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The frontopolar cortex and human cognition: Evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex

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Christoff, Kalina, Gabrieli, John D. E.·2000·Psychobiology

Abstract

Numerous brain lesion and functional neuroimaging studies have suggested that the dorsolateral and frontopolar prefrontal regions are involved in complex cognitive processes subserving thought and memory. However, previously proposed functional subdivisions of prefrontal function have concentrated predominantly on posterior prefrontal cortex, including the dorsolateral, ventral, and medial regions. Far less consideration has been given to characterizing the psychological processes mediated by the frontopolar cortex. Here we review published neuroimaging studies of reasoning and episodic memory, two domains in which the frontopolar cortex has been frequently activated. The results suggest that dorsolateral prefrontal cortex is involved when externally generated information is being evaluated, whereas the frontopolar cortex becomes recruited when internally generated information needs to be evaluated. A hierarchical model of prefrontal function is proposed in which dorsolateral and frontopolar regions are serially recruited as a reasoning or memory task requires evaluation of internally generated information.

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Metadata

Authors
Christoff, K., & Gabrieli, J. D. E.
Venue
Psychobiology
Published
2000-06
Volume
28
Issue
2
Pages
168-186
ISSN
0889-6313 (ISSN-L)
OpenAlex
W1607685652
Cited by
682
References
10
FWCI
8.43
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: The frontopolar cortex and human cognition: Evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex. https://app.cochat.ai/papers/10.3758/bf03331976
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Christoff, K., & Gabrieli, J. D. E. (2000). The frontopolar cortex and human cognition: Evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex. Psychobiology. https://doi.org/10.3758/bf03331976

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.