miRNAs as therapeutic tools and biomarkers for prostate cancer
Open accessAbstract
Prostate cancer (PCa) is the fifth cause of tumor-related deaths in man worldwide. Despite the considerable improvement in the clinical management of PCa, several limitations emerged both in the screening for early diagnosis and in the medical treatment. The use of prostate-specific antigen (PSA)-based screening resulted in patients’ overtreatment and the standard therapy of patients suffering from locally advanced/metastatic tumors (e.g., radical prostatectomy, radiotherapy, and androgen deprivation therapy) showed time-limited efficacy with patients undergoing progression toward the lethal metastatic castration-resistant PCa (mCRPC). Although valuable alternative therapeutic options have been recently proposed (e.g., docetaxel, cabazitaxel, abiraterone, enzalutamide, and sipuleucel-T), mCRPC remains incurable. Based on this background, there is an urgent need to identify new and more accurate prostate-specific biomarkers for PCa diagnosis and prognosis and to develop innovative medical approaches to counteract mCRPC. In this context, microRNA (miRNAs) emerged as potential biomarkers in prostate tissues and biological fluids and appeared to be promising therapeutic targets/tools for cancer therapy. Here we overview the recent literature and summarize the achievements of using miRNAs as biomarkers and therapeutic targets/tools for fighting PCa.
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Expression of several microRNAs, including miR-3687 and miR-205, were altered in microfluidic devices containing LNCaPs.
“In addition, the expression of several microRNAs (miRs) identified as potential biomarkers for the early detection of CRPC (Arrighetti and Beretta, 2021; Rönnau et al., 2021), including miR-3687 and miR-205 were altered in the microfluidic devices containing LNCaPs.”
From Microphysiological systems as models for immunologically ‘cold’ tumors (2024) · cites this paper as Arrighetti and Beretta, 2021
Section 5.2 reports elevated miR-3687 in patients with metastatic CRPC and links it to shorter progression-free survival, supporting a prognostic association rather than early detection. Section 3.2 discusses miR-205 in prostate cancer cells, including LNCaP, but does not identify it as an early-detection biomarker for CRPC. The microfluidic-device result appears to be the citing authors’ own finding, not a finding attributed to this source. (LLM, conf=0.86)
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Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer
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miR-1272 Exerts Tumor-Suppressive Functions in Prostate Cancer via HIP1 Suppression
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Self-citationDiagnostic Value of Circulating miR-324 for Prostate Cancer
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Diagnostic Value of Peripheral Blood miR-374b-5p in Patients with Prostate Cancer
Pang, C., Song, X., Fu, C., Zhang, Y., Zhang, Y., & Liu, M. (2020) · Clinical Laboratory · doi:10.7754/clin.lab.2019.190620 · Cited by 6 · see citing works
Editorial Comment to Functional significance of aberrantly expressed microRNAs in prostate cancer
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A review of the biological role of miRNAs in prostate cancer suppression and progression
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Plasma-Derived Exosome MiR-19b Acts as a Diagnostic Marker for Pancreatic Cancer
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Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review
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Microphysiological systems as models for immunologically ‘cold’ tumors
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Sulforaphane inhibits the growth of prostate cancer by regulating the microRNA-3919/DJ-1 axis
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Tumor Suppressor MicroRNAs in Clinical and Preclinical Trials for Neurological Disorders
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Skingen, V. E., Salberg, U. B., Hompland, T., Fjeldbo, C. S., Helgeland, H., Frikstad, K.-A. M., Ragnum, H. B., Vlatkovic, L., Hole, K. H., Seierstad, T., et al. (2024) · The Journal of Pathology · doi:10.1002/path.6344 · Cited by 3 · see citing works
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Les marqueurs biologiques du cancer de la prostate : limites du PSA et place des nouveaux marqueurs
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Electrochemical Biosensor for Prostate Cancer
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- Authors
- Arrighetti, N., & Beretta, G. L.
- Affiliations
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Corresponding author
- Beretta, Giovanni Luca
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2021-03-13
- Volume
- 13
- Issue
- 3
- Pages
- 380
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC7999286
- OpenAlex
- W3136136801
- Cited by
- 43
- References
- 197
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 7 · 2021: 5
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- prostate cancer, microRNA, biomarkers, metastatic castration-resistant prostate cancer, miRNA-based therapy, therapeutic target, PSA screening, early diagnosis, prognosis, biological fluids
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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