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Cited by 85Nanoparticle-Based Drug DeliveryExtracellular vesicles in diseaseAdvanced Drug Delivery Systems

Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

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Li, Jianzhuang, Wei, Yanhao, Zhang, Chunlin, Bi, Rentang, Qiu, Yanmei, Li, Yanan, Hu, Bo·2023·Pharmaceutics
DOI 10.3390/pharmaceutics15020621PMC PMC9960717
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Abstract

Neurological diseases (NDs) are a significant cause of disability and death in the global population. However, effective treatments still need to be improved for most NDs. In recent years, cell-membrane-coated nanoparticles (CMCNPs) as drug-targeting delivery systems have become a research hotspot. Such a membrane-derived, nano drug-delivery system not only contributes to avoiding immune clearance but also endows nanoparticles (NPs) with various cellular and functional mimicries. This review article first provides an overview of the function and mechanism of single/hybrid cell-membrane-derived NPs. Then, we highlight the application and safety of CMCNPs in NDs. Finally, we discuss the challenges and opportunities in the field.

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  • Drug delivery systems based on different cell membrane coatings can endow brain targeting abilities.

    “many drug delivery systems based on different cells’ membrane coating, such as red cell membrane, brain tumor cell membrane, immune cell membrane, and so on, could endow the brain targeting abilities”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [194]

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Authors
Li, J., Wei, Y., Zhang, C., Bi, R., Qiu, Y., Li, Y., & Hu, B.
Affiliations
Wuhan Union Hospital (CN)
Corresponding author
  • Li, Yanan
  • Hu, Bo
ORCID
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2023-02-13
Volume
15
Issue
2
Pages
621
ISSN
1999-4923 (ISSN-L)
DOI
10.3390/pharmaceutics15020621
PMC
PMC9960717
OpenAlex
W4320492422
Cited by
85
References
153
Citations by year
2026: 23 · 2025: 27 · 2024: 29 · 2023: 6
FWCI
1.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (82071336, 82090044, 81820108010, 2018YFC1312200)
  • National Key R&D Program of China (82071336, 82090044, 81820108010, 2018YFC1312200)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
cell membrane-coated nanoparticles, targeted drug delivery, brain drug delivery, neurological disorders, immune evasion, nanoparticle safety, hybrid nanostructures, blood-brain barrier

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