The gut microbiota and the liver. Pathophysiological and clinical implications
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The term microbiota is used to describe the complete population of microorganisms that populate a certain location, such as the gut, and is preferred to the term flora as the former incorporates not just bacteria but also archaea, viruses, and other microorganisms, such as protozoa. Though the potential role of the microbiota (through such concepts as “the putrefactive principle associated with faeces” and “intestinal toxins”) in the pathogenesis of systemic disorders has been recognized since antiquity, a firm scientific basis for a role for the gut microbiome in liver disease did not emerge until the middle of the last century with the recognition of the relationship between hepatic coma and the absorption of nitrogenous substances from the intestine [1].
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A specific microbial taxonomic and functional profile has been associated with obesity and obesity-related liver disease, thus suggesting a link between microbiota and liver pathology.
“A specific microbial taxonomic and functional profile has been associated with obesity [76] and obesity-related liver disease [77] , thus suggesting a link between microbiota and liver pathology [78] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [78]
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Schaffert, C. S. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.1209 · Cited by 77 · see citing works
Gastrointestinal dysfunction in liver disease and portal hypertension
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Effects of probiotic therapy on portal pressure in patients with cirrhosis: a pilot study
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Flagged first, then by citations
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Cited by
Sorted by citations
Altered profile of human gut microbiome is associated with cirrhosis and its complications
Bajaj, J. S., Heuman, D. M., Hylemon, P. B., Sanyal, A. J., White, M. B., Monteith, P., Noble, N. A., Unser, A. B., Daita, K., Fisher, A. R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.019 · Cited by 1,099 · see citing works
Gut microbiome and liver diseases
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Gut–Liver Axis: How Do Gut Bacteria Influence the Liver?
Konturek, P. C., Harsch, I. A., Konturek, K., Schink, M., Konturek, T., Neurath, M. F., & Zopf, Y. (2018) · Medical Sciences · doi:10.3390/medsci6030079 · Cited by 168 · see citing works
Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet?
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Self-citationQuigley, E. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7010006 · Cited by 109 · see citing works
Self-citation
- Authors
- Quigley, E. M. M., Stanton, C., & Murphy, E. F.
- Affiliations
- University College Cork (IE)
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Corresponding author
- Quigley, Eamonn M.M.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 58
- Issue
- 5
- Pages
- 1020-1027
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1996326833
- Cited by
- 133
- References
- 113
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 15 · 2015: 10 · 2014: 11 · 2013: 6
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- T-Stór (Teagasc) (acceptedVersion, cc-by-sa)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, liver disease, gut-liver axis, hepatic encephalopathy, microbiome, clinical implications
- MeSH terms
- Hemodynamics, Homeostasis, Humans, Liver, Liver Diseases, Gastrointestinal Tract, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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