Lyu E.S. Analysis of the prevalence and risk factors of malnutrition among hospitalized patients in Busan Prev. Nutr. Food Sci. 2013 18 117 123 10.3746/pnf.2013.18.2.117 24471120 PMC3892498 · DOI
  79. [86]Cereda E. Pedrolli C. Lucchin L. D’Amicis A. Gentile M.G. Battistini N.C. Fusco M.A. Palmo A. Muscaritoli M. PIMAI Group Fluid intake and nutritional risk in non-critically ill patients at hospital referral Br. J. Nutr. 2010 104 878 885 10.1017/S0007114510001492 20447327 · DOI
  80. [87]Budzyński J. Tojek K. Czerniak B. Banaszkiewicz Z. Scores of nutritional risk and parameters of nutritional status assessment as predictors of in-hospital mortality and readmissions in the general hospital population Clin. Nutr. 2016 35 1464 1471 10.1016/j.clnu.2016.03.025 27113120 · DOI
  81. [88]Valero M.A. Diez L. El Kadaoui N. Jimenez A.E. Rodriguez H. Leon M. Are the tools recommended by aspen and espen comparable for assessing the nutritional status? Nutr. Hosp. 2005 20 259 267 16045128
  82. [89]Boban M. Persic V. Miletic B. Kovacicek K. Madzar Z. Heart surgery stems increased nutritional risk, expressed during the course of stationary rehabilitation Ann. Nutr. Metab. 2013 63 17 24 10.1159/000350044 23867581 · DOI
  83. [90]Felder S. Braun N. Stanga Z. Kulkarni P. Faessler L. Kutz A. Steiner D. Laukemann S. Haubitz S. Huber A. Unraveling the link between malnutrition and adverse clinical outcomes: Association of acute and chronic malnutrition measures with blood biomarkers from different pathophysiological states Ann. Nutr. Metab. 2016 68 164 172 10.1159/000444096 26855046 · DOI
  84. [91]Trufa D.I. Arhire L.I. Nita O. Gherasim A. Nita G. Graur M. The evaluation of preoperative nutritional status in patients undergoing thoracic surgery Rev. Med. Chir. Soc. Med. Nat. Iasi 2014 118 514 519 25076724
  85. [92]Cereda E. Limonta D. Pusani C. Vanotti A. Assessing elderly at risk of malnutrition: The new geriatric nutritional risk index versus nutritional risk index Nutrition 2006 22 680 682 10.1016/j.nut.2006.02.003 16635561 · DOI
  86. [93]Cereda E. Zagami A. Vanotti A. Piffer S. Pedrolli C. Geriatric nutritional risk index and overall-cause mortality prediction in institutionalised elderly: A 3-year survival analysis Clin. Nutr. 2008 27 717 723 10.1016/j.clnu.2008.07.005 18774626 · DOI
  87. [94]Bouillanne O. Morineau G. Dupont C. Coulombel I. Vincent J.P. Nicolis I. Benazeth S. Cynober L. Aussel C. Geriatric nutritional risk index: A new index for evaluating at-risk elderly medical patients Am. J. Clin. Nutr. 2005 82 777 783 16210706
  88. [95]Kunimura A. Ishii H. Uetani T. Aoki T. Harada K. Hirayama K. Negishi Y. Shibata Y. Sumi T. Kawashima K. Impact of geriatric nutritional risk index on cardiovascular outcomes in patients with stable coronary artery Dis. J. Cardiol. 2017 69 383 388 10.1016/j.jjcc.2016.09.004 27727086 · DOI
  89. [96]Raiten D.J. Namaste S. Brabin B. Combs G. L’Abbe M.R. Wasantwisut E. Darnton-Hill I. Executive summary—Biomarkers of nutrition for development: Building a consensus Am. J. Clin. Nutr. 2011 94 633S 650S 10.3945/ajcn.110.008227 21733880 PMC3142731 · DOI
  90. [97]Hickson M. Malnutrition and ageing Postgrad. Med. J. 2006 82 2 8 10.1136/pgmj.2005.037564 16397072 PMC2563720 · DOI
  91. [98]Cederholm T. Bosaeus I. Barazzoni R. Bauer J. Van Gossum A. Klek S. Muscaritoli M. Nyulasi I. Ockenga J. Schneider S.M. Diagnostic criteria for malnutrition—An espen consensus statement Clin. Nutr. 2015 34 335 340 10.1016/j.clnu.2015.03.001 25799486 · DOI · Paper page
  92. [99]Cabrerizo S. Cuadras D. Gomez-Busto F. Artaza-Artabe I. Marin-Ciancas F. Malafarina V. Serum albumin and health in older people: Review and meta analysis Maturitas 2015 81 17 27 10.1016/j.maturitas.2015.02.009 25782627 · DOI
  93. [100]Shenkin A. Serum prealbumin: Is it a marker of nutritional status or of risk of malnutrition? Clin. Chem. 2006 52 2177 2179 10.1373/clinchem.2006.077412 17138848 · DOI
  94. [101]Jain S. Gautam V. Naseem S. Acute-phase proteins: As diagnostic tool J. Pharm. Bioallied Sci. 2011 3 118 127 10.4103/0975-7406.76489 21430962 PMC3053509 · DOI
  95. [102]Sanchez-Rodriguez D. Marco E. Ronquillo-Moreno N. Miralles R. Vazquez-Ibar O. Escalada F. Muniesa J.M. Prevalence of malnutrition and sarcopenia in a post-acute care geriatric unit: Applying the new espen definition and ewgsop criteria Clin. Nutr. 2016 10.1016/j.clnu.2016.08.024 27650778 · DOI
  96. [103]Smith D.L. Anemia in the elderly Am. Fam. Physician 2000 62 1565 1572 11037074
  97. [104]Salvi F. Giorgi R. Grilli A. Morichi V. Espinosa E. Spazzafumo L. Marinozzi M.L. Dessi-Fulgheri P. Mini nutritional assessment (short form) and functional decline in older patients admitted to an acute medical ward Aging Clin. Exp. Res. 2008 20 322 328 10.1007/BF03324863 18852545 · DOI
  98. [105]Shum N.C. Hui W.W. Chu F.C. Chai J. Chow T.W. Prevalence of malnutrition and risk factors in geriatric patients of a convalescent and rehabilitation hospital Hong Kong Med. J. 2005 11 234 242 16085939
  99. [106]Bouillanne O. Golmard J.L. Coussieu C. Noel M. Durand D. Piette F. Nivet-Antoine V. Leptin a new biological marker for evaluating malnutrition in elderly patients Eur. J. Clin. Nutr. 2007 61 647 654 10.1038/sj.ejcn.1602572 17151588 · DOI
  100. [107]Chevalier S. Saoud F. Gray-Donald K. Morais J.A. The physical functional capacity of frail elderly persons undergoing ambulatory rehabilitation is related to their nutritional status J. Nutr. Health Aging 2008 12 721 726 19043647
  101. [108]Benigni I. Devos P. Rofidal T. Seguy D. The CP-MST, a malnutrition screening tool for institutionalized adult cerebral palsy patients Clin. Nutr. 2011 30 769 773 10.1016/j.clnu.2011.06.008 21764187 · DOI
  102. [109]Kawabe N. Hashimoto S. Harata M. Nitta Y. Murao M. Nakano T. Shimazaki H. Kobayashi K. Komura N. Ito H. Assessment of nutritional status of patients with hepatitis c virus-related liver cirrhosis Hepatol. Res. 2008 38 484 490 10.1111/j.1872-034X.2007.00300.x 18021235 · DOI
  103. [110]Wikby K. Ek A.C. Christensson L. Nutritional status in elderly people admitted to community residential homes: Comparisons between two cohorts J. Nutr. Health Aging 2006 10 232 238 16622585
  104. [111]Bonnefoy M. Ayzac L. Ingenbleek Y. Kostka T. Boisson R.C. Bienvenu J. Usefulness of the prognostic inflammatory and nutritional index (PINI) in hospitalized elderly patients Int. J. Vitam. Nutr. Res. 1998 68 189 195 9637950
  105. [112]Devoto G. Gallo F. Marchello C. Racchi O. Garbarini R. Bonassi S. Albalustri G. Haupt E. Prealbumin serum concentrations as a useful tool in the assessment of malnutrition in hospitalized patients Clin. Chem. 2006 52 2281 2285 10.1373/clinchem.2006.080366 17068165 · DOI

Cited by

Sorted by citations

Authors
Zhang, Z., Pereira, S., Luo, M., & Matheson, E.
Affiliations
  • University of Illinois Urbana-Champaign (US)
  • Abbott Nutrition (United States) (US)
  • Medical University of South Carolina (US)
Corresponding author
Pereira, Suzette
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2017-08-03
Volume
9
Issue
8
Pages
829
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu9080829
PMC
PMC5579622
OpenAlex
W2745090989
Cited by
531
References
2
Citations by year
2026: 43 · 2025: 74 · 2024: 79 · 2023: 87 · 2022: 77 · 2021: 70 · 2020: 57 · 2019: 24 · 2018: 18 · 2017: 2
FWCI
3.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
Keywords
malnutrition, older adults, blood biomarkers, malnutrition risk assessment, Mini Nutritional Assessment, Subjective Global Assessment, NRS-2002, serum albumin, prealbumin, hemoglobin, total cholesterol, body mass index, acute illness, hospitalized patients
MeSH terms
Serum Albumin, Human, Age Factors, Aged, Aged, 80 and over, Aging, Cholesterol, Female, Hemoglobins, Humans, Male, Middle Aged, Nutritional Status, Prealbumin, Predictive Value of Tests, Risk Factors, Biomarkers, Nutrition Assessment, Body Mass Index, Linear Models, Malnutrition

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review