Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

Resveratrol improves health and survival of mice on a high-calorie diet

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adults

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The burden of liver disease in Europe: A review of available epidemiological data

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The natural history of nonalcoholic fatty liver: A follow-up study

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Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway

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CYP2E1 and oxidative liver injury by alcohol

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Hepatic fibrosis: concept to treatment

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

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Roles of NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches

Hao, W., Li, M., Cai, Q., Wu, S., Li, X., He, Q., & Hu, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.889792 · Cited by 38

Reprogramming activated hepatic stellate cells by siRNA-loaded nanocarriers reverses liver fibrosis in mice

Younis, M. A., Sato, Y., Elewa, Y. H. A., & Harashima, H. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.021 · Cited by 37

Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy

González‐Fernández, B., Sánchez, D. I., González‐Gallego, J., & Tuñón, M. J. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00579 · Cited by 36

The progress of non-alcoholic fatty liver disease as the risk of liver metastasis in colorectal cancer

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Cholesterol Induces Oxidative Stress, Mitochondrial Damage and Death in Hepatic Stellate Cells to Mitigate Liver Fibrosis in Mice Model of NASH

Rauchbach, E., Zeigerman, H., Abu-Halaka, D., & Tirosh, O. (2022) · Antioxidants · doi:10.3390/antiox11030536 · Cited by 36

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells

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The role of microRNAs in the pathogenesis, grading and treatment of hepatic fibrosis in schistosomiasis

Chen, Q., Zhang, J., Zheng, T., Chen, H., Nie, H., Zheng, B., & Gong, Q. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3866-0 · Cited by 36

The Anti-fibrotic Effects of Heat-Killed Akkermansia muciniphila MucT on Liver Fibrosis Markers and Activation of Hepatic Stellate Cells

Raftar, S. K. A., Abdollahiyan, S., Azimirad, M., Yadegar, A., Vaziri, F., Moshiri, A., Siadat, S. D., & Zali, M. R. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09733-9 · Cited by 37

Role of Exosomes in Chronic Liver Disease Development and Their Potential Clinical Applications

Wang, C., Liu, J., Yan, Y., & Tan, Y. (2022) · Journal of Immunology Research · doi:10.1155/2022/1695802 · Cited by 37

Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases

Ding, Y., Luo, Q., Que, H., Wang, N., Gong, P., & Gu, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810972 · Cited by 36

COL1A1 affects apoptosis by regulating oxidative stress and autophagy in bovine cumulus cells

Fu, X., Chen, C., Wang, Y., Peng, Y., Wang, W.-H., Yuan, B., Gao, Y., Jiang, H., & Zhang, J. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.07.024 · Cited by 35

Icariin‐induced miR‐875‐5p attenuates epithelial‐mesenchymal transition by targeting hedgehog signaling in liver fibrosis

Ye, L., Yu, Y., & Zhao, Y. (2019) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14875 · Cited by 35

Kupffer Cells: Important Participant of Hepatic Alveolar Echinococcosis

Liu, Y., Tian, F., Shan, J., Gao, J. P., Li, B., Lv, J., Zhou, X., Cai, X., Wen, H., & Ma, X. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00008 · Cited by 36

ROS/NF-κB Signaling Pathway-Mediated Transcriptional Activation of TRIM37 Promotes HBV-Associated Hepatic Fibrosis

Xie, H., Xie, D., Zhang, J., Jin, W., Li, Y., Yao, J., Pan, Z., & Xie, D. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.08.014 · Cited by 35

LncRNA Neat1 expedites the progression of liver fibrosis in mice through targeting miR-148a-3p and miR-22-3p to upregulate Cyth3

Huang, W., Huang, F., Zhang, R., & Luo, H. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1875665 · Cited by 35

Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis

Peng, H., Zhong, L., Cheng, L., Chen, L., Tong, R., Shi, J., & Bai, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1094405 · Cited by 35

Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats

He, J., Bai, K., Hong, B., Zhang, F., & Zheng, S. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.09.013 · Cited by 36

Liver Sinusoidal Endothelial Cells in the Regulation of Immune Responses and Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease

Puri, M., & Sonawane, S. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093988 · Cited by 40

Stevia rebaudianatea prevents experimental cirrhosis via regulation of NF‐κB, Nrf2, transforming growth factor beta, Smad7, and hepatic stellate cell activation

Ramos‐Tovar, E., Flores‐Beltrán, R. E., Galindo‐Gómez, S., Vera‐Aguilar, E., Dı́az-Ruiz, A., Montes, S., Camacho, J., Tsutsumi, V., & Muriel, P. (2018) · Phytotherapy Research · doi:10.1002/ptr.6197 · Cited by 34

Progress in drug delivery system for fibrosis therapy

Xing, L., Chang, X. Y., Shen, L., Zhang, C., Fan, Y., Cho, C., Zhang, Z., & Jiang, H. (2020) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2020.06.005 · Cited by 34

The Differential and Dynamic Progression of Hepatic Inflammation and Immune Responses During Liver Fibrosis Induced by Schistosoma japonicum or Carbon Tetrachloride in Mice

Song, L.-J., Yin, X.-R., Mu, S., Li, J.-H., Gao, H., Zhang, Y., Dong, P., Mei, C., & Hua, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.570524 · Cited by 34

Gut microbiota mediated molecular events and therapy in liver diseases

Qi, X., Yang, M. J., Stenberg, J., Dey, R., Fogwe, L., Alam, M. S., Kimchi, E. T., Staveley-O’Carroll, K. F., & Li, G. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i48.7603 · Cited by 34

Limonin relieves TGF-β-induced hepatocyte EMT and hepatic stellate cell activation in vitro and CCl4-induced liver fibrosis in mice via upregulating Smad7 and subsequent suppression of TGF-β/Smad cascade

Shu, G., Dai, C., Yusuf, A., Sun, H. M., & Deng, X. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109039 · Cited by 35

Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/ IL-17/ IL-23 immunoinflammatory pathway

Abdelrahman, R. S., & El‐Tanbouly, G. S. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115931 · Cited by 33

Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis

Kim, M., Yoo, G., Randy, A., Son, Y., Hong, C. R., Kim, S. M., & Nho, C. W. (2020) · Nutrients · doi:10.3390/nu12041166 · Cited by 32

hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis

Li, S., Song, F., Xu, L., Li, J., Fang, L., & Tan, H. (2020) · Aging · doi:10.18632/aging.103257 · Cited by 31

Effect of Atorvastatin, Curcumin, and Quercetin on miR-21 and miR-122 and their correlation with TGFβ1 expression in experimental liver fibrosis

Nozari, E., Moradi, A., & Samadi, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118293 · Cited by 32

The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression

Wang, G., Duan, J., Pu, G., Ye, C., Li, Y., Xiu, W., Xu, J., Liu, B., Zhu, Y., & Wang, C. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166413 · Cited by 33

Automated detection and classification of liver fibrosis stages using contourlet transform and nonlinear features

Acharya, U. R., Raghavendra, U., Koh, J. E. W., Meiburger, K. M., Ciaccio, E. J., Hagiwara, Y., Molinari, F., Leong, W. L., Vijayananthan, A., Yaakup, N. A., et al. (2018) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2018.10.006 · Cited by 31

Hepatic Stellate Cell: A Potential Target for Hepatocellular Carcinoma

Wu, M., Miao, H., Fu, R., Zhang, J., & Zheng, W. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200224102820 · Cited by 31

Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease

Oates, J. R., Sawada, K., Giles, D. A., Alarcon, P. C., Damen, M. S. M. A., Szabo, S., Stankiewicz, T. E., Moreno‐Fernandez, M. E., & Divanovic, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1095132 · Cited by 30

Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ

Liu, F., Li, S., Chen, P., Gu, Y., Wang, S., Wang, L., Chen, C., Wang, R., & Yuan, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110550 · Cited by 31

Global trends and hotspots of treatment for nonalcoholic fatty liver disease: A bibliometric and visualization analysis (2010-2023)

Dai, J.-J., Zhang, Y., & Zhang, Z. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i37.5339 · Cited by 31

Galectin-3 and Severity of Liver Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease

Sotoudeheian, M. (2024) · Protein and Peptide Letters · doi:10.2174/0109298665301698240404061300 · Cited by 32

Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway

Zhou, X., Xiong, J., Lu, S., Luo, L., Chen, Z.-L., Yang, F., Jin, F., Wang, Y., Ma, Q., Luo, Y., et al. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500794 · Cited by 30

PDGFRβ-targeted TRAIL specifically induces apoptosis of activated hepatic stellate cells and ameliorates liver fibrosis

Li, R., Zhao, L., Feng, Y., Yang, H., Shi, Q., Tao, Z., Cheng, J., & Lu, X. (2020) · APOPTOSIS · doi:10.1007/s10495-019-01583-3 · Cited by 31

Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis

George, J., Tsuchishima, M., & Tsutsumi, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113111 · Cited by 30

Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2

Lee, E., Lee, J., ‍Kim, D. Y., Lee, Y.-S., Jo, Y., Dao, T., Kim, K. E., Song, D., Seo, J. H., Seo, Y., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01213-2 · Cited by 29

Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials

Huang, W.-C., Li, Y.-C., Chen, P.-X., Ma, K. S.-K., & Wang, L.-T. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04127-y · Cited by 29

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway

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Traditional Chinese medicine: An important source for discovering candidate agents against hepatic fibrosis

Li, W., Liu, W., Qian, D., Liu, J., Zhou, S.-Q., Zhang, L., Peng, W., Su, L., & Zhang, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.962525 · Cited by 29

SENP2 alleviates CCl4-induced liver fibrosis by promoting activated hepatic stellate cell apoptosis and reversion

Bu, F., Chen, Y., Yu, H., Chen, X., Yang, Y., Pan, X., Wang, Q., Wu, Y., Huang, C., Meng, X., et al. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.03.010 · Cited by 28

Antifibrotic effect of methylated quercetin derivatives on TGFβ-induced hepatic stellate cells

Ganbold, M., Shimamoto, Y., Ferdousi, F., Tominaga, K., & Isoda, H. (2019) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2019.100678 · Cited by 28

20S-Protopanaxatriol Ameliorates Hepatic Fibrosis, Potentially Involving FXR-Mediated Inflammatory Signaling Cascades

Song, J., Cui, Z., Lian, L., Han, X., Hou, L., Wang, G., Gao, L., Zhu, Y., Jiang, Y., Dou, J.-Y., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01978 · Cited by 28

LPS-TLR4/MD-2–TNF-α signaling mediates alcohol-induced liver fibrosis in rats

Mou, W., Chen, S.-R., Wu, Z., Hu, L., Zhang, J.-Y., Chang, H.-J., Zhou, H., & Liu, Y. (2022) · Journal of Toxicologic Pathology · doi:10.1293/tox.2021-0018 · Cited by 30

Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression

Luo, J., Li, L., Chang, B. Y., Zhu, Z., Deng, F., Hu, M., Yu, Y., Lu, X., Chen, Z., Zuo, D., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.03.011 · Cited by 30

Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease

Warner, J. B., Guenthner, S. C., Hardesty, J., McClain, C. J., Warner, D. R., & Kirpich, I. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i36.5280 · Cited by 31

Hyperphosphorylation of EGFR/ERK signaling facilitates long-term arsenite-induced hepatocytes epithelial-mesenchymal transition and liver fibrosis in sprague-dawley rats

Wang, D., Xu, H., Fan, L., Ruan, W., Song, Q., Diao, H., He, R., & Jin, Y. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114386 · Cited by 28

Eupatilin Ameliorates Hepatic Fibrosis and Hepatic Stellate Cell Activation by Suppressing β-catenin/PAI-1 Pathway

Hu, J., Liu, Y., Pan, Z., Huang, X., Wang, J., Cao, W., & Chen, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065933 · Cited by 30

A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation

Hajny, S., & Christoffersen, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081636 · Cited by 28

Paeonol alleviates CCl4-induced liver fibrosis through suppression of hepatic stellate cells activation via inhibiting the TGF-β/Smad3 signaling

Wu, S., Liu, L., Yang, S., Kuang, G., Yin, X., Wang, Y., Xu, F., Xiong, L., Zhang, M., Wan, J., et al. (2019) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2019.1613427 · Cited by 27

Specific Overexpression of Mitofusin-2 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in Mice Model

Zhu, H., Shan, Y., Ge, K., Lü, J., Kong, W., & Jia, C. (2019) · Human Gene Therapy · doi:10.1089/hum.2019.153 · Cited by 27

Anti-fibrotic effect of extracellular vesicles derived from tea leaves in hepatic stellate cells and liver fibrosis mice

Gong, Q., Zeng, Z.-Y., Jiang, T., Bai, X., Pu, C., Hao, Y., & Guo, Y. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1009139 · Cited by 27

Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug

Li, H., Hu, P., Zou, Y., Yuan, L., Xu, Y., Zhang, X., Luo, X., & Zhang, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1071415 · Cited by 27

Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice

Choi, M. J., Yu, H., Kim, J. I., Seo, H., Kim, J. G., Kim, S., Lee, H. S., & Cheon, H. G. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03096-x · Cited by 28

The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability – A Network Pharmacology and Transcriptomics Approach

Xing, X., Chen, S., Li, L., Cao, Y., Chen, L., Wang, X., & Zhu, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00525 · Cited by 27

Bioprotective Role of Phytocompounds Against the Pathogenesis of Non-alcoholic Fatty Liver Disease to Non-alcoholic Steatohepatitis: Unravelling Underlying Molecular Mechanisms

Banerjee, T., Sarkar, A., Ali, S. Z., Bhowmik, R., Karmakar, S., Halder, A. K., & Ghosh, N. (2024) · Planta Medica · doi:10.1055/a-2277-4805 · Cited by 26

Metal-based mesoporous polydopamine with dual enzyme-like activity as biomimetic nanodrug for alleviating liver fibrosis

Liu, X., Mu, X., Wang, Y., Liu, Z., Li, Y., Lan, J., Feng, S., Wang, S., & Zhao, Q. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.01.081 · Cited by 28

Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens

Moreira, G. C. M., Salvian, M., Boschiero, C., César, A. S. M., Reecy, J. M., Godoy, T. F., Ledur, M. C., Garrick, D. J., Mourão, G. B., & Coutinho, L. L. (2019) · BMC Genomics · doi:10.1186/s12864-019-6040-3 · Cited by 26

Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo

Khodayari, N., Oshins, R. A., Holliday, L. S., Clark, V., Xiao, Q., Marek, G. W., Mehrad, B., & Brantly, M. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00648-0 · Cited by 26

FGF21 ameliorates hepatic fibrosis by multiple mechanisms

Meng, F., Khoso, M. H., Kang, K., He, Q., Cao, Y., Jiang, X., Xiao, W. L., & Li, D. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06707-0 · Cited by 26

Dehydrozingerone ameliorates thioacetamide-induced liver fibrosis via inhibition of hepatic stellate cells activation through modulation of the MAPK pathway

Sharma, N., Shaikh, T. B., Eedara, A., Kuncha, M., Sistla, R., & Andugulapati, S. B. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175366 · Cited by 26

Cellular senescence primes liver fibrosis regression through Notch‐EZH2

Song, P., Duan, J., Ding, J. H., Liu, J., Fang, Z., Xu, H., Li, Z., Du, W., Xu, M., Ling, Y., et al. (2023) · MedComm · doi:10.1002/mco2.346 · Cited by 25

Molecular mechanism for the influence of gender dimorphism on alcoholic liver injury in mice

Li, S.-Q., Wang, P., Dm, W., Lu, H.-J., Li, R.-F., Duan, L.-X., Zhu, S., Wang, S.-L., Zhang, Y., & Wang, Y. (2018) · Human & Experimental Toxicology · doi:10.1177/0960327118777869 · Cited by 26

Water-Soluble Pristine C 60 Fullerenes Inhibit Liver Fibrotic Alteration and Prevent Liver Cirrhosis in Rats

Kuznietsova, H. M., Dziubenko, N., Hurmach, V. V., Chereschuk, I. O., Motuziuk, O., Ogloblya, O. V., & Prylutskyy, Y. І. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8061246 · Cited by 26

Progress of mesenchymal stem cells (MSCs) & MSC-Exosomes combined with drugs intervention in liver fibrosis

Xu, Y., Zhou, X., Wang, X., Jin, Y., Zhou, L., & Ye, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116848 · Cited by 25

Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells

Fu, Q., Ohnishi, S., & Sakamoto, N. (2018) · Stem Cells International · doi:10.1155/2018/4898152 · Cited by 25

MiR-15b and miR-16 suppress TGF-β1-induced proliferation and fibrogenesis by regulating LOXL1 in hepatic stellate cells

Ma, L., Liu, J., Xiao, E., Ning, H., Li, K., Shang, J., & Kang, Y. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119144 · Cited by 25

Nrf2/ARE axis signalling in hepatocyte cellular death

Ghanim, B. Y., & Qinna, N. A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07125-6 · Cited by 32

Perivascular Mesenchymal Stem/Stromal Cells, an Immune Privileged Niche for Viruses?

Lebeau, G., Ah-Pine, F., Daniel, M., Bedoui, Y., Vagner, D., Frumence, É., & Gasque, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148038 · Cited by 25

Revealing immune infiltrate characteristics and potential immune-related genes in hepatic fibrosis: based on bioinformatics, transcriptomics and q-PCR experiments

Bai, Y.-M., Liang, S., & Zhou, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133543 · Cited by 26

Efficacy and potential mechanisms of the main active ingredients of astragalus mongholicus in animal models of liver fibrosis: A systematic review and meta-analysis

Dan, L., Hao, Y., Song, H., Wang, T., Li, J. X., He, X., & Su, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117198 · Cited by 25

Advances in the diagnosis and treatment of liver fibrosis

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Thymosinβ4 alleviates cholestatic liver fibrosis in mice through downregulating PDGF/PDGFR and TGFβ/Smad pathways

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Pharmaceutical Efficacy of Gypenoside LXXV on Non-Alcoholic Steatohepatitis (NASH)

Lee, J. H., Oh, J. Y., Kim, S. H., Oh, I. J., Lee, Y., Lee, K. W., Lee, W. H., & Kim, J. (2020) · Biomolecules · doi:10.3390/biom10101426 · Cited by 24

Hepatic stellate cells specific liposomes with the Toll‐like receptor 4 shRNA attenuates liver fibrosis

Zhang, Y., Li, Y., Mu, T., Tong, N., & Cheng, P. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16209 · Cited by 24

Interleukin-24 protects against liver injury in mouse models

Wang, H.-H., Huang, J.-H., Sue, M.-H., Ho, W.-C., Hsu, Y.-H., Chang, K., & Chang, M. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103213 · Cited by 24

Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity

Pivovarova‐Ramich, O., Loske, J., Hornemann, S., Markova, M., Seebeck, N., Rosenthal, A., Klauschen, F., Castro, J. P., Buschow, R., Grune, T., et al. (2021) · Cells · doi:10.3390/cells10051048 · Cited by 25

Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies

Ali, E., Trailin, A. V., Ambrożkiewicz, F., Liška, V., & Hemminki, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315292 · Cited by 25

Anti-Fibrotic Efficacy of Apigenin in a Mice Model of Carbon Tetrachloride-Induced Hepatic Fibrosis by Modulation of Oxidative Stress, Inflammation, and Fibrogenesis: A Preclinical Study

Melaibari, M., Alkreathy, H. M., Esmat, A., Rajeh, N. A., Shaik, R. A., Alghamdi, A. A., & Ahmad, A. (2023) · Biomedicines · doi:10.3390/biomedicines11051342 · Cited by 24

Human Wharton’s jelly mesenchymal stem cells derived-exosomes enriched by miR-124 promote an anti-fibrotic response in an experimental model of liver fibrosis

Niknam, B., Baghaei, K., Hashemi, S. M., Hatami, B., Zali, M. R., & Amani, D. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110294 · Cited by 26

Novel cytisine derivatives exert anti-liver fibrosis effect via PI3K/Akt/Smad pathway

Tang, S., Li, Y., Bao, Y., Dai, Z., Niu, T., Wang, K., He, H., & Song, D. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103032 · Cited by 24

Long non-coding RNAs in metabolic disorders: pathogenetic relevance and potential biomarkers and therapeutic targets

Alipoor, B., Nikooei, S., Rezaeinejad, F., Malakooti-Dehkordi, S.-N., Sabati, Z., & Ghasemi, H. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01559-8 · Cited by 25

In Vitro and In Vivo Study on the Toxic Effects of Propiconazole Fungicide in the Pathogenesis of Liver Fibrosis

Kwon, H.-C., Sohn, H., Kim, D. H., Shin, D., Jeong, C. H., Chang, Y. H., Yune, J. H., Kim, Y., Kim, D.-W., Kim, S.-H., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c01086 · Cited by 23

MicroRNA-195-3p promotes hepatic stellate cell activation and liver fibrosis by suppressing PTEN expression

Wang, A., Bu, F., Li, J., Zhang, Y., Jia, P., You, H., Wu, S., Wu, Y., Zhu, S., Huang, C. Z., et al. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.11.014 · Cited by 23

β-catenin/TCF4 inhibitors ICG-001 and LF3 alleviate BDL-induced liver fibrosis by suppressing LECT2 signaling

Gao, Y., Fan, S., Zhao, P., Li, H., Cai, C., Li, X., Zhou, Y., Huang, M., & Bi, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110350 · Cited by 25

Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB

Macías-Pérez, J. R., Vázquez-López, B. J., Muñoz‐Ortega, M. H., Aldaba-Muruato, L. R., Martínez-Hernández, S. L., Sánchez‐Alemán, E., & Ventura‐Juárez, J. (2019) · Journal of Immunology Research · doi:10.1155/2019/3019794 · Cited by 23

Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats

Ohara, M., Ohnishi, S., Hosono, H., Yamamoto, K., Fu, Q., Maehara, O., Suda, G., & Sakamoto, N. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00709 · Cited by 24

Interaction of non‑parenchymal hepatocytes in the process of hepatic fibrosis (Review)

Cheng, Q.-N., Yang, X. Y., Wu, J., Ai, W., & Ni, Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12003 · Cited by 22

Cellular heterogeneity and plasticity during NAFLD progression

Park, H., Choi, J., Kim, H.-M., Yang, D.-Y., An, T. H., Lee, E., Han, B., Lee, S. C., Kim, W. K., Bae, K., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1221669 · Cited by 22

Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH

Fernández-Ginés, R., Encinar, J. A., Escoll, M., Carnicero-Senabre, D., Jiménez-Villegas, J., García‐Yagüe, Á. J., González‐Rodríguez, Á., García‐Martinez, I., Valverde, Á. M., Rojo, A. I., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103027 · Cited by 23

The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model

van Riet, S., Julien, A., Atanasov, A., Nordling, Å., & Ingelman‐Sundberg, M. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000374 · Cited by 22

An aqueous extract of Stevia rebaudiana variety Morita II prevents liver damage in a rat model of cirrhosis that mimics the human disease

Ramos‐Tovar, E., Flores‐Beltrán, R. E., Galindo‐Gómez, S., Camacho, J., Tsutsumi, V., & Muriel, P. (2019) · Annals of Hepatology · doi:10.1016/j.aohep.2018.10.002 · Cited by 22

Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

Brandão, E., Romero, S., da Silva, M. A. L., & Santos, F. L. N. (2017) · Infectious Diseases of Poverty · doi:10.1186/s40249-017-0369-0 · Cited by 22

Differential fibrotic phenotypes of hepatic stellate cells within 3D liver organoids

Brovold, M., Keller, D., & Soker, S. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27379 · Cited by 21

A new strategy for the extrahepatic delivery of lipid-based nanomedicines: a protein corona-mediated selective targeting system based on an ionizable cationic lipid library

Younis, M. A., Sato, Y., Kimura, S., & Harashima, H. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00079c · Cited by 24

Modulation of Autophagy: A Novel “Rejuvenation” Strategy for the Aging Liver

Xu, F., Tautenhahn, H., Dirsch, O., & Dahmen, U. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6611126 · Cited by 21

Role of the S100 protein family in liver disease (Review)

Yao, S., Yang, X., An, J., Jin, H. D., Wen, G., Wang, H., & Tuo, B. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4999 · Cited by 20

Successful induction of human chemically induced liver progenitors with small molecules from damaged liver

Miyoshi, T., Hidaka, M., Miyamoto, D., Sakai, Y., Murakami, S., Huang, Y. G., Hara, T., Soyama, A., Kanetaka, K., Ochiya, T., et al. (2022) · Journal of Gastroenterology · doi:10.1007/s00535-022-01869-5 · Cited by 23

Sesamol protects against liver fibrosis induced in rats by modulating lysophosphatidic acid receptor expression and TGF-β/Smad3 signaling pathway

Elrazik, N. A. A., El‐Mesery, M., & El‐Shishtawy, M. M. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02259-7 · Cited by 21

Liver sinusoidal cells in the diagnosis and treatment of liver diseases: Role of hepatic stellate cells

Caon, E., Forlano, R., Mullish, B. H., Manousou, P., & Rombouts, K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00025-5 · Cited by 1

Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

Elpek, G. Ö. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7260 · Cited by 399

Mechanisms of Cellular and Molecular in the Pathogenesis of Liver Fibrosis

Tin, S. (2015)

Hepatic stellate cells in liver fibrosis: From biology to pathology

Esselmani, H., Nadir, Y., Ennadi, R., Zouhairi, N., Hiba, O. E., Lkousse, M. A., Najimi, M., & Merzouki, M. (2025) · Open Veterinary Journal · doi:10.5455/ovj.2025.v15.i12.4

Hepatic stellate cells and the reversal of fibrosis

Kisseleva, T., & Brenner, D. A. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04584.x · Cited by 283