Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy

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Quercetin Suppresses MIP-1α–Induced Adipose Inflammation by Downregulating Its Receptors CCR1/CCR5 and Inhibiting Inflammatory Signaling

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The influence of isoflavone for denervation-induced muscle atrophy

Tabata, S., Aizawa, M., Kinoshita, M., Ito, Y., Kawamura, Y., Takebe, M., Pan, W., & Sakuma, K. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1593-x · Cited by 26 · see citing works

Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice

Chan, S.-T., Chuang, C., Lin, Y., Liao, J., Lii, C., & Yeh, S.-L. (2017) · Food & Function · doi:10.1039/c7fo01444a · Cited by 26 · see citing works

Nutrient weight against sarcopenia: regulation of the IGF-1/PI3K/Akt/FOXO pathway in quinoa metabolites

Liu, P., Hu, Y., Wang, M.-J., & Kang, L. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.10.001 · Cited by 24 · see citing works

α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice <i>via</i> activation of cAMP signaling

Tong, T., Kim, M., & Park, T. (2019) · Food &amp; Function · doi:10.1039/c8fo01992d · Cited by 23 · see citing works

Molecular mechanisms of myoprotective action of chondroitin sulfate and glucosamine sulfate in sarcopenia

Громова, О. А., Torshin, I. Y., Lila, A. M., Shostak, N. A., & Владимирович, Р. К. (2019) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2019-1-117-124 · Cited by 23 · see citing works

Medicinal Plants As Natural Polarizers of Macrophages: Phytochemicals and Pharmacological Effects

Davoodvandi, A., Sahebnasagh, R., Mardanshah, O., Asemi, Z., Nejati, M., Shahrzad, M. K., Mirzaei, H. R., & Mirzaei, H. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190829154934 · Cited by 24 · see citing works

Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging

Kim, J. G., Sharma, A. R., Lee, Y., Chatterjee, S., Choi, Y. J., Rajvansh, R., Chakraborty, C., & Lee, S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0282 · Cited by 24 · see citing works

Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control

Zhang, W., You, B., Qi, D., Qiu, L., Ripley-Gonzalez, J. W., Zheng, F., Fu, S., Li, C., Dun, Y., & Liu, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-98771-6 · Cited by 22 · see citing works

The Effects of Flavonoids on Skeletal Muscle Mass, Muscle Function, and Physical Performance in Individuals with Sarcopenia: A Systematic Review of Randomized Controlled Trials

Wu, C., & Suzuki, K. (2023) · Nutrients · doi:10.3390/nu15183897 · Cited by 22 · see citing works

Natural compounds as obesity pharmacotherapies

Zhao, X.-Y., Wang, J.-Q., Neely, G. G., Shi, Y., & Wang, Q.-P. (2023) · Phytotherapy Research · doi:10.1002/ptr.8083 · Cited by 17 · see citing works

Natural constituents from food sources: potential therapeutic agents against muscle wasting

Shen, S., Yu, H., Gan, L., Yang, Y., & Lin, L. (2019) · Food & Function · doi:10.1039/c9fo00912d · Cited by 20 · see citing works

(-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells

Edwards, S. J., Carter, S., Nicholson, T., Allen, S., Morgan, P. T., Jones, S. W., Rendeiro, C., & Breen, L. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109150 · Cited by 18 · see citing works

Platycodon grandiflorum-derived saponin attenuates the eccentric exercise-induced muscle damage

Kim, Y.-A., Oh, S.-H., Lee, G.-H., Hoa, P. T., Jin, S. W., Chung, Y., Lee, Y. C., & Jeong, H. G. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.12.045 · Cited by 18 · see citing works

Effects of Quercetin Glycoside Supplementation Combined With Low-Intensity Resistance Training on Muscle Quantity and Stiffness: A Randomized, Controlled Trial

Otsuka, Y., Miyamoto, N., Nagai, A., Izumo, T., Nakai, M., Fukuda, M., Arimitsu, T., Yamada, Y., & Hashimoto, T. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.912217 · Cited by 17 · see citing works

Anti-Sarcopenic Obesity Effects of Lonicera caerulea Extract in High-Fat Diet-Fed Mice

Lee, Y., Park, E., Kim, S. M., Kim, J., & Lee, H. (2021) · Antioxidants · doi:10.3390/antiox10101633 · Cited by 17 · see citing works

Whole grain cereal attenuates obesity-induced muscle atrophy by activating the PI3K/Akt pathway in obese C57BL/6N mice

Lee, S., Kim, M., Kim, C., & Hwang, J. (2017) · Food Science and Biotechnology · doi:10.1007/s10068-017-0277-x · Cited by 17 · see citing works

Lespedeza bicolor extract supplementation reduced hyperglycemia-induced skeletal muscle damage by regulation of AMPK/SIRT/PGC1α–related energy metabolism in type 2 diabetic mice

Lee, H., Kim, S. Y., & Lim, Y. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.12.007 · Cited by 17 · see citing works

Rice Bran Supplementation Ameliorates Gut Dysbiosis and Muscle Atrophy in Ovariectomized Mice Fed with a High-Fat Diet

Huang, P., Yeh, C., Yang, S., Shirakawa, H., Chang, C., Chen, L., Chiu, Y.-S., & Chiu, W. (2023) · Nutrients · doi:10.3390/nu15163514 · Cited by 15 · see citing works

Unraveling Quercetin's Potential: A Comprehensive Review of Its Properties and Mechanisms of Action, in Diabetes and Obesity Complications

Yi, R., Liu, Y., Zhang, X., Sun, X., Wang, N., Zhang, C., Deng, H., Yao, X., Wang, S., & Guang, Y. (2024) · Phytotherapy Research · doi:10.1002/ptr.8332 · Cited by 15 · see citing works

Molecular targets of exercise mimetics and their natural activators

Jang, Y. J., & Byun, S. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.12.151 · Cited by 16 · see citing works

NEFAs Influence the Inflammatory and Insulin Signaling Pathways Through TLR4 in Primary Calf Hepatocytes in vitro

Deng, Q., Du, L., Zhang, Y., & Liu, G. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.755505 · Cited by 15 · see citing works

Effect of Moringa oleifera leaf extract on exercise and dexamethasone-induced functional impairment in skeletal muscles

Barodia, K., Cheruku, S. P., Kanwal, A., Menon, A., Valapil, R., Rukade, A., Shenoy, R. U. K., Prabhu, C., Sharma, V., Divya, K. P., et al. (2021) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2021.07.019 · Cited by 15 · see citing works

Sarcopenia and Ageing

Cheng, K. Y.-K., Bao, Z., Long, Y., Liu, C., Huang, T., Cui, C., Chow, S. K.-H., Wong, R. M. Y., & Cheung, W.-H. (2023) · Subcellular Biochemistry · doi:10.1007/978-3-031-26576-1_6 · Cited by 14 · see citing works

Natural Flavonoids for the Prevention of Sarcopenia: Therapeutic Potential and Mechanisms

Yoon, Y. E., Ju, S. H., Kim, Y., & Lee, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157458 · Cited by 13 · see citing works

The hypoglycemic activity of buckwheat and the underlying mechanisms: A mechanistic review

Jin, X., He, C., Guo, Z., Li, Y., Li, Y., Gao, J., Wang, M., & Han, L. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105046 · Cited by 13 · see citing works

Effects of eicosapentaenoic acid and docosahexaenoic acid on C2C12 cell adipogenesis and inhibition of myotube formation

Ghnaimawi, S., Shelby, S., Baum, J., & Huang, Y. (2019) · Animal Cells and Systems · doi:10.1080/19768354.2019.1661282 · Cited by 13 · see citing works

Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation (J Obes Metab Syndr 2018;27:102–9)

Choi, H., Kim, C.-S., & Yu, R. (2019) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2019.28.1.71 · Cited by 13 · see citing works

Effects of first-generation in utero exposure to diesel engine exhaust on second-generation placental function, fatty acid profiles and foetal metabolism in rabbits: preliminary results

Rousseau‐Ralliard, D., Valentino, S., Aubrière, M.-C., Dahirel, M., Lallemand, M.-S., Archilla, C., Jouneau, L., Fournier, N., Richard, C., Aı̈oun, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46130-x · Cited by 13 · see citing works

Flavan 3-ol Delays the Progression of Disuse Atrophy Induced by Hindlimb Suspension in Mice

Ito, M., Kudo, N., Miyake, Y., Imai, T., Unno, T., Yamashita, Y., Hirota, Y., Ashida, H., & Osakabe, N. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.07.010 · Cited by 10 · see citing works

YuPingFeng (YPF) upregulates caveolin-1 (CAV1) to alleviate pulmonary fibrosis through the TGF-β1/Smad2 pathway

Chen, X., Wei, M., Li, G., Sun, Q.-L., Fan, J.-Q., Li, J., Yun, C.-M., Liu, D., Shi, H., & Qu, Y.-Q. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117357 · Cited by 10 · see citing works

Korean Mint (Agastache rugosa) Extract and Its Bioactive Compound Tilianin Alleviate Muscle Atrophy via the PI3K/Akt/FoxO3 Pathway in C2C12 Myotubes

Woo, Y. K., Kang, M., Kim, C., & Hwang, J. (2024) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2024.29.2.154 · Cited by 10 · see citing works

Quercetin induces pannexin 1 expression via an alternative transcript with a translationally active 5′ leader in rhabdomyosarcoma

Xiang, X., Hoang, H., Gilchrist, V. H., Langlois, S., Alain, T., & Cowan, K. N. (2022) · Oncogenesis · doi:10.1038/s41389-022-00384-9 · Cited by 10 · see citing works

Fish oil enriched ω-3 fatty acids ameliorates protein synthesis/degradation imbalance, inflammation, and wasting in muscles of diet-induced obese rats

Liu, S., Chen, Y., Tzeng, H.-P., & Chiang, M. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104755 · Cited by 10 · see citing works

Molecular weight‐dependent effects of Undaria pinnatifida fucoidan isolates on palmitate‐induced inflammation and muscle atrophy in C2C12 myotubes

Kim, J., Park, E., & Lee, H. (2023) · Journal of Applied Phycology · doi:10.1007/s10811-023-03111-y · Cited by 9 · see citing works

Dietary Alaska Pollack Protein Induces Acute and Sustainable Skeletal Muscle Hypertrophy in Rats

Uchida, K., Fujitani, M., Mizushige, T., Kawabata, F., Hayamizu, K., Uozumi, K., Hara, Y., Sawai, M., Uehigashi, R., Okada, S., et al. (2022) · Nutrients · doi:10.3390/nu14030547 · Cited by 9 · see citing works

Functional Foods in fad diets: A review

Navarro, D. A., Raz, O., Gabriel, S., Shriqui, V. K., Gonen, E., & Boaz, M. (2017) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v7i9.346 · Cited by 9 · see citing works

Inhibitory Effects of Standardized Leonurus japonicus Extract and Its Bioactive Leonurine on TNF-α-Induced Muscle Atrophy in L6 Myotubes

Lee, J., Kim, C., Lee, H., & Hwang, J. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2005.05023 · Cited by 9 · see citing works

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

Iglesias‐Carres, L., & Neilson, A. P. (2021) · Food & Function · doi:10.1039/d1fo02782d · Cited by 9 · see citing works

Obesity and muscle‐macrophage crosstalk in humans and mice: A systematic review

Rudrapatna, S., Bhatt, M., Wang, K., Bierbrier, R., Wang, P., Banfield, L. E., Elsheikh, W., Sims, E. D., Peterson, D. C., Thabane, L., et al. (2019) · Obesity Reviews · doi:10.1111/obr.12922 · Cited by 9 · see citing works

Quercetin supplementation attenuates muscle wasting in cancer-associated cachexia in mice

Levolger, S., van den Engel, S., Ambagtsheer, G., IJzermans, J. N. M., & de Bruin, R. W. F. (2020) · Nutrition and Healthy Aging · doi:10.3233/nha-200084 · Cited by 9 · see citing works

β-Hydroxy-β-Methylbutyrate Supplementation Promotes Antitumor Immunity in an Obesity Responsive Mouse Model of Pancreatic Ductal Adenocarcinoma

Coleman, M. F., Liu, K. A., Pfeil, A. J., Etigunta, S. K., Tang, X., Fabela, S., Lashinger, L. M., Cui, Z., & Hursting, S. D. (2021) · Cancers · doi:10.3390/cancers13246359 · Cited by 8 · see citing works

Effects of Alnus japonica Hot Water Extract and Oregonin on Muscle Loss and Muscle Atrophy in C2C12 Murine Skeletal Muscle Cells

An, D. H., Lee, C. H., Kwon, Y., Kim, T. H., Kim, E. J., Jung, J. I., Min, S., Cheong, E. J., Kim, S., Kim, H. K., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17121661 · Cited by 8 · see citing works

A Combination of Resveratrol and Quercetin Prevents Sarcopenic Obesity: Its Role as a Signaling Inhibitor of Myostatin/ActRIIA and ActRIIB/Smad and as an Enhancer of Insulin Actions

Cano-Martı́nez, A., Méndez-Castro, J. A., García-Vázquez, V. E., Carreón‐Torres, E., Díaz‐Díaz, E., Sánchez-Aguilar, M., Castrejón-Téllez, V., & Rubio-Ruiz, M. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104952 · Cited by 9 · see citing works

Effects of quercetin nanoemulsion on SIRT1 activation and mitochondrial biogenesis in the skeletal muscle of high-fat diet-fed mice

Lee, M.-S., Doo, M., & Kim, Y. (2024) · Nutrition Research and Practice · doi:10.4162/nrp.2024.18.6.806 · Cited by 7 · see citing works

Polyphenols and Exercise in Mitochondrial Biogenesis: Focus on Age-Related CNS Disorders

Tu, J. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05121-y · Cited by 10 · see citing works

Solanum melongena extract supplementation protected skeletal muscle and brain damage by regulation of BDNF/PGC1α/irisin pathway via brain function-related myokines in high-fat diet induced obese mice

Lee, H., Kim, S. Y., & Lim, Y. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109537 · Cited by 7 · see citing works

Quercetin prevents sarcopenia by reversing oxidative stress and mitochondrial damage

Sun, J., Liu, H., Yan, Y., & Fang, F. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10411-9 · Cited by 7 · see citing works

The clinical status and treatment options for osteoarthritis in patients with frailty

Naumov, A. V., Khovasova, N. O., Мороз, В. И., Tkacheva, O. N., & Shavlovskaya, O. A. (2019) · Terapevticheskii arkhiv · doi:10.26442/00403660.2019.12.000487 · Cited by 7 · see citing works

Dietary Plant Extracts in Improving Skeletal Muscle Development and Metabolic Function

Xiang, J., Du, ‬., & Wang, H. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2087669 · Cited by 8 · see citing works

Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction

Pan, C., Yang, Y., Zhao, Z., & Hu, J.-Y. (2025) · APOPTOSIS · doi:10.1007/s10495-024-02069-7 · Cited by 6 · see citing works

Research Article Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy

Kawada, T. G. T. (2016)

Quercetin Reduces Tumor Necrosis Factor Alpha-Induced Muscle Atrophy by Upregulation of Heme Oxygenase-1

Kim, Y., Kim, C.-S., Joe, Y., Chung, H. T., Ha, T. Y., & Yu, R. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.4108 · Cited by 69 · see citing works

Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes

Anhê, G. F., Okamoto, M. M., Kinote, A. P. B. D. M., Sollon, C. S., Lellis‐Santos, C., Anhê, F. F., Lima, G. A., Hirabara, S. M., Velloso, L. A., Bordin, S. A., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.007 · Cited by 84 · see citing works

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

Dong, J., Zhang, X., Zhang, L., Bian, H., Xu, N., Bao, B., & Liu, J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m038786 · Cited by 295 · see citing works

Isoquercetin Ameliorates Obesity-Associated Muscle Atrophy and Modulates the Gut Microbiota–Bile Acid Axis

Song, Y., Dong, T., Fu, Z., Ao, X., Zhao, G., Chen, Y., Du, J., Wang, W., Sun, C., & Tian, Z. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c16221 · Cited by 2 · see citing works