Distinct immediate and prolonged effects of separation on plasma cortisol in adult female squirrel monkeys
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Adult female squirrel monkeys exhibited reduced plasma cortisol levels 1 h following separation from their female cagemate. By 6–8 days following separation, however, cortisol levels in these females had increased significantly. When each female was subsequently paired with an unfamiliar female, cortisol levels showed an additional rise 1 h later and then declined over the following 8 days. The decline could not be accounted for by an increase in affiliation between pairmates or by a decrease in locomotor activity. Furthermore, the decline was comparable for pairs that were and were not observed to fight. These results indicate that separation of adult primates can produce slowly emerging physiological changes that differ from the immediate response to separation, and that social factors other than affiliation appear to regulate endocrine activity in adult female squirrel monkeys.
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The HPA axis in squirrel monkeys is unresponsive to isolation from polygamous partners or adult peers, but separation of squirrel monkey mothers from their infant produces significant increases in plasma cortisol levels in both the mother and the infant.
“In contrast, the HPA axis in the squirrel monkeys is unresponsive to isolation from polygamous partners or adult peers (Hennessy 1986, Mendoza et al. 1992), but the separation of squirrel monkey mothers from their infant produces significant increases in plasma cortisol levels in both the mother and the infant (Coe et al. 1978, Mendoza et al. 1978, Vogt & Levine 1980).”
From The neuroendocrinology of social isolation (2015) · cites this paper as Mendoza et al. 1992
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- Authors
- Mendoza, S. P., Hennessy, M. B., & Lyons, D. M.
- Affiliations
- University of California, Davis (US)
- Wright State University (US)
- Corresponding author
- Mendoza, Sally P.
- ORCID
- Hennessy, Michael B.
- Venue
- Psychobiology
- Published
- 1992-12
- Volume
- 20
- Issue
- 4
- Pages
- 300-306
- ISSN
- 0889-6313 (ISSN-L)
- OpenAlex
- W2155933209
- Cited by
- 27
- References
- 45
- Citations by year
- 2025: 1 · 2023: 1 · 2017: 1 · 2016: 1 · 2014: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Psychobiology (publishedVersion)
- CORE Scholar (Wright State University) (submittedVersion)
- Journal of Bioresource Management (submittedVersion)
- Funders
- National Science Foundation (8701620, 8822240)
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- plasma cortisol, social separation, squirrel monkey, female primates, social stress, social affiliation, pair bonding, locomotor activity, hormonal regulation
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