Antimicrobial, antioxidant, anticancer activity and phytochemical analysis of the red alga, laurencia papillosa
Abstract
Background and Objective: Marine macro-algae contain bioactive compounds and can produce a great variety of secondary metabolites useful to human health.The present study was meant to evaluate the biological activities of extracts from the red alga, Laurencia papillosa (L.papillosa).Materials and Methods: The dichloromethane, dichloromethane:methanol (1:1 v/v), methanol and water were used to obtain the algal extract.The antimicrobial activity of the different extracts was evaluated against gram-positive bacteria (Staphylococcus aureus (S. aureus), Staphylococcus saprophyticus and Streptococcus agaloctiae) and gram-negative bacteria (Escherichia coli (E.coli), Pseudomonas aeruginosa (P.aeruginosa) and Proteus mirabilis (P.mirabilis)) and two fungal strains (Candida albicans and Candida tropicalis (C.tropicalis)) by the well diffusion method.The algal extract was assayed for DPPH radical scavenging activity and MTT cell viability using HCT-116 colon cancer.The phytochemical composition of L. papillosa was studied.The FT-IR and GC-MS analysis were performed for the most effective algal extract.Results: The dichloromethane:methanol (1:1) extract revealed a wide range of antimicrobial activity against tested pathogens, which mostly inhibited the growth of P. aeruginosa, S. aureus, C. tropicalis, E. coli and P. mirabilis with inhibition zones range of 13-15 mm.The algal extracts exhibited bactericidal effect against the tested strains at the ratio of MBC/MIC >2.0.Among the algal extracts, dichloromethane: methanol (1:1) exhibited the highest antioxidant and anticancer activities with a very low IC 50 (110.8and 196 µg mLG 1 , respectively).The pigments, protein, carbohydrates, lipid, total phenolic, flavonoid and tannin contents of alga were assayed.The FTIR analysis of extract revealed the presence of alcohols, phenols, ester and alkanes.The results indicated the presence of long chain unsaturated and saturated fatty acids with the dominance of palmitic acid (53.3%).Conclusion: The results indicated that L. papillosa contains different biologically active compounds and can act as a promising antioxidant, antimicrobial, anticancer agents and may represent an application in the therapeutic uses.
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Seaweed antioxidant capacity in vitro is attributed to the presence of new antioxidant compounds like carotenoids, certain polysaccharides, and polyphenols, which show scavenger activity and can neutralize reactive oxygen species through their own oxidation.
“Different researches have demonstrated seaweed antioxidant capacity in vitro, attributed to the presence of new antioxidant compounds like carotenoids, certain polysaccharides, and polyphenols, which show scavenger activity, being able to neutralize those reactive oxygen species through their own oxidation, since their affinity to those oxidative compounds is very high [56,68,80,81,82,83,84,85].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [56]
L. papillosa contains bioactive compounds that could serve as promising potential antioxidant, antimicrobial, and anticancer agents.
“L. papillosa algae was also studied and the conclusion was that it contains some bioactive compounds that could serve as a promising potential antioxidant, antimicrobial, and anticancer agents [56].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [56]
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- Authors
- Omar, H., Al-Judaibi, A., & El-Gendy, A.
- Affiliations
- King Abdulaziz University (SA)
- Venue
- International Journal of Pharmacology
- Publisher
- IMR Press
- Published
- 2018-05-01
- Volume
- 14
- Issue
- 4
- Pages
- 572-583
- ISSN
- 1811-7775 (ISSN-L)
- OpenAlex
- W2801679037
- Cited by
- 31
- References
- 43
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 4 · 2020: 4 · 2019: 4
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmacology (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Laurencia papillosa, red algae, seaweed, antimicrobial activity, antioxidant activity, anticancer activity, HCT-116 colon cancer cells, DPPH radical scavenging, phytochemical composition, fatty acid composition, palmitic acid, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans
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