Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells

Hyun, Jae-Hee; Kim, Sang-Cheol; Kang, Jung-Il; Kim, Min-Kyoung; Boo, Hye-Jin; Kwon, Jung-Mi; Koh, Young-Sang; Hyun, Jin-Won; Park, Deok-Bae; Yoo, Eun-Sook; Kang, Hee-Kyoung

doi:10.1248/bpb.32.1760

Cited by 150Seaweed-derived Bioactive CompoundsCell death mechanisms and regulationEchinoderm biology and ecology

Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells

Open access

Hyun, Jae-Hee, Kim, Sang-Cheol, Kang, Jung-Il, Kim, Min-Kyoung, Boo, Hye-Jin, Kwon, Jung-Mi, Koh, Young-Sang, Hyun, Jin-Won +3 more·2009·Biological & Pharmaceutical Bulletin

DOI 10.1248/bpb.32.1760

Open this paper in CoChat — free account Open PDF

Abstract

The antitumor activity of fucoidan from Fucus vesiculosus was investigated in human colon carcinoma cells. The crude fucoidan, a polysaccharide composed predominantly of sulfated fucose, markedly inhibited the growth of HCT-15 cells (human colon carcinoma cells). After HCT-15 cells were treated with fucoidan, several apoptotic events such as DNA fragmentation, chromatin condensation and increase of the population of sub-G1 hypodiploid cells were observed. In the mechanism of fucoidan-induced apoptosis, we examined changes in Bcl-2 and Bax protein expression levels and activation of caspases. Fucoidan decreased Bcl-2 expression, whereas the expression of Bax was increased in a time-dependent manner compared to the control. In addition, the active forms of caspase-9 and caspase-3 were increased, and the cleavage of poly(ADP-ribose) polymerase (PARP), a vital substrate of effector caspase, was observed. Furthermore, the induction of apoptosis was also accompanied by a strong activation of extracellular signal-regulated kinase (ERK) and p38 kinase and an inactivation of phosphatidylinositol 3-kinase (PI3K)/Akt in a time-dependent manner. These findings provide evidence demonstrating that the pro-apoptotic effect of fucoidan is mediated through the activation of ERK, p38 and the blocking of the PI3K/Akt signal pathway in HCT-15 cells. These data support the hypothesis that fucoidan may have potential in colon cancer treatment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1248/bpb.32.1760

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Fucoidans induce apoptosis of HT-29, HCT116, HCT-15 colon cancer cells, MCF-7, SK-Mel-28, T-47D, and human promyeloid leukemic cell lines.
“Fucoidans were shown to induce apoptosis of some other cancer cells, for example HT-29, HCT116, and HCT-15 human colon cancer cells [42,43] as well as MCF-7 (breast adenocarcinoma) [44], melanoma SK-Mel-28, breast cancer T-47D [45], and human promyeloid leukemic cell lines [46].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [42]
Pro-apoptotic effect of fucoidan from F. vesiculosus was mediated by activation of ERKs, p38 and blocking of PI3K/Akt signaling in HCT-15 cells.
“Another group reported that the pro-apoptotic effect of fucoidan from F. vesiculosus was mediated by the activation of ERKs, p38 and by the blocking of PI3K/Akt signaling pathway in HCT-15 cells [42].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [42]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003 · see citing works
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,037 · see citing works
The MAPK signaling cascade
Seger, R., & Krebs, E. G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.9.7601337 · Cited by 3,631 · see citing works
The protein kinase B/Akt signalling pathway in human malignancy
Nicholson, K. M., & Anderson, N. G. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00271-6 · Cited by 1,631 · see citing works
Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.
Oberhammer, F., Wilson, J. W., Dive, C., Morris, I. D., Hickman, J. A., Wakeling, A. E., Walker, P. R., & Sikorska, M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06042.x · Cited by 1,130 · see citing works
A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026 · see citing works
A revised structure for fucoidan may explain some of its biological activities.
Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531 · see citing works
Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities
Koyanagi, S., Tanigawa, N., Nakagawa, H., Soeda, S., & Shimeno, H. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01478-8 · Cited by 479 · see citing works
Unravelling the activation mechanisms of protein kinase B/Akt
Scheid, M. P., & Woodgett, J. R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00562-3 · Cited by 389 · see citing works
Development of anticancer drugs targeting the MAP kinase pathway
Sebolt–Leopold, J. S. (2000) · Oncogene · doi:10.1038/sj.onc.1204083 · Cited by 321 · see citing works
Fucoidan induces apoptosis of human HS-Sultan cells accompanied by activation of caspase-3 and down-regulation of ERK Pathways
Aisa, Y., Miyakawa, Y., Nakazato, T., Shibata, H., Saito, K., Ikeda, Y., & Kizaki, M. (2005) · American Journal of Hematology · doi:10.1002/ajh.20182 · Cited by 307 · see citing works
A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. P., & Colliec‐Jouault, S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00314-1 · Cited by 304 · see citing works
Stress-Responsive Protein Kinases in Redox-Regulated Apoptosis Signaling
Matsuzawa, A., & Ichijo, H. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.472 · Cited by 283 · see citing works
Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells
Sweeney, E. A., Lortat‐Jacob, H., Priestley, G. V., Nakamoto, B., & Papayannopoulou, T. (2002) · Blood · doi:10.1182/blood.v99.1.44 · Cited by 223 · see citing works
Antitumor Active Fucoidan from the Brown Seaweed,Umitoranoo(Sargassum thunbergii)
Zhuang, C., Itoh, H., Mizuno, T., & Ito, H. (1995) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.59.563 · Cited by 184 · see citing works
Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
Hong, Y.-S., Ham, Y. A., Choi, J.-H., & Kim, J. (2000) · Experimental & Molecular Medicine · doi:10.1038/emm.2000.22 · Cited by 183 · see citing works
Diallyl disulfide induces apoptosis of human colon tumor cells
Sundaram, S. G., & Milner, J. A. (1996) · Carcinogenesis · doi:10.1093/carcin/17.4.669 · Cited by 175 · see citing works
Signal transduction events elicited by cancer prevention compounds
Kong, A. T., Yu, R., Hebbar, V., Chen, C., Owuor, E. D., Hu, R., Ee, P. L. R., & Mandlekar, S. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00182-8 · Cited by 169 · see citing works
Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells11Abbreviations: Ac-DEVD-CHO, N-acetyl-Asp-Glu-Val-Asp-CHO (aldehyde); Ac-DEVD-AFC, N-acetyl-Asp-Glu-Val-Asp-AFC (7-amino-4-trifluoromethyl-coumaine); Ac-YVAD-CHO, N-acetyl-Tyr-Val-Ala-Asp-CHO (aldehyde); CAD, caspase-activated deoxyribonuclease; CM-H2DCFDA, 5-(and -6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate; DADS, diallyl disulfide; FACS, fluorescence-activated cell sorter; FITC, fluorescein isothiocyanate; ICAD, inhibitor of caspase-activated deoxyribonuclease; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NAC, N-acetylcysteine; PARP, poly(ADP-ribose) polymerase; PI, propidium iodide; and ROI, reactive oxygen intermediate.
Kwon, K., Yoo, S.-J., Ryu, D., Yang, J., Rho, H., Kim, J., Park, J., Kim, H.-R., & Park, B. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00860-7 · Cited by 162 · see citing works
Demystifying SP cell purification: viability, yield, and phenotype are defined by isolation parameters
Montanaro, F., Liadaki, K. N., Schienda, J., Flint, A., Gussoni, E., & Kunkel, L. M. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.010 · Cited by 158 · see citing works
Anti-proliferative activity of oversulfated fucoidan from commercially cultured Cladosiphon okamuranus TOKIDA in U937 cells
Teruya, T., Konishi, T., Uechi, S., Tamaki, H., & Tako, M. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.02.010 · Cited by 156 · see citing works
In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance
Shi, Y., & Gaestel, M. (2002) · Biological Chemistry · doi:10.1515/bc.2002.173 · Cited by 154 · see citing works
The Role of NK cells in Antitumor Activity of Dietary Fucoidan from Undaria pinnatifida Sporophylls (Mekabu)
Maruyama, H., Tamauchi, H., Iizuka, M., & Nakano, T. (2006) · Planta Medica · doi:10.1055/s-2006-951703 · Cited by 151 · see citing works
Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells
Pettersson, M., Jernberg‐Wiklund, H., Larsson, L., Sundström, C., Givol, I., Tsujimoto, Y., & Nilsson, K. (1992) · Blood · doi:10.1182/blood.v79.2.495.495 · Cited by 132 · see citing works
Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms
Frenette, P. S., & Weiss, L. A. (2000) · Blood · doi:10.1182/blood.v96.7.2460 · Cited by 131 · see citing works
ANTICOAGULANT FUCOIDAN FRACTIONS FROM FUCUS VESICULOSUS INDUCE PLATELET ACTIVATION IN VITRO
Dürig, J., Bruhn, T., Zurborn, K. ‐., Gutensohn, K., Bruhn, H. D., & Béress, L. (1997) · Thrombosis Research · doi:10.1016/s0049-3848(97)00037-6 · Cited by 115 · see citing works
Antiviral activity of Undaria pinnatiﬁda against herpes simplex virus
Thompson, K. D., & Dragar, C. (2004) · Phytotherapy Research · doi:10.1002/ptr.1487 · Cited by 85 · see citing works
Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells
Uesato, S., Kitagawa, Y., Kamishimoto, M., Kumagai, A., Hori, H., & Nagasawa, H. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00571-7 · Cited by 83 · see citing works
Bcl‐XL is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy
Heere‐Ress, E., Thallinger, C., Lucas, T., Schlagbauer‐Wadl, H., Wacheck, V., Monia, B. P., Wolff, K. S., Pehamberger, H., & Jansen, B. (2002) · International Journal of Cancer · doi:10.1002/ijc.10248 · Cited by 78 · see citing works
Induction of Apoptosis by the Anti-Tubulin Drug Colcemid: Relationship of Mitotic Checkpoint Control to the Induction of Apoptosis in HeLa S3 Cells
Sherwood, S. W., Sheridan, J. P., & SCHIMKE, R. T. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1354 · Cited by 63 · see citing works
Antithrombin Activity of an Algal Polysaccharide
Trento, F., Cattaneo, F., Pescador, R., Porta, R., & Ferro, L. (2001) · Thrombosis Research · doi:10.1016/s0049-3848(01)00264-x · Cited by 59 · see citing works
Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells
Tan, H., Ling, H. Y., He, J., Yi, L., Zhou, J., Lin, M., & Su, Q. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-001-1227-0 · Cited by 32 · see citing works
Catalytic synthesis of N-alkylacrylamide from acrylonitrile and 1-adamantanol with a novel solid heteropoly compound
Matsuda, H., & Okuhara, T. (1998) · Catalysis Letters · doi:10.1023/a:1019085818706 · Cited by 20 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Pearson G., Robinson F., Beers Gibson T., Xu B., Karandikar M., Berman K., Cobb M. H., Endocr. Rev., 22, 153-183 (2001).

Sorted by citations

Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review
Yu, Y., Shen, M., Song, Q., & Xie, J. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.12.009 · Cited by 1,425 · see citing works
Anticancer polysaccharides from natural resources: A review of recent research
Zong, A., Cao, H., & Wang, F. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.07.026 · Cited by 667 · see citing works
Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies
Wang, Y., Xing, M., Cao, Q., Ji, A., Liang, H., & Song, S. (2019) · Marine Drugs · doi:10.3390/md17030183 · Cited by 514 · see citing works
Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential
Atashrazm, F., Lowenthal, R. M., Woods, G. M., Holloway, A. F., & Dickinson, J. L. (2015) · Marine Drugs · doi:10.3390/md13042327 · Cited by 361 · see citing works
Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer
Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S.-K. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.06.030 · Cited by 340 · see citing works
Self-citation
Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms
van Weelden, G. H., Bobiński, M. S., Okła, K., van Weelden, W. J., Romano, A., & Pijnenborg, J. M. A. (2019) · Marine Drugs · doi:10.3390/md17010032 · Cited by 336 · see citing works
Fucoidans Disrupt Adherence ofHelicobacter pylorito AGS CellsIn Vitro
Chua, E. G., Verbrugghe, P., Perkins, T. T., & Tay, C. Y. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/120981 · Cited by 276 · see citing works
Fucoidan present in brown algae induces apoptosis of human colon cancer cells
Kim, E. J., Park, S. Y., Lee, J.-Y., & Park, J. H. Y. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-96 · Cited by 275 · see citing works
Isolation of fucoidan from Sargassum polycystum brown algae: Structural characterization, in vitro antioxidant and anticancer activity
Palanisamy, S., Vinosha, M., Marudhupandi, T., Rajasekar, P., & Prabhu, N. M. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.03.182 · Cited by 273 · see citing works
Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo
Ale, M. T., Maruyama, H., Tamauchi, H., Mikkelsen, J. D., & Meyer, A. S. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2011.05.009 · Cited by 267 · see citing works
Brown Algae Carbohydrates: Structures, Pharmaceutical Properties, and Research Challenges
Li, Y., Zheng, Y., Zhang, Y., Yang, Y., Wang, P., Imre, B., Wong, A. C. Y., Hsieh, Y. S. Y., & Wang, D. (2021) · Marine Drugs · doi:10.3390/md19110620 · Cited by 232 · see citing works
A review about the development of fucoidan in antitumor activity: Progress and challenges
Wu, L., Sun, J., Su, X., Yu, Q., Yu, Q., & Zhang, P. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.08.005 · Cited by 214 · see citing works
Phycochemical Constituents and Biological Activities of Fucus spp.
Catarino, M. D., Silva, A. M. S., & Cardoso, S. M. (2018) · Marine Drugs · doi:10.3390/md16080249 · Cited by 212 · see citing works
A State of the Art Review on the Cultivation of Algae for Energy and Other Valuable Products: Application, Challenges, and Opportunities
Kumar, B. R., Mathimani, T., Sudhakar, M. P., Rajendran, K., Nizami, A.-S., Brindhadevi, K., & Pugazhendhi, A. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2020.110649 · Cited by 208 · see citing works
Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer
Pádua, D., Rocha, E., Gargiulo, D., & Ramos, A. A. (2015) · Phytochemistry Letters · doi:10.1016/j.phytol.2015.09.007 · Cited by 207 · see citing works
Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works
Anticancer and Antitumor Potential of Fucoidan and Fucoxanthin, Two Main Metabolites Isolated from Brown Algae
Moghadamtousi, S. Z., Karimian, H., Khanabdali, R., Razavi, M., Firoozinia, M., Zandi, K., & Kadir, H. A. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/768323 · Cited by 182 · see citing works
Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway
Yang, L., Wang, P., Wang, H., Li, Q., Teng, H., Liu, Z., Yang, W., Hou, L., & Zou, X. (2013) · Marine Drugs · doi:10.3390/md11061961 · Cited by 178 · see citing works
Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways
Zhang, Z., Teruya, K., Eto, H., & Shirahata, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027441 · Cited by 167 · see citing works
Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field
Barbosa, A. I., Coutinho, A. J., Lima, S. A. C., & Reis, S. (2019) · Marine Drugs · doi:10.3390/md17120654 · Cited by 166 · see citing works
Anticancer activity of seaweeds
Gutiérrez, A. G., Juárez-Portilla, C. J., Olivares-Bañuelos, T. N., & Zepeda, R. C. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.10.019 · Cited by 153 · see citing works
Anticancer Effects of Different Seaweeds on Human Colon and Breast Cancers
Moussavou, G., Kwak, D. H., Obiang-Obonou, B., Ogandaga, C. A. M., Dinzouna-Boutamba, S.-D., Lee, D., Pissibanganga, O. G. M., Ko, K., Seo, J. W., & Choo, Y. K. (2014) · Marine Drugs · doi:10.3390/md12094898 · Cited by 150 · see citing works
Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells
Zhang, Z., Teruya, K., Yoshida, T., Eto, H., & Shirahata, S. (2013) · Marine Drugs · doi:10.3390/md11010081 · Cited by 147 · see citing works
An Unfractionated Fucoidan from Ascophyllum nodosum: Extraction, Characterization, and Apoptotic Effects in Vitro
Foley, S. A., Szegezdi, E., Mulloy, B., Samali, A., & Tuohy, M. G. (2011) · Journal of Natural Products · doi:10.1021/np200124m · Cited by 142 · see citing works
Cell Wall Polysaccharides of Marine Algae
Synytsya, A., Čopı́ková, J., Kim, W. J., & Park, Y. I. (2015) · Springer eBooks · doi:10.1007/978-3-642-53971-8_22 · Cited by 142 · see citing works
The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
Boo, H., Hong, J.-Y., Kim, S.-C., Kang, J.-I., Kim, M., Kim, E., Hyun, J. W., Koh, Y., Yoo, E.-S., Kwon, J.-M., et al. (2013) · Marine Drugs · doi:10.3390/md11082982 · Cited by 138 · see citing works
Self-citation
Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.)
Choi, J., Synytsya, A., Capek, P., Bleha, R., Pohl, R., & Park, Y. I. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.03.043 · Cited by 133 · see citing works
Cordyceps sinensis polysaccharide inhibits colon cancer cells growth by inducing apoptosis and autophagy flux blockage via mTOR signaling
Qi, W., Zhou, X., Wang, J., Zhang, K., Zhou, Y., Chen, S., Nie, S., & Xie, M. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116113 · Cited by 131 · see citing works
Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei
Thinh, P. D., Menshova, R. V., Ermakova, S. P., Anastyuk, S. D., Ly, B., & Николаевна, З. Т. (2013) · Marine Drugs · doi:10.3390/md11051456 · Cited by 129 · see citing works
The fucoidans from brown algae of Far-Eastern seas: Anti-tumor activity and structure-function relationship
Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.065 · Cited by 117 · see citing works
Antiproliferative activity of fucoidan was associated with the induction of apoptosis and autophagy in AGS human gastric cancer cells
Park, H. S., Kim, G., Nam, T., Deuk Kim, N., & Hyun Choi, Y. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02099.x · Cited by 116 · see citing works
Fucoidan from Undaria pinnatifida Induces Apoptosis in A549 Human Lung Carcinoma Cells
Boo, H., Hyun, J., Kim, S., Kang, J., Kim, M., Sun-Yeou, K., Cho, H., Yoo, E.-S., & Kang, H. (2011) · Phytotherapy Research · doi:10.1002/ptr.3489 · Cited by 115 · see citing works
Self-citation
Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer
IKEGUCHI, M., YAMAMOTO, M., ARAI, Y., MAETA, Y., ASHIDA, K., KATANO, K., MIKI, Y., & KIMURA, T. (2011) · Oncology Letters · doi:10.3892/ol.2011.254 · Cited by 113 · see citing works
Investigation of antioxidant and anticancer potential of fucoidan from Sargassum polycystum
Palanisamy, S., Vinosha, M., Manikandakrishnan, M., Anjali, R., Rajasekar, P., Marudhupandi, T., Manikandan, R., Vaseeharan, B., & Prabhu, N. M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.04.163 · Cited by 111 · see citing works
In vitro anticancer activity of fucoidan extracted from Sargassum cinereum against Caco-2 cells
Narayani, S. S., Saravanan, S., Jaganathan, R., Ramasamy, M. S., & Chitra, J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.07.127 · Cited by 105 · see citing works
Modulation of Multiple Signaling Pathways of the Plant-Derived Natural Products in Cancer
Sun, L., Zhou, W. X., Zhang, H., Guo, Q., Yang, W., Li, B.-J., Sun, Z., Gao, S., & Cui, R. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01153 · Cited by 102 · see citing works
Fungi and Algae as Sources of Medicinal and Other Biologically Active Compounds: A Review
Ślusarczyk, J., Adamska, E., & Czerwik-Marcinkowska, J. (2021) · Nutrients · doi:10.3390/nu13093178 · Cited by 99 · see citing works
Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed dictyopteris delicatula
Magalhaes, K. D., Costa, L. S., Fidelis, G. P., Oliveira, R. M., Nobre, L. T. D. B., Dantas-Santos, N., Camara, R. B. G., Albuquerque, I. R. L., Cordeiro, S. L., Sabry, D. A., et al. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12053352 · Cited by 97 · see citing works
The potential of seaweed as a source of drugs for use in cancer chemotherapy
Murphy, C., Hotchkiss, S., Worthington, J., & McKEOWN, S. R. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0245-2 · Cited by 92 · see citing works
Antioxidant activity and growth inhibition of human colon cancer cells by crude and purified fucoidan preparations extracted from Sargassum cristaefolium
Wang, C.-Y., Wu, T.-C., Hsieh, S., Tsai, Y., Yeh, C.-W., & Huang, C.-Y. (2015) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2015.07.002 · Cited by 91 · see citing works
Fucoidans from Brown Alga Fucus evanescens: Structure and Biological Activity
Menshova, R. V., Shevchenko, N. M., Imbs, T. I., Zvyagintseva, T. N., Malyarenko, O. S., Zaporoshets, T. S., Besednova, N. N., & Ermakova, S. P. (2016) · Frontiers in Marine Science · doi:10.3389/fmars.2016.00129 · Cited by 85 · see citing works
Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family
Park, H. J., Hwang, H. J., Kim, G., Cha, H., Kim, W., Kim, N., Yoo, Y. H., & Choi, Y. H. (2013) · Marine Drugs · doi:10.3390/md11072347 · Cited by 80 · see citing works
Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
Jin, J., Yadav, D., Madhwani, K., Puranik, N., Chavda, V. K., & Song, M. (2022) · Molecules · doi:10.3390/molecules27186032 · Cited by 78 · see citing works
Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells
Zhang, Z., Teruya, K., Hiroshi, E. T. O., & Shirahata, S. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120631 · Cited by 77 · see citing works
Fucoidan Inhibits the Proliferation of Human Urinary Bladder Cancer T24 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis
Park, H., Kim, G., Moon, S., Kim, W., Yoo, Y. H., & Choi, Y. H. (2014) · Molecules · doi:10.3390/molecules19055981 · Cited by 77 · see citing works
Fucoidan induces G1 phase arrest and apoptosis through caspases-dependent pathway and ROS induction in human breast cancer MCF-7 cells
Banafa, A. M., Roshan, S., Liu, Y., Chen, H., Chen, M., Yang, G., & He, G. (2013) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-013-1186-8 · Cited by 74 · see citing works
Ultrasound-assisted extraction of polysaccharides from brown alga Fucus evanescens. Structure and biological activity of the new fucoidan fractions.
Hmelkov, A. B., Николаевна, З. Т., Шевченко, Н. М., Rasin, A. B., & Ermakova, S. P. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1342-9 · Cited by 74 · see citing works
Seaweeds in Human Health
Déléris, P., Nazih, H., & Bard, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802772-1.00010-5 · Cited by 73 · see citing works
Fucoidan Inhibited 4T1 Mouse Breast Cancer Cell Growth In Vivo and In Vitro Via Downregulation of Wnt/β-Catenin Signaling
Xue, M., Ge, Y., Zhang, J., Liu, Y., Wang, Q., Hou, L., & Zheng, Z. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.757628 · Cited by 68 · see citing works
Efficiency of brown seaweed ( Sargassum longifolium ) polysaccharides encapsulated in nanoemulsion and nanostructured lipid carrier against colon cancer cell lines HCT 116
Infant, S. S., Jayakumar, K., Mukherjee, A., & Chandrasekaran, N. (2018) · RSC Advances · doi:10.1039/c8ra02616e · Cited by 68 · see citing works
Fucoidan-based nanomaterial and its multifunctional role for pharmaceutical and biomedical applications
Iqbal, M. W., Riaz, T., Mahmood, S., Bilal, M., Manzoor, M. F., Qamar, S. A., & Qi, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2106182 · Cited by 61 · see citing works
Fucoidan Induces ROS‐Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity via Inactivation of the PI3K/Akt Signaling Pathway
Han, M. H., Lee, D., Jeong, J., Hong, S. H., Choi, I., Cha, H., Kim, S., Kim, H., Park, C., Kim, G., et al. (2016) · Drug Development Research · doi:10.1002/ddr.21367 · Cited by 61 · see citing works
Self-citation
Fucoidan from marine brown algae attenuates pancreatic cancer progression by regulating p53 – NFκB crosstalk
Delma, C. R., Somasundaram, S. T., Srinivasan, G. P., Raviprakash, N., Manna, S. K., Natarajan, M., & Aravindan, N. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.112078 · Cited by 59 · see citing works
Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells
Ramos, S., Rodríguez‐Ramiro, I., Martín, M. Á., Goya, L., & Bravo, L. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.09.007 · Cited by 58 · see citing works
PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth
Vishchuk, O. S., Sun, H., Wang, Z., Ermakova, S. P., Xiao, J., Lu, T., Xue, P., Николаевна, З. Т., Xiong, H., Shao, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7708 · Cited by 57 · see citing works
Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines
Isnansetyo, A., Lutfia, F. N. L., Nursid, M., Trijoko, T., & Susidarti, R. A. (2016) · Pharmacognosy Journal · doi:10.5530/pj.2017.1.3 · Cited by 52 · see citing works
Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
Silva Costa, L., Silva Telles, C. B., Medeiros Oliveira, R., Duarte Barreto Nobre, L. T., Dantas-Santos, N., Barros Gomes Camara, R., Santana Santos Pereira Costa, M., Almeida-Lima, J., Melo-Silveira, R. F., Lopes Albuquerque, I. R., et al. (2011) · Marine Drugs · doi:10.3390/md9040603 · Cited by 51 · see citing works
The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines
Min, E., Kim, I., LEE, J., Kim, E., Choi, Y., & Nam, T. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2426 · Cited by 51 · see citing works
Fucoidan Promotes Apoptosis and Inhibits EMT of Breast Cancer Cells
He, X., Xue, M., Jiang, S., Li, W., Yu, J., & Xiang, S. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00777 · Cited by 51 · see citing works
The Effect of Sulfated (1→3)-α-l-Fucan from the Brown Alga Saccharina cichorioides Miyabe on Resveratrol-Induced Apoptosis in Colon Carcinoma Cells
Vishchuk, O., Ermakova, S., & Zvyagintseva, T. (2013) · Marine Drugs · doi:10.3390/md11010194 · Cited by 50 · see citing works
Fucoidan Suppresses the Growth of Human Acute Promyelocytic Leukemia Cells In Vitro and In Vivo
Atashrazm, F., Lowenthal, R. M., Woods, G. M., Holloway, A. F., Karpiniec, S. S., & Dickinson, J. L. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25119 · Cited by 48 · see citing works
Effects of polysaccharides derived from Orostachys japonicus on induction of cell cycle arrest and apoptotic cell death in human colon cancer cells
Ryu, D., Baek, G.-O., Kim, E., Kim, K., & Lee, D. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.11.750 · Cited by 48 · see citing works
6-Cinnamoyl-4-arylaminothienopyrimidines as highly potent cytotoxic agents: Design, synthesis and structure-activity relationship studies
Toolabi, M., Moghimi, S., Bakhshaiesh, T. O., Salarinejad, S., Aghcheli, A., Hasanvand, Z., Nazeri, E., Khalaj, A., Esmaeili, R., & Foroumadi, A. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111786 · Cited by 46 · see citing works
Seaweed sulfated polysaccharides and their medicinal properties
Zaitseva, O. O., Sergushkina, M. I., Khudyakov, A. N., Polezhaeva, T. V., & Solomina, O. N. (2022) · Algal Research · doi:10.1016/j.algal.2022.102885 · Cited by 44 · see citing works
High cytotoxicity and anti-proliferative activity of algae extracts on an in vitro model of human hepatocellular carcinoma
Alves, C., Pintéus, S., Horta, A., & Pedrosa, R. (2016) · SpringerPlus · doi:10.1186/s40064-016-2938-2 · Cited by 44 · see citing works
Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells
Kim, I., Kwon, M., & Nam, T. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6520 · Cited by 44 · see citing works
Characterization and Cytotoxic Activity of Microwave-Assisted Extracted Crude Fucoidans from Different Brown Seaweeds
Zayed, A., Finkelmeier, D., Hahn, T., Rebers, L., Shanmugam, A., Burger‐Kentischer, A., & Ulber, R. (2023) · Marine Drugs · doi:10.3390/md21010048 · Cited by 43 · see citing works
Fucoidan Inhibition of Osteosarcoma Cells is Species and Molecular Weight Dependent
Gupta, D., Silva, M., Radziun, K., Martinez, D. C., Hill, C. J., Marshall, J., Hearnden, V. L., Puertas-Mejía, M. A., & Reilly, G. C. (2020) · Marine Drugs · doi:10.3390/md18020104 · Cited by 43 · see citing works
Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer
Zhang, W., Hwang, J., Yadav, D., An, E., Kwak, M., Lee, P. C.-W., & Jin, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179125 · Cited by 42 · see citing works
Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells
Kim, I., & Nam, T. (2018) · Oncology Reports · doi:10.3892/or.2018.6193 · Cited by 40 · see citing works
Epicatechin Gallate Induces Cell Death via p53 Activation and Stimulation of p38 and JNK in Human Colon Cancer SW480 Cells
Cordero‐Herrera, I., Martín, M. Á., Bravo, L., Goya, L., & Ramos, S. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.795981 · Cited by 38 · see citing works
Investigation of antioxidant and anticancer potential of fucoidan (in-vitro & in-silico) from brown seaweed Padina boergesenii
Ragunath, C., & Ramasubramanian, V. (2024) · Algal Research · doi:10.1016/j.algal.2024.103442 · Cited by 35 · see citing works
Anticancer Effects of Fucoidan
Kalimuthu, S., & Kim, S. (2014) · Advances in food and nutrition research · doi:10.1016/b978-0-12-800269-8.00011-7 · Cited by 35 · see citing works
Self-citation
Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death
Choi, J., Lee, J., Kim, S. C., You, S., Lee, C. W., Shin, J., & Park, Y. I. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.12.001 · Cited by 34 · see citing works
Self-citation
Are Bioactive Molecules from Seaweeds a Novel and Challenging Option for the Prevention of HPV Infection and Cervical Cancer Therapy?—A Review
Moga, M., Dima, L., Bălan, A., Blidaru, A., Dimienescu, O. G., Podașcă, C., & Toma, S. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020629 · Cited by 34 · see citing works
Structures and anti-melanoma activities of two polysaccharides from Angelica sinensis (Oliv.) Diels
Zhang, T., Liu, W., Fu, C.-Y., Qiao, Y.-H., Xiao, K., Ren, L., Feng, C., Wang, J., Yang, W., Li, X., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.021 · Cited by 34 · see citing works
Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells
Zhang, H., Qian, Y., Liu, Y., Li, G., Cui, P., Zhu, Y., Ma, H., Ji, X., Guo, S., & Hisamitsu, T. (2012) · 中医杂志：英文版 · doi:10.1016/s0254-6272(13)60081-3 · Cited by 33 · see citing works
Fucoidans: The importance of processing on their anti-tumoral properties
Torres, M. D., Flórez-Fernández, N., Simón‐Vázquez, R., Giménez-Abián, J. F., Díaz, J. F., González‐Fernández, Á., & Domı́nguez, H. (2019) · Algal Research · doi:10.1016/j.algal.2019.101748 · Cited by 33 · see citing works
Fucoidan-Supplemented Diet Potentiates Immune Checkpoint Blockage by Enhancing Antitumor Immunity
Yang, J., Yang, X., Pan, W., Wang, M., Lu, Y., Zhang, J., Fang, Z., Zhang, X., Ji, Y., Bei, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.733246 · Cited by 33 · see citing works
A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis
Ahn, G., Lee, W., Kim, K., Lee, J., Heo, S., Kang, N., Lee, S., Ahn, C., & Jeon, Y. (2015) · EXCLI journal · doi:10.17179/excli2014-676 · Cited by 32 · see citing works
Antimicrobial, antioxidant, anticancer activity and phytochemical analysis of the red alga, laurencia papillosa
Omar, H., Al-Judaibi, A., & El-Gendy, A. (2018) · International Journal of Pharmacology · doi:10.3923/ijp.2018.572.583 · Cited by 31 · see citing works
Antitumor properties of nonstarch polysaccharides: Fucoidans and chitosans
Khotimchenko, Y. S. (2010) · Russian Journal of Marine Biology · doi:10.1134/s1063074010050019 · Cited by 30 · see citing works
Antitumor Effect of a Polypeptide Fraction from Arca subcrenata in Vitro and in Vivo
Hu, X., Song, L., Huang, L., Zheng, Q., & Yu, R. (2012) · Marine Drugs · doi:10.3390/md10122782 · Cited by 30 · see citing works
Fucoidan Does Not Exert Anti-Tumorigenic Effects on Uveal Melanoma Cell Lines
Dithmer, M., Kirsch, A. M., Richert, E., Fuchs, S., Wang, F., Schmidt, H., Coupland, S. E., Roider, J. B., & Klettner, A. (2017) · Marine Drugs · doi:10.3390/md15070193 · Cited by 29 · see citing works
Supplementation of the fermented soy product ImmuBalance™ effectively reduces itching behavior of atopic NC/Tnd mice
Matsuda, A., Tanaka, A., Pan, W., Okamoto, N., Oida, K., Kingyo, N., Amagai, Y., Xia, Y., Jang, H., Nishikawa, S., et al. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.05.011 · Cited by 29 · see citing works
Kahweol induces apoptosis by suppressing BTF3 expression through the ERK signaling pathway in non-small cell lung cancer cells
Jeon, Y., Bang, W., Cho, J. H., Lee, R. H., Kim, S., Kim, M. S., Park, S., Shin, J., Chung, H., Oh, K. B., et al. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3727 · Cited by 29 · see citing works
Self-citation
Associations among dietary seaweed intake, c-MYC rs6983267 polymorphism, and risk of colorectal cancer in a Korean population: a case–control study
Kim, J., Lee, J., Oh, J. H., Chang, H. J., Sohn, D. K., Shin, A., & Kim, J. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02046-w · Cited by 28 · see citing works
Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer.
Alves, C., Pintéus, S., Rodrigues, A. J., Horta, A., & Pedrosa, R. (2018) · PubMed Central · doi:10.4103/pr.pr_151_16 · Cited by 27 · see citing works
Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer
Kalimuthu, S., & Kim, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_7 · Cited by 26 · see citing works
Self-citation
Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells
LEE, H.-E., Choi, E., Shin, J., Lee, S., Park, K., Cho, N., & Cho, S. (2013) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2013.1368 · Cited by 26 · see citing works
Fucoidan affects oral squamous cell carcinoma cell functions in vitro by regulating FLNA‐derived circular RNA
Zhang, N., Gao, L., Ren, W., Li, S., Zhang, D., Song, X., Zhao, C., & Zhi, K. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14190 · Cited by 24 · see citing works
Fucoidan Exerts Anticancer Effects Against Head and Neck Squamous Cell Carcinoma In Vitro
Błaszczak, W., Lach, M., Barczak, W., & Suchorska, W. M. (2018) · Molecules · doi:10.3390/molecules23123302 · Cited by 22 · see citing works
Health Benefits of Bioactive Seaweed Substances
Qin, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813312-5.00009-1 · Cited by 21 · see citing works
The Effect of Fucoidan, a Potential New, Natural, Anti-Neoplastic Agent on Uterine Sarcomas and Carcinosarcoma Cell Lines: ENITEC Collaborative Study
Bobiński, M. S., Okła, K., Bednarek, W., Wawruszak, A., Dmoszyńska‐Graniczka, M., García‐Sanz, P., Wertel, I., & Kotarski, J. (2019) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-019-00534-9 · Cited by 21 · see citing works
Fucoidans: Anticancer Activity and Molecular Mechanisms of Action
Malyarenko, O. S., & Ermakova, S. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809816-5.00010-4 · Cited by 20 · see citing works
Trends in red biotechnology
Deniz, İ., García‐Vaquero, M., & İmamoğlu, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-101023-5.00018-2 · Cited by 20 · see citing works
Imidazo[1,2-a]quinazolines as novel, potent EGFR-TK inhibitors: Design, synthesis, bioactivity evaluation, and in silico studies
Hasanvand, Z., Bakhshaiesh, T. O., Peytam, F., Firoozpour, L., Hosseinzadeh, E., Motahari, R., Moghimi, S., Nazeri, E., Toolabi, M., Momeni, F., et al. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106383 · Cited by 19 · see citing works
Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer
Ikeguchi, M., Saito, H., Miki, Y., & Kimura, T. (2015) · Journal of Cancer Therapy · doi:10.4236/jct.2015.611111 · Cited by 19 · see citing works
Industrial Applications of Macroalgae
Samaraweera, A. M., Vidanarachchi, J. K., & Kurukulasuriya, M. S. (2011) · Wiley eBooks · doi:10.1002/9781119977087.ch33 · Cited by 19 · see citing works
Antitumor and immunostimulating sulfated polysaccharides from brown algae Dictyota caribaea
Assef, A. N. B., da Costa, B. B., Moreira, T. A., do Carmo, L. D., de Souza, T. D. F. G., de Alencar, N. M. N., Alves, A. P. N. N., Cinelli, L. P., & Wilke, D. V. (2021) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2021.100142 · Cited by 18 · see citing works

Fucoidan from Undaria pinnatifida Induces Apoptosis in A549 Human Lung Carcinoma Cells
Boo, H., Hyun, J., Kim, S., Kang, J., Kim, M., Sun-Yeou, K., Cho, H., Yoo, E.-S., & Kang, H. (2011) · Phytotherapy Research · doi:10.1002/ptr.3489 · Cited by 115 · see citing works
Self-citation
Activation of caspase‐8 contributes to fucoidan‐induced apoptosis in HT‐29 human colon cancer cells
Kim, E. J., Park, S., Park, H. S., Hong, J. E., Sin, M. J., Shin, H., Kwon, D. Y., Surh, Y., & Park, J. H. Y. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.5.a50-c
Fucoidan Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma via the p38 MAPK/ERK and PI3K/Akt Signal Pathways
Duan, Y., Li, J., Jing, X., Ding, X., Yu, Y., & Zhao, Q. (2020) · Cancer Management and Research · doi:10.2147/cmar.s243495 · Cited by 66 · see citing works
Fucoidan present in brown algae induces apoptosis of human colon cancer cells
Kim, E. J., Park, S. Y., Lee, J.-Y., & Park, J. H. Y. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-96 · Cited by 275 · see citing works
Open Access
Kim, E. J. (2013)

Authors: Hyun, J.-H., Kim, S.-C., Kang, J.-I., Kim, M.-K., Boo, H.-J., Kwon, J.-M., Koh, Y.-S., Hyun, J.-W., Park, D.-B., Yoo, E.-S., & Kang, H.-K.
Affiliations: Jeju National University (KR)
School of Medicine, Institute of Medical Sciences, Jeju National University
ORCID: Kim, Sang-Cheol
Boo, Hye-Jin
Kwon, Jung-Mi
Hyun, Jin-Won
Yoo, Eun-Sook
Kang, Hee-Kyoung
Venue: Biological & Pharmaceutical Bulletin
Publisher: Pharmaceutical Society of Japan
Published: 2009
Volume: 32
Issue: 10
Pages: 1760-1764
ISSN: 0918-6158 (ISSN-L)
1347-5215
DOI: 10.1248/bpb.32.1760
OpenAlex: W2084350967
Cited by: 150
References: 35
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 13 · 2020: 8 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 5
FWCI: 11.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biological and Pharmaceutical Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: Jeju National University
Jeju National University Hospital
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Keywords: fucoidan, Fucus vesiculosus, apoptosis, colon cancer, HCT-15 cells, Bcl-2, Bax, caspase-9, caspase-3, PARP cleavage, ERK, p38 MAPK, PI3K/Akt signaling, anticancer activity
MeSH terms: Adenocarcinoma, Antineoplastic Agents, Phytogenic, Colonic Neoplasms, Humans, Phytotherapy, Plant Extracts, Poly(ADP-ribose) Polymerases, Polysaccharides, Signal Transduction, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Phosphatidylinositol 3-Kinases, Fucus, Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases, p38 Mitogen-Activated Protein Kinases, bcl-2-Associated X Protein, Proto-Oncogene Proteins c-akt, Caspase 3, Caspase 9

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks