Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma
Open accessAbstract
AIM: To evaluate the relationship between glycemic control [assessed by glycated hemoglobin (HbA1c)], antidiabetic therapies and the risk of hepatocellular carcinoma (HCC). METHODS: We recruited 465 patients with HCC, 618 cases with liver cirrhosis and 490 controls with no liver disease. Among subjects with type 2 diabetes mellitus (DM2), the associations between the antidiabetic strategies and HbA1c level with HCC were determined through 2 series of multivariate logistic regression models using cirrhotic patients and controls as comparison groups. RESULTS: DM2 prevalence was 31.2% in patients with HCC, 23.2% in cirrhotic patients and 12.6% in controls (P < 0.0001). In 86% of study subjects, DM2 had been diagnosed for more than 1 year before the HCC diagnosis. HCC patients with DM2 had a 1.5-2.5-fold increased risk of liver cancer. The HbA1c mean levels were significantly higher in DM2 patients with HCC than in cirrhotic and control DM2 patients. Antidiabetic treatment with metformin was more common among cirrhotic and control DM2 subjects than among cases with HCC. In both series of multivariate analyses, treatment with metformin significantly reduced the risk of HCC by more than 80% compared with sulphonylureas and insulin therapy. No significant differences were seen between sulphonylureas and insulin treatment. Elevated HbA1c levels were positively related to the risk for HCC in diabetic patients, with a 26%-50% increase in risk for each 1% increase in HbA1c values. CONCLUSION: In patients with preexisting DM2, the risk of HCC is positively associated with poor chronic glycemic control and significantly decreased by metformin therapy.
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Patients with type 2 diabetes who are prescribed metformin had a lower risk of cancer compared to patients who did not take it.
“Patients with type 2 diabetes who are prescribed metformin had a lower risk of cancer compared to patients who did not take it.”
From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [136]
The reduced risk of cancer and cancer mortality observed in studies of metformin users has been consistently in the range of 25% to 30%.
“The reduced risk of cancer and cancer mortality observed in these studies has been consistently in the range of 25% to 30% [135-139,145-147].”
From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [136]
An observational cohort study of new metformin users with type 2 diabetes found a significant decrease in cancer incidence among metformin users (7.3%) compared to controls (11.6%), with an unadjusted hazard ratio of 0.46 (95% CI 0.40-0.53).
“An observational cohort study with type 2 diabetics who were new metformin users found a significant decrease in cancer incidence among metformin users (7.3%) compared to controls (11.6%). The unadjusted hazard ratio (95% CI) for cancer was 0.46 (0.40–0.53).”
From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [136]
Cites
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696 · see citing works
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Calle, E. E., & Kaaks, R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1408 · Cited by 3,613 · see citing works
Metformin and reduced risk of cancer in diabetic patients
Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., & Morris, A. D. (2005) · BMJ · doi:10.1136/bmj.38415.708634.f7 · Cited by 2,388 · see citing works
Non-invasive evaluation of liver fibrosis using transient elastography
Castéra, L., Forns, X., & Alberti, A. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.02.008 · Cited by 1,433 · see citing works
Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
El‐Serag, H. B., Tran, T., & Everhart, J. E. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.10.065 · Cited by 1,232 · see citing works
The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
Currie, C. J., Poole, C. D., & Gale, E. A. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1440-6 · Cited by 1,124 · see citing works
New Users of Metformin Are at Low Risk of Incident Cancer
Libby, G., Donnelly, L. A., Donnan, P. T., Alessi, D. R., Morris, A. D., & Evans, J. M. M. (2009) · Diabetes Care · doi:10.2337/dc08-2175 · Cited by 996 · see citing works
Dowling, R. J. O., Zakikhani, M., Fantus, I. G., Pollak, M., & Sonenberg, N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2310 · Cited by 933 · see citing works
Barone, B. B. (2008) · JAMA · doi:10.1001/jama.2008.824 · Cited by 881 · see citing works
Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M.-C., Hortobagyi, G. N., & Gonzalez-Angulo, A. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.19.6410 · Cited by 880 · see citing works
Diabetes Mellitus as a Predictor of Cancer Mortality in a Large Cohort of US Adults
Coughlin, S. S., Calle, E. E., Teras, L. R., Petrelli, J. M., & Thun, M. J. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh161 · Cited by 795 · see citing works
Davila, J. A., Morgan, R. O., Shaib, Y. H., McGlynn, K. A., & El‐Serag, H. B. (2005) · Gut · doi:10.1136/gut.2004.052167 · Cited by 703 · see citing works
Hoelzel, W., Weykamp, C., Jeppsson, J.-O., Miedema, K., Barr, J. R., Goodall, I., Hoshino, T., John, W. G., Kobold, U., Little, R., et al. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.024802 · Cited by 690 · see citing works
Antidiabetic Therapies Affect Risk of Pancreatic Cancer
Li, D., Yeung, S. J., Hassan, M. M., Konopleva, M., & Abbruzzese, J. L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.013 · Cited by 584 · see citing works
Inoue, M. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.17.1871 · Cited by 561 · see citing works
Giovannucci, E. L., & Michaud, D. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.050 · Cited by 545 · see citing works
Chen, C., Yang, H., Yang, W., Liu, C., Chen, P., You, S., Wang, L., Sun, C., Lu, S., Chen, D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.073 · Cited by 544 · see citing works
Prevalence of chronic liver disease in the general population of northern Italy: The dionysos study
Bellentani, S., Tiribelli, C., Saccoccio, G., Sodde, M., Fratti, N., Martin, C. D., & Christianini, G. (1994) · Hepatology · doi:10.1002/hep.1840200611 · Cited by 515 · see citing works
Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes
Landman, G. W. D., Kleefstra, N., van Hateren, K. J. J., Groenier, K. H., Gans, R. O. B., & Bilo, H. J. G. (2010) · Diabetes Care · doi:10.2337/dc09-1380 · Cited by 502 · see citing works
Prospective Study of Hyperglycemia and Cancer Risk
Stattin, P. E., Björ, O., Ferrari, P., Lukanova, A., Lenner, P., Lindahl, B., Hallmans, G., & Kaaks, R. (2007) · Diabetes Care · doi:10.2337/dc06-0922 · Cited by 352 · see citing works
Does diabetes therapy influence the risk of cancer?
Smith, U., & Gale, E. A. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1441-5 · Cited by 316 · see citing works
Zakikhani, M., Dowling, R. J. O., Sonenberg, N., & Pollak, M. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0081 · Cited by 294 · see citing works
Veldt, B. J., Chen, W., Heathcote, J., Wedemeyer, H. H., Reichen, J., Hofmann, P., de Knegt, R. J., Zeuzem, S., Manns, M. P., Hansen, B. E., et al. (2008) · Hepatology · doi:10.1002/hep.22251 · Cited by 281 · see citing works
Trends in mortality from hepatocellular carcinoma in Europe, 1980‐2004†
Bosetti, C., Levi, F., Boffetta, P., Lucchini, F., Negri, E., & Vecchia, C. L. (2008) · Hepatology · doi:10.1002/hep.22312 · Cited by 277 · see citing works
Wright, J. L., & Stanford, J. L. (2009) · Cancer Causes & Control · doi:10.1007/s10552-009-9407-y · Cited by 276 · see citing works
The role of diabetes in hepatocellular carcinoma: a case-control study among United States veterans
El‐Serag, H. B., Richardson, P., & Everhart, J. E. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04054.x · Cited by 273 · see citing works
Nutrition, Insulin, Insulin-like Growth Factors and Cancer
Giovannucci, E. L. (2003) · Hormone and Metabolic Research · doi:10.1055/s-2004-814147 · Cited by 272 · see citing works
Hepatocellular carcinoma: present status and future prospects
Llovet, J. M., & Beaugrand, M. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00432-4 · Cited by 249 · see citing works
the Metascreen Writing Committee (2006) · Diabetes Care · doi:10.2337/dc06-0942 · Cited by 188 · see citing works
Type 2 diabetes and hepatocellular carcinoma
Lai, M., Hsieh, M., Chiu, Y., & Chen, T. H. (2006) · Hepatology · doi:10.1002/hep.21208 · Cited by 187 · see citing works
The Growing Burden of Diabetes Mellitus in the US Elderly Population
Sloan, F. A. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2007.35 · Cited by 176 · see citing works
Khaw, K., Wareham, N. J., Bingham, S. A., Luben, R., Welch, A. A., & Day, N. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.915.13.6 · Cited by 169 · see citing works
Metabolic syndrome, hyperinsulinemia, and cancer
Hsu, I. R., Kim, S. P., Kabir, M., & Bergman, R. N. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.867s · Cited by 159 · see citing works
Mortality From Site-Specific Malignancies in Type 2 Diabetic Patients From Verona
Verlato, G., Zoppini, G., Bonora, E., & Muggeo, M. (2003) · Diabetes Care · doi:10.2337/diacare.26.4.1047 · Cited by 138 · see citing works
The Provincial Group for the Study of Chronic Liver Disease, Corrao, G., Lepore, A. R., Torchio, P., Valenti, M., GALATOLA, G., D’Amicis, A., Aricò, S., & di Orio, F. (1994) · European Journal of Epidemiology · doi:10.1007/bf01719277 · Cited by 132 · see citing works
Siddiqui, A. A., Spechler, S. J., Huerta, S., Dredar, S., Little, B. B., & Cryer, B. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0264-4 · Cited by 94 · see citing works
Diabetes, insulin resistance and sugars
Laville, M., & Nazare, J. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00562.x · Cited by 90 · see citing works
Diabetes Mellitus May Be Associated with Hepatocarcinogenesis in Patients with Chronic Hepatitis C
Tazawa, J., Maeda, M., Nakagawa, M., Ohbayashi, H., Kusano, F., Yamane, M., Sakai, Y., & Suzuki, K. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1014715327729 · Cited by 79 · see citing works
Donadon, V., Balbi, M., Casarin, P., Vario, A., & Alberti, A. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5695 · Cited by 72 · see citing works
Self-citationTakamatsu, S., Noguchi, N., Kudo, A., Nakamura, N., Kawamura, T., Teramoto, K., Igari, T., & Arii, S. (2008) · PubMed · Cited by 62 · see citing works
Impact of diabetes mellitus on outcome of HCC
Amarapurkar, D. N., Patel, N. D., & Kamani, P. M. (2008) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31871-x · Cited by 53 · see citing works
Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection
Rossi, M., Lipworth, L. P., Maso, L. D., Talamini, R., Montella, M., Polesel, J., McLaughlin, J. K., Parpinel, M. T., Franceschi, S., Λάγιου, Π., et al. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp058 · Cited by 47 · see citing works
Konishi, I., Hiasa, Y., Shigematsu, S., Hirooka, M., Furukawa, S., Abe, M., Matsuura, B., Michitaka, K., Horiike, N., & Onji, M. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02043.x · Cited by 44 · see citing works
Donadon, V., Balbi, M., & Zanette, G. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.09.41 · Cited by 29 · see citing works
Self-citationEpidemiology of hepatitis C virus infection.
Bellentani, S., Miglioli, L., Bedogni, G., Croce’, S. L., & Tiribelli, C. (2005) · PubMed · Cited by 13 · see citing works
[Diabetes in Italy: a public health problem].
Pilotto, L., Gaggioli, A., Noce, C. L., Dima, F., Palmieri, L., Uguccioni, M., Pede, S., Giampaoli, S., & Vanuzzo, D. (2004) · PubMed · Cited by 7 · see citing works
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Epidemiology of hepatocellular carcinoma in the United States: Where are we? Where do we go?
El‐Serag, H. B., & Kanwal, F. (2014) · Hepatology · doi:10.1002/hep.27222 · Cited by 645 · see citing works
Metformin: An Old But Still the Best Treatment for Type 2 Diabetes
Rojas, L. B. A., & Gomes, M. B. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-6 · Cited by 567 · see citing works
Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo
Williams, K., Shackel, N. A., Gorrell, M. D., McLennan, S. V., & Twigg, S. M. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1009 · Cited by 232 · see citing works
Liver and diabetes. A vicious circle
Loria, P., Lonardo, A., & Anania, F. A. (2012) · Hepatology Research · doi:10.1111/j.1872-034x.2012.01031.x · Cited by 206 · see citing works
Diabetes, cancer, and metformin: connections of metabolism and cell proliferation
Gallagher, E. J., & LeRoith, D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06285.x · Cited by 205 · see citing works
Thakkar, B., Aronis, K. N., Vamvini, M. T., Shields, K. S., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.01.014 · Cited by 186 · see citing works
Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma
Noureddin, M., & Rinella, M. E. (2015) · Clinics in Liver Disease · doi:10.1016/j.cld.2015.01.012 · Cited by 181 · see citing works
Identification of Key Pathways and Genes in the Dynamic Progression of HCC Based on WGCNA
Li, Y., Cai, Z., Zhu, B., & Xu, C. (2018) · Genes · doi:10.3390/genes9020092 · Cited by 168 · see citing works
Impact of Metformin on the Prognosis of Cirrhosis Induced by Viral Hepatitis C in Diabetic Patients
Nkontchou, G., Cosson, E., Aout, M., Mahmoudi, A., Bourcier, V., Charif, I., Ganne‐Carrié, N., Grando–Lemaire, V., Vicaut, É., Trinchet, J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2415 · Cited by 165 · see citing works
Simon, T. G., King, L. Y., Chong, D. Q., Nguyen, L. H., Ma, Y., VoPham, T., Giovannucci, E. L., Fuchs, C. S., Meyerhardt, J. A., Corey, K. E., et al. (2018) · Hepatology · doi:10.1002/hep.29660 · Cited by 160 · see citing works
Metformin and cancer: An existing drug for cancer prevention and therapy (Review)
Zi, F., Zi, H., Li, Y., He, J., Shi, Q., & Cai, Z. (2017) · Oncology Letters · doi:10.3892/ol.2017.7412 · Cited by 152 · see citing works
Metformin and reduced risk of hepatocellular carcinoma in diabetic patients: a meta-analysis
Zhang, H., Gao, C., Fang, L., Zhao, H.-C., & Yao, S. (2012) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2012.719926 · Cited by 149 · see citing works
Schlesinger, S., Aleksandrova, K., Pischon, T., Jenab, M., Fedirko, V., Trépo, E., Overvad, K., Roswall, N., Tjønneland, A. M., Boutron‐Ruault, M., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt204 · Cited by 146 · see citing works
Chettouh, H., Fartoux, L., Aoudjehane, L., Wendum, D., Clapéron, A., Chrétien, Y., Rey, C., Scatton, O., Soubrane, O., Conti, F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3824 · Cited by 131 · see citing works
Habib, S. L., & Rojna, M. (2013) · ISRN Oncology · doi:10.1155/2013/583786 · Cited by 128 · see citing works
Does cancer risk increase with HbA1c, independent of diabetes?
de Beer, J. C., & Liebenberg, L. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.150 · Cited by 124 · see citing works
Metformin; an old antidiabetic drug with new potentials in bone disorders
Bahrambeigi, S., Yousefi, B., Rahimi, M., & Shafiei‐Irannejad, V. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.032 · Cited by 122 · see citing works
Karlstad, Ø., Starup‐Linde, J., Vestergaard, P., Hjellvik, V., Bazelier, M. T., Schmidt, M. K., Andersen, M., Auvinen, A. P., Haukka, J. K., Furu, K., et al. (2013) · Current Drug Safety · doi:10.2174/15680266113136660067 · Cited by 119 · see citing works
Insulin resistance and chronic liver disease
Kawaguchi, T. (2011) · World Journal of Hepatology · doi:10.4254/wjh.v3.i5.99 · Cited by 108 · see citing works
Ciancio, A., Bosio, R., Bo, S., Pellegrini, M., SACCO, M., Vogliotti, E., Fassio, G., Degerfeld, A. B. M., Gallo, M., Giordanino, C., et al. (2017) · Journal of Medical Virology · doi:10.1002/jmv.24954 · Cited by 101 · see citing works
Meta-analysis of studies using metformin as a reducer for liver cancer risk in diabetic patients
Ma, S., Zheng, Y., Xiao, Y., Zhou, P., & Tan, H. (2017) · Medicine · doi:10.1097/md.0000000000006888 · Cited by 89 · see citing works
Systematic review and meta-analysis of insulin therapy and risk of cancer
Janghorbani, M., Dehghani, M., & Salehi-Marzijarani, M. (2012) · Hormones and Cancer · doi:10.1007/s12672-012-0112-z · Cited by 86 · see citing works
Systematic review: Preventive and therapeutic applications of metformin in liver disease
Bhat, A. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i12.1652 · Cited by 86 · see citing works
Diabetes Mellitus and Risk of Hepatocellular Carcinoma
Li, X., Wang, X., & Gao, P. (2017) · BioMed Research International · doi:10.1155/2017/5202684 · Cited by 86 · see citing works
Effects of metformin on clinical outcome in diabetic patients with advanced HCC receiving sorafenib
Gardini, A. C., Marisi, G., Scarpi, E., Scartozzi, M., Faloppi, L., Silvestris, N., Masi, G., Vivaldi, C., Brunetti, O., Tamberi, S., et al. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1102887 · Cited by 69 · see citing works
Diabetes, Glycated Hemoglobin, and Risk of Cancer in the UK Biobank Study
Peila, R., & Rohan, T. E. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-1623 · Cited by 66 · see citing works
Treatment of type 2 diabetes mellitus by viral eradication in chronic hepatitis C: Myth or reality?
Vanni, E., Bugianesi, E., & Saracco, G. M. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.10.016 · Cited by 66 · see citing works
Metformin and cancer in type 2 diabetes: a systematic review and comprehensive bias evaluation
Farmer, R. E., Ford, D., Forbes, H. J., Chaturvedi, N., Kaplan, R. S., Smeeth, L. L., & Bhaskaran, K. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw275 · Cited by 53 · see citing works
Bahrambeigi, S., & Shafiei‐Irannejad, V. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113787 · Cited by 51 · see citing works
Chouhan, S., Singh, S., Athavale, D., Ramteke, P. L., Pandey, V., Joseph, J., Mohan, R., Shetty, P. K., & Bhat, M. K. (2016) · Scientific Reports · doi:10.1038/srep27558 · Cited by 51 · see citing works
Risk factors for cancer development in type 2 diabetes: A retrospective case-control study
Dąbrowski, M., Szymańska‐Garbacz, E., Miszczyszyn, Z., Dereziński, T., & Czupryniak, L. (2016) · BMC Cancer · doi:10.1186/s12885-016-2836-6 · Cited by 45 · see citing works
Glycated Hemoglobin Levels in Patients with Decompensated Cirrhosis
Nadelson, J., Satapathy, S. K., & Nair, S. P. (2016) · International Journal of Endocrinology · doi:10.1155/2016/8390210 · Cited by 44 · see citing works
Safety and Efficacy of Metformin in Patients With Type 2 Diabetes Mellitus and Chronic Hepatitis C
Harris, K., & Smith, L. S. (2013) · Annals of Pharmacotherapy · doi:10.1177/1060028013503108 · Cited by 42 · see citing works
Li, C., Chen, H.-J., Lai, H., Liu, C.-S., Lin, W., Li, T., & Lin, C. (2014) · International Journal of Cancer · doi:10.1002/ijc.29321 · Cited by 39 · see citing works
Bhat, M., Yanagiya, A., Graber, T. E., Razumilava, N., Bronk, S. F., Zammit, D., Zhao, Y., Zakaria, C., Metrakos, P. P., Pollak, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10671 · Cited by 27 · see citing works
Watt, G. P., de la Cerda, I., Pan, J., Fallon, M. B., Beretta, L., Loomba, R. S., Lee, M., McCormick, J. B., & Fisher‐Hoch, S. P. (2020) · Hepatology Communications · doi:10.1002/hep4.1603 · Cited by 25 · see citing works
Kaneda, K., Uenishi, T., Takemura, S., Shinkawa, H., Urata, Y., Sakae, M., Yamamoto, T., & Kubo, S. (2011) · Journal of Surgical Oncology · doi:10.1002/jso.22137 · Cited by 23 · see citing works
Insulin Therapy and Cancer in Type 2 Diabetes
Mannucci, E. (2012) · ISRN Endocrinology · doi:10.5402/2012/240634 · Cited by 20 · see citing works
Insulin therapy in diabetes and cancer risk: Current understanding and implications for future study
Gough, S. C. L., Belda-Iniesta, C., Poole, C., Weber, M. M., Russell-Jones, D. L., Hansen, B. F., Mannucci, E., & Tuomilehto, J. O. (2011) · Advances in Therapy · doi:10.1007/s12325-011-0047-8 · Cited by 17 · see citing works
Giordanino, C., Ceretto, S., Bo, S., Smedile, A., Ciancio, A., Bugianesi, E., Pellicano, R., Fagoonee, S., Versino, E., Costa, G., et al. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.12.003 · Cited by 16 · see citing works
Alhusayen, R. O., Dienes, S., Lam, M., Alavi, A., Alikhan, A., Aleshin, M. A., Bahashwan, E., Daveluy, S. D., Goldfarb, N. I., Garg, A., et al. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2024.11.071 · Cited by 16 · see citing works
Kour, B., Shukla, N., Bhargava, H., Sharma, D. K., Sharma, A., Singh, A., Valadi, J. K., Sadasukhi, T. C., Vuree, S., & Suravajhala, P. (2023) · Current Genomics · doi:10.2174/0113892029240239231109082805 · Cited by 12 · see citing works
Attia, M. M., Hashim, A. M., Kandeel, H. T., Hendy, O., Elmola, K. A. M., & El-Raey, F. (2017) · Al-Azhar Assiut Medical Journal · doi:10.4103/azmj.azmj_7_18 · Cited by 12 · see citing works
Inhibitory effect of metformin on bone metastasis of cancer via OPG/RANKL/RANK system
Jian, W., Chen, T., Qin, S., Duan, Y., & Wang, G. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.08.032 · Cited by 12 · see citing works
Metformin Potential Impact on the Growth of Vestibular Schwannomas
Feng, A. Y., Enríquez-Marulanda, A., Kouhi, A., Ali, N., Moore, J. M., & Vaisbuch, Y. (2020) · Otology & Neurotology · doi:10.1097/mao.0000000000002545 · Cited by 11 · see citing works
Glycated hemoglobin, diabetes treatment and cancer risk in type 2 diabetes. A case-control study.
Dąbrowski, M. (2013) · PubMed · Cited by 10 · see citing works
SACCO, M., Ribaldone, D. G., & Saracco, G. M. (2023) · Viruses · doi:10.3390/v15122451 · Cited by 8 · see citing works
Cheng, T., Bai, Y., Huang, S., Wang, Y., Zhou, S., Liu, H., Zhang, R., Luo, X., & Yu, P. (2022) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-825 · Cited by 8 · see citing works
Gray, M. E., Singh, S., & Zucker, S. D. (2019) · Hepatology Communications · doi:10.1002/hep4.1323 · Cited by 8 · see citing works
Azit, N. A., Sahran, S., Meng, L. V., Subramaniam, M., Mokhtar, S., & Nawi, A. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260675 · Cited by 8 · see citing works
Quels bénéfices antitumoraux attendre de la metformine ?
Beck, E., & Scheen, A. J. (2013) · Annales d Endocrinologie · doi:10.1016/j.ando.2013.02.009 · Cited by 6 · see citing works
Yoshida, N., Midorikawa, Y., Higaki, T., Nakayama, H., Tsuji, S., Matsuoka, S., Ishihara, H., Moriyama, M., & Takayama, T. (2017) · Hepatology Research · doi:10.1111/hepr.12888 · Cited by 6 · see citing works
Banal, K. A. C., Paz-Pacheco, E. T., & de Villa, V. (2017) · Journal of the ASEAN Federation of Endocrine Societies · doi:10.15605/jafes.032.01.06 · Cited by 5 · see citing works
Dango, D., & Umeta, M. (2016) · Journal of Pharmacogenomics & Pharmacoproteomics · doi:10.4172/2153-0645.1000163 · Cited by 4 · see citing works
Cao, J., Wang, Z., Yu, J. C., Tao, Y., Yang, Y., Liu, H., Zhou, W., Lu, J., & Huang, Q. (2022) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-478 · Cited by 3 · see citing works
Chen, I.-W., Huang, C., Liu, P., Lin, C.-W., Hung, S., & Huang, Y. (2025) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848251356198 · Cited by 2 · see citing works
The association between diabetes and liver disease: The need for a consensus
Hamed, A. E. (2014) · Arab Journal of Gastroenterology · doi:10.1016/j.ajg.2014.09.002 · Cited by 2 · see citing works
Editorial: diabetes and its association with hepatocellular carcinoma in chronic hepatitis B
Konerman, M. C., & Loomba, R. S. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13225 · Cited by 2 · see citing works
Vita, E. D., Limongi, F., Veronese, N., Gennaro, F. D., Saracino, A., & Maggi, S. (2024) · Diseases · doi:10.3390/diseases12080187 · Cited by 1 · see citing works
Alqahtani, A., Holly, J. M. P., & Perks, C. M. (2022) · Journal of cancer research updates · doi:10.30683/1929-2279.2022.11.02 · Cited by 1 · see citing works
Metformin and Its Implication in Cancer Therapy
Mazilu, L., Stănculeanu, D. L., Gheorghe, A. D., Suceveanu, A., Parepa, I. R., Voinea, F., Catrinoiu, D., & Suceveanu, A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88803 · Cited by 1 · see citing works
Integrative model of lifestyle effects on cancer via the HbA1c biomarker
de Beer, & Catharina, J. (2014)
Gordon-Dseagu, V. (2014) · UCL Discovery (University College London)
Hepatitis C–Associated Diabetes Mellitus
Bilić-Čurčić, I., Roguljić, H., Ivandić, M., Včev, A., Smolić, R., & Smolić, M. (2017) · InTech eBooks · doi:10.5772/intechopen.70721
Association between hepatocellular carcinoma and type 2 diabetes in a sample of Egyptian patients
Wakeel, M. E. S. E., Hassan, Z., El-Naggar, A., & Elsayed, M. A. N. (2020) · The Scientific Journal of Al-Azhar Medical Faculty Girls · doi:10.4103/sjamf.sjamf_31_20
Effect of HCV Eradication on Glycemic Control of Type 2 Diabetes Mellitus
Sayed, I. A. M., Abd-elHafez, F. F., & Salem, H. M. (2020) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2020.86702
- Authors
- Donadon, V.
- Affiliations
- Azienda Ospedaliera Santa Maria Degli Angeli (IT)
- Corresponding author
- Donadon, Valter
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2010
- Volume
- 16
- Issue
- 24
- Pages
- 3025
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC2890943
- OpenAlex
- W2141761015
- Cited by
- 66
- References
- 46
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 10 · 2012: 6
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- hepatocellular carcinoma, HbA1c, glycemic control, type 2 diabetes, antidiabetic therapy, metformin, sulfonylureas, insulin therapy, liver cirrhosis, cancer risk factors
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Hepatitis B, Hepatitis C, Carcinoma, Hepatocellular, Humans, Liver Diseases, Liver Neoplasms, Male, Retrospective Studies, Risk Factors, Diabetes Complications
About these checks
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