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Metal and Metalloid Toxicity in Plants: An Overview on Molecular Aspects
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Worldwide, the effects of metal and metalloid toxicity are increasing, mainly due to anthropogenic causes. Soil contamination ranks among the most important factors, since it affects crop yield, and the metals/metalloids can enter the food chain and undergo biomagnification, having concomitant effects on human health and alterations to the environment. Plants have developed complex mechanisms to overcome these biotic and abiotic stresses during evolution. Metals and metalloids exert several effects on plants generated by elements such as Zn, Cu, Al, Pb, Cd, and As, among others. The main strategies involve hyperaccumulation, tolerance, exclusion, and chelation with organic molecules. Recent studies in the omics era have increased knowledge on the plant genome and transcriptome plasticity to defend against these stimuli. The aim of the present review is to summarize relevant findings on the mechanisms by which plants take up, accumulate, transport, tolerate, and respond to this metal/metalloid stress. We also address some of the potential applications of biotechnology to improve plant tolerance or increase accumulation.
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“However, when present in concentrations exceeding the threshold level (>10,000 mg/kg), zinc becomes toxic, leading to impaired growth, disrupted physiological functions, and even plant death.”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Angulo-Bejarano et al., 2021
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“In addition, these plant species have evolved to possess adaptations for hypertolerance and detoxification of metal and metalloids (Angulo-Bejarano et al., 2021; Peng et al., 2021; Rai et al., 2021).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Angulo-Bejarano et al., 2021
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Metadata
- Authors
- Angulo-Bejarano, P. I., Puente-Rivera, J., & Cruz-Ortega, R.
- Affiliations
- Laboratorio de Alelopatía, Departamento de Ecología Funcional, Instituto de Ecología, Universidad Nacional Autónoma de México, UNAM, 275, Ciudad Universitaria D.F. Circuito Exterior s/n Anexo al Jardín Botánico Exterior, México City 04510, Mexico
- Instituto de Ecología (MX)
- Venue
- Plants
- Publisher
- MDPI AG
- Published
- 2021-03-27
- Volume
- 10
- Issue
- 4
- Pages
- 635
- ISSN
- 2223-7747 (ISSN-L)
- PMC
- PMC8066251
- OpenAlex
- W3151778362
- Cited by
- 357
- References
- 198
- Citations by year
- 2026: 48 · 2025: 86 · 2024: 102 · 2023: 60 · 2022: 51 · 2021: 10
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Plants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (IN205912)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Keywords
- metal toxicity, metalloid toxicity, plant stress tolerance, hyperaccumulation, metal exclusion, metal chelation, metal transport, soil contamination, cadmium, lead, arsenic, zinc, copper, aluminum, biomagnification, plant biotechnology
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