The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Biofilms: Formation, drug resistance and alternatives to conventional approaches
Open accessAbstract
Biofilms are aggregates of bacteria, in most cases, which are resistant usually to broad-spectrum antibiotics in their typical concentrations or even in higher doses. A trend of increasing multi-drug resistance in biofilms, which are responsible for emerging life-threatening nosocomial infections, is becoming a serious problem. Biofilms, however, are at various sensitivity levels to environmental factors and are versatile in infectivity depending on virulence factors. This review presents the fundamental information about biofilms: formation, antibiotic resistance, impacts on public health and alternatives to conventional approaches. Novel developments in micro-biosystems that help reveal the new treatment tools by sensing and characterization of biofilms will also be discussed. Understanding the formation, structure, physiology and properties of biofilms better helps eliminate them by the usage of appropriate antibiotics or their control by novel therapy approaches, such as anti-biofilm molecules, effective gene editing, drug-delivery systems and probiotics.
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Cites
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
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RNA-guided editing of bacterial genomes using CRISPR-Cas systems
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Definitions and guidelines for research on antibiotic persistence
Balaban, N. Q., Helaine, S., Lewis, K., Ackermann, M., Aldridge, B., Andersson, D. I., Brynildsen, M. P., Bumann, D., Camilli, A., Collins, J. J., et al. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0196-3 · Cited by 1,313
Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses
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“In-depth knowledge and understanding of the mechanisms of biofilm matrix formation, its structural components and how communication occurs aid in developing better methods to impede colonization on medical or non-medical devices [69].”
BackgroundInfluentialNovel Strategies for the Prevention and Treatment of Biofilm Related Infections
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Role of Multicellular Aggregates in Biofilm Formation
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Cited by
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Naik, G. A. R. R., Roy, A. A., Mutalik, S., & Dhas, N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134977 · Cited by 47
Mafe, A. N., & Büsselberg, D. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070820 · Cited by 18
Teymouri, S., Yousefi, M. H., Heidari, S., Farokhi, S., Afkhami, H., & Kashfi, M. (2025) · Molecular Biology Reports · doi:10.1007/s11033-024-10163-x · Cited by 11
Metadata
- Authors
- Mirghani, R., Saba, T., Khaliq, H., Mitchell, J., Do, L., Chambi, L., Diaz, K., Kennedy, T., Alkassab, K., Huynh, T., Elmi, M., Martinez, J., Sawan, S., & Rijal, G.
- Venue
- AIMS Microbiology
- Published
- 2022
- Volume
- 8
- Issue
- 3
- Pages
- 239-277
- ISSN
- 2471-1888 (ISSN-L)
- OpenAlex
- W4285131573
- Cited by
- 333
- References
- 13
- FWCI
- 18.16
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mirghani, R., Saba, T., Khaliq, H., Mitchell, J., Do, L., Chambi, L., Diaz, K., Kennedy, T., Alkassab, K., Huynh, T., Elmi, M., Martinez, J., Sawan, S., & Rijal, G. (2022). Biofilms: Formation, drug resistance and alternatives to conventional approaches. AIMS Microbiology. https://doi.org/10.3934/microbiol.2022019
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
