The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes
Open accessAbstract
New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are being developed every year, making it vital to find a non-invasive route such as nasal or pulmonary for their administration. However, a major concern for some of these newly developed therapeutic agents is their poor absorption. Therefore, absorption enhancers have been investigated to address this major administration problem. This paper describes the basic concepts of transmucosal administration of drugs, and in particular the use of the pulmonary or nasal routes for administration of drugs with poor absorption. Strategies for the exploitation of absorption enhancers for the improvement of pulmonary or nasal administration are discussed, including use of surfactants, cyclodextrins, protease inhibitors, and tight junction modulators, as well as application of carriers such as liposomes and nanoparticles.
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Cites
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Cited by
Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Liu, Y., Liang, Y., Yuhong, J., Xin, P., Han, J. L., Du, Y., Yu, X., Zhu, R., Zhang, M., Chen, W., et al. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s447496 · Cited by 365
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Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications
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Aati, S., Farouk, H. O., Elkarmalawy, M. H., Aati, H. Y., Tolba, N. S., Hassan, H. M., Rateb, M. E., & Hamad, D. S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16111432 · Cited by 9
Metadata
- Authors
- Ghadiri, M., Young, P. M., & Traini, D.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2019-03-11
- Volume
- 11
- Issue
- 3
- Pages
- 113
- ISSN
- 1999-4923 (ISSN-L)
- OpenAlex
- W2921248422
- Cited by
- 284
- References
- 97
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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