The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease.
Open accessAbstract
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood. Over the years many studies have proposed various pathophysiological hypotheses, among which the currently most widely accepted is the "multiple parallel hits" theory. According to this model, lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury, inflammation and fibrosis. Among these factors, adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role. Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue, and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD. Furthermore, given the strong association between these conditions, current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD. The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction, and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity, together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.
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“its development is associated with the insulin receptor, low-grade inflammation, and ectopic lipid deposition”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Cimini et al., 2017
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“Consequently, NAFLD is exacerbated with AT dysfunction”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Cimini et al., 2017
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Cites
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Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
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Ma, L., & Abudureyimu, M. (2026) · Medicine · doi:10.1097/md.0000000000049980
Metadata
- Authors
- Cimini, F. A., Barchetta, I., Carotti, S., Bertoccini, L., Baroni, M. G., Vespasiani-Gentilucci, U., Cavallo, M.-G., & Morini, S.
- Affiliations
- Università Campus Bio-Medico (IT)
- Corresponding author
- Morini, Sergio
- ORCID
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2017
- Volume
- 23
- Issue
- 19
- Pages
- 3407
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC5442077
- OpenAlex
- W2616329440
- Cited by
- 101
- References
- 166
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 9 · 2021: 13 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 4
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- non-alcoholic fatty liver disease, adipose tissue dysfunction, vitamin D deficiency, insulin resistance, low-grade inflammation, obesity, hepatic lipid accumulation, vitamin D supplementation, liver fibrosis
- MeSH terms
- Adipose Tissue, Animals, Fibrosis, Humans, Inflammation, Lipids, Liver, Obesity, Vitamin D, Vitamin D Deficiency, Hepatocytes, Adiposity, Mice, Adipokines, Non-alcoholic Fatty Liver Disease
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