CoChat
Sign Up
Cited by 100Nutrition, Genetics, and DiseaseRetinoids in leukemia and cellular processesGenetic Associations and Epidemiology

Genetic Variations Associated with Vitamin A Status and Vitamin A Bioavailability

Open access
Borel, Patrick, Desmarchelier, Charles·2017·Nutrients
DOI 10.3390/nu9030246PMC PMC5372909
Open this paper in CoChat — free accountOpen PDF

Abstract

Blood concentration of vitamin A (VA), which is present as different molecules, i.e., mainly retinol and provitamin A carotenoids, plus retinyl esters in the postprandial period after a VA-containing meal, is affected by numerous factors: dietary VA intake, VA absorption efficiency, efficiency of provitamin A carotenoid conversion to VA, VA tissue uptake, etc. Most of these factors are in turn modulated by genetic variations in genes encoding proteins involved in VA metabolism. Genome-wide association studies (GWAS) and candidate gene association studies have identified single nucleotide polymorphisms (SNPs) associated with blood concentrations of retinol and β-carotene, as well as with β-carotene bioavailability. These genetic variations likely explain, at least in part, interindividual variability in VA status and in VA bioavailability. However, much work remains to be done to identify all of the SNPs involved in VA status and bioavailability and to assess the possible involvement of other kinds of genetic variations, e.g., copy number variants and insertions/deletions, in these phenotypes. Yet, the potential usefulness of this area of research is exciting regarding the proposition of more personalized dietary recommendations in VA, particularly in populations at risk of VA deficiency.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/nu9030246

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Vitamin A in all forms found in biological processes is derived from two dietary sources: β-carotene from plant sources and retinyl palmitate from animal sources.

    “The base isoprenoid structure of vitamin A in all forms found in biological processes are derived from two dietary sources: β-carotene from plant sources and retinyl palmitate from animal sources [1,2,3].”

    From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [1]

    The Introduction distinguishes animal-derived preformed vitamin A from plant-derived provitamin A carotenoids, and Section 2 identifies retinyl palmitate and β-carotene as their chief dietary forms. But the Introduction also names other provitamin A carotenoids, so the source does not support the claim that those two molecules are the only dietary sources. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Ejected all-trans retinol associates with RBP4 and transthyretin to form a complex that allows movement through lymphatic and cardiovascular vessels.

    “Ejected all-trans retinol then associates with RBP4 and transthyretin to form a complex that allows movement through lymphatic and cardiovascular vessels [1,2,3] (Figure 1).”

    From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [1]

    Section 6 (page not provided) says retinol released by the liver into blood binds RBP4, which binds transthyretin to stabilize the complex. It does not describe that complex moving through lymphatic vessels. Section 5 instead says most newly absorbed retinol is secreted from the intestine as retinyl esters in chylomicrons, so the claim conflates that route with the liver-to-blood route. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 105

  1. [2]Dowling J.E. George wald (1906-97)—Biologist who discovered the role of vitamin A in vision—Obituary Nature 1997 387 356 10.1038/387356a0 9163416 · DOI
  2. [3]Viewpoint A.P. Maumenee A.E. The history of vitamin A and its ophthalmic implications Arch. Aphthalmol. 1993 111 547 550 8470990
  3. [4]Rando R.R. The chemistry of vitamin A and vision Angew. Chem. Int. Ed. Engl. 1990 29 461 480 10.1002/anie.199004611 · DOI
  4. [5]Wright C.B. Redmond T.M. Nickerson J.M. A history of the classical visual cycle Prog. Mol. Biol. Transl. Sci. 2015 134 433 448 26310169
  5. [6]Ross A.C. Gardner E.M. The function of vitamin A in cellular growth and differentiation, and its roles during pregnancy and lactation Adv. Exp. Med. Biol. 1994 352 187 200 7832047
  6. [7]Love J.M. Gudas L.J. Vitamin A, differentiation and cancer Curr. Opin. Cell Biol. 1994 6 825 831 10.1016/0955-0674(94)90051-5 7880529 · DOI
  7. [9]Clagett-Dame M. de Luca H.F. The role of vitamin A in mammalian reproduction and embryonic development Annu. Rev. Nutr. 2002 22 347 381 10.1146/annurev.nutr.22.010402.102745E 12055350 · DOI · Paper page
  8. [11]Mason J. Greiner T. Shrimpton R. Sanders D. Yukich J. Vitamin A policies need rethinking Int. J. Epidemiol. 2015 44 283 292 10.1093/ije/dyu194 25306559 · DOI
  9. [12]Troesch B. Hoeft B. McBurney M. Eggersdorfer M. Weber P. Dietary surveys indicate vitamin intakes below recommendations are common in representative western countries Br. J. Nutr. 2012 108 692 698 10.1017/S0007114512001808 22691229 · DOI
  10. [13]Weber D. Grune T. The contribution of beta-carotene to Vitamin A supply of humans Mol. Nutr. Food Res. 2012 56 251 258 10.1002/mnfr.201100230 21957049 · DOI
  11. [14]Borel P. Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols) Clin. Chem. Lab. Med. 2003 41 979 994 10.1515/CCLM.2003.151 12964802 · DOI
  12. [16]Tyssandier V. Reboul E. Dumas J.F. Bouteloup-Demange C. Armand M. Marcand J. Sallas M. Borel P. Processing of vegetable-born carotenoids in the human stomach and duodenum Am. J. Physiol. Gastrointest. Liver Physiol. 2003 284 G913 G923 10.1152/ajpgi.00410.2002 12736146 · DOI
  13. [17]Borel P. Pasquier B. Armand M. Tyssandier V. Grolier P. Alexandre-Gouabau M.C. Andre M. Senft M. Peyrot J. Jaussan V. Processing of Vitamin A and E in the human gastrointestinal tract Am. J. Physiol. Gastrointest. Liver Physiol. 2001 280 G95 G103 11123202
  14. [18]Desmarchelier C. Borel P. Overview of carotenoid bioavailability determinants: From dietary factors to host genetic variations Trends Food Sci. Technol. 2017 in press
  15. [19]Mensi A. Borel P. Goncalves A. Nowicki M. Gleize B. Roi S. Chobert J.M. Haertle T. Reboul E. Beta-lactoglobulin as a vector for beta-carotene food fortification J. Agric. Food Chem. 2014 62 5916 5924 10.1021/jf501683s 24857546 · DOI
  16. [20]Tyssandier V. Lyan B. Borel P. Main factors governing the transfer of carotenoids from emulsion lipid droplets to micelles Biochim. Biophys. Acta 2001 1533 285 292 10.1016/S1388-1981(01)00163-9 11731338 · DOI
  17. [21]Rigtrup K.M. Kakkad B. Ong D.E. Purification and partial characterization of a retinyl ester hydrolase from the brush border of rat small intestine mucosa: Probable identity with brush border phospholipase b Biochemistry (Mosc.) 1994 33 2661 2666 10.1021/bi00175a039 8117729 · DOI
  18. [22]Fernandez E. Borgstrom B. Intestinal absorption of retinol and retinyl palmitate in the rat. Effects of tetrahydrolipstatin Lipids 1990 25 549 552 10.1007/BF02537163 2250593 · DOI
  19. [23]Hollander D. Muralidhara K.S. Vitamin a1 intestinal absorption in vivo: Influence of luminal factors on transport Am. J. Physiol. Gastrointest. Liver Physiol. 1977 232 E471 E477 16498
  20. [24]Porter C.J. Trevaskis N.L. Charman W.N. Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs Nat. Rev. Drug Discov. 2007 6 231 248 10.1038/nrd2197 17330072 · DOI · Paper page
  21. [25]Reboul E. Soayfane Z. Goncalves A. Cantiello M. Bott R. Nauze M. Terce F. Collet X. Comera C. Respective contributions of intestinal niemann-pick c1-like 1 and scavenger receptor class b type i to cholesterol and tocopherol uptake: In vivo v. In vitro studies Br. J. Nutr. 2012 107 1296 1304 10.1017/S0007114511004405 21929836 · DOI
  22. [26]Reboul E. Klein A. Bietrix F. Gleize B. Malezet-Desmoulins C. Schneider M. Margotat A. Lagrost L. Collet X. Borel P. Scavenger receptor class b type i (sr-bi) is involved in vitamin e transport across the enterocyte J. Biol. Chem. 2006 281 4739 4745 10.1074/jbc.M509042200 16380385 PMC2045115 · DOI
  23. [27]Goncalves A. Margier M. Roi S. Collet X. Niot I. Goupy P. Caris-Veyrat C. Reboul E. Intestinal scavenger receptors are involved in vitamin k1 absorption J. Biol. Chem. 2014 10.1074/jbc.M114.587659 25228690 PMC4215251 · DOI
  24. [28]Borel P. Lietz G. Goncalves A. Szabo de Edelenyi F. Lecompte S. Curtis P. Goumidi L. Caslake M.J. Miles E.A. Packard C. Cd36 and sr-bi are involved in cellular uptake of provitamin A carotenoids by caco-2 and hek cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans J. Nutr. 2013 143 448 456 10.3945/jn.112.172734 23427331 · DOI · Paper page
  25. [29]During A. Dawson H.D. Harrison E.H. Carotenoid transport is decreased and expression of the lipid transporters sr-bi, npc1l1, and abca1 is downregulated in caco-2 cells treated with ezetimibe J. Nutr. 2005 135 2305 2312 16177187
  26. [31]During A. Doraiswamy S. Harrison E.H. Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a srbi-dependent mechanism J. Lipid Res. 2008 49 1715 1724 10.1194/jlr.M700580-JLR200 18424859 PMC2444002 · DOI
  27. [32]Hollander D. Wang H.P. Chu C.Y.T. Badawi M.A. Preleminary characterization of a small intestinal binding component for retinol and fatty acids in the rat Life Sci. 1978 23 1011 1018 10.1016/0024-3205(78)90660-4 713679 · DOI
  28. [33]Ong D.E. Page D.L. Cellular retinol-binding protein (type two) is abundant in human small intestine J. Lipid Res. 1987 28 739 745 3611975
  29. [34]Wongsiriroj N. Piantedosi R. Palczewski K. Goldberg I.J. Johnston T.P. Li E. Blaner W.S. The molecular basis of retinoid absorption: A genetic dissection J. Biol. Chem. 2008 283 13510 13519 10.1074/jbc.M800777200 18348983 PMC2376245 · DOI · Paper page
  30. [35]O’Byrne S.M. Wongsiriroj N. Libien J. Vogel S. Goldberg I.J. Baehr W. Palczewski K. Blaner W.S. Retinoid absorption and storage is impaired in mice lacking lecithin:Retinol acyltransferase (lrat) J. Biol. Chem. 2005 280 35647 35657 10.1074/jbc.M507924200 16115871 PMC1352312 · DOI · Paper page
  31. [36]Ables G.P. Yang K.J. Vogel S. Hernandez-Ono A. Yu S. Yuen J.J. Birtles S. Buckett L.K. Turnbull A.V. Goldberg I.J. Intestinal dgat1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying J. Lipid Res. 2012 53 2364 2379 10.1194/jlr.M029041 22911105 PMC3466005 · DOI
  32. [37]Sauvant P. Mekki N. Charbonnier M. Portugal H. Lairon D. Borel P. Amounts and types of fatty acids in meals affect the pattern of retinoids secreted in human chylomicrons after a high-dose preformed vitamin A intake Metabolism 2003 52 514 519 10.1053/meta.2003.50082 12701068 · DOI
  33. [38]Reboul E. Borel P. Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes Prog. Lipid Res. 2011 50 388 402 10.1016/j.plipres.2011.07.001 21763723 · DOI
  34. [39]Duszka C. Grolier P. Azim E.M. Alexandre-Gouabau M.C. Borel P. Azais-Braesco V. Rat intestinal beta-carotene dioxygenase activity is located primarily in the cytosol of mature jejunal enterocytes J. Nutr. 1996 126 2550 2556 8857516
  35. [40]Grolier P. Duszka C. Borel P. Alexandre-Gouabau M.C. Azais-Braesco V. In vitro and in vivo inhibition of beta-carotene dioxygenase activity by canthaxanthin in rat intestine Arch. Biochem. Biophys. 1997 348 233 238 10.1006/abbi.1997.0388 9434733 · DOI
  36. [41]Dela Sena C. Riedl K.M. Narayanasamy S. Curley R.W. Jr. Schwartz S.J. Harrison E.H. The human enzyme that converts dietary provitamin A carotenoids to vitamin A is a dioxygenase J. Biol. Chem. 2014 289 13661 13666 10.1074/jbc.M114.557710 24668807 PMC4036370 · DOI
  37. [42]Dela Sena C. Narayanasamy S. Riedl K.M. Curley R.W. Jr. Schwartz S.J. Harrison E.H. Substrate specificity of purified recombinant human beta-carotene 15,15′-oxygenase (bco1) J. Biol. Chem. 2013 288 37094 37103 10.1074/jbc.M113.507160 24187135 PMC3873565 · DOI
  38. [43]Amengual J. Widjaja-Adhi M.A. Rodriguez-Santiago S. Hessel S. Golczak M. Palczewski K. von Lintig J. Two carotenoid oxygenases contribute to mammalian provitamin A metabolism J. Biol. Chem. 2013 288 34081 34096 10.1074/jbc.M113.501049 24106281 PMC3837149 · DOI
  39. [44]Raghuvanshi S. Reed V. Blaner W.S. Harrison E.H. Cellular localization of beta-carotene 15,15′ oxygenase-1 (bco1) and beta-carotene 9′,10′ oxygenase-2 (bco2) in rat liver and intestine Arch. Biochem. Biophys. 2015 572 19 27 10.1016/j.abb.2014.12.024 25575786 PMC4685714 · DOI
  40. [45]Gajda A.M. Storch J. Enterocyte fatty acid-binding proteins (fabps): Different functions of liver and intestinal fabps in the intestine Prostaglandins Leukot. Essent. Fatty Acids 2015 93 9 16 10.1016/j.plefa.2014.10.001 25458898 PMC4323920 · DOI
  41. [46]Tang G. Qin J. Dolnikowski G.G. Russell R.M. Short-term (intestinal) and long-term (postintestinal) conversion of beta-carotene to retinol in adults as assessed by a stable-isotope reference method Am. J. Clin. Nutr. 2003 78 259 266 12885706
  42. [47]Borel P. Grolier P. Mekki N. Boirie Y. Rochette Y. le Roy B. Alexandre-Gouabau M.C. Lairon D. Azais-Braesco V. Low and high responders to pharmacological doses of beta-carotene: Proportion in the population, mechanisms involved and consequences on beta-carotene metabolism J. Lipid Res. 1998 39 2250 2260 9799811
  43. [48]Nayak N. Harrison E.H. Hussain M.M. Retinyl ester secretion by intestinal cells: A specific and regulated process dependent on assembly and secretion of chylomicrons J. Lipid Res. 2001 42 272 280 11181758
  44. [49]Lobo G.P. Amengual J. Baus D. Shivdasani R.A. Taylor D. von Lintig J. Genetics and diet regulate vitamin A production via the homeobox transcription factor isx J. Biol. Chem. 2013 288 9017 9027 10.1074/jbc.M112.444240 23393141 PMC3610974 · DOI · Paper page
  45. [51]Mondloch S. Gannon B.M. Davis C.R. Chileshe J. Kaliwile C. Masi C. Rios-Avila L. Gregory J.F. 3rd Tanumihardjo S.A. High provitamin A carotenoid serum concentrations, elevated retinyl esters, and saturated retinol-binding protein in zambian preschool children are consistent with the presence of high liver vitamin A stores Am. J. Clin. Nutr. 2015 102 497 504 10.3945/ajcn.115.112383 26178727 PMC6546228 · DOI
  46. [52]Blomhoff R. Helgerud P. Dueland S. Berg T. Pedersen J.I. Norum K.R. Drevon C.A. Lymphatic absorption and transport of retinol and vitamin d-3 from rat intestine. Evidence for different pathways Biochim. Biophys. Acta 1984 772 109 116 10.1016/0005-2736(84)90033-6 6326820 · DOI
  47. [53]Tyssandier V. Choubert G. Grolier P. Borel P. Carotenoids, mostly the xanthophylls, exchange between plasma lipoproteins Int. J. Vitam. Nutr. Res. 2002 72 300 308 10.1024/0300-9831.72.5.300 12463105 · DOI
  48. [54]Dallinga-Thie G.M. Franssen R. Mooij H.L. Visser M.E. Hassing H.C. Peelman F. Kastelein J.J. Peterfy M. Nieuwdorp M. The metabolism of triglyceride-rich lipoproteins revisited: New players, new insight Atherosclerosis 2010 211 1 8 10.1016/j.atherosclerosis.2009.12.027 20117784 PMC3924774 · DOI
  49. [55]Blomhoff R. Helgerud P. Rasmussen M. Berg T. Norum K.R. In vivo uptake of chylomicron [3h]retinyl ester by rat liver: Evidence for retinol transfer from parenchymal to nonparenchymal cells Proc. Natl. Acad. Sci. USA 1982 79 7326 7330 10.1073/pnas.79.23.7326 6961410 PMC347332 · DOI · Paper page
  50. [56]O’Byrne S.M. Blaner W.S. Retinol and retinyl esters: Biochemistry and physiology J. Lipid Res. 2013 54 1731 1743 10.1194/jlr.R037648 23625372 PMC3679378 · DOI · Paper page
  51. [57]Ong D.E. Purufication and partial characterization of cellular retinol-binding protein from human liver Cancer Res. 1982 42 1033 1037 7199377
  52. [58]Ong D.E. MacDonald P.N. Gubitosi A.M. Esterification of retinol in rat liver J. Biol. Chem. 1988 263 5789 5796 3281946
  53. [59]Rose A.C. Retinol esterification by rat liver microsomes J. Biol. Chem. 1982 257 2453 2459 7061433
  54. [60]Nagatsuma K. Hayashi Y. Hano H. Sagara H. Murakami K. Saito M. Masaki T. Lu T. Tanaka M. Enzan H. Lecithin: Retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver Liver Int. 2009 29 47 54 10.1111/j.1478-3231.2008.01773.x 18544127 · DOI
  55. [61]Wake K. Development of vitamin A-rich lipid droplets in multivesicular bodies or rat liver stellate cells J. Cell Biol. 1974 63 683 691 10.1083/jcb.63.2.683 4421899 PMC2110931 · DOI
  56. [62]Wake K. Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs Int. Rev. Cytol. 1980 66 303 353 6993411
  57. [63]Taschler U. Schreiber R. Chitraju C. Grabner G.F. Romauch M. Wolinski H. Haemmerle G. Breinbauer R. Zechner R. Lass A. Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells Biochim. Biophys. Acta 2015 1851 937 945 10.1016/j.bbalip.2015.02.017 25732851 PMC4408194 · DOI
  58. [64]Pirazzi C. Valenti L. Motta B.M. Pingitore P. Hedfalk K. Mancina R.M. Burza M.A. Indiveri C. Ferro Y. Montalcini T. Pnpla3 has retinyl-palmitate lipase activity in human hepatic stellate cells Hum. Mol. Genet. 2014 23 4077 4085 10.1093/hmg/ddu121 24670599 PMC4082369 · DOI
  59. [65]Pingitore P. Pirazzi C. Mancina R.M. Motta B.M. Indiveri C. Pujia A. Montalcini T. Hedfalk K. Romeo S. Recombinant pnpla3 protein shows triglyceride hydrolase activity and its i148m mutation results in loss of function Biochim. Biophys. Acta 2014 1841 574 580 10.1016/j.bbalip.2013.12.006 24369119 · DOI
  60. [66]He S. McPhaul C. Li J.Z. Garuti R. Kinch L. Grishin N.V. Cohen J.C. Hobbs H.H. A sequence variation (i148m) in pnpla3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis J. Biol. Chem. 2010 285 6706 6715 10.1074/jbc.M109.064501 20034933 PMC2825465 · DOI
  61. [67]Shmarakov I. Fleshman M.K. D’Ambrosio D.N. Piantedosi R. Riedl K.M. Schwartz S.J. Curley R.W. Jr. von Lintig J. Rubin L.P. Harrison E.H. Hepatic stellate cells are an important cellular site for beta-carotene conversion to retinoid Arch. Biochem. Biophys. 2010 504 3 10 10.1016/j.abb.2010.05.010 20470748 PMC3692274 · DOI
  62. [68]Lakshman M.R. Asher K.A. Attlesey M.G. Satchithanandam S. Mychkovsky I. Coutlakis P.J. Absorption, storage, and distribution of beta-carotene in normal and beta-carotene-fed rats: Roles of parenchymal and stellate cells J. Lipid Res. 1989 30 1545 1550 2614257
  63. [69]Zachman R.D. Singer M.B. Olson J.A. Biliary secretion of metabolites of retinol and of retinoic acid in the guinea pig and chick J. Nutr. 1966 88 137 142 5900622
  64. [70]Zachman R.D. Olson J.A. Formation and enterohepatic circulation of water-soluble metabolites of retinol(vitamin A)in the rat Nature 1964 201 1222 1223 10.1038/2011222a0 14151377 · DOI
  65. [71]Peterson P.A. Characteristics of a vitamin A transporting protein complex occurring in human serum J. Biol. Chem. 1971 246 34 43 5541770
  66. [74]Amengual J. Golczak M. Palczewski K. von Lintig J. Lecithin:Retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein J. Biol. Chem. 2012 287 24216 24227 10.1074/jbc.M112.353979 22637576 PMC3397848 · DOI · Paper page
  67. [75]Thomas S.E. Harrison E.H. Mechanisms of selective delivery of xanthophylls to retinal pigment epithelial cells by human lipoproteins J. Lipid Res. 2016 57 1865 1878 10.1194/jlr.M070193 27538825 PMC5036367 · DOI
  68. [76]Chambon P. The molecular and genetic dissection of the retinoid signalling pathway Gene 1993 135 223 228 10.1016/0378-1119(93)90069-F 8276261 · DOI
  69. [77]Iskakova M. Karbyshev M. Piskunov A. Rochette-Egly C. Nuclear and extranuclear effects of vitamin A Can. J. Physiol. Pharmacol. 2015 93 1065 1075 10.1139/cjpp-2014-0522 26459513 · DOI
  70. [78]Strom K. Gundersen T.E. Hansson O. Lucas S. Fernandez C. Blomhoff R. Holm C. Hormone-sensitive lipase (hsl) is also a retinyl ester hydrolase: Evidence from mice lacking hsl FASEB J. 2009 23 2307 2316 10.1096/fj.08-120923 19246492 · DOI
  71. [79]Tanumihardjo S.A. Russell R.M. Stephensen C.B. Gannon B.M. Craft N.E. Haskell M.J. Lietz G. Schulze K. Raiten D.J. Biomarkers of nutrition for development (bond)-vitamin A review J. Nutr. 2016 146 1816S 1848S 10.3945/jn.115.229708 27511929 PMC4997277 · DOI · Paper page
  72. [80]Herbeth B. Zittoun J. Miravet L. Bourgeay-Causse M. Carreguery G. Delacoux E. le Devehat C. Lemoine A. Mareschi J.P. Martin J. Reference intervals for vitamins B1, B2, E, D, retinol, beta-carotene, and folate in blood: Usefulness of dietary selection criteria Clin. Chem. 1986 32 1756 1759 3742801
  73. [81]Muto Y. Smith J.E. Milch P.O. Goodman D.S. Regulation of retinol-binding protein metabolism by vitamin A status in the rat J. Biol. Chem. 1972 247 2542 2550 5019962
  74. [82]Loerch J.D. Underwood B.A. Lewis K.C. Response of plasma levels of vitamin A to a dose of vitamin A as an indicator of hepatic vitamin A reserves in rats J. Nutr. 1979 109 778 786 438896
  75. [83]Olson J.A. The reproducibility, sensitivity and specificity of the relative dose response (rdr) test for determining vitamin A status J. Nutr. 1991 121 917 920 2033476
  76. [84]Wahed M.A. Alvarez J.O. Khaled M.A. Mahalanabis D. Rahman M.M. Habte D. Comparison of the modified relative dose response (mrdr) and the relative dose response (rdr) in the assessment of vitamin A status in malnourished children Am. J. Clin. Nutr. 1995 61 1253 1256 7762526
  77. [85]Tanumihardjo S.A. Olson J.A. The reproducibility of the modified relative dose response (mrdr) assay in healthy individuals over time and its comparison with conjunctival impression cytology (cic) Eur. J. Clin. Nutr. 1991 45 407 411 1761001
  78. [86]Borel P. Grolier P. Armand M. Partier A. Lafont H. Lairon D. Azais-Braesco V. Carotenoids in biological emulsions: Solubility, surface-to-core distribution, and release from lipid droplets J. Lipid Res. 1996 37 250 261 9026524
  79. [87]Clevidence B.A. Bieri J.G. Association of carotenoids with human plasma lipoproteins Methods Enzymol. 1993 214 33 46 8469147
  80. [89]Berr F. Kern F. Plasma clearance of chylomicrons labeled with retinyl palmitate in healthy human subjects J. Lipid Res. 1984 25 805 812 6491526
  81. [90]Perez-Martinez P. Delgado-Lista J. Perez-Jimenez F. Lopez-Miranda J. Update on genetics of postprandial lipemia Atheroscler. Suppl. 2010 11 39 43 10.1016/j.atherosclerosissup.2010.03.002 20434407 · DOI
  82. [91]Desmarchelier C. Martin J.C. Planells R. Gastaldi M. Nowicki M. Goncalves A. Valero R. Lairon D. Borel P. The postprandial chylomicron triacylglycerol response to dietary fat in healthy male adults is significantly explained by a combination of single nucleotide polymorphisms in genes involved in triacylglycerol metabolism J. Clin. Endocrinol. Metab. 2014 99 E484 E488 10.1210/jc.2013-3962 24423365 · DOI
  83. [93]Furr H.C. Green M.H. Haskell M. Mokhtar N. Nestel P. Newton S. Ribaya-Mercado J.D. Tang G. Tanumihardjo S. Wasantwisut E. Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans Public Health Nutr. 2005 8 596 607 10.1079/PHN2004715 16236189 · DOI
  84. [94]Kovarova M. Konigsrainer I. Konigsrainer A. Machicao F. Haring H.U. Schleicher E. Peter A. The genetic variant i148m in pnpla3 is associated with increased hepatic retinyl-palmitate storage in humans J. Clin. Endocrinol. Metab. 2015 100 E1568 E1574 10.1210/jc.2015-2978 26439088 · DOI
  85. [95]Genomes Project C. Auton A. Brooks L.D. Durbin R.M. Garrison E.P. Kang H.M. Korbel J.O. Marchini J.L. McCarthy S. McVean G.A. A global reference for human genetic variation Nature 2015 526 68 74 26432245 PMC4750478
  86. [96]Pirazzi C. Adiels M. Burza M.A. Mancina R.M. Levin M. Stahlman M. Taskinen M.R. Orho-Melander M. Perman J. Pujia A. Patatin-like phospholipase domain-containing 3 (pnpla3) i148m (rs738409) affects hepatic vldl secretion in humans and in vitro J. Hepatol. 2012 57 1276 1282 10.1016/j.jhep.2012.07.030 22878467 · DOI
  87. [97]Fischer J. Lefevre C. Morava E. Mussini J.M. Laforet P. Negre-Salvayre A. Lathrop M. Salvayre R. The gene encoding adipose triglyceride lipase (pnpla2) is mutated in neutral lipid storage disease with myopathy Nat. Genet. 2007 39 28 30 10.1038/ng1951 17187067 · DOI
  88. [99]Trepo E. Romeo S. Zucman-Rossi J. Nahon P. Pnpla3 gene in liver diseases J. Hepatol. 2016 65 399 412 10.1016/j.jhep.2016.03.011 27038645 · DOI
  89. [100]Waits R.P. Yamada T. Uemichi T. Benson M.D. Low plasma concentrations of retinol-binding protein in individuals with mutations affecting position 84 of the transthyretin molecule Clin. Chem. 1995 41 1288 1291 7656439
  90. [102]Folli C. Viglione S. Busconi M. Berni R. Biochemical basis for retinol deficiency induced by the i41n and g75d mutations in human plasma retinol-binding protein Biochem. Biophys. Res. Commun. 2005 336 1017 1022 10.1016/j.bbrc.2005.08.227 16157297 · DOI
  91. [103]Mondul A.M. Yu K. Wheeler W. Zhang H. Weinstein S.J. Major J.M. Cornelis M.C. Mannisto S. Hazra A. Hsing A.W. Genome-wide association study of circulating retinol levels Hum. Mol. Genet. 2011 20 4724 4731 10.1093/hmg/ddr387 21878437 PMC3209826 · DOI
  92. [104]Hendrickson S.J. Hazra A. Chen C. Eliassen A.H. Kraft P. Rosner B.A. Willett W.C. Beta-carotene 15,15′-monooxygenase 1 single nucleotide polymorphisms in relation to plasma carotenoid and retinol concentrations in women of european descent Am. J. Clin. Nutr. 2012 96 1379 1389 10.3945/ajcn.112.034934 23134893 PMC3497927 · DOI
  93. [105]Mondul A. Mancina R.M. Merlo A. Dongiovanni P. Rametta R. Montalcini T. Valenti L. Albanes D. Romeo S. Pnpla3 i148m variant influences circulating retinol in adults with nonalcoholic fatty liver disease or obesity J. Nutr. 2015 145 1687 1691 10.3945/jn.115.210633 26136587 PMC4516767 · DOI
  94. [106]Ferrucci L. Perry J.R. Matteini A. Perola M. Tanaka T. Silander K. Rice N. Melzer D. Murray A. Cluett C. Common variation in the beta-carotene 15,15′-monooxygenase 1 gene affects circulating levels of carotenoids: A genome-wide association study Am. J. Hum. Genet. 2009 84 123 133 10.1016/j.ajhg.2008.12.019 19185284 PMC2668002 · DOI
  95. [107]Yabuta S. Urata M. Wai Kun R.Y. Masaki M. Shidoji Y. Common snp rs6564851 in the bco1 gene affects the circulating levels of beta-carotene and the daily intake of carotenoids in healthy Japanese women PLoS ONE 2016 11 e0168857 10.1371/journal.pone.0168857 28005968 PMC5179075 · DOI
  96. [108]Herbeth B. Gueguen S. Leroy P. Siest G. Visvikis-Siest S. The lipoprotein lipase serine 447 stop polymorphism is associated with altered serum carotenoid concentrations in the stanislas family study J. Am. Coll. Nutr. 2007 26 655 662 10.1080/07315724.2007.10719644 18187430 · DOI
  97. [109]Borel P. Moussa M. Reboul E. Lyan B. Defoort C. Vincent-Baudry S. Maillot M. Gastaldi M. Darmon M. Portugal H. Human fasting plasma concentrations of vitamin e and carotenoids, and their association with genetic variants in apo c-iii, cholesteryl ester transfer protein, hepatic lipase, intestinal fatty acid binding protein and microsomal triacylglycerol transfer protein Br. J. Nutr. 2009 101 680 687 18662427
  98. [110]Borel P. Moussa M. Reboul E. Lyan B. Defoort C. Vincent-Baudry S. Maillot M. Gastaldi M. Darmon M. Portugal H. Human plasma levels of vitamin e and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism J. Nutr. 2007 137 2653 2659 18029479
  99. [111]Hoekstra M. SR-BI as target in atherosclerosis and cardiovascular disease—A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease Atherosclerosis 2017 10.1016/j.atherosclerosis.2017.01.034 28162236 · DOI
  100. [112]Harrison E.H. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids Biochim. Biophys. Acta 2012 1821 70 77 10.1016/j.bbalip.2011.06.002 21718801 PMC3525326 · DOI · Paper page
  101. [113]Borel P. Desmarchelier C. Nowicki M. Bott R. A combination of single-nucleotide polymorphisms is associated with interindividual variability in dietary beta-carotene bioavailability in healthy men J. Nutr. 2015 145 1740 1747 10.3945/jn.115.212837 26063065 · DOI
  102. [114]Lietz G. Oxley A. Leung W. Hesketh J. Single nucleotide polymorphisms upstream from the beta-carotene 15,15′-monoxygenase gene influence provitamin A conversion efficiency in female volunteers J. Nutr. 2012 142 161S 165S 10.3945/jn.111.140756 22113863 · DOI
  103. [115]Leung W.C. Hessel S. Meplan C. Flint J. Oberhauser V. Tourniaire F. Hesketh J.E. von Lintig J. Lietz G. Two common single nucleotide polymorphisms in the gene encoding beta-carotene 15,15′-monoxygenase alter beta-carotene metabolism in female volunteers FASEB J. 2009 23 1041 1053 10.1096/fj.08-121962 19103647 · DOI
  104. [117]Wood A.R. Perry J.R. Tanaka T. Hernandez D.G. Zheng H.F. Melzer D. Gibbs J.R. Nalls M.A. Weedon M.N. Spector T.D. Imputation of variants from the 1000 genomes project modestly improves known associations and can identify low-frequency variant—Phenotype associations undetected by hapmap based imputation PLoS ONE 2013 8 e64343 10.1371/journal.pone.0064343 23696881 PMC3655956 · DOI
  105. [118]Van Ommen B. El-Sohemy A. Hesketh J. Kaput J. Fenech M. Evelo C.T. McArdle H.J. Bouwman J. Lietz G. Mathers J.C. The micronutrient genomics project: A community-driven knowledge base for micronutrient research Genes Nutr. 2010 5 285 296 10.1007/s12263-010-0192-8 21189865 PMC2989004 · DOI

Cited by

Sorted by citations

Authors
Borel, P., & Desmarchelier, C.
Affiliations
Inserm (FR)
Corresponding author
  • Borel, Patrick
  • Desmarchelier, Charles
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2017-03-08
Volume
9
Issue
3
Pages
246
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu9030246
PMC
PMC5372909
OpenAlex
W2593993810
Cited by
100
References
10
Citations by year
2026: 10 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 11 · 2021: 19 · 2020: 17 · 2019: 9 · 2018: 10 · 2017: 3
FWCI
1.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL AMU (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
vitamin A status, vitamin A bioavailability, genetic variation, single nucleotide polymorphisms, retinol, beta-carotene, provitamin A carotenoids, vitamin A metabolism, vitamin A deficiency, personalized nutrition, copy number variation, indels
MeSH terms
Biological Availability, Diet, Humans, Liver, Vitamin A, Vitamin A Deficiency, Postprandial Period, Polymorphism, Single Nucleotide, Genetic Association Studies, DNA Copy Number Variations, Recommended Dietary Allowances, Gastrointestinal Absorption

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review