Effect of Probiotics and Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Bias in meta-analysis detected by a simple, graphical test

Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722

Meta-analysis in clinical trials

DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552

Quantifying heterogeneity in a meta‐analysis

Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648

Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration

Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544

The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses

Hobson, D., Curry, R. L., Beare, A. S., & Ward-Gardner, A. (1972) · Epidemiology and Infection · doi:10.1017/s0022172400022610 · Cited by 1,003

Use of the Inactivated Intranasal Influenza Vaccine and the Risk of Bell's Palsy in Switzerland

Mütsch, M., Zhou, W., Rhodes, P., Bopp, M., Chen, R. T., Linder, T. E., Spyr, C., & Steffen, R. P. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa030595 · Cited by 925

Mechanisms of probiotic actions – A review

Oelschlaeger, T. A. (2009) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2009.08.005 · Cited by 720

Aging of the innate immune system

Shaw, A. C., Joshi, S., Greenwood, H., Panda, A., & Lord, J. M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.05.003 · Cited by 647

Nutrition, immunity and COVID-19

Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 612

The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies

Wiertsema, S. P., van Bergenhenegouwen, J., Garssen, J., & Knippels, L. M. J. (2021) · Nutrients · doi:10.3390/nu13030886 · Cited by 590

The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties

Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381

The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

DeJong, E. N., Surette, M. G., & Bowdish, D. M. E. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.013 · Cited by 370

Probiotics in Medicine: A Long Debate

Stavropoulou, E., & Bezirtzoglou, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02192 · Cited by 312

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota

Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 133

Gut microbiota and old age: Modulating factors and interventions for healthy longevity

Coman, V., & Vodnar, D. C. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111095 · Cited by 129

Nutrition and immunity: lessons for COVID-19

Calder, P. C. (2021) · Nutrition and Diabetes · doi:10.1038/s41387-021-00165-0 · Cited by 117

The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: A systematic review and meta-analysis of randomized controlled trials

Yeh, T.-L., Shih, P.-C., Liu, S.-J., Lin, C.-H., Liu, J.-M., Lei, W.-T., & Lin, C.-Y. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s155110 · Cited by 93

Nutrition and immunity: lessons for COVID-19

Calder, P. C. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00949-8 · Cited by 139

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis

Lee, M.-D., Lin, C., Lei, W., Chang, H.-Y., Lee, H., Yeung, C., Chiu, N., Chi, H., Liu, J., Hsu, R., et al. (2018) · Nutrients · doi:10.3390/nu10040409 · Cited by 89

Kefir: A protective dietary supplementation against viral infection

Hamida, R. S., Shami, A., Ali, M. A., Almohawes, Z. N., Mohammed, A. E., & Bin-Meferij, M. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110974 · Cited by 93

Adjuvant Probiotics and the Intestinal Microbiome: Enhancing Vaccines and Immunotherapy Outcomes

Vitetta, L., Saltzman, E., Thomsen, M., Nikov, T., & Hall, S. (2017) · Vaccines · doi:10.3390/vaccines5040050 · Cited by 83

Healthy ageing: the natural consequences of good nutrition—a conference report

Marsman, D. S., Belsky, D. W., Gregori, D., Johnson, M. A., Dog, T. L., Meydani, S. N., Pigat, S., Sadana, R., Shao, A., & Griffiths, J. C. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1723-0 · Cited by 85

Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

Morais, A. H. D. A., Passos, T. S., Maciel, B. L. L., & da Silva-Maia, J. K. (2020) · Nutrients · doi:10.3390/nu12061737 · Cited by 78

Probiotics and prebiotics in clinical tests: an update

Brüssow, H. (2019) · F1000Research · doi:10.12688/f1000research.19043.1 · Cited by 78

Current Progress and Future Perspectives on the Use of Bacillus clausii

Ghelardi, E., y Abreu, A. T. A., Marzet, C. B., Calatayud, G. Á., Perez, M. I., & Castro, A. P. M. (2022) · Microorganisms · doi:10.3390/microorganisms10061246 · Cited by 79

Aging Fits the Disease Criteria of the International Classification of Diseases

Khaltourina, D. A., Matveyev, Y., Alekseev, A., Cortese, F., & Ioviţă, A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111230 · Cited by 78

Mechanisms linking the human gut microbiome to prophylactic and treatment strategies for COVID-19

Walton, G., Gibson, G. R., & Hunter, K. A. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003980 · Cited by 66

Microbiota and COVID-19: Long-term and complex influencing factors

Gang, J., Wang, H., Xue, X., & Zhang, S. J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.963488 · Cited by 62

Ingestion, Immunity, and Infection: Nutrition and Viral Respiratory Tract Infections

Govers, C., Calder, P. C., Savelkoul, H. F. J., Albers, R., & van Neerven, R. J. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.841532 · Cited by 71

Probiotics and prebiotics: potential prevention and therapeutic target for nutritional management of COVID-19?

Batista, K. S., de Albuquerque, J. G., de Vasconcelos, M. H. A., Bezerra, M. L. R., Barbalho, M. B. D. S., Pinheiro, R. O., & Aquino, J. D. S. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000317 · Cited by 56

The emerging role of probiotics as a mitigation strategy against coronavirus disease 2019 (COVID-19)

Mirzaei, R., Attar, A., Papizadeh, S., Jeda, A. S., Hosseini‐Fard, S. R., Jamasbi, E., Kazemi, S., Amerkani, S., Talei, G. R., Moradi, P., et al. (2021) · Archives of Virology · doi:10.1007/s00705-021-05036-8 · Cited by 59

Could nutritional supplements act as therapeutic adjuvants in COVID-19?

Costagliola, G., Spada, E., Comberiati, P., & Peroni, D. G. (2021) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-021-00990-0 · Cited by 49

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Catalano, A. A., Iacopetta, D., Ceramella, J., Maio, A. C. D., Basile, G., Giuzio, F., Bonomo, M. G., Aquaro, S., Walsh, T. J., Sinicropi, M. S., et al. (2022) · Foods · doi:10.3390/foods11182884 · Cited by 48

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

Kazemifard, N., Dehkohneh, A., & Ghavami, S. B. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.940454 · Cited by 48

Evidence map on the contributions of traditional, complementary and integrative medicines for health care in times of COVID-19

Portella, C. F. S., Ghelman, R., Abdala, C. V. M., & Schveitzer, M. C. (2020) · Integrative Medicine Research · doi:10.1016/j.imr.2020.100473 · Cited by 42

The Potential Role of Probiotics in Protection against Influenza a Virus Infection in Mice

Lu, W., Fang, Z., Liu, X., Li, L., Zhang, P., Zhao, J., Zhang, H., & Chen, W. (2021) · Foods · doi:10.3390/foods10040902 · Cited by 48

Therapeutic Potential of Nutraceuticals and Dietary Supplements in the Prevention of Viral Diseases: A Review

Singh, S. P., Kola, P., Kaur, D., Singla, G., Mishra, V., Panesar, P. S., Mallikarjunan, K., & Krishania, M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.679312 · Cited by 41

Influence of human gut microbiome on the healthy and the neurodegenerative aging

Borrego-Ruiz, A., & Borrego, J. J. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112497 · Cited by 43

From the Role of Microbiota in Gut‐Lung Axis to SARS‐CoV‐2 Pathogenesis

Badi, S. A., Tarashi, S., Fateh, A., Rohani, P., Masotti, A., & Siadat, S. D. (2021) · Mediators of Inflammation · doi:10.1155/2021/6611222 · Cited by 39

Direct evidence of the preventive effect of milk replacer–based probiotic feeding in calves against severe diarrhea

Kayasaki, F., Okagawa, T., Konnai, S., Kohara, J., Sajiki, Y., Watari, K., Ganbaatar, O., Goto, S., Nakamura, H., Shimakura, H., et al. (2021) · Veterinary Microbiology · doi:10.1016/j.vetmic.2020.108976 · Cited by 44

Probiotic supplementation has a limited effect on circulating immune and inflammatory markers in healthy adults: A systematic review of randomized controlled trials

Mohr, A. E., Basile, A. J., Crawford, M. S., Sweazea, K. L., & Carpenter, K. C. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.08.018 · Cited by 37

The direct and indirect effects of bioactive compounds against coronavirus

Tomaş, M., Çapanoğlu, E., Bahrami, A., Hosseini, H., Akbari‐Alavijeh, S., Shaddel, R., Rehman, A., Rezaei, A., Rashidinejad, A., Garavand, F., et al. (2021) · Food Frontiers · doi:10.1002/fft2.119 · Cited by 38

Effects of probiotic administration on immune responses of children and adolescents with type 1 diabetes to a quadrivalent inactivated influenza vaccine

Bianchini, S., Orabona, C., Camilloni, B., Berioli, M. G., Argentiero, A., Matino, D., Alunno, A., Albini, E., Vacca, C., Pallotta, M. T., et al. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1633877 · Cited by 37

Exploring the Effect of Probiotics, Prebiotics, and Postbiotics in Strengthening Immune Activity in the Elderly

Akatsu, H. (2021) · Vaccines · doi:10.3390/vaccines9020136 · Cited by 38

Lactobacillus plantarum induces innate cytokine responses that potentially provide a protective benefit against COVID‑19: A single‑arm, double‑blind, prospective trial combined with an in vitro cytokine response assay

Kageyama, Y., Nishizaki, Y., Aida, K., Yayama, K., Ebisui, T., Akiyama, T., & Nakamura, T. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10942 · Cited by 37

End-Stage Renal Disease-Related Accelerated Immune Senescence: Is Rejuvenation of the Immune System a Therapeutic Goal?

Ducloux, D., Legendre, M., Bamoulid, J., Saas, P., Courivaud, C., & Crépin, T. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.720402 · Cited by 38

The intestinal microbiota and improving the efficacy of COVID-19 vaccinations

Chen, J., Vitetta, L., Henson, J. D., & Hall, S. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104850 · Cited by 32

Probiotics and Prebiotics

Sanders, M. E., Goh, Y. J., & Klaenhammer, T. R. (2019) · ASM Press eBooks · doi:10.1128/9781555819972.ch32 · Cited by 32

Probiotics as Adjuvants in Vaccine Strategy: Is There More Room for Improvement?

Peroni, D. G., & Morelli, L. (2021) · Vaccines · doi:10.3390/vaccines9080811 · Cited by 35

Gut microbiome, Vitamin D, ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection

Shenoy, S. (2021) · Inflammation Research · doi:10.1007/s00011-021-01510-w · Cited by 31

Efficacy of probiotic treatment as post-exposure prophylaxis for COVID-19: A double-blind, Placebo-Controlled Randomized trial

Wischmeyer, P. E., Tang, H., Ren, Y., Bohannon, L. M., Jiang, D., Bergens, M. A., Ramirez, Z. E., Andermann, T. M., Messina, J. A., Sung, J., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.11.043 · Cited by 32

Systematic review of the impact of intestinal microbiota on vaccine responses

Ardura‐Garcia, C., Curtis, N. C., & Zimmermann, P. (2024) · npj Vaccines · doi:10.1038/s41541-024-01000-0 · Cited by 36

Probiotic therapy, African fermented foods and food-derived bioactive peptides in the management of SARS-CoV-2 cases and other viral infections

Mgbodile, F. C., & Nwagu, T. N. (2023) · Biotechnology Reports · doi:10.1016/j.btre.2023.e00795 · Cited by 35

Potential probiotics for regulation of the gut-lung axis to prevent or alleviate influenza in vulnerable populations

Wang, Y.-H., Limaye, A., Liu, J., & Wu, T.-N. (2022) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2022.08.004 · Cited by 30

Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age

Brown, J. A., Bashir, H., & Zeng, M. Y. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.01.006 · Cited by 31

Effects of diets, foods and nutrients on immunity: Implications for COVID‐19?

Lockyer, S. (2020) · Nutrition Bulletin · doi:10.1111/nbu.12470 · Cited by 28

Probiotic Bacteria and Their Cell Walls Induce Th1-Type Immunity Against Salmonella Typhimurium Challenge

Lemme‐Dumit, J. M., Cazorla, S. I., Perdigón, G., & Maldonado-Galdeano, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660854 · Cited by 26

Patient Nutrition and Probiotic Therapy in COVID-19: What Do We Know in 2021?

Hawryłkowicz, V., Lietz–Kijak, D., Kaźmierczak-Siedlecka, K., Sołek-Pastuszka, J., Stachowska, L., Folwarski, M., Parczewski, M., & Stachowska, E. (2021) · Nutrients · doi:10.3390/nu13103385 · Cited by 25

Gut Microbiota-targeted Interventions for Reducing the Incidence, Duration, and Severity of Respiratory Tract Infections in Healthy Non-elderly Adults

Karl, J. P. (2020) · Military Medicine · doi:10.1093/milmed/usaa261 · Cited by 23

Gastrointestinal Disease and COVID-19: A Review of Current Evidence

Chen, F., Dai, Z., Huang, C., Chen, H., Wang, X., & Li, X. (2021) · Digestive Diseases · doi:10.1159/000519412 · Cited by 23

Effectiveness of Multistrain Probiotic Formulation on Common Infectious Disease Symptoms and Gut Microbiota Modulation in Flu‐Vaccinated Healthy Elderly Subjects

Sandionigi, A., Giani, A. D., Tursi, F., Michelotti, A., Cestone, E., Giardina, S., Zampolli, J., & Gennaro, P. D. (2022) · BioMed Research International · doi:10.1155/2022/3860896 · Cited by 24

Microbiota and the Response to Vaccines Against Respiratory Virus

Gonçalves, J. I. B., Borges, T. J., & de Souza, A. P. D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.889945 · Cited by 23

Mapping Host-Related Correlates of Influenza Vaccine-Induced Immune Response: An Umbrella Review of the Available Systematic Reviews and Meta-Analyses

Domnich, A., Manini, I., Calabrò, G. E., de Waure, C., & Montomoli, E. (2019) · Vaccines · doi:10.3390/vaccines7040215 · Cited by 23

Daily Lactobacillus Probiotic versus Placebo in COVID-19-Exposed Household Contacts (PROTECT-EHC): A Randomized Clinical TrialPreprint

Wischmeyer, P. E., Tang, H., Ren, Y., Bohannon, L. M., Ramirez, Z. E., Andermann, T. M., Messina, J. A., Sung, J., Jensen, D., Jung, S., et al. (2022) · medRxiv · doi:10.1101/2022.01.04.21268275 · Cited by 24

The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions

Rossouw, C., Ryan, F. J., & Lynn, D. J. (2024) · FEBS Journal · doi:10.1111/febs.17241 · Cited by 22

A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention

Budhwar, S., Sethi, K., & Chakraborty, M. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00325-1 · Cited by 23

Probiotics in the Management of Mental and Gastrointestinal Post-COVID Symptomes

Łoniewski, I., Skonieczna‐Żydecka, K., Sołek-Pastuszka, J., & Marlicz, W. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175155 · Cited by 22

Galacto-Oligosaccharides and the Elderly Gut: Implications for Immune Restoration and Health

Hu, Y., Aljumaah, M. R., & Azcárate-Peril, M. A. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100263 · Cited by 26

Gastrointestinal Microbiome and Multiple Health Outcomes: Umbrella Review

Chang, C., Yuan, X., Zhang, X., Chen, X., & Li, K. (2022) · Nutrients · doi:10.3390/nu14183726 · Cited by 22

Probiotics: A gut response to the COVID-19 pandemic but what does the evidence show?

Brahma, S., Naik, A. S., & Lordan, R. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.08.023 · Cited by 21

Vaccines, Microbiota and Immunonutrition: Food for Thought

Renzo, L. D., Franza, L., Monsignore, D., Esposito, E., Rio, P., Gasbarrini, A., Gambassi, G., Cianci, R., & LORENZO, A. D. (2022) · Vaccines · doi:10.3390/vaccines10020294 · Cited by 17

Impact of the intestinal environment on the immune responses to vaccination

Hosomi, K., & Kunisawa, J. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.08.079 · Cited by 18

Selection of Probiotics in the Prevention of Respiratory Tract Infections and Their Impact on Occupational Health: Scoping Review

Picó-Monllor, J. A., Ruzafa-Costas, B., Núñez-Delegido, E., Sánchez-Pellicer, P., Peris-Berraco, J., & Navarro‐López, V. (2021) · Nutrients · doi:10.3390/nu13124419 · Cited by 18

A Review on the Antiviral Activity of Functional Foods Against COVID-19 and Viral Respiratory Tract Infections

Omer, A. K., Khorshidi, S., Mortazavi, N., & Rahman, H. S. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s361001 · Cited by 19

Vitamin D supplementation: An alternative to enhance the effectiveness of vaccines against SARS-CoV-2?

Inserra, F., Tajer, C. D., Antonietti, L., Mariani, J. A., Ferder, L., & Manucha, W. A. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.07.031 · Cited by 16

Effect of probiotics as an immune modulator for the management of COVID-19

Ray, M., Manjunath, A., & Halami, P. M. (2023) · Archives of Microbiology · doi:10.1007/s00203-023-03504-0 · Cited by 18

Foods to deliver immune-supporting nutrients

Calder, P. C. (2021) · Current Opinion in Food Science · doi:10.1016/j.cofs.2021.12.006 · Cited by 23

Development and management of gastrointestinal symptoms in long-term COVID-19

He, K.-Y., Lei, X., Zhang, L., Wu, D., Li, J., Lu, L., Laila, U. E., Cui, C.-Y., Xu, Z.-X., & Jian, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1278479 · Cited by 17

Effects of select dietary supplements on the prevention and treatment of viral respiratory tract infections: a systematic review of randomized controlled trials

Mashhadi, N. S., Kazemi, M., Saadat, S., & Moradi, S. (2021) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1918546 · Cited by 15

Probiotics for the Management of Infectious Diseases: Reviewing the State of the Art

Wiegers, C., van de Burgwal, L., & Larsen, O. F. A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.877142 · Cited by 15

Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review

El‐Saadony, M. T., Saad, A. M., Sitohy, M. Z., Alkafaas, S. S., Dladla, M., Ghosh, S., Mohammed, D. M., Ibrahim, E. H., Fahmy, M. A., Elkelish, A., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1713426 · Cited by 16

The effect of oral probiotics on response to vaccination in older adults: a systematic review of randomised controlled trials

Tunc, H. A., Childs, C. E., Swann, J. R., & Calder, P. C. (2024) · Age and Ageing · doi:10.1093/ageing/afae033 · Cited by 15

Immunomodulation by the Commensal Microbiome During Immune-Targeted Interventions: Focus on Cancer Immune Checkpoint Inhibitor Therapy and Vaccination

Reens, A. L., Cabral, D. J., Liang, X., Norton, J. E., Therien, A. G., Hazuda, D. J., & Swaminathan, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643255 · Cited by 14

Nutrition and immunity: lessons from coronavirus disease-2019

Calder, P. C. (2023) · Proceedings of The Nutrition Society · doi:10.1017/s0029665123004792 · Cited by 15

The effect of partially hydrolyzed guar gum on preventing influenza infection

Takahashi, C., & Kozawa, M. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.11.030 · Cited by 11

Gut microbiota on human health and disease

Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00006-2 · Cited by 11

Influence of biotic interventions on the immune response to vaccines in young and older adults

Spacova, I., Patusco, R., Lebeer, S., & Jensen, M. G. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.01.001 · Cited by 13

A paediatric influenza update 100 years after the Skyros island Spanish flu outbreak

Mammas, I., Theodoridou, M., Thiagarajan, P., Melidou, A., Papaioannou, G. C., Korovessi, P., Koutsaftiki, C., Papatheodoropoulou, A., Calachanis, M., Dalianis, T., et al. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7515 · Cited by 10

Immunonutrition and SARS-CoV-2 Infection in Children with Obesity

D’Auria, E., Calcaterra, V., Verduci, E., Ghezzi, M., Lamberti, R., Vizzuso, S., Baldassarre, P., Pendezza, E., Perico, V., Bosetti, A., et al. (2022) · Nutrients · doi:10.3390/nu14091701 · Cited by 10

Potential of Synbiotics and Probiotics as Chemopreventive Agent

Chin, K. W., Khoo, S. C., Paul, R. P. M., Luang‐In, V., Lam, S. D., & Ling, N. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10299-z · Cited by 9

Microbiota and probiotics: chances and challenges – a symposium report

Ruxton, C. H. S., Kajita, C., Rocca, P., & Pot, B. (2023) · Gut Microbiome · doi:10.1017/gmb.2023.4 · Cited by 10

Bacillus subtilis supplemented feeding as a method to increase IgM titers and affinity in response to fish vaccination

Vicente‐Gil, S., Simón, R., Mérida, S. N., Nuñez-Ortiz, N., Fouz, B., Serra, C. R., Ordás, M. C., Abós, B., Herranz-Jusdado, J. G., Morel, E., et al. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110335 · Cited by 8

Deciphering the Potential of Probiotics in Vaccines

Xu, C., Aqib, A. I., Fatima, M., Muneer, S., Zaheer, T., Peng, S., Ibrahim, E. H., & Li, K. (2024) · Vaccines · doi:10.3390/vaccines12070711 · Cited by 9

Diet, microbiome, and probiotics establish a crucial link in vaccine efficacy

Dutta, S., Chatterjee, N., Gallina, N. L. F., Kar, S., Koley, H., Nanda, P. K., Biswas, O., Das, A. K., Biswas, S., Bhunia, A. K., et al. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2480230 · Cited by 7

Recombinant Probiotic Preparations: Current State, Development and Application Prospects

Khablenko, A., Danylenko, S., Yalovenko, O., Дуган, О. М., Potemska, O., & Prykhodko, D. (2023) · Innovative Biosystems and Bioengineering · doi:10.20535/ibb.2022.6.3-4.268349 · Cited by 8

Probiotics and the immunological response to infant vaccinations; a double-blind randomized controlled trial

Sørensen, C. A., Fuglsang, E., Jørgensen, C. S., Laursen, R. P., Larnkjær, A., Mølgaard, C., Ritz, C., Michaelsen, K. F., Krogfelt, K. A., & Frøkiær, H. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.07.031 · Cited by 7

Impact of aging on gut-lung-adipose tissue interactions and lipid metabolism during influenza infection in mice

Bogard, G., Makki, K., Rodrigues, P. B., Tan, J., Molendi‐Coste, O., Barthelemy, J., Descat, A., Bouilloux, F., Lecœur, C., Grangette, C., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-21363-1 · Cited by 5

The immunomodulatory effects of long-term supplementation with Lactobacillus casei Shirota depend on ovalbumin presentation in BALB/c mice

Chen, L., Pan, C., Huang, S., Chan, C.-H., & Huang, H.-Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-98791-2 · Cited by 5

Immunomodulatory Effects of Probiotic Lactobacillus casei On GM-CSF-adjuvanted Influenza Dna Vaccine

Mahooti, M., Abdolalipour, E., Farahmand, B., Shirian, S., & Ghaemi, A. (2022) · Future Virology · doi:10.2217/fvl-2021-0327 · Cited by 5

Oligosaccharide equine feed supplement, Immulix, has minor impact on vaccine responses in mice

Henriksen, I. W., Castro-Mejía, J. L., Mentzel, C. M. J., Lindenberg, F., & Hansen, A. K. (2022) · Scientific Reports · doi:10.1038/s41598-021-04132-8 · Cited by 5

Human microbiome in post-acute COVID-19 syndrome (PACS)

Fallah, A., Sedighian, H., Kachuei, R., & Fooladi, A. A. I. (2024) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2024.100324 · Cited by 6

Increasing Efficacy of Covid-19 Vaccines by Lifestyle Interventions.

Gasmi, A., Mujawdiya, P. K., Noor, S., Piscopo, S., Resimont, S., & Menzel, A. (2022) · PubMed Central · doi:10.22092/ari.2021.356491.1854 · Cited by 4

Nutraceuticals: Health effects and clinical applications

Chen, O., & Mah, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821848-8.00043-3 · Cited by 5

Vaccinations in preterm infants: Which and when?

Schmitt, C., Goedicke‐Fritz, S., Fortmann, M. I., & Zemlin, M. (2025) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2025.101670 · Cited by 10

The Role of Selected Bioactive Compounds and Micronutrients with Immune-enhancing Activity on the Prevention and Mitigation of SARS-CoV-2

Baştürk, A., Ceylan, M. M., Alaca, K., & Yıldız, G. (2021) · European Journal of Nutrition & Food Safety · doi:10.9734/ejnfs/2021/v13i1230468 · Cited by 3

A Concise Review: Nutritional Interventions for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Dhakad, P. K., Mishra, R., & Mishra, I. (2023) · Natural Resources for Human Health · doi:10.53365/nrfhh/175070 · Cited by 3

Probiotics as Edible Vaccines

Pandya, A., Pulakkat, S., Jadhav, S. A., & Patravale, V. B. (2021) · Springer eBooks · doi:10.1007/978-981-16-5628-6_11 · Cited by 3

PENDIDIKAN KESEHATAN: MENINGKATKAN IMUNITAS DAN KESEHATAN MENTAL MELALUI DIET PROBIOTIK DAN PREBIOTIK SELAMA PANDEMI COVID-19

Maulana, S., Platini, H., Musthofa, F., Andriani, D., Purba, F. D., Iskandarsyah, A., & Hinduan, Z. R. (2021) · Kumawula Jurnal Pengabdian Kepada Masyarakat · doi:10.24198/kumawula.v4i3.33744 · Cited by 3

The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: A systematic review and meta-analysis of randomized controlled trials

Yeh, T.-L., Shih, P.-C., Liu, S.-J., Lin, C.-H., Liu, J.-M., Lei, W.-T., & Lin, C.-Y. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s155110 · Cited by 93

The effect of oral probiotics on response to vaccination in older adults: a systematic review of randomised controlled trials

Tunc, H. A., Childs, C. E., Swann, J. R., & Calder, P. C. (2024) · Age and Ageing · doi:10.1093/ageing/afae033 · Cited by 15

A randomized controlled trial to evaluate the effect of influenza vaccination and probiotic supplementation on immune response and incidence of influenza-like illness in an elderly population in Indonesia

Koesnoe, S., Masjkuri, N. M. K., Adisasmita, A. C., Djauzi, S., Kartasasmita, C. B., Sundoro, J., Nadjib, M., Korib, M., Muthia, A. N., Muzellina, V. N., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250234 · Cited by 8

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials

Boge, T., Remigy, M., Vaudaine, S., Tanguy, J., Bourdet‐Sicard, R., & van der Werf, S. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.06.094 · Cited by 221

The Effect of Probiotics on the Response to Vaccination in Older Adults: A Systematic Review of Randomised Controlled Trials

Tunc, H. A., & Calder, P. C. (2024) · European Nutrition Conference (FENS) · doi:10.3390/proceedings2023091171