Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly
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Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (10(8) cells/g) but decreases (P < 0.05) in the elderly.
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This reduction allows the entry of pathogenic bacteria and their metabolites into the blood and increases inflammatory factors such as IL-6, IL-1β, and TNF-α.
“This reduction allows the entry of pathogenic bacteria and their metabolites into the blood and increases inflammatory factors such as IL-6, IL-1β, and TNF-α [36].”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [36]
Dysbiosis of the intestinal microbiota can lead to decreased expression of intestinal tight-junction-associated proteins.
“whose dysbiosis can lead to decreased expression of intestinal tight-junction-associated proteins”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [36]
Many studies have shown that Akkermansia can effectively improve symptoms in mouse models of ALS, progeria, and chronic colitis by promoting healing and recovery of intestinal mucosal layer and reducing the expression of proinflammatory cytokines such as TNF-α and IFN-γ in the colon.
“Many studies have shown that Akkermansia can effectively improve symptoms in mouse models of diseases such as ALS [34], progeria [35], and chronic colitis [36] by promoting healing and recovery of intestinal mucosal layer and reducing the expression of proinflammatory cytokines such as TNF-α and interferon gamma (IFN-γ) in the colon.”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [36]
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- Authors
- Collado, M. C., Derrien, M., Isolauri, E., de Vos, W. M., & Salminen, S.
- Affiliations
- University of Turku (FI)
- Wageningen University & Research (NL)
- Laboratory of Microbiology, Wageningen University, 6703 HB Wageningen, The Netherlands
- Corresponding author
- Collado, M. Carmen
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2007-12
- Volume
- 73
- Issue
- 23
- Pages
- 7767-7770
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC2168041
- OpenAlex
- W2021251015
- Cited by
- 706
- References
- 1
- Citations by year
- 2026: 34 · 2025: 54 · 2024: 75 · 2023: 60 · 2022: 76 · 2021: 82 · 2020: 76 · 2019: 54 · 2018: 37 · 2017: 34 · 2016: 34 · 2015: 13 · 2014: 17 · 2013: 14 · 2012: 15
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- Akkermansia muciniphila, gut microbiota, mucin degradation, intestinal integrity, infants, older adults, 16S rRNA gene
- MeSH terms
- Adult, Aged, 80 and over, Bacteria, Feces, Humans, Infant, Infant, Newborn, Intestines, Mucins, RNA, Ribosomal, 16S, Polymerase Chain Reaction, In Situ Hybridization, Fluorescence
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