The DOI matches its OpenAlex record; 10 of the 10 references it cites were found in a registry or an index.
[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].
Open accessAbstract
OBJECTIVE: To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of patients with moderate coronavirus disease 2019 (COVID-19). METHODS: We prospectively enrolled 30 treatment-naïve patients with confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. The patients were randomized 1：1 to HCQ group and the control group. Patients in HCQ group were given HCQ 400 mg per day for 5 days plus conventional treatments, while those in the control group were given conventional treatment only. The primary endpoint was negative conversion rate of SARS-CoV-2 nucleic acid in respiratory pharyngeal swab on days 7 after randomization. This study has been approved by the Ethics Committee of Shanghai Public Health Clinical Center and registered online (NCT04261517). RESULTS: >0.05). CONCLUSIONS: The prognosis of COVID-19 moderate patients is good. Larger sample size study are needed to investigate the effects of HCQ in the treatment of COVID-19. Subsequent research should determine better endpoint and fully consider the feasibility of experiments such as sample size.
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Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30251-8 · Cited by 11,907
Self-citationChan, J. F.-W., Yuan, S., Kok, K.-H., To, K. K.-W., Chu, H., Yang, J., Xing, F., Liu, J., Yip, C. C.-Y., Poon, R. W.-S., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30154-9 · Cited by 8,944
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Vincent, M. J., Bergeron, E., Benjannet, S., Erickson, B. R., Rollin, P. E., Ksiazek, T. G., Seidah, N. G., & Nichol, S. T. (2005) · Virology Journal · doi:10.1186/1743-422x-2-69 · Cited by 1,811
Effects of chloroquine on viral infections: an old drug against today's diseases
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Drug treatment options for the 2019-new coronavirus (2019-nCoV)
Lu, H. (2020) · BioScience Trends · doi:10.5582/bst.2020.01020 · Cited by 1,133
Self-citationSpecial Article - Acute myocardial injury in patients hospitalized with COVID-19 infection: A review
Bavishi, C., Bonow, R. O., Trivedi, V., Abbott, J. D., Messerli, F. H., & Bhatt, D. L. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.05.013 · Cited by 298
COVID-19 infection: the China and Italy perspectives
Chen, J., Lu, H., Melino, G., Boccia, S., Piacentini, M., Ricciardi, W., Wang, Y., Shi, Y., & Zhu, T. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2603-0 · Cited by 130
Self-citationShukla, A. M., & Shukla, A. W. (2019) · Drugs in Context · doi:10.7573/dic.2019-9-1 · Cited by 54
Perspectives on repositioning chloroquine and hydroxychloroquine for the treatment of Covid-19
Adeel, A. (2020) · Sudanese Journal of Paediatrics · doi:10.24911/sjp.106-1587122398 · Cited by 14
Dalton, B., Dresser, L., Thirion, D. J. G., & Lau, T. T. Y. (2020) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v73i2.2992 · Cited by 5
Cited by
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review
Sanders, J. M., Monogue, M. L., Jodlowski, T. Z., & Cutrell, J. B. (2020) · JAMA · doi:10.1001/jama.2020.6019 · Cited by 2,347
Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19
Geleris, J., Sun, Y., Platt, J., Zucker, J., Baldwin, M., Hripcsak, G., Labella, A., Manson, D. K., Kubin, C., Barr, R. G., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2012410 · Cited by 1,625
Immunology of COVID-19: Current State of the Science
Vabret, N., Britton, G. J., Gruber, C., Hegde, S., Kim, J., Kuksin, M., Levantovsky, R., Malle, L., Moreira, A., Park, M. D., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.002 · Cited by 1,623
Mehra, M. R., Desai, S. S., Ruschitzka, F., & Patel, A. N. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31180-6 · Cited by 1,200
RetractedBourgonje, A. R., Abdulle, A. E., Timens, W., Hillebrands, J., Navis, G. J., Gordijn, S. J., Bolling, M. C., Dijkstra, G., Voors, A. A., Osterhaus, A. D., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5471 · Cited by 1,081
Metadata
- Authors
- Chen, J., Liu, D., Liu, L., Liu, P., Xu, Q., Xia, L., Ling, Y., Huang, D. F., Song, S., Zhang, D., Qian, Z., Li, T., Shen, Y., & Lu, H.
- Venue
- PubMed
- Publisher
- National Institutes of Health
- Published
- 2020-05-25
- Volume
- 49
- Issue
- 2
- Pages
- 215-219
- OpenAlex
- W3010992334
- Cited by
- 664
- References
- 10
- FWCI
- 19.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, J., Liu, D., Liu, L., Liu, P., Xu, Q., Xia, L., Ling, Y., Huang, D. F., Song, S., Zhang, D., Qian, Z., Li, T., Shen, Y., & Lu, H. (2020). [A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19]. PubMed. https://doi.org/10.3785/j.issn.1008-9292.2020.03.03
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