Cited by 517Substance Abuse Treatment and OutcomesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

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Alcohol Use Disorder and Depressive Disorders

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McHugh, RK·2019·Alcohol Research: Current Reviews

DOI 10.35946/arcr.v40.1.01PMC PMC6799954

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Abstract

Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance. The aim of this review is to characterize the prevalence, course, and treatment of co-occurring AUD and depressive disorders. Studies have indicated that the co-occurrence of AUD and depressive disorders is associated with greater severity and worse prognosis for both disorders. Both pharmacologic and behavioral treatments have demonstrated efficacy for this population. However, treatment response is somewhat modest, particularly for drinking outcomes, highlighting the importance of further research on the etiology and treatment of co-occurring AUD and depressive disorders. Key future directions include studies to understand the heterogeneity of both AUD and depressive disorders, research on novel treatment approaches to enhance outcomes, and better understanding of sex and gender differences.

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“This may point to differing underlying psychological mechanisms for maladaptive alcohol behaviours, such as shared biological risk factors, depressive symptomatology, or underlying traits of obsessive compulsiveness [14,43].”
Background
Effect of the COVID-19 Emergency State in the Latvian General Population with Depression and Distress on Changes of Patterns of Smoking and Psychoactive Substance Use
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“A large number of studies have previously linked alcohol consumption, smoking, and substance abuse to mood spectrum disorders (Davis et al ., 2008; Holma and Ketokivi, 2013; McHugh and Weiss, 2019).”
Background
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Determinants of depressive and alcohol use disorders among female sex workers in Ethiopia: evidence from a national bio-behavioral survey, 2020
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“Studies have shown that eliminating depression entirely could lead to a 10% decrease in mortality rate (1, 16, 17).”
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Bouighoulidne, S. A., Aquil, A., Raouani, O., Guerroumi, M., Kherchi, O. E., Haddou, M. B., Ami, S. A., Laamırı, F. Z., & Elgot, A. (2024) · Journal of Substance Use · doi:10.1080/14659891.2024.2407623 · Cited by 1
“Both cannabis and alcohol have been associated with anxiety and depression (Calarco & Lobo, 2021; Feingold & Weinstein, 2021; McHugh, 2019).”
Identifying Factors Linked to Current Patterns of Alcohol Consumption in U.S. Veterans with a History of Alcohol Use Disorder
Khave, L. J., Stefanovics, E. A., Potenza, M. N., & Pietrzak, R. H. (2024) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-024-01412-y · Cited by 1
“Many individuals with AUD also experience co-occurring psychiatric disorders, with major depressive disorder (MDD) being among the most prevalent (McHugh & Weiss, 2019).”
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Потенциальные маркеры алкогольной зависимости: состояния тревоги и депрессии, индивидуально-личностные характеристики
Иванова, Т. И., Васильченко, К. Ф., Blokh, A. I., Федорова, А. Ю., Усова, А. А., Novikov, D. G., Kirichenko, N. A., & Тагаков, К. С. (2020) · Сибирский вестник психиатрии и наркологии · doi:10.26617/1810-3111-2020-4(109)-51-57 · Cited by 1
Logistic Regression Model of Demographic Predictors and Confounders of Binge Alcohol Use Among Adults with Major Depression
Omary, A. (2022) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-022-00808-y · Cited by 1
Alcoholic beverages and health effects
Haghparast, P., & Tchalikian, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00244-x · Cited by 1
Circadian gene Bmal1 in the lateral habenula regulates alcohol drinking behavior in a sex specific mannerPreprint
Goldfarb, C., Hasenhundl, V., Menasce, A., Amir, S., & Schöttner, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.13.607765 · Cited by 1
“…Mansour et al., 2006; Roybal et al., 2007; Russell et al., 2021; Schnell et al., 2015; Serretti et al., 2005; Zhao & Gammie, 2018), and anxiety and mood disorders commonly occur with alcohol use disorder, and the co-occurrence is associated with increased severity of both (McHugh & Weiss, 2019).”
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Neuroanatomical features reveal accelerated brain age in alcohol use disorderPreprint
Kamarajan, C., Ardekani, B. A., Pandey, A. K., Meyers, J. L., Chorlian, D. B., Kinreich, S., Pandey, G., de Viteri, S. S., Richard, C., Bingly, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.30.679671 · Cited by 1
“This discord could be due to heterogeneity of both AUD and depressive disorder in terms of internalizing and externalizing traits, types of impulsivity, etiological pathways, and gender/sex differences [116-118].”
Ciclos circadianos desajustados en la relación del consumo de alcohol y depresión
Gaytán, J. M. Q., Herrera, M. M., & Llanes, N. H. (2020) · Revista Internacional de Investigación en Adicciones · doi:10.28931/riiad.2020.2.07
Baseline Lateral Habenula Firing Rate Negatively Correlates with Increase in Ethanol Intake over Days in Adult Long Evans RatsPreprint
Tandon, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.27.428307
“Likewise, individuals with certain neuronal traits are more at risk to develop AUD in the future [5].”
BackgroundInfluential
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Azevedo, J. (2020) · Psicologia Saúde & Doenças · doi:10.15309/20psd210321
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Викторовна, М. Е., Vyalova, N. M., Fedorenko, O. Y., Рощина, О. В., Simutkin, G. G., Bokhan, N. A., & Ivanova, S. А. (2021) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2021-3-48-52
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Psychological stressors predicting increased hazardous drinking during the COVID-19 crisis: A longitudinal national survey study of workers in Finland (Preprint)Preprint
Oksanen, A., Savolainen, I., Savela, N., & Oksa, R. (2020) · doi:10.2196/preprints.23837
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Afridi, M. I., Lal, C., Dharwarwala, R. A., Dars, J. A., Iqbal, F., & Juseja, A. K. (2021) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs2115123562
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Gallus, S., Lugo, A., Borroni, E., Vignoli, T., Lungaro, L., Caio, G., GIORGIO, R. D., Zoli, G., & Caputo, F. (2022) · MISSION · doi:10.3280/mis56-2020oa13087
Severity of depressive symptomatology and socio-demographic characteristics of patients with alcoholism in the Republic of Dagestan depending on territorial patterns of residence
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“Таблица 2 Характеристика алкогольной зависимости у обследованных пациентов Показатель Количество обследованных Критерия Манна-Уитни, р Городская местность Сельская местность Длительность заболевания (лет) 14 [11; 17] 13 [11; 16,5] 0,591 Возраст постановки на учет (лет) 51 [44; 59] 52,5 [42,5; 57,5] 0,845 Количество дн…”
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Turner, M. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.235393
Clinical and genetic associations of the CLOCK circadian rhythm gene and depressive disorders in patients with alcohol dependence syndrome during the period of alcohol abstinence
Tulbaeva, N. R., Nasyrova, R. F., Smirnova, D. A., Ashurov, Z., Efremov, I. S., Добродеева, В. С., Abdrakhmanova, A. E., & Asadullin, A. R. (2022) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2022-5-43-48
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“Primary researchers used 7 different depressive instruments: (1) Depression Anxiety and Stress Scale (DASS-21, s = 2), (2) Beck Depression Inventory (BDI-II, s = 9), (3) Center for Epidemiological Studies Depression (CES-D, s = 4), (4) Overall Depression Severity and Impairment Scale (ODSIS, s = 1), (5) Hamilton Depre…”
BackgroundMethod

Authors: McHugh, R.
Affiliations: Harvard University (US)
Corresponding author: McHugh, RK
ORCID: McHugh, RK
Venue: Alcohol Research: Current Reviews
Publisher: National Institute on Alcohol Abuse and Alcoholism
Published: 2019
Volume: 40
Issue: 1
ISSN: 2168-3492 (ISSN-L)
2169-4796
DOI: 10.35946/arcr.v40.1.01
PMC: PMC6799954
OpenAlex: W2972722553
Cited by: 517
References: 64
Citations by year: 2026: 38 · 2025: 125 · 2024: 104 · 2023: 93 · 2022: 93 · 2021: 48 · 2020: 16
FWCI: 5.72
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: public-domain
Locations: Alcohol research (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: Charles Engelhard Foundation
National Institute on Drug Abuse (K24DA022288, K23DA035297)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: alcoholism, depressive disorders, comorbidities, prevalence, clinical course, treatment response, pharmacotherapy, behavior therapy, prognosis, sex and gender differences
MeSH terms: Alcoholism, Depressive Disorder, Humans, Prognosis, Comorbidity, Prevalence

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