The effects of L-carnitine supplementation on lipid concentrations inpatients with type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials
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This meta-analysis was performed to assess the effect of L-carnitine supplementation on lipid profile. A systematic search were conducted in PubMed and Scopus to identify randomized clinical trials (RCTs) which evaluated the effects of L-carnitine on lipid profile. Pooled effect sizes were measured using random-effect model (Dersimonian-Laird). Meta-analysis showed that L-carnitine supplementation significantly reduced total cholesterol (TC) (weighted mean difference [WMD]: -8.17 mg/dL; 95% CI,-14.68 to -1.65, I2=52.2%, P = 0.041). Baseline level of TC was a source of heterogeneity, with a greater effect in studies with a baseline level of more than 200 mg/d (WMD: -11.93 mg/dL; 95% CI, -20.80 to-3.05). L-carnitine also significantly decreased low-density lipoprotein-cholesterol (LDL-C) (WMD:-5.22 mg/dL; 95% CI, -9.54 to -0.91, I2=66.7%, P = 0.010), and LDL-C level <100 mg/dL), trial duration,and L-carnitine dosage were potential sources of heterogeneity. L-carnitine supplementation appeared to have no significant effect on high-density lipoprotein-cholesterol (HDL-C) (WMD: -0.51 mg/dL;95% CI, -2.45 to 1.44) and triglyceride (TG) (WMD: 2.80 mg/dL; 95% CI, -8.09 to 13.69). This meta-analysisrevealed that L-carnitine may have favorable effects on lipid profile, especially LDL-C and TC. However, further RCTs are needed to confirm the veracity of these results, particularly among hyperlipidemic patients.
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Lipid disturbances such as high LDL-C, hypertriglyceridemia, and low HDL-C are well-known risk factors for cardiovascular disease.
“Lipid disturbances, such as high LDL-C, hypertriglyceridemia, and low HDL-C, are well-known risk factors for cardiovascular disease [11–14].”
From Ketogenic diet-induced changes in adult lipid metabolism: a comprehensive systematic review and meta-regression of randomized controlled trials (2026) · cites this paper as [13]
The Introduction identifies low HDL-C, elevated triglycerides, and elevated LDL-C as dyslipidemia and calls dyslipidemia a key cardiovascular risk factor in people with diabetes. The citing sentence states this without that population qualifier, extending the source's statement to people generally. (LLM, conf=0.82)
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- Authors
- Asbaghi, O., Kashkooli, S., Amini, M. R., Shahinfar, H., Djafarian, K., Clark, C. C. T., & Shab-Bidar, S.
- Affiliations
- Lorestan University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Coventry University (GB)
- ORCID
- Venue
- Journal of Cardiovascular and Thoracic Research
- Publisher
- Maad Rayan Publishing Company
- Published
- 2020-09-07
- Volume
- 12
- Issue
- 4
- Pages
- 246-255
- ISSN
- 2008-5117 (ISSN-L)
- 2008-6830
- PMC
- PMC7828761
- OpenAlex
- W3112502916
- Cited by
- 23
- References
- 59
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 3 · 2022: 1 · 2021: 3
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Cardiovascular and Thoracic Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure (Coventry University) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- L-carnitine, dietary supplementation, lipid profile, type 2 diabetes, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, hyperlipidemia
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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