Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding
Open accessAbstract
AIM: To investigate the effects of the probiotic Bifidobacterium longum BB536 on the health management of elderly patients receiving enteral feeding. METHODS: Two double-blind, placebo-controlled trials were performed with long-term inpatients receiving enteral tube feeding at Kitakyushu Hospital Group, Fukuoka, Japan. BB536 was administered as BB536-L and BB536-H powders that contained approximately 2.5 × 10¹⁰ and 5 × 10¹⁰ cfu of BB536, respectively. In the first trial, 83 patients (age range: 67-101 years) were randomized into 2 groups that received placebo (placebo group) or BB536-H (BB536 group) powders. In the second trial, 123 patients (age range: 65-102 years) were randomized into 3 groups, and each group received placebo (placebo group), BB536-L (BB536-L group), or BB536-H (BB536-H group) powders. Each patient received the study medication for 16 wk after 1 wk of pre-observation. Fecal samples were collected from each patient prior to and after the intervention during Trial 2. Clinical observations included body temperature, occurrence of infection, frequency of defecation, and fecal microbiota. RESULTS: No significant changes were observed in the frequency of defecation for either treatment in Trial 1. However, a significant change was noted in the BB536-L group (P = 0.0439) in Trial 2 but not in the placebo or BB536-H groups. Subgroup analyses based on the frequency of defecation for each patient during the pre-observation period for both trials revealed significant increases in bowel movements in patients with a low frequency of defecation and significant decreases in the bowel movements of patients with a high frequency of defecation during the intervention period in the BB536 groups. The combination of Trials 1 and 2 data revealed a modulatory effect of BB536 ingestion on the changes in bowel movements. Significantly increased bowel movements were observed in patients in the low frequency subgroup with significant intergroup differences (P < 0.01). Significantly decreased bowel movements were observed in patients in the high subgroup, but no significant intergroup differences were observed compared with the placebo group. BB536 ingestion increased the prevalence of normally formed stools. BB536 intake also significantly (P < 0.01) increased the cell numbers of bifidobacteria in fecal microbiota, and significant intergroup differences were observed at week 16. No adverse events were reported in any group. CONCLUSION: Our results suggest that BB536 ingestion modulated the intestinal environment and may have improved the health care of elderly patients receiving enteral feeding.
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The systematic review included 17 randomised controlled trials comprising 1256 adult patients with functional constipation.
“17 studies, comprising 1256 participants, were included with perfect agreements between two researchers (kappa statistic=0.797).”
Five of six studies revealed that probiotics-containing products significantly increased the relative abundance of specific gut micro-organism which corresponded with the probiotics-containing supplement.
“More comprehensively, five of six studies revealed that probiotics-containing products significantly increased the relative abundance of specific gut micro-organism which corresponded with the probiotics-containing supplement.21 23 26 29 30”
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- Authors
- Kondo, J.
- Corresponding author
- Kondo, Junko
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2013
- Volume
- 19
- Issue
- 14
- Pages
- 2162
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3627880
- OpenAlex
- W2026246850
- Cited by
- 54
- References
- 32
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 1
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium longum BB536, probiotics, stool frequency, defecation, elderly patients, enteral nutrition, fecal microbiota, stool consistency, fecal odor, fecal pH, fecal water content, fecal bile acids
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Analysis of Variance, Bifidobacterium, Defecation, Double-Blind Method, Enteral Nutrition, Feces, Female, Humans, Inpatients, Intestines, Japan, Male, Time Factors, Geriatric Assessment, Treatment Outcome, Probiotics
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