Effects of focal frontal lesions on response inhibition

Picton, T. W.; Stuss, D. T.; Alexander, M. P.; Shallice, T.; Binns, M. A.; Gillingham, S.

doi:10.1093/cercor/bhk031

Cited by 387Neural and Behavioral Psychology StudiesHistorical and Modern Theater StudiesNeurobiology of Language and Bilingualism

Effects of focal frontal lesions on response inhibition

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Picton, T. W., Stuss, D. T., Alexander, M. P., Shallice, T., Binns, M. A., Gillingham, S.·2006·Cerebral Cortex

DOI 10.1093/cercor/bhk031

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Abstract

This study examined the performance of 38 normal subjects and 43 patients with focal lesions of the frontal lobes on a simple go-nogo task where the probability of the nogo stimulus was either 75% or 25%. Patients with lesions to the superior medial parts of the frontal lobes, in particular to the left superior portion of Brodmann area 6 (which includes the supplementary motor areas and the premotor areas for the right hand) had an increased number of false alarms (incorrect responses to the nogo stimulus). These results indicate that area 6 is specifically involved in the inhibition of response. Patients with lesions to the right anterior cingulate (areas 24 and 32) were slower and more variable in their reaction time. These findings could be explained by an inability to sustain stimulus-response contingencies. Lesions to the right ventrolateral prefrontal cortex (Brodmann areas 44, 45, 47) also increased the variability of response, perhaps by disrupting monitoring performance.

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In the three largest human frontal lesion studies of response inhibition to date, poor inhibitory performance was associated with lesions of the superior medial frontal lobe.
“In the three largest human frontal lesion studies of response inhibition to date, poor inhibitory performance was associated with lesions of the superior medial frontal lobe (Drewe et al, 1975; Floden & Stuss, 2006; Picton et al., 2006).”
From Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent (2008) · cites this paper as Picton et al., 2006

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Authors: Picton, T. W., Stuss, D. T., Alexander, M. P., Shallice, T., Binns, M. A., & Gillingham, S.
Affiliations: University of Toronto (CA)
Beth Israel Deaconess Medical Center (US)
University College London (GB)
Rotman Research Institute (CA)
ORCID: Stuss, D. T.
Alexander, M. P.
Binns, M. A.
Venue: Cerebral Cortex
Publisher: Oxford University Press (OUP)
Published: 2006-05-17
Volume: 17
Issue: 4
Pages: 826-838
ISSN: 1047-3211 (ISSN-L)
1460-2199
DOI: 10.1093/cercor/bhk031
OpenAlex: W2132709875
Cited by: 387
References: 88
Citations by year: 2026: 3 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 8 · 2021: 20 · 2020: 18 · 2019: 13 · 2018: 22 · 2017: 23 · 2016: 21 · 2015: 26 · 2014: 30 · 2013: 29 · 2012: 27
FWCI: 9.22
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Licence: other-oa
Locations: Cerebral Cortex (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion, other-oa)
SDL (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Keywords: response inhibition, go/no-go task, frontal lobe lesions, Brodmann area 6, supplementary motor area, premotor cortex, anterior cingulate cortex, ventrolateral prefrontal cortex, false alarm rate, reaction time variability
MeSH terms: Brain Damage, Chronic, Frontal Lobe, Humans, Neural Inhibition, Reaction Time, Task Performance and Analysis

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Effects of focal frontal lesions on response inhibition

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