Cited by 123Pharmaceutical Practices and Patient OutcomesSubstance Abuse Treatment and OutcomesOpioid Use Disorder Treatment

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Minimal interventions to decrease long-term use of benzodiazepines in primary care: a systematic review and meta-analysis

Open access

Mugunthan, Kayalvili, McGuire, Treasure, Glasziou, Paul·2011·British Journal of General Practice

DOI 10.3399/bjgp11x593857PMC PMC3162180

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Long-term use of benzodiazepines (BZDs) is common. Not only is such use ineffective, but it also has several risks in addition to dependence, and remains a significant problem among the older population. AIM: To systematically review randomised controlled trials that evaluate the effectiveness of minimal interventions to reduce the long-term use of BZDs in primary care. DESIGN AND SETTING: Systematic review and meta-analysis of randomised controlled trials in UK general practices. METHOD: Cochrane Central, MEDLINE, and Embase (1967-2010) were searched for trials of minimal interventions (such as a single letter or one consultation from a GP) for patients in primary care with long-term (>3 months) BZD use. Pooled risk differences were calculated with 95% confidence intervals. RESULTS: From 646 potentially relevant abstracts, three studies (615 patients) met all the inclusion criteria. The pooled risk ratio showed a significant reduction/cessation in BZD consumption in the minimal intervention groups compared to usual care (risk ratio [RR] = 2.04, 95% confidence interval [CI] = 1.5 to 2.8, [corrected] P<0.001; RR = 2.4, 95% CI = 1.3 to 4.3, P = 0.008) respectively. Two studies also reported a significant proportional reduction in consumption of BZD from baseline to 6 months in intervention groups compared to the control group. The secondary outcome of general health status was measured in two studies; both showed a significant improvement in the intervention group. CONCLUSION: A brief intervention in the form of either a letter or a single consultation by GPs, for long-term users of BZD, is an effective and efficient strategy to decrease or stop their medication, without causing adverse consequences.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3399/bjgp11x593857

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
Glass, J., Lanctôt, K. L., Herrmann, N., Sproule, B. A., & Busto, U. E. (2005) · BMJ · doi:10.1136/bmj.38623.768588.47 · Cited by 1,161
Randomized Clinical Trial of Supervised Tapering and Cognitive Behavior Therapy to Facilitate Benzodiazepine Discontinuation in Older Adults with Chronic Insomnia
Morin, C. M., Bastien, C., Guay, B., Radouco-Thomas, M., Leblanc, J., & Vallières, A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.332 · Cited by 348
Strategies for discontinuing long-term benzodiazepine use: Meta-analysis
Voshaar, R. C. O., Couvée, J. E., Van Balkom, A. J. L. M., Mulder, P. G. H., & Zitman, F. G. (2006) · British Journal of Psychiatry · doi:10.1192/bjp.189.3.213 · Cited by 205
Controlled evaluation of brief intervention by general practitioners to reduce chronic use of benzodiazepines.
Bashir, K., King, M., & Ashworth, M. J. (1994) · Europe PMC (PubMed Central) · Cited by 143
Prevalence of insomnia in elderly general practice attenders and the current treatment modalities
Hohagen, F., Käppler, C. D. O., Schramm, E., Rink, K., Weyerer, S. B., Riemann, D. W., & Berger, T. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb01563.x · Cited by 140
Psychotropic Prescription Use by Community‐Dwelling Elderly in the United States
Aparasu, R. R., Mort, J. R., & Brandt, H. (2003) · Journal of the American Geriatrics Society · doi:10.1034/j.1600-0579.2003.00212.x · Cited by 136
Evaluation of an easy, cost-effective strategy for cutting benzodiazepine use in general practice.
Cormack, M., Sweeney, K., Hughes-Jones, H., & Foot, G. A. (1994) · Europe PMC (PubMed Central) · Cited by 131
Psychotropic Medication and Insomnia Complaints in Two Epidemiological Studies
Ohayon, M. M., & Caulet, M. (1996) · The Canadian Journal of Psychiatry · doi:10.1177/070674379604100711 · Cited by 100
Systematic review of the benzodiazepines.
Priest, R. G. (1980) · BMJ · doi:10.1136/bmj.280.6221.1085-a · Cited by 93
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
(1980) · BMJ · doi:10.1136/bmj.280.6218.910 · Cited by 86

Show all 20 references

Research works printed but not linked: 1

Petursson H (1993) in Benzodiazepine dependence, An international perspective on benzodiazepine abuse, ed Hallstrom C (Oxford University Press, Oxford) Chapter 12.

Sorted by citations

Benzodiazepine Use in the United States
Olfson, M., King, M., & Schoenbaum, M. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1763 · Cited by 786
Treatment of Benzodiazepine Dependence
Soyka, M. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1611832 · Cited by 465
Long-term use of benzodiazepines: Definitions, prevalence and usage patterns – a systematic review of register-based studies
Kurko, T., Saastamoinen, L., Tähkäpää, S.-M., Tuulio‐Henriksson, A., Taiminen, T. J., Tiihonen, J., Airaksinen, M., & Hietala, J. A. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.09.003 · Cited by 283
Polypharmacy Management in Older Patients
Hoel, R. W., Connolly, R. M. G., & Takahashi, P. Y. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.06.012 · Cited by 235
Swimming Against the Tide: Primary Care Physicians’ Views on Deprescribing in Everyday Practice
Wallis, K. A., Andrews, A., & Henderson, M. (2017) · The Annals of Family Medicine · doi:10.1370/afm.2094 · Cited by 160
Interventions for Reducing Benzodiazepine Use in Older People: Meta-Analysis of Randomised Controlled Trials
Gould, R. L., Coulson, M. C., Patel, N., Highton-Williamson, E., & Howard, R. J. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.126003 · Cited by 156
Psychosocial interventions for benzodiazepine harmful use, abuse or dependence
Darker, C. D., Sweeney, B. P., Barry, J. M., Farrell, M. F., & Donnelly-Swift, E. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009652.pub2 · Cited by 142
Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients
Ng, B. J., Le Couteur, D. G., & Hilmer, S. N. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0544-4 · Cited by 118
Deprescribing benzodiazepines and Z-drugs in community-dwelling adults: a scoping review
Pollmann, A. S., Murphy, A. L., Bergman, J. C., & Gardner, D. M. (2015) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-015-0019-8 · Cited by 114
Development of an intervention to improve appropriate polypharmacy in older people in primary care using a theory-based method
Cadogan, C. A., Ryan, C. A., Francis, J., Gormley, G., Passmore, P., Kerse, N. M., & Hughes, C. M. (2016) · BMC Health Services Research · doi:10.1186/s12913-016-1907-3 · Cited by 96
What sixty years of research says about the effectiveness of patient education on health: a second order meta-analysis
Simonsmeier, B. A., Flaig, M., Simacek, T., & Schneider, M. (2022) · Health Psychology Review · doi:10.1080/17437199.2021.1967184 · Cited by 81
Brief interventions targeting long‐term benzodiazepine and Z‐drug use in primary care: a systematic review and meta‐analysis
Lynch, T., Ryan, C. A., Hughes, C. M., Presseau, J., van Allen, Z., Bradley, C., & Cadogan, C. A. (2020) · Addiction · doi:10.1111/add.14981 · Cited by 86
Trends in the consumption rates of benzodiazepines and benzodiazepine-related drugs in the health region of Lleida from 2002 to 2015
Torres-Bondia, F., de Batlle, J., Galván, L., Buti, M., Barbé, F., & Piñol-Ripoll, G. (2020) · BMC Public Health · doi:10.1186/s12889-020-08984-z · Cited by 69
Bridging the gap between education and appropriate use of benzodiazepines in psychiatric clinical practice
Fiorillo, A., Dell’Osso, B. M., Albert, U., Atti, A. R., Carmassi, C., Carrà, G., Cosci, F., Vecchio, V. D., Nicola, M. D., Ferrari, S., et al. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s83130 · Cited by 69
Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders
Chapoutot, M., Peter-Derex, L., Bastuji, H., Leslie, W., Schoendorff, B., Heinzer, R., Siclari, F., Nicolas, A., Lemoine, P., Higgins, S., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph181910222 · Cited by 59
Discontinuation of psychotropic medication: a synthesis of evidence across medication classes.
Vinkers, C. H., Kupka, R. W., Penninx, B. W., Ruhé, H. G., van Gaalen, J. M., van Haaren, P. C. F., Schellekens, A. F. A., Jauhar, S., Ramos-Quiroga, J. A., Vieta, E., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02445-4 · Cited by 51
Substance use in older HIV-infected patients
Edelman, E. J., Tetrault, J. M., & Fiellin, D. A. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000069 · Cited by 49
Use of Benzodiazepines and Association with Falls in Older People Admitted to Hospital: A Prospective Cohort Study
Ballóková, A. L., Peel, N. M., Fialová, D., Scott, I. A., Gray, L., & Hubbard, R. E. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0159-3 · Cited by 50
Fatalities associated with gabapentinoids in England (2004–2020)
Kalk, N. J., Chiu, C., Sadoughi, R., Baho, H., Williams, B. D., Taylor, D. M., & Copeland, C. S. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15352 · Cited by 47
Patterns of benzodiazepines use in primary care adults with anxiety disorders
Bernard, M.-M. T., Luc, M., Carrier, J., Fournier, L., Duhoux, A., Côté, É., Lessard, O., Gibeault, C., Bocti, C., & Roberge, P. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00688 · Cited by 54
Feasibility and effectiveness of deprescribing benzodiazepines and Z‐drugs: systematic review and meta‐analysis
Soni, A., Thiyagarajan, A., & Reeve, J. (2023) · Addiction · doi:10.1111/add.15997 · Cited by 41
Prevalence of and pathways to benzodiazepine use in Brazil: the role of depression, sleep, and sedentary lifestyle
Madruga, C. S., Paim, T. L., Alves, H. N. P., Miguel, A. C., Massaro, L. T. S., Caetano, R., & Laranjeira, R. (2018) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2018-0088 · Cited by 40
Did the new French pay-for-performance system modify benzodiazepine prescribing practices?
Rat, C., Penhouet, G., Gaultier, A., Chaslerie, A., Pivette, J., Nguyen, J., & Victorri‐Vigneau, C. (2014) · BMC Health Services Research · doi:10.1186/1472-6963-14-301 · Cited by 42
The prevalence and prescribing patterns of benzodiazepines and Z-drugs in older nursing home residents in different European countries and Israel: retrospective results from the EU SHELTER study
Lukačišinová, A., Fialová, D., Peel, N. M., Hubbard, R. E., Brkic, J., Onder, G., Topinková, E., Gindin, J., Shochat, T., Gray, L., et al. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02213-x · Cited by 35
Geriatric Consultation Reduces High-risk Medication Usage at Discharge in Elderly Trauma Patients
Sharma, J., Parulekar, M. S., Stewart, P. J., Blatt, M., Zielonka, T., Nyirenda, T. L., Rogers, C., & Tank, L. (2018) · Cureus · doi:10.7759/cureus.3649 · Cited by 35
Prescribing benzodiazepines in general practice
Kennedy, K. M., & O’Riordan, J. (2019) · British Journal of General Practice · doi:10.3399/bjgp19x701753 · Cited by 35
Canadian Guidelines on Benzodiazepine Receptor Agonist Use Disorder Among Older Adults
Conn, D. K., Hogan, D. B., Amdam, L., Cassidy, K.-L., Cordell, P., Frank, C., Gardner, D., Goldhar, M., Ho, J. M.-W., Kitamura, C., et al. (2020) · Canadian Geriatrics Journal · doi:10.5770/cgj.23.419 · Cited by 32
Clinical management of withdrawal from benzodiazepine anxiolytic and hypnotic medications
Baldwin, D. S. (2022) · Addiction · doi:10.1111/add.15695 · Cited by 28
Illicit Drug Dependence
Degenhardt, L. J., Stockings, E., Strang, J., Marsden, J., & Hall, W. (2016) · World Bank, Washington, DC eBooks · doi:10.1596/978-1-4648-0426-7_ch6 · Cited by 26
Call for Action: Benzodiazepine Prescription Prevalence Analysis Shows Off-Label Prescription in One in Eleven Citizens
López‐Pelayo, H., Coma, A. V., Gual, A., Zara, C., & Lligoña, A. (2019) · European Addiction Research · doi:10.1159/000502518 · Cited by 23
Safer Prescribing and Care for the Elderly (SPACE): feasibility of audit and feedback plus practice mail-out to patients with high-risk prescribing
Wallis, K. A., & Tuckey, R. (2017) · Journal of Primary Health Care · doi:10.1071/hc17018 · Cited by 22
Electroacupuncture for tapering off long-term benzodiazepine use: A randomized controlled trial
Yeung, W., Chung, K., Zhang, Z.-J., Zhang, S., Chan, W. C., Ng, R. M.-K., Chan, C. L.-W., Ho, L., Yu, B. Y., Chau, J. C.-S., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.11.015 · Cited by 22
Safer Prescribing and Care for the Elderly (SPACE): Protocol of a Cluster Randomized Controlled Trial in Primary Care
Wallis, K. A., Elley, C. R., Lee, A. C.-L., Moyes, S. A., & Kerse, N. M. (2018) · JMIR Research Protocols · doi:10.2196/resprot.9839 · Cited by 20
Patient-centered care interventions to reduce the inappropriate prescription and use of benzodiazepines and z-drugs: a systematic review
Mokhar, A., Topp, J., Härter, M. C., Schulz, H., Kühn, S., Verthein, U., & Dirmaier, J. (2018) · PeerJ · doi:10.7717/peerj.5535 · Cited by 20
Role of the prescriber in supporting patients to discontinue benzodiazepines: a qualitative study
Oldenhof, E., Mason, T., Anderson‐Wurf, J., & Staiger, P. K. (2021) · British Journal of General Practice · doi:10.3399/bjgp.2020.1062 · Cited by 21
Discontinuation of chronic benzodiazepine use in primary care: a nonrandomized intervention
Fernandes, M., Neves, I., Oliveira, J., Santos, O., Aguiar, P. M. V., Atalaia, P., Matos, F., Freitas, M. C. D. N. B., Alvim, A., & Maria, V. A. J. (2021) · Family Practice · doi:10.1093/fampra/cmab143 · Cited by 22
NSAID Use after Bariatric Surgery: a Randomized Controlled Intervention Study
Yska, J. P., Gertsen, S., Flapper, G., Emous, M., Wilffert, B., & van Roon, E. N. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2218-9 · Cited by 19
Long-term benzodiazepine use in patients taking antidepressants in a public health setting in Brazil: a cross-sectional study
Fulone, I., Silva, M. T., & Lopes, L. C. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-018956 · Cited by 19
Drug-free holiday in patients with rheumatoid arthritis: a qualitative study to explore patients’ opinion
Markusse, I. M., Akdemir, G., Huizinga, T. W. J., & Allaart, C. F. (2014) · Clinical Rheumatology · doi:10.1007/s10067-014-2500-y · Cited by 16
Failed Warnings
Moss, B. G., & Yeaton, W. H. (2015) · Evaluation Review · doi:10.1177/0193841x15610192 · Cited by 16
Long-term use of benzodiazepines and Z drugs: a qualitative study of patients’ and healthcare professionals’ perceptions and possible levers for change
Mokhar, A., Kühn, S., Topp, J., Dirmaier, J., Härter, M. C., & Verthein, U. (2019) · BJGP Open · doi:10.3399/bjgpopen18x101626 · Cited by 14
Benzocarta: intervención mínima para la desprescripción de benzodiacepinas en pacientes con insomnio
Bueno, M. B., Artaza, E. R. D. V., Uría, J. F., & Iturbe, A. G. (2019) · Gaceta Sanitaria · doi:10.1016/j.gaceta.2019.06.012 · Cited by 14
Effects of Mindfulness-Based Relapse Prevention on the Chronic use of Hypnotics in Treatment-Seeking Women with Insomnia: a Randomized Controlled Trial
de Barros, V. V., Opaleye, E. S., Demarzo, M., Curado, D. F., Bowen, S. W., Hachul, H., & Noto, A. R. (2021) · International Journal of Behavioral Medicine · doi:10.1007/s12529-021-10002-4 · Cited by 12
Benzodiazepine Prescribing in People with Chronic Obstructive Pulmonary Disease: Clinical Considerations
Currow, D. C., & Agar, M. R. (2020) · Drugs & Aging · doi:10.1007/s40266-020-00756-z · Cited by 13
Impact of Differences in Economic Development and Socioeconomic Stability on Benzodiazepine Exposure between the Three Balkans Countries.
Marković, S. Z., Jovanović, N. I. D., Sedić, B., Vuković, M., Okjan, J. J., Dimitrijević, I., Trikos, L., Mojović, M., & Kastratović, D. A. (2019) · PubMed · Cited by 12
Benzodiazepine usage and patient preference for alternative therapies: A descriptive study
Sake, F., WONG, K. K. H., Bartlett, D. J., & Saini, B. (2019) · Health Science Reports · doi:10.1002/hsr2.116 · Cited by 11
Dispositional mindfulness, anticipation and abstinence symptoms related to hypnotic dependence among insomniac women who seek treatment: A cross-sectional study
Barros, V. V., Opaleye, E. S., Demarzo, M., Bowen, S., Curado, D. F., Hachul, H., & Noto, A. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194035 · Cited by 9
Suchtpotenzial und andere Risiken von Benzodiazepinen und Z-Drugs im Alter
Wolter, D. K. (2017) · SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice · doi:10.1024/0939-5911/a000474 · Cited by 9
Prospective associations between benzodiazepine use and later life satisfaction, somatic pain and psychological health among the elderly
Nordfjærn, T. (2013) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2316 · Cited by 9
Prescribing safety: the case of inappropriate medicines
Payne, R. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x593730 · Cited by 9
Community pharmacists’ role in benzodiazepine supply in Ireland: a questionnaire of pharmacists’ views and experiences
Cadogan, C. A., & Ryder, S. A. (2015) · International Journal of Pharmacy Practice · doi:10.1111/ijpp.12182 · Cited by 8
Benzodiazepine Withdrawal: Clinical Aspects
Wright, S. L. (2020) · The Benzodiazepines Crisis · doi:10.1093/med/9780197517277.003.0008 · Cited by 7
Effectiveness of a blended care programme for the discontinuation of benzodiazepine use for sleeping problems in primary care: study protocol of a cluster randomised trial, the Big Bird trial
Coteur, K., Nuland, M. V., Vanmeerbeek, M., Henrard, G., Anthierens, S., den Broeck, K. V., Sutter, A. D., Creupelandt, H., Devroey, D., Overmeire, R. V., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-033688 · Cited by 7
Prescribing and facilitating withdrawal from benzodiazepines in primary health care
Oliveira, J., Neves, I., Fernandes, M., Santos, O., & Maria, V. A. J. (2019) · Revista Portuguesa de Clínica Geral · doi:10.32385/rpmgf.v35i4.12239 · Cited by 7
Deprescribing: An umbrella review
Japelj, N., Horvat, N., Knez, L., & Kos, M. (2024) · Acta Pharmaceutica · doi:10.2478/acph-2024-0011 · Cited by 7
Verordnung von Benzodiazepinen und Z-Drugs in hausärztlichen Praxen – eine Querschnittanalyse
Moßhammer, D., Haumann, H., Muche, R., Scheub, D., Joos, S., & Laux, G. (2017) · Das Gesundheitswesen · doi:10.1055/s-0043-104694 · Cited by 6
Predicting chronic benzodiazepine use in adults with depressive disorder: Retrospective cohort study using administrative data in Quebec.
Carrier, J., Roberge, P., Courteau, J., & Vanasse, A. (2016) · PubMed Central · Cited by 6
Stratégies de sevrage de benzodiazépines en ambulatoire. Revue de la littérature
Naccache, F., & Vorspan, F. (2018) · La Presse Médicale · doi:10.1016/j.lpm.2018.10.007 · Cited by 7
An Analysis of Benzodiazepine Prescribing to Primary Care Patients in a Large Healthcare System from 2019-2020
Weleff, J., Anand, A., Squeri, M., Sieke, R., Thompson, N. R., & Barnett, B. S. (2023) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2023.2191610 · Cited by 6
Benzodiazepine and Nonbenzodiazepine Hypnotics (Z-Drugs): The Other Epidemic
Umbricht, A., & Vélez, M. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-36391-8_11 · Cited by 5
Anxiolytics: Misuse, Dependence, and Withdrawal Syndromes
Tang, V. M., & Davies, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_405 · Cited by 4
Therapie der Benzodiazepinabhängigkeit
Soyka, M., & München, B. (2019) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-0836-7514 · Cited by 5
Effektivität von Screeningverfahren zur Identifizierung von Medikamentenabhängigkeit: Vergleich der Severity of Dependence Scale (SDS) und des Kurzfragebogens zu Medikamentenmissbrauch (KMM)
Bischof, G., Otto, C., Bischof, A., & Rumpf, H. (2020) · Suchttherapie · doi:10.1055/a-1128-5050 · Cited by 4
Prescription Drug Abuse: Risks and Prevention
Bramness, J. G. (2014) · Springer eBooks · doi:10.1007/978-88-470-5322-9_29 · Cited by 4
De-implementing inappropriate benzodiazepine prescribing in primary care: an overview of systematic reviews informed by behavioral frameworks
Duarte-Anselmi, G., Pousada, M., Gómez‐Zúñiga, B., & Armayones, M. (2026) · Implementation Science Communications · doi:10.1186/s43058-026-00879-1 · Cited by 3
Environmentally conscious psychopharmacotherapy: Practice recommendations for psychiatrists
Luykx, J. J., Moermond, C., Page, L., Lertxundi, U., & Vinkers, C. H. (2024) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2024.10.003 · Cited by 3
A narrative review of strategies for discontinuing long-term benzodiazepine use and methodological recommendations: Is a success rate of only one in three patients sufficient?
Chapoutot, M., Meloni, F., Peter‐Derex, L., Bastuji, H., Leslie, W., Schoendorff, B., Heinzer, R. C., Nicolas, A., Higgins, S., Bourgeois, A., et al. (2025) · Journal of Behavioral and Cognitive Therapy · doi:10.1016/j.jbct.2025.100533 · Cited by 4
Missbrauch und Abhängigkeit von Benzodiazepinen und Z-Drugs
Soyka, M. (2021) · Nervenheilkunde · doi:10.1055/a-1523-5718 · Cited by 3
Intervención para la deprescripción de inhibidores de la bomba de protones mediante envío de carta (IBP-carta)
Artaza, E. R. D. V., Bueno, M. B., Uría, J. F., & Iturbe, A. G. (2021) · Atención Primaria · doi:10.1016/j.aprim.2021.102191 · Cited by 3
Sedatives and Hypnotics Abuse
Soyka, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00033-5 · Cited by 2
Afbouwen van chronisch benzodiazepinegebruik
Klaasen, G., Helsen, C., Klaasen, B., & Nuland, M. V. (2015) · Huisarts Nu · doi:10.1007/s40954-015-0079-4 · Cited by 2
INTERVENÇÕES NO USO PROLONGADO DE BENZODIAZEPÍNICOS: UMA REVISÃO.
de Carvalho, M. R. F., Rodrigues, E. T., & Golzio, A. M. F. D. O. (2016) · Revista Saúde & Ciência Online · doi:10.35572/rsc.v5i2.366 · Cited by 2
Risk perception, attitudes, and quality of life in a multicomponent benzodiazepine deprescription strategy
López, I. F., Lima, A. O. D. L., Gutiérrez‐Valencia, A., Bermúdez, E. G., Martín, F. A., Morente, A. G.-D., Fernández, M. D. M., Cañete, Y. S., & Bermúdez‐Tamayo, C. (2025) · Exploratory Research in Clinical and Social Pharmacy · doi:10.1016/j.rcsop.2025.100666 · Cited by 1
Safety and effectiveness of strategies to deprescribe chronic benzodiazepine receptor agonist use in older adults: a systematic review
O'Hara‐Veintimilla, K., Páez‐García, S., Ramírez-Triana, J., Torres-Tello, K., Forero, P. R. V., & Borda, M. G. (2026) · Age and Ageing · doi:10.1093/ageing/afag112 · Cited by 3
Tiltak mot misbruk av vanedannende midler
Bramness, J. G. (2012) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.12.0093 · Cited by 1
Knowledge regarding Proper Use Guidelines for Benzodiazepines
Inada, K. (2015) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.15-00228-2 · Cited by 1
Take a multifaceted stepwise approach when deprescribing benzodiazepines in older patients
Writers, A. M. (2018) · Drugs & Therapy Perspectives · doi:10.1007/s40267-018-0578-z · Cited by 1
Association between benzodiazepine prescriptions and potential risk factors of adverse drug reactions among elderly and very elderly: findings from Friuli Venezia Giulia region, Italy
Castelpietra, G., Balestrieri, M., Brusaferro, S., & Arnoldo, L. (2022) · Epidemiology Biostatistics and Public Health · doi:10.2427/13157 · Cited by 1
Affective Disorders
Bongiorno, P. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00142-4 · Cited by 2
Community‐based counselling for benzodiazepine withdrawal: A mixed‐methods study of client outcomes
Wurf, G., & O’Neal, P. (2022) · Counselling and Psychotherapy Research · doi:10.1002/capr.12547 · Cited by 1
Effect of a short video on patients’ motivation for dose reduction or cessation of hypnotics
Amagai, M., Ozone, M., Utsumi, T., Hotchi, A., Iwashita, M., Yamadera, W., & Shigeta, M. (2023) · Sleep and Biological Rhythms · doi:10.1007/s41105-023-00446-4 · Cited by 1
Anxiety Disorders
Baldwin, D. S., Impey, B., & Masdrakis, V. G. (2024) · Cambridge University Press eBooks · doi:10.1017/9781911623861.014 · Cited by 2
Dispensación de benzodiacepinas y análogos en farmacias comunitarias de Valladolid
Sevillano, L. G., & Blanco, C. S. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1
Interventions for benzodiazepine withdrawal: Perceptions of benzodiazepine counsellors
Wurf, G., & Swing, A. (2021) · Counselling and Psychotherapy Research · doi:10.1002/capr.12453 · Cited by 1
Exploring optimal pharmacotherapy after bariatric surgery: where two worlds meet
Yska, J. P. (2017) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 1
Therapie der Benzodiazepinabhängigkeit
Soyka, M. (2018) · PSYCH up2date · doi:10.1055/a-0525-5277 · Cited by 1
Uma revisão sistemática e metanálise sobre os eventos adversos decorrentes do uso de benzodiazepínicos pos idosos.
Basile, R. P. (2014) · doi:10.11606/d.42.2014.tde-20022015-143145
GABAA receptor subunit-related neuroanatomical substrates for attenuation of anxiety
Hellsten, K. (2015) · Työväentutkimus Vuosikirja
Surconsommation des benzodiazépines anxiolytiques et hypnotiques en France : perspectives d'amélioration de la prescription et du sevrage en médecine générale
Duboy, A. (2015) · HAL
Употреба на бензодијазепини кај пациенти на метадонски третман
Петрушевска, Т. (2015) · Macedonian Medical Electronic Journal · doi:10.3889/mmej.2015.50006
Élaboration d’un outil de formation en ligne de type RPIB (Repérage Précoce et Intervention Brève) pour l’optimisation des prescriptions des benzodiazépines en médecine générale
Coispeau, É. (2016) · HAL
Mye søvnplager – for mye hypnotika
Øyane, N., & Steihaug, O. M. (2013) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.13.1178
Abhängigkeit von Hypnotika und Tranquilizern
Soyka, M. (2015) · DNP - Der Neurologe und Psychiater · doi:10.1007/s15202-015-0843-0
Benzodiazepine Withdrawal in the Elderly: A Practical Approach
Mallet, L. (2016) · Springer eBooks · doi:10.1007/978-3-319-32304-6_18
Elaboration d'un outil de formation en ligne de type
Coispeau, É. (2016)
Benzodiazepine im Fokus
Aigner, M. (2016) · psychopraxis neuropraxis · doi:10.1007/s00739-016-0336-8
Predicting chronic benzodiazepine use in adults with depressive disorder
Carrier, J., Roberge, P., Courteau, J., & Vanasse, A. (2016) · Canadian Family Physician
Managing benzodiazepine dependence
Cosh, A., & Carslaw, H. (2017) · InnovAiT Education and inspiration for general practice · doi:10.1177/1755738017715275
4 Chronisch slaapmiddelengebruik
Jong, J. K.-D. (2016) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-1082-1_4
Prescription Drug Abuse: Risks, Diversion, and Prevention
Bramness, J. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-36391-8_22

Authors: Mugunthan, K., McGuire, T., & Glasziou, P.
Affiliations: Bond University (AU)
ORCID: McGuire, Treasure
Glasziou, Paul
Venue: British Journal of General Practice
Publisher: Royal College of General Practitioners
Published: 2011-09
Volume: 61
Issue: 590
Pages: e573-e578
ISSN: 0960-1643 (ISSN-L)
1478-5242
DOI: 10.3399/bjgp11x593857
PMC: PMC3162180
OpenAlex: W2153607529
Cited by: 123
References: 20
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 15 · 2020: 11 · 2019: 9 · 2018: 19 · 2017: 8 · 2016: 11 · 2015: 12 · 2014: 10 · 2013: 4 · 2012: 1
FWCI: 0.42
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: British Journal of General Practice (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Bond University Research Portal (Bond University) (submittedVersion, other-oa)
e-publications@bond (Bond University) (submittedVersion)
Funders: Bond University
National Health and Medical Research Council (527500)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords: benzodiazepines, long-term benzodiazepine use, brief intervention, primary care, general practice, patient letters, health status, older adults, benzodiazepine dependence
MeSH terms: Adolescent, Adult, Aged, Anxiety Disorders, Benzodiazepines, Communication, Female, United Kingdom, Humans, Long-Term Care, Male, Middle Aged, Patient Education as Topic, Physician-Patient Relations, Referral and Consultation, Risk Factors, Randomized Controlled Trials as Topic, Young Adult, General Practice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Minimal interventions to decrease long-term use of benzodiazepines in primary care: a systematic review and meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks