Specific probiotics alleviate allergic rhinitis during the birch pollen season
Open accessAbstract
AIM: To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these. METHODS: Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L. acidophilus) NCFM (ATCC 700396) and Bifidobacterium lactis (B. lactis) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo, starting prior to onset of the birch pollen season. Symptoms were recorded in a diary. Blood samples were taken for analysis of cytokines and eosinophils. Fecal samples were analysed for microbiota components, calprotectin and IgA. Nasal swabs were taken for analysis of eosinophils. RESULTS: The pollen season induced a reduction in Bifidobacterium, Clostridium and Bacteroides which could not be prevented by the probiotic intervention. During the intervention, significantly higher numbers of B. lactis 11.2 x 10(7) +/- 4.2 x 10(7) vs 0.1 x 10(7) +/- 0.1 x 10(7) bacteria/g feces (P < 0.0001) and L. acidophilus NCFM 3.5 x 10(6) +/- 1.3 x 10(6) vs 0.2 x 10(6) +/- 0.1 x 10(6) bacteria/g feces (P < 0.0001) were observed in the probiotic group compared to the placebo group. During May, there was a tendency for fewer subjects, (76.2% vs 95.2%, P = 0.078) to report runny nose, while during June, fewer subjects, 11.1% vs 33.3%, reported nasal blocking in the probiotics group (P = 0.101). Concomitantly, fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group, 57.1% vs 95% (P = 0.013). Eye symptoms tended to be slightly more frequent in the probiotic group, 12.5 d [interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P = 0.066) during May. Fecal IgA was increased in the placebo group during the pollen season; this increase was prevented by the probiotics (P = 0.028). CONCLUSION: Birch pollen allergy was shown to be associated with changes in fecal microbiota composition. The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa, and indicated a trend for reduced nasal symptoms.
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The same probiotic combination indicated a trend for reduced nasal symptoms in birch pollen allergy.
“and indicated a trend for reduced nasal symptoms [160]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [160]
The same probiotic combination was able to prevent pollen-induced infiltration of eosinophils into the nasal mucosa in birch pollen allergy.
“was able to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa in birch pollen allergy”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [160]
A combination of probiotics, including one strain of L. acidophilus and two strains of B. animalis subsp. lactis, was associated with changes in faecal microbiota composition in birch pollen allergy.
“a combination of probiotics, including one strain of L. acidophilus and two strains of B. animalis subsp.lactis, was shown to be associated with changes in faecal microbiota composition”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [160]
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Cites
Asher, M. I., Montefort, S., Björkstén, B., Lai, C. K., Strachan, D. P., Weiland, S. K., & Williams, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69283-0 · Cited by 4,223 · see citing works
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,434 · see citing works
Self-citationGuidelines for the evaluation of probiotics in food
Who, F. (2002) · Medical Entomology and Zoology · Cited by 1,843 · see citing works
Kalliomäki, M. A., Salminen, S., Poussa, T. A., Arvilommi, H. S., & Isolauri, E. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13490-3 · Cited by 1,340 · see citing works
Self-citationHarmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326 · see citing works
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255 · see citing works
Self-citationProbiotics in the management of atopic eczema
Isolauri, E., Arvola, T., Sütas, Y., Moilanen, E., & Salminen, S. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00943.x · Cited by 977 · see citing works
Self-citationCollado, M. C., Derrien, M., Isolauri, E., de Vos, W. M., & Salminen, S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01477-07 · Cited by 706 · see citing works
Self-citationSettipane, R. J., Hagy, G. W., & Settipane, G. A. (1994) · Allergy and Asthma Proceedings · doi:10.2500/108854194778816634 · Cited by 471 · see citing works
Braunstahl, G.-J., Overbeek, S. E., KleinJan, A., Prins, J.-B., Hoogsteden, H. C., & Fokkens, W. J. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.113046 · Cited by 454 · see citing works
Kalliomäki, M. A., Salminen, S., Poussa, T. A., & Isolauri, E. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.608 · Cited by 453 · see citing works
Self-citationCorrelation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria
Foligné, B. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i2.236 · Cited by 427 · see citing works
Holben, W. E., Williams, P. M., Saarinen, M., Särkilahti, L. K., & Apajalahti, J. (2002) · Microbial Ecology · doi:10.1007/s00248-002-1011-6 · Cited by 370 · see citing works
Helin, T., Haahtela, S., & Haahtela, T. (2002) · Allergy · doi:10.1034/j.1398-9995.2002.1s3299.x · Cited by 245 · see citing works
Harmsen, H. J. M., Gibson, G. R., Elfferich, P., Raangs, G. C., Wildeboer-Veloo, A. C. M., Argaiz, A., Roberfroid, M. B., & Welling, G. W. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb08945.x · Cited by 219 · see citing works
BRAUNSTAHL, G.-J., OVERBEEK, S. E., FOKKENS, W. J., KLEINJAN, A., McEUEN, A. R., WALLS, A. F., HOOGSTEDEN, H. C., & PRINS, J. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2006082 · Cited by 207 · see citing works
Huurre, A., Laitinen, K., Rautava, S., Korkeamäki, M., & Isolauri, E. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03008.x · Cited by 205 · see citing works
Self-citationNew Real-Time Quantitative PCR Procedure for Quantification of Bifidobacteria in Human Fecal Samples
Gueimonde, M., Tölkkö, S., Korpimäki, T., & Salminen, S. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.7.4165-4169.2004 · Cited by 177 · see citing works
Self-citationOuwehand, A. C., Tiihonen, K., Saarinen, M., Putaala, H., & Rautonen, N. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508003097 · Cited by 170 · see citing works
Self-citationIvory, K., Chambers, S. J., Pin, C., Prieto, E., Arqués, J. L., & Nicoletti, C. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03025.x · Cited by 144 · see citing works
Selecting Lactic Acid Bacteria for Their Safety and Functionality by Use of a Mouse Colitis Model
Daniel, C., Poiret, S., Goudercourt, D., Dennin, V., Leyer, G. J., & Pot, B. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.00109-06 · Cited by 131 · see citing works
ISHIDA, Y., Nakamura, F., Kanzato, H., Sawada, D., Yamamoto, N., Kagata, H., Ohida, M., Takeuchi, H., & FUJIWARA, S. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.1652 · Cited by 121 · see citing works
Tamura, M., Shikina, T., Morihana, T., Hayama, M., Kajimoto, O., Sakamoto, A., Kajimoto, Y., Watanabe, O., Nonaka, C., Shida, K., et al. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000098318 · Cited by 118 · see citing works
Kawase, M., He, F., Kubota, A., Hiramatsu, M., Saito, H., Ishii, T., Yasueda, H., & Akiyama, K. (2008) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2008.09.017 · Cited by 98 · see citing works
Peuranen, S., Tiihonen, K., Apajalahti, J., et al. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041114 · Cited by 88 · see citing works
Xiao, J., Kondo, S., Yanagisawa, N., Miyaji, K., Enomoto, K., Sakoda, T., Iwatsuki, K., & Enomoto, T. (2007) · Allergology International · doi:10.2332/allergolint.o-06-455 · Cited by 73 · see citing works
Odamaki, T., Xiao, J.-Z., Iwabuchi, N., Sakamoto, M., Takahashi, N., Kondo, S., Iwatsuki, K., Kokubo, S., Togashi, H., Enomoto, T., et al. (2007) · PubMed · Cited by 51 · see citing works
Factors contributing to nasal allergic late phase eosinophilia
Kramer, M. F., Jordan, T., Klemens, C., Hilgert, E., Hempel, J. M., Pfrogner, E., & Rasp, G. (2006) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2005.09.013 · Cited by 39 · see citing works
Reduced structural proteins in the conjunctival epithelium in allergic eye disease
Hughes, J. L., Lackie, P. M., Wilson, S. J., et al. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01207.x · Cited by 37 · see citing works
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Research works printed but not linked: 1
- Braunstahl GJ, Overbeek SE, Kleinjan A, Prins JB, Hoogsteden HC, Fokkens WJ. Nasal allergen provocation i n d u c e s a d h e s i o n m o l e c u l e e x p r e s s i o n a n d t i s e eosinophilia in upper and lower airways. J Allergy Clin Immunol 2001; 107: 469-476
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International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557 · see citing works
Gut-Lung Axis: The Microbial Contributions and Clinical Implications
He, Y., Wen, Q., Yao, F., Xu, D., Huang, Y., & Wang, J. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1176988 · Cited by 301 · see citing works
Singh, A., Hacini-Rachinel, F., Gosoniu, M. L., Bourdeau, T., Holvoet, S., Doucet-Ladeveze, R., Beaumont, M., Mercenier, A., & Nutten, S. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.197 · Cited by 93 · see citing works
Spacova, I., Van Beeck, W., Seys, S., Devos, F., Vanoirbeek, J., Vanderleyden, J., Ceuppens, J., Petrova, M., & Lebeer, S. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1766345 · Cited by 87 · see citing works
Safety of probiotics and synbiotics in children under 18 years of age
van den Nieuwboer, M., Brummer, R. J., Guarner, F., Morelli, L., Cabana, M., & Claassen, E. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0157 · Cited by 83 · see citing works
Perrin, Y., Nutten, S., Audran, R., Berger, B., Bibiloni, R., Wassenberg, J., Barbier, N., Aubert, V., Moulin, J., Singh, A., et al. (2014) · Clinical and Translational Allergy · doi:10.1186/2045-7022-4-1 · Cited by 38 · see citing works
Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria
Abou Hachem, M., Andersen, J. M., Barrangou, R., Møller, M. S., Fredslund, F., Majumder, A., Ejby, M., Lahtinen, S. J., Jacobsen, S., Lo Leggio, L., et al. (2013) · Biocatalysis and Biotransformation · doi:10.3109/10242422.2013.828048 · Cited by 25 · see citing works
- Authors
- Ouwehand, A. C., Nermes, M., Collado, M. C., Rautonen, N., Salminen, S., & Isolauri, E.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2009
- Volume
- 15
- Issue
- 26
- Pages
- 3261
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC2710782
- OpenAlex
- W2114574400
- Cited by
- 128
- References
- 29
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 4 · 2016: 9 · 2015: 8 · 2014: 10 · 2013: 9 · 2012: 11
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Generalitat Valenciana
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- allergic rhinitis, birch pollen allergy, probiotics, Lactobacillus acidophilus NCFM, gut microbiota, pollen season, eosinophil infiltration, nasal symptoms, IgA, calprotectin, children, cytokines, nasal mucosa, ocular symptoms
- MeSH terms
- Adolescent, Allergens, Bifidobacterium, Child, Child, Preschool, Double-Blind Method, Eosinophils, Feces, Female, Rhinitis, Allergic, Seasonal, Humans, Lactobacillus acidophilus, Male, Placebos, Pollen, Seasons, Cytokines, Probiotics, Betula
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