The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Randomised double-blind placebo-controlled study of the effect of Lactobacillus paracasei NCC 2461 on skin reactivity
Open accessAbstract
In recent decades, the prevalence of subjects with reactive skin has considerably increased in industrialised countries. 50% of women and 30% of men report cutaneous discomfort classified under reactive/sensitive skin. Several topical approaches have been proposed, in particular through improvement of galenic forms or protection of epidermal surface. We propose to act differently, deeply from inside the body via an innovative nutritional approach. To this purpose, Lactobacillus paracasei NCC 2461 (ST11) was selected because of its specific beneficial skin properties discovered in in vitro studies, i.e. diminution of neurogenic inflammation and promotion of the recovery of skin barrier function. We designed a randomised double-blind placebo-controlled clinical study with a two-month supplementation in two female treatment groups (n=32 per group). A capsaicin test was performed to monitor the time course of skin sensitivity. Moreover, transepidermal water loss was assessed to analyse the rate of skin barrier function recovery; dryness of the leg and roughness of the cheeks was investigated by a dermatologist as well as by self-assessment. The results of the present clinical trial show that oral supplementation with the probiotic decreases skin sensitivity and increases the rate of barrier function recovery. Thus, the data provide evidence that daily intake of ST11 could improve reactive skin condition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A randomized, double-blind, placebo-controlled clinical trial showed that lactobacillus paracasei NCC 2461 decreased skin sensitivity through inhibition of the release of the neuromediators involved in sensitivity reaction, and improved skin barrier function in leg and cheek skin [142].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [142]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Pinnagoda, J., Tupkek, R. A., Agner, T., & Serup, J. (1990) · Contact Dermatitis · doi:10.1111/j.1600-0536.1990.tb01553.x · Cited by 1,092
Tannock, G. W., Munro, K., Harmsen, H. J. M., Welling, G. W., Smart, J., & Gopal, P. K. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.6.2578-2588.2000 · Cited by 671
Nickoloff, B. J., & Naidu, Y. M. (1994) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(94)70059-1 · Cited by 463
Measurement of water exchange through skin
Nilsson, G. (1977) · Medical & Biological Engineering & Computing · doi:10.1007/bf02441040 · Cited by 448
Modern Aspects of Cutaneous Neurogenic Inflammation
Steinhoff, M. S., Ständer, S., Seeliger, S., Ansel, J. C., Schmelz, M., & Luger, T. A. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.11.1479 · Cited by 345
Sensitive skin: an epidemiological study
Willis, C. M., Shaw, S., de Lacharrière, O., Baverel, M., Reiche, L., Jourdain, R., Bastien, P., & Wilkinson, J. D. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04343.x · Cited by 275
Self-citationvon der Weid, T., Bulliard, C., & Schiffrin, E. J. (2001) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.8.4.695-701.2001 · Cited by 241
Ibnou-Zekri, N., Blum, S., Schiffrin, E. J., & von der Weid, T. (2002) · Infection and Immunity · doi:10.1128/iai.71.1.428-436.2003 · Cited by 216
Self-citationChoi, E., Brown, B. E., Crumrine, D. A., Chang, S., Man, M., Elias, P. M., & Feingold, K. R. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23589.x · Cited by 212
Baseline biophysical parameters in subjects with sensitive skin
Seidenari, S., Francomano, M., & Mantovani, L. (1998) · Contact Dermatitis · doi:10.1111/j.1600-0536.1998.tb05764.x · Cited by 175
Research works printed but not linked: 13
- Digestive and Liver Diseases, 34, S68
- European Journal of Dermatology, 20, 731
- Journal of the Society of Cosmetic Chemists, 29, 573
- Journal of Cosmetic Science, 56, 153
- Journal of Japanese Cosmetic Science Society, 23, 163
- European Journal of Dermatology, 18, 504
- News in Physiological Sciences, 16, 33
- Archives of Dermatology, 139, 1479
- Stress, pathologie et immunité
- Journal of the Society of Cosmetic Chemists, 32, 175
- American Journal of Pathology, 131, 171
- IFSCC Magazine, 6, 303
- Pharmacological Reports, 58, 13
Cited by
Sorted by citations
The gut microbiome as a major regulator of the gut-skin axis
Salem, I., Ramser, A., Isham, N., & Ghannoum, M. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01459 · Cited by 707
Pessemier, B. D., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021) · Microorganisms · doi:10.3390/microorganisms9020353 · Cited by 689
How Probiotics Affect the Microbiota
Wieërs, G., Belkhir, L., Enaud, R., Leclercq, S., de Foy, J.-M. P., Dequenne, I., de Timary, P., & Cani, P. D. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00454 · Cited by 557
The microbiome in patients with atopic dermatitis
Paller, A. S., Kong, H. H., Seed, P., Naik, S., Scharschmidt, T. C., Gallo, R. L., Luger, T., & Irvine, A. D. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.11.015 · Cited by 525
The gut-skin axis in health and disease: A paradigm with therapeutic implications
O'Neill, C. A., Monteleone, G., McLaughlin, J. T., & Paus, R. (2016) · BioEssays · doi:10.1002/bies.201600008 · Cited by 449
Metadata
- Authors
- Gueniche, A., Philippe, D., Bastien, P., Reuteler, G., Blum, S., Castiel-Higounenc, I., Breton, L., & Benyacoub, J.
- Affiliations
- L’Oréal Research and Innovation, 1 avenue Eugène shueller, 93 601 Aulnay sous Bois, France
- Nestlé (Switzerland) (CH)
- L'Oréal (France) (FR)
- Venue
- Beneficial Microbes
- Publisher
- Walter de Gruyter GmbH
- Published
- 2014-06-01
- Volume
- 5
- Issue
- 2
- Pages
- 137-145
- ISSN
- 1876-2883 (ISSN-L)
- 1876-2891
- OpenAlex
- W2104922674
- Cited by
- 114
- References
- 35
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 17 · 2021: 20 · 2020: 14 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 1 · 2014: 3
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Beneficial Microbes (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- probiotics, sensitive skin, skin barrier function, transepidermal water loss, oral supplementation, neurogenic inflammation, dry skin, skin roughness
- MeSH terms
- Administration, Oral, Capsaicin, Dehydration, Dermatitis, Double-Blind Method, Humans, Lactobacillus, Placebos, Skin Diseases, Skin Physiological Phenomena, Treatment Outcome, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
