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Cited by 101Liver Disease Diagnosis and TreatmentVitamin D Research StudiesAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.

Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease.

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Cimini, Flavia A, Barchetta, Ilaria, Carotti, Simone, Bertoccini, Laura, Baroni, Marco G, Vespasiani-Gentilucci, Umberto, Cavallo, Maria-Gisella, Morini, Sergio·2017·World Journal of Gastroenterology
DOI 10.3748/wjg.v23.i19.3407PMC PMC5442077
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Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood. Over the years many studies have proposed various pathophysiological hypotheses, among which the currently most widely accepted is the "multiple parallel hits" theory. According to this model, lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury, inflammation and fibrosis. Among these factors, adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role. Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue, and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD. Furthermore, given the strong association between these conditions, current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD. The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction, and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity, together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.

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Crossref · 10.3748/wjg.v23.i19.3407

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Figure 1 Normal visceral adipose tissue consists of a loose connective tissue that is populated with tightly packed adipocytes. In lean individuals VAT homeostasis is maintained by adiponectin released by adipocytes and by M2 macrophages through the secretion of anti-inflammatory cytokines, such as interleukin (IL)-10 and arginase-1. During obesity, dysfunctional visceral adipose tissue (VAT) undergoes excessive fibrosis and accumulation of inflammatory cells. Active macrophages surround dying adipocytes (DA) in typical “crown-like structures”. Pro-M1 polarized macrophages secrete pro-inflammatory cytokines including TNFα, IL-1β and IL-6, which can promote chronic local and systemic inflammation. VAT secretes a large number of adipokines which could play a pivotal role in development of NAFLD. NAFLD: Non-alcoholic fatty liver disease.
Figure 1 Normal visceral adipose tissue consists of a loose connective tissue that is populated with tightly packed adipocytes. In lean individuals VAT homeostasis is maintained by adiponectin released by adipocytes and by M2 macrophages through the secretion of anti-inflammatory cytokines, such as interleukin (IL)-10 and arginase-1. During obesity, dysfunctional visceral adipose tissue (VAT) undergoes excessive fibrosis and accumulation of inflammatory cells. Active macrophages surround dying adipocytes (DA) in typical “crown-like structures”. Pro-M1 polarized macrophages secrete pro-inflammatory cytokines including TNFα, IL-1β and IL-6, which can promote chronic local and systemic inflammation. VAT secretes a large number of adipokines which could play a pivotal role in development of NAFLD. NAFLD: Non-alcoholic fatty liver disease.CC BY-NC · PubMed Central

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  1. 10.1111/j.1478-3231.2005.01191 · DOI
  2. 10.1371/journal.pone.0052171.PubMed · DOI

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Metadata

Authors
Cimini, F. A., Barchetta, I., Carotti, S., Bertoccini, L., Baroni, M. G., Vespasiani-Gentilucci, U., Cavallo, M.-G., & Morini, S.
Affiliations
Università Campus Bio-Medico (IT)
Corresponding author
Morini, Sergio
ORCID
Venue
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Inc.
Published
2017
Volume
23
Issue
19
Pages
3407
ISSN
1007-9327 (ISSN-L)
DOI
10.3748/wjg.v23.i19.3407
PMC
PMC5442077
OpenAlex
W2616329440
Cited by
101
References
166
Citations by year
2026: 4 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 9 · 2021: 13 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 4
FWCI
1.34
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
  • Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
non-alcoholic fatty liver disease, adipose tissue dysfunction, vitamin D deficiency, insulin resistance, low-grade inflammation, obesity, hepatic lipid accumulation, vitamin D supplementation, liver fibrosis
MeSH terms
Adipose Tissue, Animals, Fibrosis, Humans, Inflammation, Lipids, Liver, Obesity, Vitamin D, Vitamin D Deficiency, Hepatocytes, Adiposity, Mice, Adipokines, Non-alcoholic Fatty Liver Disease

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