l-Arginine and Beetroot Extract Supplementation in the Prevention of Sarcopenia
Open accessAbstract
Aging is associated with a significant decline in neuromuscular function, leading to a reduction in muscle mass and strength. The aim of the present report was to evaluate the effect of supplementation with nitric oxide precursors (l-arginine and beetroot extract) in muscular function during a training period of 6 weeks in elderly men and women. The study (double-blind, placebo-controlled) involved 66 subjects randomly divided into three groups: placebo, arginine-supplemented and beetroot extract-supplemented. At the end of this period, no changes in anthropometric parameters were observed. Regarding other circulating parameters, urea levels were significantly (p < 0.05) lower in women of the beetroot-supplemented group (31.6 ± 5.9 mg/dL) compared to placebo (41.3 ± 8.5 mg/dL) after 6 weeks of training. In addition, the circulating creatine kinase activity, as an index of muscle functionality, was significantly (p < 0.05) higher in women of the arginine- (214.1 ± 162.2 mIU/L) compared to the beetroot-supplemented group (84.4 ± 36.8 mIU/L) at the end of intervention. No significant effects were noticed with l-arginine or beetroot extract supplementation regarding strength, endurance and SPPB index. Only beetroot extract supplementation improved physical fitness significantly (p < 0.05) in the sprint exercise in men after 6 weeks (2.33 ± 0.59 s) compared to the baseline (2.72 ± 0.41 s). In conclusion, beetroot seems to be more efficient during short-term training while supplementing, preserving muscle functionality in women (decreased levels of circulating creatine kinase) and with modest effects in men.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dietary nitrate increases NO bioavailability via the nitrate-nitrite-NO pathway, particularly in conditions of hypoxia or high metabolic demand characteristic of ageing muscle.
“Dietary nitrate, which is found in high concentrations in vegetables such as beetroot, increases NO bioavailability via the nitrate-nitrite-NO pathway, particularly in conditions of hypoxia or high metabolic demand, which are characteristic of ageing muscle [41,59,185,186].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [186]
The Introduction (page not provided) describes dietary nitrate as a nitric-oxide precursor, and the Discussion (page not provided) describes NO production through nitrate–nitrite intake from beetroot. Neither passage says this pathway is particularly active under hypoxia or high metabolic demand, or that those conditions characterize ageing muscle. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works
Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works
Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afy169 · Cited by 13,818 · see citing works
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works
Invited Review: Aging and sarcopenia
Doherty, T. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00347.2003 · Cited by 1,764 · see citing works
Signaling Pathways in Skeletal Muscle Remodeling
Bassel‐Duby, R., & Olson, E. N. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142622 · Cited by 799 · see citing works
Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans
Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689 · cited 1× · see citing works
“Nevertheless, an alternative mechanism proposes that nitrate directly alters mitochondrial efficiency through attenuation of the ATP/oxygen ratio [45].”
BackgroundEffects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works
The Potential Benefits of Red Beetroot Supplementation in Health and Disease
Clifford, T., Howatson, G., West, D., & Stevenson, E. (2015) · Nutrients · doi:10.3390/nu7042801 · Cited by 635 · see citing works
Bailey, S. J., Fulford, J., Vanhatalo, A., Winyard, P. G., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Benjamin, N., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00046.2010 · Cited by 607 · see citing works
Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Pavey, T. G., Wilkerson, D. P., Benjamin, N., Winyard, P. G., & Jones, A. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00206.2010 · Cited by 529 · see citing works
A Role for Nitric Oxide in Muscle Repair: Nitric Oxide–mediated Activation of Muscle Satellite Cells
Anderson, J. E. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1859 · Cited by 455 · see citing works
Programmed cell death in aging
Tower, J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.002 · Cited by 426 · see citing works
Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy.
Chang, W. J., Iannaccone, S. T., Lau, K. S., Masters, B. S. S., McCabe, T. J., McMillan, K., Padre, R. C., Spencer, M. J., Tidball, J. G., & Stull, J. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9142 · Cited by 367 · see citing works
Buck, M., & Chojkier, M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00524.x · Cited by 327 · see citing works
Measurement of muscle mass in sarcopenia: from imaging to biochemical markers
Tosato, M., Marzetti, E., Cesari, M., Savera, G., Miller, R. R., Bernabei, R., Landi, F., & Calvani, R. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0717-0 · Cited by 321 · see citing works
Rector, T. S., Bank, A. J., Mullen, K. A., Tschumperlin, L. K., Sih, R. T., Pillai, K., & Kubo, S. H. (1996) · Circulation · doi:10.1161/01.cir.93.12.2135 · Cited by 275 · see citing works
The Effect of Nitric-Oxide-Related Supplements on Human Performance
Bescós, R., Sureda, A., Tur, J. A., & Pons, A. (2012) · Sports Medicine · doi:10.2165/11596860-000000000-00000 · Cited by 231 · see citing works
Dietary Nitrate and Physical Performance
Jones, A. M., Thompson, C., Wylie, L. J., & Vanhatalo, A. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051622 · Cited by 206 · cited 1× · see citing works
“A possible explanation is that dietary supplementation with nitrate, administered in the form of beetroot extract, improves skeletal muscle contractile function and thereby improves muscle power and sprint performance [43].”
BackgroundPlasma arginine and citrulline kinetics in adults given adequate and arginine-free diets.
Castillo, L., Chapman, T. E., Mendiola, M. S., Yu, Y., Burke, J. F., Ajami, A. M., Vogt, J., & Young, V. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7749 · Cited by 204 · see citing works
Creatine Supplementation and Lower Limb Strength Performance: A Systematic Review and Meta-Analyses
Lanhers, C., Pereira, B., Naughton, G., Trousselard, M., Lesage, F.-X., & Dutheil, F. (2015) · Sports Medicine · doi:10.1007/s40279-015-0337-4 · Cited by 189 · see citing works
Chen, N., He, X., Feng, Y., Ainsworth, B. E., & Liu, Y. (2021) · European Review of Aging and Physical Activity · doi:10.1186/s11556-021-00277-7 · Cited by 178 · see citing works
Chronic Exercise Preserves Lean Muscle Mass in Masters Athletes
Wroblewski, A. P., Amati, F., Smiley, M. A., Goodpaster, B. H., & Wright, V. J. (2011) · The Physician and Sportsmedicine · doi:10.3810/psm.2011.09.1933 · Cited by 159 · see citing works
Marco, S. D., Mazrouï, R., Dallaire, P., Chittur, S. V., Tenenbaum, S. A., Radzioch, D., Marette, A., & Gallouzi, I. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6533-6545.2005 · Cited by 154 · see citing works
Nitric oxide inhibits calpain-mediated proteolysis of talin in skeletal muscle cells
Koh, T. J., & Tidball, J. G. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c806 · Cited by 142 · see citing works
Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle
Dickinson, J. M., Volpi, E., & Rasmussen, B. B. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182a4e699 · Cited by 139 · see citing works
Acute Administration of Inorganic Nitrate Reduces V˙O2peak in Endurance Athletes
BESCÓS, R., RODRÍGUEZ, F. A., IGLESIAS, X., FERRER, M. D., IBORRA, E., & PONS, A. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318217d439 · Cited by 137 · see citing works
Skeletal muscle nNOSμ protein content is increased by exercise training in humans
McConell, G. K., Bradley, S. J., Stephens, T. J., Canny, B. J., Kingwell, B. A., & Lee-Young, R. S. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00796.2006 · Cited by 136 · see citing works
Bailey, S. J., Winyard, P. G., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00503.2010 · Cited by 132 · see citing works
Rating of perceived exertion on resistance training in elderly subjects
Morishita, S., Tsubaki, A., Nakamura, M., Nashimoto, S., Fu, J. B., & Onishi, H. (2018) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2019.1561278 · Cited by 132 · see citing works
Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis
Lanhers, C., Pereira, B., Naughton, G., Trousselard, M., Lesage, F.-X., & Dutheil, F. (2017) · Sports Medicine · doi:10.1007/s40279-016-0571-4 · Cited by 127 · see citing works
Sarcopenia: Molecular Pathways and Potential Targets for Intervention
Pascual-Fernández, J., Fernández-Montero, A., Córdova-Martínez, A., Pastor, D., Martínez-Rodríguez, A., & Roche, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228844 · Cited by 125 · see citing works
Self-citationIntracellular generation of reactive oxygen species by contracting skeletal muscle cells
McArdle, F., Pattwell, D. M., Vasilaki, A., McArdle, A., & Jackson, M. J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.010 · Cited by 119 · see citing works
L-Arginine Reduces Exercise-Induced Increase in Plasma Lactate and Ammonia
Schaefer, A., Piquard, F., Gény, B., Doutreleau, S., Lampert, E., Mettauer, B., & Lonsdorfer, J. (2002) · International Journal of Sports Medicine · doi:10.1055/s-2002-33743 · Cited by 112 · see citing works
Archer, J. D., Vargas, C. C., & Anderson, J. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-4821fje · Cited by 108 · see citing works
Sodium Nitrate Supplementation Does Not Enhance Performance of Endurance Athletes
BESCÓS, R., FERRER-ROCA, V., GALILEA, P. A., ROIG, A., DROBNIC, F., SUREDA, A., MARTORELL, M., CORDOVA, A., TUR, J. A., & PONS, A. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182687e5c · Cited by 107 · see citing works
Involvement of nitric oxide synthase in skeletal muscle adaptation to chronic overload
Smith, L. W., Smith, J. D., & Criswell, D. S. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00950.2001 · Cited by 103 · see citing works
Rudnick, J., Püttmann, B., Tesch, P. A., Alkner, B. A., Schoser, B. G. H., Michele Salanova, A., Kirsch, K. A., Gunga, H., Schiffl, G., Lück, G., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0792fje · Cited by 103 · see citing works
Prediction of sarcopenia using a battery of circulating biomarkers
Qaisar, R., Karim, A., Muhammad, T., Shah, I., & Khan, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-87974-6 · Cited by 103 · see citing works
Liu, T.-H., Wu, C.-L., Chiang, C.-W., Lo, Y.-W., Tseng, H.-F., & Chang, C.-K. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.05.005 · Cited by 101 · see citing works
Endocrine determinants of incident sarcopenia in middle-aged and elderly European men
Gielen, E., O’Neill, T. W., Pye, S. R., Adams, J. E., Wu, F. C. W., Laurent, M. R., Claessens, F., Ward, K. A., Boonen, S., Bouillon, R., et al. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12030 · Cited by 98 · see citing works
l -Arginine enhances aerobic exercise capacity in association with augmented nitric oxide production
Maxwell, A. J., Ho, H. –. V., Le, C. Q., Lin, P. S., Bernstein, D., & Cooke, J. P. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.3.933 · Cited by 69 · see citing works
Wang, R., Jiao, H., Zhao, J., Wang, X., & Lin, H. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7569127 · Cited by 69 · see citing works
Arginine and Citrulline Supplementation in Sports and Exercise: Ergogenic Nutrients?
Sureda, A., & Pons, A. (2012) · Medicine and sport science/Medicine and sport · doi:10.1159/000341937 · Cited by 61 · see citing works
Biomarkers Profile of People With Sarcopenia: A Cross-sectional Analysis From UK Biobank
Petermann-Rocha, F. E., Gray, S. R., Pell, J. P., Celis-Morales, C. A., & Ho, F. K. W. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.05.005 · Cited by 56 · see citing works
Wallengren, O., Bosaeus, I. G., Frändin, K., Lissner, L., Falk, H., Wetterberg, H., Sterner, T. R., Rydén, L., Rothenberg, E. M., & Skoog, I. G. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02533-y · Cited by 56 · see citing works
Oba, H., Matsui, Y., Arai, H., Watanabe, T., Iida, H., Mizuno, T., Yamashita, S., Ishizuka, S., Suzuki, Y., Hiraiwa, H., et al. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02187-w · Cited by 55 · see citing works
Arginine supplementation induces myoblast fusion via augmentation of nitric oxide production
Long, J. H. D., Lira, V. A., Soltow, Q. A., Betters, J. L., Sellman, J. E., & Criswell, D. S. (2006) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-006-9078-1 · Cited by 52 · see citing works
Effects of Dietary L-Arginine Intake on Cardiorespiratory and Metabolic Adaptation in Athletes
Bescós, R., González‐Haro, C., Pujol, P., Drobnic, F., Alonso, E., Santolaria, M. L., Ruiz, O. L. C., Estève, M., & Galilea, P. A. (2009) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.19.4.355 · Cited by 47 · see citing works
The dynamics of the nitric oxide release-transient from stretched muscle cells
Wozniak, A. C., & Anderson, J. E. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.07.005 · Cited by 46 · see citing works
Frandsen, U., Höffner, L., Betak, A., Saltin, B., Bangsbo, J., & Hellsten, Y. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.3.1033 · Cited by 44 · see citing works
de Souza, A. V., Giolo, J. S., Teixeira, R. R., Vilela, D. D., Peixoto, L. G., Justino, A. B., Caixeta, D. C., Puga, G. M., & Espíndola, F. S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5425021 · Cited by 39 · see citing works
Kameda, M., Teruya, T., Yanagida, M., & Kondoh, H. (2021) · Aging · doi:10.18632/aging.203498 · Cited by 39 · see citing works
l-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults
Figueroa, A., Jaime, S. J., Morita, M., Gonzales, J. U., & Moinard, C. (2020) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000223 · Cited by 33 · see citing works
Amino Acids in Health and Endocrine Function
Flynn, N. E., Shaw, M. H., & Becker, J. T. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-45328-2_6 · Cited by 29 · see citing works
Effect of aerobic exercise intervention on DDT degradation and oxidative stress in rats
Li, K., Zhu, X., Wang, Y., Zheng, S., & Dong, G. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.01.040 · Cited by 22 · see citing works
Rezaei, S., Gholamalizadeh, M., Tabrizi, R., Nowrouzi‐Sohrabi, P., Rastgoo, S., & Doaei, S. (2021) · Physiological Reports · doi:10.14814/phy2.14739 · Cited by 21 · see citing works
Carter, S. J., Gruber, A. H., Raglin, J. S., Baranauskas, M. N., & Coggan, A. R. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109732 · Cited by 21 · see citing works
Sawada, S., Ozaki, H., Natsume, T., Nakano, D., Deng, P., Yoshihara, T., Osawa, T., Kobayashi, H., Machida, S., & Naıto, H. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02403-7 · Cited by 16 · see citing works
Ferrer, M. D., Capó, X., Reynés, C., Quetglas‐Llabrés, M. M., Salaberry, E., Tonolo, F., Suau, R., Marí, B., Tur, J. A., Sureda, A., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122618 · Cited by 12 · see citing works
Capó, X., Ferrer, M. D., Olek, R. A., Salaberry, E., Suau, R., Marí, B., Llompart, I., Tur, J. A., Sureda, A., & Pons, A. (2020) · Antioxidants · doi:10.3390/antiox9070596 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diet for the prevention and management of sarcopenia
Calvani, R., Picca, A., Coelho‐Júnior, H. J., Tosato, M., Marzetti, E., & Landi, F. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155637 · Cited by 153 · see citing works
Dietary protein and amino acid intakes for mitigating sarcopenia in humans
He, W., Connolly, E. D., Cross, H. R., & Wu, G. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2348549 · Cited by 37 · see citing works
Diet and exercise in frailty and sarcopenia. Molecular aspects
Millan-Domingo, F., Garcia-Dominguez, E., Gambini, J., Olaso-Gonzalez, G., Viña, J., & Gomez-Cabrera, M. C. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101322 · Cited by 31 · see citing works
Norouzzadeh, M., Rashedi, M. H., Payandeh, N., Harijani, A. M., & Shahinfar, H. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106082 · Cited by 19 · see citing works
Kang, Y., Dillon, K. N., Martinez, M. A., Maharaj, A., Fischer, S. M., & Figueroa, A. (2022) · Nutrients · doi:10.3390/nu15010074 · Cited by 19 · see citing works
Extract of Alnus japonica prevents dexamethasone-induced muscle atrophy in mice
Lee, H.-J., Lee, K. S., Jeong, J. H., Yoon, J. S., Hwang, S. H., Kim, S., Yeon, S. H., & Ryu, J. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105419 · Cited by 13 · see citing works
Bielecka-Dabrowa, A. M., Banach, M., Wittczak, A., Cicero, A. F. G., Kallel, A., Kubilius, R., Mikhailidis, D. P., Sahebkar, A., Stoian, A. P., Vinereanu, D., et al. (2023) · Archives of Medical Science · doi:10.5114/aoms/167799 · Cited by 14 · see citing works
Nutritional aspects of prehabilitation in adults with cirrhosis awaiting liver transplant
Cruz, C., Prado, C. M. M., Gillis, C., Martindale, R. G., Bémeur, C., Lai, J. C., & Tandon, P. (2024) · Hepatology · doi:10.1097/hep.0000000000000818 · Cited by 12 · see citing works
Córdova, A., Caballero-García, A., Noriega, D. C., Bello, H. J., Pons, A., & Roche, E. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19105938 · Cited by 10 · see citing works
Self-citationWang, Y., He, Z., Long, C., Li, Y., Yuan, Y., & Huang, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-16917-2 · Cited by 6 · see citing works
Amino acid neurotransmitters in sarcopenia and healthy aging
Jonk, S. M., Tribble, J. R., Swoboda, P., & Williams, P. A. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111437 · Cited by 5 · see citing works
Prajapati, P., Kumar, A., Mangrulkar, S. V., Chaple, D., Saraf, S. A., & Kushwaha, S. (2023) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0265 · Cited by 4 · see citing works
Afrisham, R., Farrokhi, V., Ghanavati, M., Asbaghi, O., Mohammadi, S., Mohammadian, M., Taghvaei-Yazdeli, T., Safaei-Kooyshahi, S., Jadidi, Y., & Ashtary‐Larky, D. (2023) · British Journal Of Nutrition · doi:10.1017/s000711452300034x · Cited by 3 · see citing works
Kurhaluk, N., Kołodziejska, R., Buyun, L., Kamiński, P., & Tkaczenko, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083461 · Cited by 3 · see citing works
“Dietary nitrate, which is found in high concentrations in vegetables such as beetroot, increases NO bioavailability via the nitrate-nitrite-NO pathway, particularly in conditions of hypoxia or high metabolic demand, which are characteristic of ageing muscle [41,59,185,186].”
Wang, R., Ma, Y., Sun, M., Li, L., & Zhang, Z. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250092 · Cited by 2 · see citing works
Park, H. S., Yoon, J.-H., & Oh, J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020615 · Cited by 2 · see citing works
Renji, R., Robinson, S. M., & Witham, M. D. (2024) · JCSM Communications · doi:10.1002/rco2.105 · Cited by 1 · see citing works
Na, J., Tan, Y., Zhang, Y., Na, X., Shi, X., Yang, C., Li, Z., Ji, J. S., & Zhao, A. (2024) · Foods · doi:10.3390/foods14010043 · Cited by 1 · see citing works
Yuan, W., Ao, P., Wu, F., Xu, F., Ma, Y., Ma, Y., Wei, S., & Yuan, L. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1763219
Ramirez, C. T. V., Torres, E., Ortega, P., & Mendes, S. (2026) · Bulletin of pioneering researches of medical and clinical science · doi:10.51847/2bvoipymjg
Ramos-Hernández, R., Pascual-Fernández, J., Álvarez-Pardo, S., Fernández‐Lázaro, D., Martínez‐Ferrán, M., Busto, N., & Mielgo‐Ayuso, J. (2026) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2026.103356
- Authors
- Córdova-Martínez, A., Caballero-García, A., Bello, H. J., Pons-Biescas, A., Noriega, D. C., & Roche, E.
- Affiliations
- Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, GIR Physical Exercise and Aging, University of Valladolid, Campus Duques de Soria, 42004 Soria, Spain
- Universidad de Valladolid (ES)
- Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, 07122 Palma de Mallorca, Balearic Islands, Spain
- Hospital Clínico Universitario de Valladolid (ES)
- Corresponding author
- Roche, Enrique
- ORCID
- Venue
- Pharmaceuticals
- Publisher
- MDPI AG
- Published
- 2022-02-26
- Volume
- 15
- Issue
- 3
- Pages
- 290
- ISSN
- 1424-8247 (ISSN-L)
- PMC
- PMC8954952
- OpenAlex
- W4214772010
- Cited by
- 21
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 2
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceuticals (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Hispana (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) (submittedVersion, cc-by)
- Funders
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- L-arginine, beetroot extract, sarcopenia prevention, nitric oxide precursor, aging, muscle strength, muscular endurance, creatine kinase, urea, physical fitness, sex differences, elderly men and women, short-term training
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
