The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“insulin-induced nutritive blood flow (i.e. microvascular perfusion) can be improved in older adults for up to 16 h by as little as 45 min of moderate-paced walking, which is concomitant with an increase in intramuscular anabolic signaling (e.g. mechanistic target of rapamycin; mTOR) and muscle protein synthesis to exogenous insulin and/or amino acids [40, 41].”
From Protein Requirements for Master Athletes: Just Older Versions of Their Younger Selves (2021) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
DeSouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., Tanaka, H., & Seals, D. R. (2000) · Circulation · doi:10.1161/01.cir.102.12.1351 · Cited by 896 · cited 1×
“The nutrient-induced vasodilation was likely due to a direct effect of endogenous hyperinsulinemia on endothelial-dependent nitric oxide synthesis— a process that is impaired in sedentary older adults (8, 16, 36, 37) but can be restored by aerobic physical activity (25, 38).”
BackgroundDreyer, H. C., Fujita, S., Cadenas, J. G., Chinkes, D. L., Volpi, E., & Rasmussen, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113175 · Cited by 570 · cited 1×
“Specific details of our immunoblotting technique have been reported elsewhere (32).”
MethodSelf-citationAmino acid ingestion improves muscle protein synthesis in the young and elderly
Paddon-Jones, D., Sheffield-Moore, M., Zhang, X.-J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00368.2003 · Cited by 467
Self-citationVolpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464
Self-citationBiolo, G., Declan Fleming, R. Y., & Wolfe, R. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117731 · Cited by 442
Guillet, C., Prod'homme, M., Balage, M., Gachon, P., Giraudet, C., Morin, L., Grizard, J., & Boirie, Y. (2004) · The FASEB Journal · doi:10.1096/fj.03-1341fje · Cited by 412
Fujita, S., Rasmussen, B. B., Cadenas, J. G., Drummond, M. J., Glynn, E. L., Sattler, F. R., & Volpi, E. (2007) · Diabetes · doi:10.2337/db06-1566 · Cited by 224
Self-citation
Research works printed but not linked: 30
- Fried LP, Hadley EC, Walston JD, Newman AB, Guralnik JM, Studenski S, Harris TB, Ershler WB, Ferrucci L. From bedside to bench: research agenda for frailty. Sci Aging Knowledge Environ 2005;2005:pe24. · DOI · Paper page
- Janssen, 2004, Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women, Am J Epidemiol, 159, 413, 10.1093/aje/kwh058 · DOI · Paper page
- Sayer, 2006, Falls, sarcopenia, and growth in early life: findings from the Hertfordshire cohort study, Am J Epidemiol, 164, 665, 10.1093/aje/kwj255 · DOI
- Volpi, 2001, Basal muscle amino acid kinetics and protein synthesis in healthy young and older men, JAMA, 286, 1206, 10.1001/jama.286.10.1206 · DOI · Paper page
- Katsanos, 2005, Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids, Am J Clin Nutr, 82, 1065, 10.1093/ajcn/82.5.1065 · DOI · Paper page
- Rasmussen, 2002, Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly, J Nutr Health Aging, 6, 358
- Symons, 2007, Aging does not impair the anabolic response to a protein-rich meal, Am J Clin Nutr, 86, 451, 10.1093/ajcn/86.2.451 · DOI · Paper page
- Symons, 2009, A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects, J Am Diet Assoc, 109, 1582, 10.1016/j.jada.2009.06.369 · DOI · Paper page
- Volpi, 1999, Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction, Am J Physiol, 277, E513
- Rasmussen, 2006, Insulin resistance of muscle protein metabolism in aging, FASEB J, 20, 768, 10.1096/fj.05-4607fje · DOI · Paper page
- Timmerman, 2010, Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling, J Clin Endocrinol Metab, 95, 3848, 10.1210/jc.2009-2696 · DOI · Paper page
- Bennet, 1990, Euglycemic hyperinsulinemia augments amino acid uptake by human leg tissues during hyperaminoacidemia, Am J Physiol, 259, E185
- Bennet, 1991, Protein anabolic actions of insulin in the human body, Diabet Med, 8, 199, 10.1111/j.1464-5491.1991.tb01572.x · DOI
- Fujita, 2006, Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability, Am J Physiol Endocrinol Metab, 291, E745, 10.1152/ajpendo.00271.2005 · DOI · Paper page
- Hillier, 1998, Extreme hyperinsulinemia unmasks insulin’s effect to stimulate protein synthesis in the human forearm, Am J Physiol, 274, E1067
- Fujita, 2009, Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism, Diabetologia, 52, 1889, 10.1007/s00125-009-1430-8 · DOI · Paper page
- Jorfeldt, 1971, Leg blood flow during exercise in man, Clin Sci, 41, 459, 10.1042/cs0410459 · DOI · Paper page
- Jorfeldt, 1978, The influence of ethanol on splanchnic and skeletal muscle metabolism in man, Metabolism, 27, 97, 10.1016/0026-0495(78)90128-2 · DOI
- Clerk, 2006, Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle, Diabetes, 55, 1436, 10.2337/db05-1373 · DOI · Paper page
- Dawson, 2002, Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound, Am J Physiol Endocrinol Metab, 282, E714, 10.1152/ajpendo.00373.2001 · DOI
- Vincent, 2006, Mixed meal and light exercise each recruit muscle capillaries in healthy humans, Am J Physiol Endocrinol Metab, 290, E1191, 10.1152/ajpendo.00497.2005 · DOI
- Wei, 1998, Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion, Circulation, 97, 473, 10.1161/01.CIR.97.5.473 · DOI · Paper page
- Wolfe RR, Chinkes DL. Isotope tracers in metabolic research. Principles and practice of kinetic analysis. New York, NY: Wiley-Liss, 2005.
- Wolfe RR. Radioactive and stable isotope tracers in biomedicine. Principles and practice of kinetic analysis. New York, NY: Wiley-Liss, 1992.
- Calder, 1992, The determination of low d5-phenylalanine enrichment (0.002-0.09 atom percent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gas chromatography/electron ionization mass spectrometry, Rapid Commun Mass Spectrom, 6, 421, 10.1002/rcm.1290060704 · DOI
- Taddei, 2001, Age-related reduction of NO availability and oxidative stress in humans, Hypertension, 38, 274, 10.1161/01.HYP.38.2.274 · DOI · Paper page
- Galetta, 2006, Ambulatory blood pressure monitoring and endothelium-dependent vasodilation in the elderly athletes, Biomed Pharmacother, 60, 443, 10.1016/j.biopha.2006.07.013 · DOI
- Möller-Loswick, 1994, Insulin selectively attenuates breakdown of nonmyofibrillar proteins in peripheral tissues of normal men, Am J Physiol, 266, E645
- Greenhaff, 2008, Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle, Am J Physiol Endocrinol Metab, 295, E595, 10.1152/ajpendo.90411.2008 · DOI · Paper page
- Tudor-Locke, 2004, How many steps/day are enough? Preliminary pedometer indices for public health, Sports Med, 34, 1, 10.2165/00007256-200434010-00001 · DOI · Paper page
Cited by
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553
Self-citationDeutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738
Moore, D. R., Churchward-Venne, T. A., Witard, O., Breen, L., Burd, N. A., Tipton, K. D., & Phillips, S. M. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu103 · Cited by 770
Anabolic Resistance of Muscle Protein Synthesis with Aging
Burd, N. A., Gorissen, S. H., & van Loon, L. J. C. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318292f3d5 · Cited by 384
Sarcopenic obesity in older adults: a clinical overview
Prado, C. M., Batsis, J. A., Donini, L. M., Gonzalez, M. C., & Siervo, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00943-z · Cited by 355
Metadata
- Authors
- Timmerman, K. L., Dhanani, S., Glynn, E. L., Fry, C. S., Drummond, M. J., Jennings, K., Rasmussen, B. B., & Volpi, E.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 95
- Issue
- 6
- Pages
- 1403-1412
- ISSN
- 0002-9165
- Cited by
- 120
- References
- 13
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3918 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. https://app.cochat.ai/papers/10.3945/ajcn.111.020800
- The paper
- Timmerman, K. L., Dhanani, S., Glynn, E. L., Fry, C. S., Drummond, M. J., Jennings, K., Rasmussen, B. B., & Volpi, E. (2012). A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. The American Journal of Clinical Nutrition. https://doi.org/10.3945/ajcn.111.020800
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.