Cited by 218Redox biology and oxidative stressCancer and biochemical researchAntioxidant Activity and Oxidative Stress

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Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies

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Andrés, Celia María Curieses, Pérez de la Lastra, José Manuel, Juan, Celia Andrés, Plou, Francisco J., Pérez-Lebeña, Eduardo·2022·Stresses

DOI 10.3390/stresses2030019

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Abstract

Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H2S) and the nitric oxide radical (•NO), activating specific oxidations that determine the metabolic response. The reaction triggered determines cell survival or apoptosis, depending on which downstream metabolic pathways are activated. There are several ways to produce H2O2 in cells, and cellular systems tightly control its concentration. At the cellular level, the accumulation of hydrogen peroxide can trigger inflammation and even apoptosis, and when its concentration in the blood reaches toxic levels, it can lead to bioenergetic failure. This review summarizes existing research from a chemical perspective on the role of H2O2 in various enzymatic pathways and how this biochemistry leads to physiological or pathological responses.

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Authors: Andrés, C. M. C., Pérez de la Lastra, J. M., Juan, C. A., Plou, F. J., & Pérez-Lebeña, E.
Affiliations: Hospital Clínico Universitario de Valladolid (ES)
Institute of Natural Products and Agrobiology, CSIC-Spanish Research Council, Avda. Astrofísico Fco. Sánchez, 3, 38206 La Laguna, Spain
Cinquima Institute and Department of Organic Chemistry, Faculty of Sciences, Valladolid University, Paseo de Belén, 7, 47011 Valladolid, Spain
Consejo Superior de Investigaciones Científicas (ES)
Sistemas de Biotecnología y Recursos Naturales, 47625 Valladolid, Spain
ORCID: Andrés, Celia María Curieses
Pérez de la Lastra, José Manuel
Plou, Francisco J.
Venue: Stresses
Publisher: MDPI AG
Published: 2022-07-25
Volume: 2
Issue: 3
Pages: 256-274
ISSN: 2673-7140 (ISSN-L)
DOI: 10.3390/stresses2030019
OpenAlex: W4287879577
Cited by: 218
References: 107
Citations by year: 2026: 29 · 2025: 65 · 2024: 68 · 2023: 51 · 2022: 5
FWCI: 15.44
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Stresses (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Junta de Castilla y León (FEDER-VA115P17, VA149G18, ProID2020010134, 2019SP43, PID2019-105838RB-C31)
European Funds for Regional Development-FEDER (FEDER-VA115P17, VA149G18, ProID2020010134, 2019SP43, PID2019-105838RB-C31)
Caja Canarias (FEDER-VA115P17, VA149G18, ProID2020010134, 2019SP43, PID2019-105838RB-C31)
Spanish Ministry of Economy and Competitiveness (FEDER-VA115P17, VA149G18, ProID2020010134, 2019SP43, PID2019-105838RB-C31)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: hydrogen peroxide, redox signaling, hydrogen sulfide, nitric oxide, apoptosis, inflammation, oxidative stress, bioenergetic failure, enzymatic pathways, mammalian cells, pathology

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Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies

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