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The discovery of placenta growth factor and its biological activity
Open accessAbstract
Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and ovary during the different phases of the menstrual cycle and to the heart and skeletal muscles after prolonged and sustained physical exercise. Conversly, angiogenesis is one of the major pathological changes associated with several complex diseases like cancer, atherosclerosis, arthritis, diabetic retinopathy and age-related macular degeneration. Among the several molecular players involved in angiogenesis, some members of VEGF family, VEGF-A, VEGF-B and placenta growth factor (PlGF), and the related receptors VEGF receptor 1 (VEGFR-1, also known as Flt-1) and VEGF receptor 2 (VEGFR-2, also known as Flk-1 in mice and KDR in human) have a decisive role. In this review, we describe the discovery and molecular characteristics of PlGF, and discuss the biological role of this growth factor in physiological and pathological conditions.
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“A similar pattern is observed for VEGF, stimulating angiogenesis and promoting capillary permeability,29 leading to expansion of the interstitium.30, 31”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [29]
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“VEGF expression and increased vascular permeability occur in infection,14, 35 trauma,15, 16, 36 during fetal and postnatal growth,29, 37, 38, 39 preparing for lactation,39, 40 cancer,41, 42 protein‐losing enteropathy,43 and nephrotic syndrome44, 45 (Table 1).”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [29]
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“Pregnancy 1st, 2nd, 3rd trimester | ↓ to ↓↓ | ↑ to↑↑ | ↑ | NA | NA | ↑ to↑↑ | ↑29 | Increasing permeability and distribution volume in the course of pregnancy”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [29]
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Metadata
- Authors
- De Falco, S.
- Affiliations
- Angiogenesis Laboratory and Stem Cell Fate Laboratory, Institute of Genetics and Biophysics, 'Adriano Buzzati-Traverso' - CNR - Via Pietro Castellino, 111, 80131 Napoli, Italy.
- Venue
- Experimental and Molecular Medicine
- Published
- 2012
- Volume
- 44
- Issue
- 1
- Pages
- 1
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- PMC
- PMC3277892
- OpenAlex
- W2097881605
- Cited by
- 425
- References
- 99
- Citations by year
- 2026: 10 · 2025: 33 · 2024: 34 · 2023: 39 · 2022: 35 · 2021: 28 · 2020: 38 · 2019: 44 · 2018: 35 · 2017: 32 · 2016: 22 · 2015: 23 · 2014: 35 · 2013: 14 · 2012: 2
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- placental growth factor, angiogenesis, VEGF family, VEGF receptor 1, VEGF receptor 2, Flt-1, Flk-1, KDR, VEGF-A, VEGF-B, biological activity, pathogenesis
- MeSH terms
- Placenta Growth Factor, Animals, Female, Humans, Neovascularization, Pathologic, Nitric Oxide, Placenta, Pregnancy, Pregnancy Proteins, Mice, Knockout, Gene Expression Regulation, Developmental, Neovascularization, Physiologic, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A, Endothelial Cells, Mice
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