Cited by 43MicroRNA in disease regulationProstate Cancer Treatment and ResearchExtracellular vesicles in disease

miRNAs as therapeutic tools and biomarkers for prostate cancer

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Arrighetti, Noemi, Beretta, Giovanni Luca·2021·Pharmaceutics

Abstract

Prostate cancer (PCa) is the fifth cause of tumor-related deaths in man worldwide. Despite the considerable improvement in the clinical management of PCa, several limitations emerged both in the screening for early diagnosis and in the medical treatment. The use of prostate-specific antigen (PSA)-based screening resulted in patients’ overtreatment and the standard therapy of patients suffering from locally advanced/metastatic tumors (e.g., radical prostatectomy, radiotherapy, and androgen deprivation therapy) showed time-limited efficacy with patients undergoing progression toward the lethal metastatic castration-resistant PCa (mCRPC). Although valuable alternative therapeutic options have been recently proposed (e.g., docetaxel, cabazitaxel, abiraterone, enzalutamide, and sipuleucel-T), mCRPC remains incurable. Based on this background, there is an urgent need to identify new and more accurate prostate-specific biomarkers for PCa diagnosis and prognosis and to develop innovative medical approaches to counteract mCRPC. In this context, microRNA (miRNAs) emerged as potential biomarkers in prostate tissues and biological fluids and appeared to be promising therapeutic targets/tools for cancer therapy. Here we overview the recent literature and summarize the achievements of using miRNAs as biomarkers and therapeutic targets/tools for fighting PCa.

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Crossref · 10.3390/pharmaceutics13030380

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  • Expression of several microRNAs, including miR-3687 and miR-205, were altered in microfluidic devices containing LNCaPs.

    “In addition, the expression of several microRNAs (miRs) identified as potential biomarkers for the early detection of CRPC (Arrighetti and Beretta, 2021; Rönnau et al., 2021), including miR-3687 and miR-205 were altered in the microfluidic devices containing LNCaPs.”

    From Microphysiological systems as models for immunologically ‘cold’ tumors (2024) · cites this paper as Arrighetti and Beretta, 2021

    Section 5.2 reports elevated miR-3687 in patients with metastatic CRPC and links it to shorter progression-free survival, supporting a prognostic association rather than early detection. Section 3.2 discusses miR-205 in prostate cancer cells, including LNCaP, but does not identify it as an early-detection biomarker for CRPC. The microfluidic-device result appears to be the citing authors’ own finding, not a finding attributed to this source. (LLM, conf=0.86)

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1 retracted

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Authors
Arrighetti, N., & Beretta, G. L.
Affiliations
Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Corresponding author
Beretta, Giovanni Luca
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2021-03-13
Volume
13
Issue
3
Pages
380
ISSN
1999-4923 (ISSN-L)
OpenAlex
W3136136801
Cited by
43
References
197
Citations by year
2026: 4 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 7 · 2021: 5
FWCI
0.93
Type
journal article
Language
en
Open access
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
prostate cancer, microRNA, biomarkers, metastatic castration-resistant prostate cancer, miRNA-based therapy, therapeutic target, PSA screening, early diagnosis, prognosis, biological fluids

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