The Longitudinal Outcome of Fibromyalgia: A Study of 1555 Patients
Open accessAbstract
Objective.: To describe the diagnosis status and outcome of patients diagnosed with fibromyalgia (FM) by US rheumatologists. Methods.: We assessed 1555 patients with FM with detailed outcome questionnaires during 11,006 semiannual observations for up to 11 years. At entry, all patients satisfied American College of Rheumatology preliminary 2010 FM criteria modified for survey research. We determined diagnosis status, rates of improvement, responder subgroups, and standardized mean differences (effect sizes) between start and study completion scores of global well-being, pain, sleep problems, and health related quality of life. (QOL) Results.: The 5-year improvement rates were pain 0.4 (95% CI 0.2, 0.5), fatigue 0.4 (95% CI 0.2, 0.05), and global 0.0 (95% CI −0.1, 0.1). The standardized mean differences were patient global 0.03 (95% CI −0.02, 0.08), pain 0.22 (95% CI 0.16, 0.28), sleep problems 0.20 (95% CI 0.14, 0.25), physical component summary of the Short-form 36 (SF-36) 0.11 (95% CI −0.14, −0.07), and SF-36 mental component summary 0.03 (95% CI −0.07, 0.02). Patients switched between criteria-positive and criteria-negative states, with 716 patients (44.0%) failing to meet criteria at least once during 4228.5 patient-years (7448 observations). About 10% of patients had substantial improvement and about 15% had moderate improvement of pain. Overall, FM severity worsened in 35.9% and pain in 38.6%. Conclusion.: Although we found no average clinically meaningful improvement in symptom severity overall, 25% had at least moderate improvement of pain over time. The result that emerged from this longitudinal study was one of generally continuing high levels of self-reported symptoms and distress for most patients, but a slight trend toward improvement.
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Only about one fourth of the sample showed meaningful improvement, including 10% with substantial improvement in symptom severity.
“Only about one fourth of the sample showed meaningful improvement, including 10% with substantial improvement in symptom severity [41].”
In a recent longitudinal study including 1555 patients with fibromyalgia receiving standard care, with a mean follow-up period of 4 years, no clinically meaningful improvement in overall symptom severity was found for the sample.
“In a recent longitudinal study including 1555 patients with fibromyalgia receiving standard care, with a mean follow-up period of 4 years, no clinically meaningful improvement in overall symptom severity was found for the sample.”
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- Authors
- WALITT, B., FITZCHARLES, M.-A., HASSETT, A. L., KATZ, R. S., HÄUSER, W., & WOLFE, F.
- Affiliations
- The National Databank for Rheumatic Diseases (US)
- Georgetown University (US)
- University of Michigan (US)
- Rush University Medical Center (US)
- University of Kansas (US)
- ORCID
- Venue
- The Journal of Rheumatology
- Publisher
- The Journal of Rheumatology
- Published
- 2011-07-15
- Volume
- 38
- Issue
- 10
- Pages
- 2238-2246
- ISSN
- 0315-162X (ISSN-L)
- 1499-2752
- OpenAlex
- W2150833219
- Cited by
- 154
- References
- 32
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 6 · 2021: 15 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 17 · 2012: 16
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Jazz Pharmaceuticals
- Cilag
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- fibromyalgia, longitudinal outcomes, symptom improvement, pain, fatigue, sleep disorders, health-related quality of life, disease severity, diagnostic status, SF-36
- MeSH terms
- Adult, Aged, Fatigue, Female, Fibromyalgia, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Pain, Pain Measurement, Quality of Life, Severity of Illness Index, Patient Satisfaction
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