P50 sensory gating is related to performance on select tasks of cognitive inhibition
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P50 suppression deficits have been documented in clinical and nonclinical populations, but the behavioral correlates of impaired auditory sensory gating remain poorly understood. In the present study, we examined the relationship between P50 gating and healthy adults' performance on cognitive inhibition tasks. On the basis of load theory (Lavie, Hirst, de Fockert, & Viding, 2004), we predicted that a high perceptual load, a possible consequence of poor auditory P50 sensory gating, would have differential (i.e., positive vs. negative) effects on performance of cognitive inhibition tasks. A dissociation was observed such that P50 gating was negatively related to interference resolution on a Stroop task and positively related to response inhibition on a go/no-go task. Our findings support the idea that a high perceptual load may be beneficial to Stroop performance because of the reduced processing of distractors but detrimental to performance on the go/no-go task because of interference with stimulus discrimination.
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In healthy participants, P50 gating can relate to response inhibition or Stroop interference, but these associations differ across cognitive tasks and may depend on perceptual load, response strategy, and task modality rather than on a single general inhibitory mechanism.
“For example, studies in healthy participants have reported that P50 gating can relate to response inhibition or Stroop interference, but these associations differ across cognitive tasks and may depend on perceptual load, response strategy, and task modality rather than on a single general inhibitory mechanism [97,172].”
Relationships between P50 gating and cognition are inconsistent and task-dependent.
“This interpretation is consistent with broader work showing that relationships between P50 gating and cognition are inconsistent and task-dependent.”
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- Authors
- Yadon, C. A., Bugg, J. M., Kisley, M. A., & Davalos, D. B.
- Affiliations
- Colorado State University (US)
- Washington University in St. Louis (US)
- University of Colorado Colorado Springs (US)
- Corresponding author
- Yadon, Carly A.
- Venue
- Cognitive, Affective, & Behavioral Neuroscience
- Published
- 2009-12
- Volume
- 9
- Issue
- 4
- Pages
- 448-458
- ISSN
- 1530-7026 (ISSN-L)
- 1531-135X
- PMC
- PMC2810148
- OpenAlex
- W2146448218
- Cited by
- 43
- References
- 76
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 7 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cognitive Affective & Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- BearWorks (Missouri State University) (submittedVersion)
- Funders
- National Institute on Aging (5 T32 AG 00030, T32AG000030)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- auditory gating, cognitive inhibition, perceptual load, load theory, Stroop interference, response inhibition, go/no-go task, distractor processing, stimulus discrimination, healthy adults
- MeSH terms
- Acoustic Stimulation, Adolescent, Adult, Cognition, Electroencephalography, Evoked Potentials, Auditory, Female, Humans, Inhibition, Psychological, Male, Neuropsychological Tests, Psychomotor Performance, Sensory Gating
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