Cited by 289Nutritional Studies and DietCardiovascular Health and Risk FactorsNuts composition and effects

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Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and meta-analysis

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Shin, Jang Yel, Xun, Pengcheng, Nakamura, Yasuyuki, He, Ka·2013·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.112.051318PMC PMC3683816

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Abstract

Background The associations of egg consumption with cardiovascular disease (CVD) and diabetes are still unclear.Objective We aimed to quantitatively summarize the literature on egg consumption and risk of CVD, cardiac mortality, and type 2 diabetes by conducting a meta-analysis of prospective cohort studies.Design A systematic literature review was conducted for published studies in PubMed and EMBASE through March 2012. Additional information was retrieved through Google or a hand review of the reference from relevant articles. Studies were included if they had a prospective study design, were published in English-language journals, and provided HRs and 95% CIs for the associations of interest. Data were independently extracted by 2 investigators, and the weighted HRs and 95% CIs for the associations of interest were estimated by using a random-effects model.Results A total of 22 independent cohorts from 16 studies were identified, including participants ranging in number from 1600 to 90,735 and in follow-up time from 5.8 to 20.0 y. Comparison of the highest category (≥1 egg/d) of egg consumption with the lowest (<1 egg/wk or never) resulted in a pooled HR (95% CI) of 0.96 (0.88, 1.05) for overall CVD, 0.97 (0.86, 1.09) for ischemic heart disease, 0.93 (0.81, 1.07) for stroke, 0.98 (0.77, 1.24) for ischemic heart disease mortality, 0.92 (0.56, 1.50) for stroke mortality, and 1.42 (1.09, 1.86) for type 2 diabetes. Of the studies conducted in diabetic patients, the pooled HR (95% CI) was 1.69 (1.09, 2.62) for overall CVD.Conclusions This meta-analysis suggests that egg consumption is not associated with the risk of CVD and cardiac mortality in the general population. However, egg consumption may be associated with an increased incidence of type 2 diabetes among the general population and CVD comorbidity among diabetic patients.

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Authors: Shin, J. Y., Xun, P., Nakamura, Y., & He, K.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: He, Ka
ORCID: Shin, Jang Yel
Xun, Pengcheng
Nakamura, Yasuyuki
He, Ka
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2013-07
Volume: 98
Issue: 1
Pages: 146-159
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.112.051318
PMC: PMC3683816
OpenAlex: W2150644041
Cited by: 289
References: 79
Citations by year: 2026: 4 · 2025: 10 · 2024: 11 · 2023: 13 · 2022: 30 · 2021: 20 · 2020: 29 · 2019: 27 · 2018: 32 · 2017: 38 · 2016: 21 · 2015: 33 · 2014: 16 · 2013: 4
FWCI: 3.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3519 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R21DK073812)
National Institute of Neurological Disorders and Stroke (R21NS056445)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
Keywords: egg consumption, cardiovascular disease, type 2 diabetes, ischemic heart disease, stroke, cardiac mortality, diabetes comorbidity, dietary cholesterol, dietary fat
MeSH terms: Cardiovascular Diseases, Diabetes Mellitus, Type 2, Eggs, Humans, Risk Factors, Incidence, Randomized Controlled Trials as Topic, Databases, Factual

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Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and meta-analysis

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