CoChat
Sign Up
Cited by 108Folate and B Vitamins ResearchChild Nutrition and Water AccessIron Metabolism and Disorders

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Cobalamin and folate status predicts mental development scores in North Indian children 12–18 mo of age

Open access
Strand, Tor A, Taneja, Sunita, Ueland, Per M, Refsum, Helga, Bahl, Rajiv, Schneede, Joern, Sommerfelt, Halvor, Bhandari, Nita·2013·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.111.032268
Open this paper in CoChat — free account

Abstract

Background Micronutrient deficiencies can affect cognitive function. Many young children in low- and middle-income countries have inadequate cobalamin (vitamin B-12) status.Objective The objective was to measure the association of plasma concentrations of folate, cobalamin, total homocysteine, and methylmalonic acid with cognitive performance at 2 occasions, 4 mo apart, in North Indian children aged 12-18 mo.Design Bayley Scales of Infant Development II were used to assess cognition. In multiple regression models adjusted for several potential confounders, we measured the association between biomarkers for folate and cobalamin status and psychomotor or mental development scores on the day of blood sampling and 4 mo thereafter.Results Each 2-fold increment in plasma cobalamin concentration was associated with a significant increment in the mental development index score of 1.3 (95% CI: 0.2, 2.4; P = 0.021). Furthermore, each 2-fold increment in homocysteine or methylmalonic acid concentration was associated with a decrement in mental development index score of 2.0 (95% CI: 0.5, 3.4; P = 0.007) or 1.1 (95% CI: 0.3, 1.8; P = 0.004) points, respectively. Plasma folate concentration was significantly and independently associated with mental development index scores only when children with poor cobalamin status were excluded, ie, in those who had cobalamin concentrations below the 25th percentile. None of these markers was associated with psychomotor scores in the multiple regression models.Conclusions Cobalamin and folate status showed a statistically significant association with cognitive performance. Given the high prevalence of deficiencies in these nutrients, folate and cobalamin supplementation trials are required to measure any beneficial effect on cognition.

Overview

Integrity signals

Registry

Crossref · 10.3945/ajcn.111.032268

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Allen, 1999, Cognitive and neuromotor performance of Guatemalan schoolers with deficient, marginal and normal plasma B-12, FASEB J, 13, A544

Cited by

Sorted by citations

See all 108

Related

See all

Metadata

Authors
Strand, T. A., Taneja, S., Ueland, P. M., Refsum, H., Bahl, R., Schneede, J., Sommerfelt, H., & Bhandari, N.
Affiliations
University of Bergen (NO)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2013-02
Volume
97
Issue
2
Pages
310-317
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.111.032268
OpenAlex
W2112708641
Cited by
108
References
38
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 13 · 2022: 14 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 4 · 2014: 10 · 2013: 2
FWCI
7.09
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
vitamin B12, folic acid, homocysteine, methylmalonic acid, cognitive development, infant cognitive development, micronutrient deficiency, plasma biomarkers, psychomotor development, North Indian children
MeSH terms
Child Development, Developmental Disabilities, Cognition Disorders, Female, Folic Acid, Folic Acid Deficiency, Homocysteine, Humans, India, Infant, Male, Methylmalonic Acid, Nutritional Status, Psychomotor Performance, Vitamin B 12, Vitamin B 12 Deficiency, Cohort Studies, Biomarkers, Prevalence, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review