Aging does not impair the anabolic response to a protein-rich meal
Open accessAbstract
Background Sarcopenia is a debilitating condition afflicting the elderly that may be facilitated by insufficient or ineffectual intake of dietary protein. We previously showed that free-form essential amino acids acutely stimulate muscle protein synthesis in both the young and the elderly. However, the ability of an actual protein-rich food to stimulate anabolism in the young and the elderly has not been explored.Objective We aimed to characterize changes in plasma amino acid concentrations and to quantify muscle protein synthesis in healthy young (41 +/- 8 y old; n = 10) and elderly (70 +/- 5 y old; n = 10) persons after ingestion of a 113-g (4-oz) serving of lean beef.Design Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 mumol/kg) constant infusion (0.08 mumol.kg(-1).min(-1)) of l-[ring-(13)C(6)] phenylalanine. Plasma amino acid concentrations were measured and a mixed-muscle fractional synthesis rate (FSR) was calculated during the premeal period and for 5 h after beef ingestion.Results Mixed-muscle FSR increased by approximately 51% in both the elderly (mean +/- SE measurements: 0.072 +/- 0.004%/h and 0.108 +/- 0.006%/h before and after the meal, respectively) and the young (0.074 +/- 0.005%/h and 0.113 +/- 0.005%/h before and after the meal, respectively) after beef ingestion (P < 0.001). Plasma amino acid concentrations peaked at approximately 100 min after beef ingestion in both age groups but were substantially higher in the elderly (2185 +/- 134 nmol/mL compared with 1403 +/- 96 nmol/mL; P < 0.001).Conclusion Despite differences in the concentration of amino acids in the plasma precursor pool, aging does not impair the ability to acutely synthesize muscle protein after ingestion of a common protein-rich food.
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Beef is considered to be of high biological value because it contains the full balance of EAAs in a fraction similar to that found in human skeletal muscle.
“Beef is a common source of dietary protein and is considered to be of high biological value because it contains the full balance of EAAs in a fraction similar to that found in human skeletal muscle [182].”
From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [182]
Meat proteins are well known to be rich sources of the EAAs.
“Meat proteins are well known to be rich sources of the EAAs [182].”
From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [182]
A 30 g dose of beef protein has been shown to stimulate protein synthesis in both young and elderly subjects.
“Moreover, this 30 g dose of beef protein has been shown to stimulate protein synthesis in both young and elderly subjects [182].”
From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [182]
Old age does not always reduce the muscle-building response to a protein-rich meal.
“Ageing does not necessarily impair the anabolic response to a protein-rich meal.138”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [138]
The muscle mass of older individuals retains the ability to mount a robust anabolic response following the ingestion of protein-rich meals.
“the muscle mass of older individuals retains the ability to mount a robust anabolic response following the ingestion of protein-rich meals [49].”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [49]
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- Authors
- Symons, T. B., Schutzler, S. E., Cocke, T. L., Chinkes, D. L., Wolfe, R. R., & Paddon-Jones, D.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 86
- Issue
- 2
- Pages
- 451-456
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2144001753
- Cited by
- 240
- References
- 33
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 20 · 2019: 5 · 2018: 15 · 2017: 10 · 2016: 13 · 2015: 24 · 2014: 19 · 2013: 18 · 2012: 22
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P30AG024832)
- National Center for Research Resources (M01 RR-00073, M01RR000073)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- aging, sarcopenia, muscle protein synthesis, dietary protein, protein-rich meals, lean beef, plasma amino acids, essential amino acids, fractional synthesis rate, vastus lateralis
- MeSH terms
- Adipose Tissue, Adult, Aged, Aging, Amino Acids, Amino Acids, Essential, Carbon Isotopes, Dietary Proteins, Female, Humans, Infusions, Intravenous, Male, Meat, Middle Aged, Phenylalanine, Body Mass Index
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