The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Development of Third-Generation Tetracycline Antibiotics and New Perspectives
Open accessAbstract
The tetracycline antibiotic class has acquired new valuable members due to the optimisation of the chemical structure. The first modern tetracycline introduced into therapy was tigecycline, followed by omadacycline, eravacycline, and sarecycline (the third generation). Structural and physicochemical key elements which led to the discovery of modern tetracyclines are approached. Thus, several chemical subgroups are distinguished, such as glycylcyclines, aminomethylcyclines, and fluorocyclines, which have excellent development potential. The antibacterial spectrum comprises several resistant bacteria, including those resistant to old tetracyclines. Sarecycline, a narrow-spectrum tetracycline, is notable for being very effective against Cutinebacterium acnes. The mechanism of antibacterial action from the perspective of the new compound is approached. Several severe bacterial infections are treated with tigecycline, omadacycline, and eravacycline (with parenteral or oral formulations). In addition, sarecycline is very useful in treating acne vulgaris. Tetracyclines also have other non-antibiotic properties that require in-depth studies, such as the anti-inflammatory effect effect of sarecycline. The main side effects of modern tetracyclines are described in accordance with published clinical studies. Undoubtedly, this class of antibiotics continues to arouse the interest of researchers. As a result, new derivatives are developed and studied primarily for the antibiotic effect and other biological effects.
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Cites
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“Thus, the protein synthesis is stopped (Figure 12) [18,81,82].”
BackgroundMinocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
Tetracyclines: Antibiotic action, uptake, and resistance mechanisms
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Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
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Cited by
Mahmud, Z., Manik, M. R. K., Rahman, A., Karim, M. M., & Islam, L. N. (2024) · Scientific Reports · doi:10.1038/s41598-024-71472-6 · Cited by 22
Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline
Li, X., Wang, M., Denk, T., Buschauer, R., Li, Y., Beckmann, R., & Cheng, J. (2024) · Nature Communications · doi:10.1038/s41467-024-49797-7 · Cited by 21
T cell toxicity induced by tigecycline binding to the mitochondrial ribosome
Shao, Q., Khawaja, A., Nguyen, M. D., Singh, V., Zhang, J., Liu, Y., Nordin, J., Adori, M., Axel Innis, C., Castro Dopico, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59388-9 · Cited by 16
Metadata
- Authors
- Rusu, A., & Buta, E. L.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2021-12-05
- Volume
- 13
- Issue
- 12
- Pages
- 2085
- ISSN
- 1999-4923 (ISSN-L)
- OpenAlex
- W4200357335
- Cited by
- 210
- References
- 9
- FWCI
- 12.31
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
