Probiotics in hepatology
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The paper provides a basic review of intestinal microflora and its importance in liver diseases. The intestinal microflora has many important functions, above all to maintain the microbial barrier against established as well as potential pathogens. Furthermore, it influences the motility and perfusion of the intestinal wall, stimulates the intestinal immune system and therefore also the so-called common mucosal immune system, reducing bacterial translocation and producing vitamins. Immune homeostasis at mucosal level results from a controlled response to intestinal luminal antigens. In liver cirrhosis, there are many changes in its function, mostly an increase in bacterial overgrowth and translocation. In this review, probiotics and their indications in hepatology are generally discussed. According to recent knowledge, these preparations are indicated in clinical practice only for cases of hepatic encephalopathy. Probiotics are able to decrease the permeability of the intestinal wall, and decrease bacterial translocation and endotoxemia in animal models as well as in clinical studies, which is extremely important in the prevention of complications of liver cirrhosis and infection after liver transplantation. Probiotics could limit oxidative and inflammatory liver damage and, in some situations, improve the histological state, and thus non-alcoholic steatohepatitis could be considered as another possible indication.
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Probiotics have shown promise in ameliorating liver injury by reducing bacterial translocation and hepatic inflammation.
“Probiotics have shown promise in ameliorating liver injury by reducing bacterial translocation and hepatic inflammation.55”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [55]
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Hepatic Encephalopathy Involves Interactions Among the Microbiota, Gut, Brain
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Does Nutrition Matter in Liver Disease?
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EFFECT OF PROBIOTIC ON INNATE IMMUNE RESPONSE IN THE LIVER OF MUS MUSCULUS BALB/C
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Prevention of Recurrence of Hepatic Encephalopathy
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Effects of Probiotics on Liver and Kidney Function Parameters
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- Authors
- Lata, J.
- Affiliations
- University of Ostrava (CZ)
- Corresponding author
- Lata, Jan
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2011
- Volume
- 17
- Issue
- 24
- Pages
- 2890
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3129503
- OpenAlex
- W2116672973
- Cited by
- 58
- References
- 69
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 1 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, gut microbiota, liver disease, liver cirrhosis, hepatic encephalopathy, bacterial translocation, intestinal barrier, endotoxemia, common mucosal immune system, nonalcoholic steatohepatitis, liver transplantation, infection control, oxidative liver damage, inflammation
- MeSH terms
- Gastroenterology, Humans, Liver Diseases, Probiotics, Gastrointestinal Tract
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