Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1
Open accessAbstract
Stimulation of the ubiquitin-proteasome pathway—especially E3 ubiquitin ligases Atrogin-1 and MuRF1—is associated with muscle loss in diabetes. Elevated lipid metabolites impair myogenesis. Oligonol, a low molecular weight polyphenol derived from lychee, exhibited anti-diabetic and anti-obesity properties, suggesting it could be a proper supplement for attenuating muscle loss. Dietary (10 weeks) oligonol supplementation (20 or 200 mg/kg diet) on the skeletal muscle loss was investigated in diabetic db/db mice. Transcription factors NF-κB and FoxO3a involved in regulation of Atrogin-1 and MuRF1 were also investigated. Attenuation of muscle loss by oligonol (both doses) was associated with down-regulation of Atrogin-1 and MuRF1 gene expression. Oligonol supplementation decreased NF-κB expression in the nuclear fraction compared with db/db mice without oligonol supplement. Upregulation of sirtuin1 (SIRT1) expression prevented FoxO3a nuclear localization in db/db mice supplemented with oligonol. Marked increases in AMPKα activity and Ppara mRNA expression leading to lower lipid accumulation by oligonol provided additional benefits for attenuating muscle loss. Oligonol limited palmitate-induced senescent phenotype and cell cycle arrest and suppressed Atrogin-1 and MuRF1 mRNA expression in palmitate-treated C2C12 muscle cells, thus contributing to improving the impaired myotube formation. In conclusion, oligonol-mediated downregulation of Atrogin-1 and MuRF1 gene expression alleviates muscle loss and improves the impaired myotube formation, indicating that oligonol supplementation may be useful for the attenuation of myotube loss.
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Dietary oligonol supplementation reduces the expression of MAFbx and MuRF1 through upregulating sirtuin-1 and FoxO3a in diabetic db/db mice.
“Moreover, dietary oligonol supplementation reduces the expression of MAFbx and MuRF1 through upregulating sirtuin-1 and FoxO3a in diabetic db/db mice [99].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [99]
Oligonol alleviates palmitate-induced senescent phenotype in C2C12 myotubes and suppresses the expression of MAFbx and MuRF1.
“Oligonol alleviates palmitate-induced senescent phenotype in C2C12 myotubes and suppresses the expression of MAFbx and MuRF1.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [99]
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- Authors
- Liu, H.-W., Chen, Y.-J., Chang, Y.-C., & Chang, S.-J.
- Affiliations
- National Taiwan Normal University (TW)
- National Cheng Kung University (TW)
- Corresponding author
- Chang, Sue-Joan
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-09-20
- Volume
- 9
- Issue
- 9
- Pages
- 1040
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5622800
- OpenAlex
- W2755424804
- Cited by
- 47
- References
- 35
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 10 · 2023: 2 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 3 · 2018: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Science and Technology, Taiwan (NSC102-2628-B006-012-MY3, 2320-B-006, MOST104-2320-B006-023-MY3)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- oligonol, muscle atrophy, skeletal muscle atrophy, diabetes mellitus, atrogin-1, MuRF1, ubiquitin-proteasome system, E3 ubiquitin ligase, NF-κB, FOXO3, SIRT1, AMPK, PPARα, lipid accumulation, myotube formation, db/db mice, dietary supplementation
- MeSH terms
- Tripartite Motif Proteins, Forkhead Box Protein O3, Animals, Catechin, Cell Differentiation, Cells, Cultured, Diabetes Mellitus, Experimental, Disease Models, Animal, Fruit, Gene Expression Regulation, Male, Mice, Inbred C57BL, Molecular Weight, Muscle Proteins, Phenols, RNA, Messenger, NF-kappa B, Muscle, Skeletal, Litchi, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Mice, Sarcopenia, Sirtuin 1, Polyphenols
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